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1. 发明申请

WO2016119039A1 PHYSIOLOGICAL PHANTOMS INCORPORATING FEEDBACK SENSORS AND SENSING MATERIALS 审中-公开
标题翻译：包含反馈传感器和感应材料的生理学手册
公开(公告)号：WO2016119039A1
公开(公告)日：2016-08-04
申请号：PCT/CA2015/050065
申请日：2015-01-29
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal , JAGGA, Arun Victor , MAK, Siu Wai Jacky
发明人： KERINS, Fergal , JAGGA, Arun Victor , MAK, Siu Wai Jacky
IPC分类号： G09B23/30 , A61B19/00 , G08B21/18 , H04B10/071 , G01B7/16 , G01B11/16 , G01B5/18
CPC分类号： G09B23/30 , A61B2017/00716 , G01L1/00 , G09B23/285 , G09B23/286 , G09B23/32 , G09B23/34 , H04B10/071
摘要： Disclosed herein are physiological phantoms incorporating sensors and sensor materials integrated with a tissue phantom of an anatomical part. The sensors and sensor materials include small diameter optical fibers containing Bragg gratings, thermochromic materials, electrical strain gauges, flexible strain gauges, shape sensing cables, electrochromic materials and etc. The sensors and sensing materials may mimic tissue as part of the tissue phantom. They may mimic the directionality, density, elasticity of the anatomical tissues they may be mimicking. The sensors and sensing materials may be sensitive to strain, heat, electricity, shape, light, and etc. similar to what may occur during medical procedures using various medical devices and tools such as a scalpel, a needle, a deep brain stimulation probe, a port used in brain or spinal surgery and etc.
摘要翻译：本文公开的是结合有解剖部件的组织体模的传感器和传感器材料的生理体模。传感器和传感器材料包括含有布拉格光栅的小直径光纤，热变色材料，电应变计，柔性应变计，形状感测电缆，电致变色材料等。传感器和传感材料可以模拟组织作为组织体模的一部分。他们可能会模仿他们可能模仿的解剖组织的方向性，密度，弹性。传感器和感测材料可能对应变，热，电，形状，光线等敏感，类似于使用各种医疗装置和工具（诸如解剖刀，针头，深脑刺激探针）的医疗过程中可能发生的变化，用于脑或脊柱手术等的端口

2. 发明申请

WO2018071999A1 MIXED REALITY TRAINING SYSTEM 审中-公开
标题翻译：混合式现实培训系统
公开(公告)号：WO2018071999A1
公开(公告)日：2018-04-26
申请号：PCT/CA2016/000266
申请日：2016-10-21
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , SELA, Gal , KERINS, Fergal , ABHARI, Kamyar , SRIMOHANARAJAH, Kirusha
发明人： SELA, Gal , KERINS, Fergal , ABHARI, Kamyar , SRIMOHANARAJAH, Kirusha
IPC分类号： G09B23/30 , A61B34/10 , A61B34/20 , G09B9/00
摘要： A training system for training a trainee to perform a surgical procedure on an anatomical region. The system includes a physical model of the anatomical region, a physical training instrument, a tracking system configured to track the location and orientation of the physical training instrument relative to the physical model, a display device, and a computer system. The computer system receives from the tracking system information indicating the location and orientation of the physical training instrument and generates and displays an augmented physical model and the physical training instrument. The display is updated based as the trainee manipulates the physical training instrument. After the trainee has completed the surgical procedure, the computer calculates a score based on the performance of the trainee. The score is a measure of the accuracy of the surgical procedure performed by the trainee or the duration of the surgical procedure.
摘要翻译：
一种训练系统，用于训练学员在解剖区域执行外科手术。该系统包括解剖区域的物理模型，物理训练仪器，被配置为跟踪物理训练仪器相对于物理模型的位置和方向的跟踪系统，显示装置和计算机系统。计算机系统从跟踪系统接收指示身体训练仪器的位置和方向的信息，并生成并显示增强的身体模型和身体训练仪器。根据学员操作物理训练仪器的情况更新显示。学员完成外科手术后，计算机根据受训者的表现计算得分。得分是由受训者进行的外科手术的准确性或外科手术的持续时间的量度。

