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1. 发明申请

US20110105439A1 Ceramide Production Promoter 有权
标题翻译：神经酰胺生产促进剂
公开(公告)号：US20110105439A1
公开(公告)日：2011-05-05
申请号：US13001701
申请日：2009-07-30
申请人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
发明人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
IPC分类号： A61K8/55 , C07F9/09 , A61Q19/00
CPC分类号： A61K8/55 , A61K8/553 , A61K31/661 , A61Q19/00 , A61Q19/007
摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
摘要翻译：提供用于促进神经酰胺生产的药物，化妆品等。本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。

2. 发明授权

US08440645B2 Ceramide production promoter 有权
标题翻译：神经酰胺生产促进剂
公开(公告)号：US08440645B2
公开(公告)日：2013-05-14
申请号：US13001701
申请日：2009-07-30
申请人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
发明人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
IPC分类号： A61K8/55 , A61Q19/00 , C07F9/06
CPC分类号： A61K8/55 , A61K8/553 , A61K31/661 , A61Q19/00 , A61Q19/007
摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
摘要翻译：提供促进神经酰胺生产的药物，化妆品等。本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。

3. 发明授权

US09445987B2 Ceramide production enhancer and moisturizer 有权
标题翻译：神经酰胺生产增强剂和保湿剂
公开(公告)号：US09445987B2
公开(公告)日：2016-09-20
申请号：US13499810
申请日：2010-09-27
申请人： Yoshie Shimotoyodome , Shotaro Ito , Yoshiya Sugai , Hiroshi Hashimoto , Junko Ishikawa
发明人： Yoshie Shimotoyodome , Shotaro Ito , Yoshiya Sugai , Hiroshi Hashimoto , Junko Ishikawa
IPC分类号： A61K31/58 , A61K8/97 , A23L1/00 , A23L1/30 , A61K8/63 , A61K36/185 , A61K36/28 , A61K36/48 , A61Q19/00 , C07D493/08
CPC分类号： A61K8/63 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/042 , A61K8/064 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/58 , A61K36/185 , A61K36/28 , A61K36/48 , A61K2800/805 , A61Q19/00 , A61Q19/007 , C07D493/08
摘要： A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).

4. 发明申请

US20120196841A1 Ceramide Production Enhancer and Moisturizer 有权
标题翻译：神经酰胺生产增效剂和保湿剂
公开(公告)号：US20120196841A1
公开(公告)日：2012-08-02
申请号：US13499810
申请日：2010-09-27
申请人： Yoshie Shimotoyodome , Shotaro Ito , Yoshiya Sugai , Hiroshi Hashimoto , Junko Ishikawa
发明人： Yoshie Shimotoyodome , Shotaro Ito , Yoshiya Sugai , Hiroshi Hashimoto , Junko Ishikawa
IPC分类号： A61K8/63 , A61Q19/00
CPC分类号： A61K8/63 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/042 , A61K8/064 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/58 , A61K36/185 , A61K36/28 , A61K36/48 , A61K2800/805 , A61Q19/00 , A61Q19/007 , C07D493/08
摘要： A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).
摘要翻译：一种神经酰胺生产增强剂和保湿剂，其含有至少一种植物的提取物作为活性成分，所述植物提取物选自杂Chen藜，美洲梧桐，靛蓝，日本C um，梓vate和万寿菊，或代表通过下式（1）表示：其中，R表示碳原子数为1〜5的酰基。

