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    • 2. 发明授权
    • Topical composition for skin
    • 皮肤专题组成
    • US07189708B2
    • 2007-03-13
    • US10252057
    • 2002-09-23
    • Yasuto SuzukiMikako WatanabeNaoko TsujiShigeru MoriwakiShinya Amano
    • Yasuto SuzukiMikako WatanabeNaoko TsujiShigeru MoriwakiShinya Amano
    • A61K31/545
    • C07C237/20A61K38/05
    • A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.
    • 含有由式(1)表示的二肽化合物或二肽盐的局部皮肤组合物:其中R 1表示氢原子,烷基,烷酰基或-CH(R' 其中R 6表示氢原子或低级烷基,R 7表示氢原子或低级烷基, 氢原子,低级烷基,低级烯基或芳烷基)。 R 2表示氢原子或可以具有取代基的烷基; R 3表示低级烷基或苯基; R 4表示氢原子或低级烷基,并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子,可以具有取代基的烷基或可具有取代基的芳烷基,并且可以与R 4一起形成杂环, ; X表示-COOR 8(其中R 8表示氢原子,低级烷基,低级烯基或芳烷基)或-SO 3 H; 并且n是0-4的整数; 和其药学上可接受的载体。
    • 3. 发明授权
    • Phosphorylated glyceryl ether aluminum salt
    • 磷酸化甘油醚铝盐
    • US07371740B2
    • 2008-05-13
    • US10930773
    • 2004-09-01
    • Shinya AmanoTomohiko SanoHiromitsu KawadaTakashi Kawata
    • Shinya AmanoTomohiko SanoHiromitsu KawadaTakashi Kawata
    • A61K31/66C07F9/02
    • A61K8/556A61K8/26A61Q19/00A61Q19/08C07F9/091
    • The present invention relates to a phosphorylated glyceryl ether aluminum salt represented by the general formula (1): (wherein R1 represents an alkyl or an alkenyl group with 8 to 32 carbon atoms; R2 represents a hydrogen atom, a phosphoric acid residue or —CH2CH(OR2)CH2OR1 (wherein R1 and R2 are the same as described above, provided that a repeated binding number is 4 at the most when R2 is —CH2CH(OR2)CH2OR1); X1 represents a hydrogen atom or a phosphoric acid residue, and at least one of X1 and R2 is a phosphoric acid residue; Y represents an alkali metal atom or an alkaline earth metal atom; m represents a number from 0.3 to 1, and n represents a number from 0 to 1), and an external dermatological agent containing the same. The compound has benefits such as an excellent pore contracting activity and also a good solubility in oil.
    • 本发明涉及由通式(1)表示的磷酸化甘油醚铝盐:(其中R 1表示具有8至32个碳原子的烷基或烯基; R 2 表示氢原子,磷酸残基或-CH 2 CH 2(OR 2)CH 2或OR 1 (其中R 1和R 2)与上述相同,条件是当R 2为重复结合数最多为4时, / SUP>是-CH 2 CH 2(OR 2)CH 2或OR 1); X < 1 表示氢原子或磷酸残基,X 1和R 2 2中的至少一个为磷酸残基; Y表示碱金属 原子或碱土金属原子; m表示0.3〜1的数,n表示0〜1的数),以及含有该原子的外用皮肤病药。 该化合物具有优异的孔收缩活性和在油中的良好的溶解性。
    • 4. 发明授权
    • Topical composition for skin
    • 皮肤专题组成
    • US06489291B1
    • 2002-12-03
    • US09678615
    • 2000-10-04
    • Yasuto SuzukiMikako WatanabeNaoko TsujiShigeru MoriwakiShinya Amano
    • Yasuto SuzukiMikako WatanabeNaoko TsujiShigeru MoriwakiShinya Amano
    • A01N3718
    • C07C237/20A61K38/05
    • A topical skin composition containing a dipeptide compound represented by, formula (1) or a salt of the dipeptide: wherein R1 represents a, hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.
    • 含有由式(1)表示的二肽化合物或二肽盐的局部皮肤组合物:其中R1表示氢原子,烷基,烷酰基或-CH(R6)COOR7(其中R6表示 氢原子或低级烷基,R7表示氢原子,低级烷基,低级烯基或芳烷基); R2表示氢原子或可具有取代基的烷基; R3表示低级 烷基或苯基; R 4表示氢原子或低级烷基,并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子,可以具有取代基的烷基或 可以具有取代基的芳烷基,也可以与R4形成杂环; X表示-COOR8(其中R8表示氢原子,低级烷基,低级烯基或芳烷基)或-SO3H; andn是0-4的整数; 和其药学上可接受的载体。
    • 9. 发明授权
    • Continuous data server apparatus and data transfer scheme enabling
multiple simultaneous data accesses
    • 连续数据服务器设备和数据传输方案支持多次同时访问数据
    • US5862403A
    • 1999-01-19
    • US603759
    • 1996-02-16
    • Tatsunori KanaiShigehiro AsanoTakeshi AikawaShinya Amano
    • Tatsunori KanaiShigehiro AsanoTakeshi AikawaShinya Amano
    • G06F3/06G06F11/10H04L12/54H04L12/861H04L12/883G06F15/02
    • H04L12/5693G06F11/1076G06F11/1088G06F3/0601H04L49/90H04L49/9021H04L49/9047H04L49/9073G06F2003/0692
    • A continuous data server apparatus incorporating a plurality of buffer memory units for storing the continuous data read out by the data memory control units and to be given to the communication control unit, at least one buffer memory unit being provided dedicatedly for each combination of one data memory control unit group formed by at least one data memory control unit and one communication control unit group formed by at least one communication control unit. The apparatus may further incorporate a plurality of calculation units connected in series, where each calculation unit is connected between corresponding one data memory control unit group and at least one buffer memory unit, and carrying out a prescribed calculation processing. The continuous data can be arranged over a plurality of data memory control units in word units, such that the data memory control units read out the continuous data in block units, the buffer memory units store the continuous data in block units, and the communication control unit transfers the continuous data obtained by reading out data the buffer memory units sequentially in word units.
    • 一种连续数据服务器装置,其包括多个缓冲存储器单元,用于存储由数据存储器控制单元读出的连续数据,并被提供给通信控制单元,至少一个缓冲存储器单元专门为一个数据的每个组合提供 由至少一个数据存储器控制单元形成的存储器控​​制单元组和由至少一个通信控制单元形成的一个通信控制单元组。 该装置还可以包括串联连接的多个计算单元,其中每个计算单元连接在相应的一个数据存储器控制单元组和至少一个缓冲存储器单元之间,并执行规定的计算处理。 连续数据可以以单位单位布置在多个数据存储器控制单元上,使得数据存储器控制单元以块为单位读出连续数据,缓冲存储器单元以块为单位存储连续数据,并且通信控制 单元通过以字为单位顺序地读出缓冲存储器单元的数据而获得的连续数据。