3. 发明申请

WO2017173518A1 MULTI-METRIC SURGERY SIMULATOR AND METHODS 审中-公开
标题翻译：多米制外科模拟器和方法
公开(公告)号：WO2017173518A1
公开(公告)日：2017-10-12
申请号：PCT/CA2016/050389
申请日：2016-04-05
申请人： GMEINER, Timotheus Anton , KERINS, Fergal , CHEUNG, Aaron Yu Lai , HOANG, Kimberly Bojanowski , SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： GMEINER, Timotheus Anton , KERINS, Fergal , CHEUNG, Aaron Yu Lai , HOANG, Kimberly Bojanowski
IPC分类号： G09B9/00 , G09B23/28 , G09B23/30
摘要： Multi-metric surgery simulator devices, systems, and methods, involving at least one sensor configured to collect surgical training performance data relevant to at least one surgical task, the at least one sensor configured to operate with a surgical navigation system comprising a processor, the processor configurable, by way of a set of executable instructions storable in relation to a non-transitory medium, to perform at least one of analyze collected data, transform the collected data, and provide feedback in relation thereto; and at least one surgery simulator apparatus operatively coupled with the at least one sensor, the at least one surgery simulator apparatus configured to operate with a tracking system, whereby collected data is obtainable and clinical performance in relation to the at least one surgical task is quantitatively evaluable and progressively improvable.
摘要翻译：涉及至少一个传感器的多度量外科手术模拟器装置，系统和方法，所述至少一个传感器被配置为收集与至少一个手术任务相关的手术训练性能数据，所述至少一个传感器被配置为利用包括处理器的外科手术导航系统，所述处理器通过一组可执行指令可相对于非临时性介质配置，以执行分析收集的数据，变换所收集的数据和提供与其有关的反馈中的至少一个 ; 以及与所述至少一个传感器可操作地耦合的至少一个手术模拟器装置，所述至少一个手术模拟器装置被配置为与跟踪系统一起操作，由此可以获得收集的数据并且定量地与所述至少一个手术任务相关的临床表现可评估和逐步改进。

4. 发明申请

WO2016181182A1 MAGNETIC RESONANCE VISIBLE LABELS AND MARKERS FOR ENCODING INFORMATION 审中-公开
标题翻译：磁共振可视标签和标记编码信息
公开(公告)号：WO2016181182A1
公开(公告)日：2016-11-17
申请号：PCT/IB2015/053396
申请日：2015-05-08
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： DYER, Kelly Noel , STAINSBY, Jeff Alan , KERINS, Fergal
IPC分类号： A61B19/00
CPC分类号： A61B5/055 , A61B90/39 , A61B90/90 , A61B90/94 , A61B90/96 , A61B2090/3933 , A61B2090/3954 , A61B2562/08 , G01R33/58
摘要： Systems and methods for manufacturing and using magnetic resonance ("MR") visible labels or markers to encode information unique to the subject or object being imaged by a magnetic resonance imaging ("MRI") system are provided. The use of such MR-visible labels or markers enables unique information associated with the subject or object being imaged to be encoded into the images of the subject or object. This information can be used to anonymize protected health information ("PHI"); to provide detailed information about a surgical simulation device, quality assurance phantom, or the like; to provide spatial orientation and registration information; or so on.
摘要翻译：提供了用于制造和使用磁共振（“MR”）可见标签或标记来编码由磁共振成像（“MRI”）系统成像的被摄体或物体特有的信息的系统和方法。使用这样的MR-可见标签或标记使与被成像对象或物体相关联的唯一信息能被编码成被摄体或物体的图像。该信息可用于匿名保护健康信息（“PHI”）; 提供关于手术模拟装置，质量保证幻影等的详细信息; 提供空间方向和注册信息; 等等。