5. 发明授权

US4907646A Heat exchanger 失效
标题翻译：热交换器
公开(公告)号：US4907646A
公开(公告)日：1990-03-13
申请号：US262821
申请日：1988-10-26
申请人： Osamu Aoyagi , Shoichi Yokoyama , Hirotada Kaneko , Eiji Nakatsuno , Shotaro Ito
发明人： Osamu Aoyagi , Shoichi Yokoyama , Hirotada Kaneko , Eiji Nakatsuno , Shotaro Ito
IPC分类号： F28F1/32
CPC分类号： F28F1/325 , Y10S165/502
摘要： A heat exchanger has groups of cutouts provided on tabular fin surfaces, projecting in the direction of arrangement of the fins. Each of the cutouts has two opposed openings in the main direction of air flow as well as two leg portions that not parallel with the main direction of air flow, the cutouts being formed on the tabular fin surfaces alternately on the front and rear sides with a fin base portion placed therebetween. The heat exchanger substantially reduces heat resistance between the air and the fin surfaces and ventilation resistance when the humidity is high, and excels in noise characteristics since the configuration of each cutout provided on the fin surface on the air inlet side of a cross flow fan is changed.
摘要翻译：热交换器具有设置在平板状翅片表面上的切口组，其沿散热片的排列方向突出。每个切口在空气流动的主要方向上具有两个相对的开口以及不与空气流的主要方向平行的两个腿部，切口在前侧和后侧交替地形成在平板状翅片表面上，翅片基部放置在其间。热交换器大大降低了空气和散热片表面之间的耐热性，并且当湿度高时具有通风阻力，并且由于设置在横流风扇的进气侧的散热片表面上的每个切口的构造是噪声特性优异的改变了

6. 发明授权

US6148631A Silencer and air conditioner 有权
标题翻译：消声器和空调
公开(公告)号：US6148631A
公开(公告)日：2000-11-21
申请号：US311343
申请日：1999-05-13
申请人： Masahito Watanabe , Yoshimasa Katsumi , Yasuki Fujii , Shotaro Ito , Masanori Tanigawa , Yasuhiro Asaida
发明人： Masahito Watanabe , Yoshimasa Katsumi , Yasuki Fujii , Shotaro Ito , Masanori Tanigawa , Yasuhiro Asaida
IPC分类号： F01N1/08 , F04B39/00 , F25B13/00 , F25B39/02 , F25B41/00 , F25B41/06 , G10K11/16 , F25D19/00
CPC分类号： F25B41/003 , F25B13/00 , F25B2313/0233 , F25B2500/12 , F25B39/028 , F25B41/062
摘要： A plurality of honeycomb pipes bundling a plurality of fine tubes are inserted and fixed at desired positions in a refrigerant piping at proper intervals to form a silencer, and noise is reduced by straightening and homogenizing the disturbance of refrigerant and attenuating transmission of pressure pulsations.
摘要翻译：将多根细管的多个蜂窝管以适当的间隔插入并固定在制冷剂配管的期望位置，形成消声器，通过矫正和均化制冷剂的扰动并减弱压力脉动的传递而降低噪音。

7. 发明授权

US4898003A Automobile air conditioner 失效
标题翻译：汽车空调
公开(公告)号：US4898003A
公开(公告)日：1990-02-06
申请号：US264884
申请日：1988-10-31
申请人： Toru Ichikawa , Shuichi Kodama , Nobuo Kagoroku , Shotaro Ito , Shuichi Honda
发明人： Toru Ichikawa , Shuichi Kodama , Nobuo Kagoroku , Shotaro Ito , Shuichi Honda
IPC分类号： B60H1/32
CPC分类号： B60H1/3229 , B60H2001/00235
摘要： An automobile air conditioner which has a generally elongated casing having air intake and outlet grilles defined at opposite sides thereof, a generally elongated evaporator accommodated within the casing so as to extend generally parallel to the direction of elongation of the casing and positioned adjacent the air intake grille, at least one cross-flow fan accommodated within the casing so as to extend generally parallel to the direction of elongation of the casing and positioned between the evaporator and the air outlet grille, and a drive unit for driving the cross-flow fan in one direction for blowing air from the inlet grille to the air outlet grille. The evaporator is supported in position within the casing in a tilted fashion with its upper edge towards the cross-flow fan.
摘要翻译：一种汽车空调机，其具有通常细长的外壳，其具有限定在其相对侧的进气和出口格栅，容纳在壳体内的大致细长的蒸发器，以便大致平行于壳体的伸长方向延伸并且定位成邻近进气口格栅，容纳在所述壳体内的至少一个横流风扇，其大致平行于所述壳体的伸长方向延伸并且位于所述蒸发器和所述排气格栅之间，以及用于驱动所述横流风扇的驱动单元从入口格栅吹送空气到排气格栅的一个方向。蒸发器以倾斜的方式支撑在壳体内的适当位置，其上边缘朝向横流风扇。

8. 发明申请

US20110200694A1 Promotors of Ceramide's Generation 审中-公开
标题翻译：神经酰胺一代的启动子
公开(公告)号：US20110200694A1
公开(公告)日：2011-08-18
申请号：US13059329
申请日：2009-08-17
申请人： Wan Zhang Qin , Chun Xin Yang , Fan Qi Kong , Hiroshi Nojiri , Shotaro Ito
发明人： Wan Zhang Qin , Chun Xin Yang , Fan Qi Kong , Hiroshi Nojiri , Shotaro Ito
IPC分类号： A61K36/484 , A61K36/232 , A61K36/64 , A61K36/284 , A61K36/898 , A61K36/704 , A61K36/346 , A61K36/53 , A61K36/8945 , A61P17/00 , A61P35/00 , A61P29/00 , A61P19/00
CPC分类号： A61K36/898 , A61K8/97 , A61K36/232 , A61K36/284 , A61K36/346 , A61K36/484 , A61K36/533 , A61K36/64 , A61K36/70 , A61K36/708 , A61K36/8945 , A61Q19/00
摘要： The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuli, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.
摘要翻译：本发明提供可以加速细胞中神经酰胺生产的药物组合物或化妆品。神经酰胺生产促进剂含有选自以下的植物：山茱萸，山茱萸，地黄，大黄，甘草，赤芍，白芍，白芍，，或其提取物作为活性成分。此外，本发明提供一种含有选自以下的植物的保湿剂，其中，所述植物选自草本植物（Rhizoma Dioscoreae）或其提取物作为活性成分。

9. 发明授权

US5257902A Blower with improved impeller vanes 失效
标题翻译：鼓风机叶轮改进
公开(公告)号：US5257902A
公开(公告)日：1993-11-02
申请号：US836741
申请日：1992-02-19
申请人： Masahiro Atarashi , Kiyoshi Sano , Shotaro Ito
发明人： Masahiro Atarashi , Kiyoshi Sano , Shotaro Ito
IPC分类号： F04D29/02 , F04D29/38 , F04D29/66
CPC分类号： F04D29/388 , F04D29/666
摘要： A blower includes a plurality of rotatable impeller vanes operable to impel air. The impeller vanes create an air pressure differential thereacross when rotated, and each of the impeller vanes has a porous central portion made of sintered resin material. The porous central portion has a plurality of pores therein which permit a portion of air to pass through the porous central portion from a relatively high air pressure side to a relatively low air pressure side of the impeller vanes. Each of the impeller vanes also has a non-porous portion surrounding the porous central portion. The non-porous portion is made of a solid resin material which prevents air from passing therethrough.
摘要翻译：鼓风机包括可操作以推动空气的多个可旋转的叶轮叶轮。叶轮叶片在旋转时产生空气压差，并且每个叶轮叶片具有由烧结树脂材料制成的多孔中心部分。多孔中心部分具有多个孔，其中一部分空气使多孔中心部分从相对较高的气压侧通过到叶轮叶片的相对较低的空气压侧。每个叶轮叶片还具有围绕多孔中心部分的无孔部分。无孔部分由防止空气通过的固体树脂材料制成。

10. 发明授权

US4538963A Impeller for cross-flow fan 失效
标题翻译：叶轮用于横流风扇
公开(公告)号：US4538963A
公开(公告)日：1985-09-03
申请号：US627724
申请日：1984-07-03
申请人： Takashi Sugio , Makoto Obata , Shotaro Ito
发明人： Takashi Sugio , Makoto Obata , Shotaro Ito
IPC分类号： F04D17/04 , F04D29/28 , F04D29/30 , F04D29/66
CPC分类号： F04D29/283 , Y10S416/50
摘要： An impeller for a cross-flow fan, including a plurality of impeller sections. Each impeller sections includes a pair of plate members and a number of blades extending between and circumferentially of the plate members such that the blades are circumferentially spaced at random pitch angles without periodicity.
摘要翻译：一种用于横流风扇的叶轮，包括多个叶轮部分。每个叶轮部分包括一对板构件和在板构件之间和周向延伸的多个叶片，使得叶片以无间距的角度周向间隔开，而没有周期性。

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