5. 发明申请

WO2016074061A1 SURGICAL TRAINING PHANTOM WITH SPECTROSCOPICALLY DISTINCT REGIONS 审中-公开
标题翻译：具有光谱学区域的手术训练手段
公开(公告)号：WO2016074061A1
公开(公告)日：2016-05-19
申请号：PCT/CA2014/051080
申请日：2014-11-10
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , PIRON, Cameron , YUWARAJ, Murugathas , KERINS, Fergal
发明人： PIRON, Cameron , YUWARAJ, Murugathas , KERINS, Fergal
IPC分类号： G09B23/30 , B29C39/12 , G09B9/00
CPC分类号： G09B23/34 , B29C39/02 , B29C39/12 , B29C45/1418 , B29L2031/40 , G09B23/286
摘要： The present disclosure discloses anatomical phantoms having one or more distinct regions spectroscopically differentiated from each other by inclusion of spectroscopically active components each having a distinct fluorescence/emission/scattering spectrum. The distinct regions may represent different anatomical components of the corresponding real anatomical part and/or tumor mimics (or other diseased tissue) and different anatomical components of the corresponding real anatomical part, or just tumor mimics and a remainder of the anatomical part. The spectroscopically active materials may be dyes such as the cyanine dyes, or spectroscopically active nanoparticles.
摘要翻译：本公开公开了具有通过包含各自具有不同的荧光/发射/散射光谱的光谱活性成分彼此光谱分化的一个或多个不同区域的解剖体模体。不同的区域可以表示对应的真实解剖部分和/或肿瘤模拟物（或其他患病组织）和相应的真实解剖部分的不同解剖部件的不同解剖组件，或仅仅是肿瘤模拟物和解剖部件的其余部分。光谱活性材料可以是染料，例如花青染料或光谱活性纳米颗粒。

6. 发明申请

WO2017049380A1 ANATOMICAL SIMULATORS PRODUCED USING 3D PRINTING 审中-公开
标题翻译：使用3D打印生产的解剖学模拟器
公开(公告)号：WO2017049380A1
公开(公告)日：2017-03-30
申请号：PCT/CA2015/050943
申请日：2015-09-23
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal , WHITTON, Gregory Allan , RICHMOND, Joshua Lee , GMEINER, Timotheus Anton
发明人： KERINS, Fergal , WHITTON, Gregory Allan , RICHMOND, Joshua Lee , GMEINER, Timotheus Anton
IPC分类号： G09B23/30 , B33Y10/00 , B33Y40/00 , B33Y80/00
CPC分类号： G09B23/303 , B29C35/0805 , B29C37/0025 , B29C67/0059 , B29C67/007 , B29C2035/0827 , B29K2083/00 , B29K2995/0037 , B29L2031/7532 , B33Y10/00 , B33Y40/00 , B33Y70/00 , B33Y80/00 , G09B23/30
摘要： Disclosed herein are anatomical simulators produced using three dimensional (3D) printing to produce interior components of the simulator. The method of producing void structures in an anatomical phantom, includes 3D printing one or more structures of one or more desired sub- anatomical features using a dissolvable material; supporting and enclosing the one or more structures in an interior of a mold of the anatomical phantom; filling a remaining internal volume in the interior of the mold between an outer surface of the one or more structures and an inner surface of the mold with a liquid precursor of a matrix material selected to mimic anatomical tissue and processing said liquid precursor to form a tissue mimic matrix material; and dissolving the one or more structures with a fluid selected to dissolve said dissolvable material to produce one or more internal cavities within the tissue mimic matrix material.
摘要翻译：本文公开了使用三维（3D）打印产生的用于产生模拟器的内部部件的解剖模拟器。在解剖体模中产生空隙结构的方法包括使用可溶解材料3D打印一个或多个期望的子解剖特征的一个或多个结构; 将所述一个或多个结构支撑并封闭在所述解剖幻影的模具的内部; 在一个或多个结构的外表面和模具的内表面之间的模具内部的剩余内部容积用基质材料的液体前体填充以选择模拟解剖组织并且处理所述液体前体以形成组织模仿基质材料; 以及用选择的溶液溶解所述一种或多种结构以溶解所述可溶解材料以在所述组织模拟基质材料内产生一个或多个内部空腔。

7. 发明申请

WO2016011539A1 METHOD OF PRODUCING ANATOMICAL PHANTOMS WITH CONSTITUENTS HAVING VARIABLE DENSITIES 审中-公开
标题翻译：生产具有不同密度的成分的解剖学方法
公开(公告)号：WO2016011539A1
公开(公告)日：2016-01-28
申请号：PCT/CA2015/050545
申请日：2015-06-12
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal
发明人： KERINS, Fergal
IPC分类号： B29C39/12 , G09B23/30
CPC分类号： G09B23/30 , B29C39/10 , B29C39/38 , B29K2029/04 , B29K2033/04 , B29K2083/005 , B29K2105/0061 , B29K2105/24 , G09B23/34
摘要： The present disclosure discloses a method of producing an anatomical phantom of an anatomical part having components of different density. The method includes providing a mold of an anatomical part, providing a mold having a size and shape corresponding to a first constituent of the anatomical part. A first liquid is place into the constituent mold and frozen which is placed into the larger anatomical mold and supported in a location corresponding to an actual location of the part in an actual anatomical part. The larger mold is then filled with a second liquid, which forms a gel after a freeze/thaw cycle, to encase the frozen first liquid in the second liquid and the temperature is dropped to freeze the second liquid. The combination is then thawed to produce an anatomical phantom of the anatomical part having a continuous seam between the first constituent part and a remainder of the anatomical part represented by the polyvinyl alcohol based gel. The first and second liquids have a composition such that upon undergoing one freeze thaw cycle, products resulting from the freeze thaw cycle have different densities approximating different constituents of the anatomical part with the second product being a gel encapsulating the first product.
摘要翻译：本公开公开了一种产生具有不同密度成分的解剖部分的解剖体模的方法。该方法包括提供解剖部件的模具，提供具有对应于解剖部件的第一部件的尺寸和形状的模具。将第一液体放置在构成模具中并冷冻，其被放置在较大的解剖模具中并且被支撑在与实际解剖部件中的部件的实际位置相对应的位置。然后，较大的模具填充第二液体，其在冷冻/解冻循环之后形成凝胶，以将冷冻的第一液体包裹在第二液体中，并且降温以冷冻第二液体。然后将组合解冻以产生解剖部位的解剖体模，其在第一组成部分和由聚乙烯醇基凝胶表示的解剖部分的其余部分之间具有连续接缝。第一和第二液体具有这样的组成，使得在经历一个冻融循环后，由冻融循环产生的产物具有接近解剖部分不同成分的不同密度，第二产物是封装第一产物的凝胶。

8. 发明申请

WO2017035626A1 CEREBROSPINAL DIFFUSION PHANTOM 审中-公开
标题翻译：骨髓扩张剂
公开(公告)号：WO2017035626A1
公开(公告)日：2017-03-09
申请号：PCT/CA2015/050849
申请日：2015-09-04
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
发明人： KERINS, Fergal , WHITTON, Gregory Allan , GMEINER, Timotheus Anton , STAINSBY, Jeff Alan , HARRIS, Chad Tyler , THINGVOLD, Sheryl Rae
IPC分类号： G09B23/30 , A61B5/055
CPC分类号： G01R33/58 , A61B5/055 , G01R33/4806 , G01R33/56341 , G09B23/30
摘要： Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are affixed to the scaffold support structure such that elongated diffusion mimicking members extend in directions needed to substantially emulate a 3 dimensional arrangement of cerebrospinal diffusion fiber tracts in a living organism; as well as modules for elimination of resolution based-bias, angular accuracy evaluation, diffusion rate calibration, and quality assurance image referencing. Each elongated diffusion mimicking member includes an aqueous component which can undergo diffusion along the elongated diffusion mimicking member. The phantom includes a cerebrospinal tissue mimic matrix material contained in the housing enveloping the array of elongated diffusion mimicking members. The housing is made of a material whose magnetic susceptibility substantially matches that of the cerebrospinal mimic matrix material.
摘要翻译：这里公开的是脑脊液扩散体，其包括壳体，该壳体的形状和尺寸被配置为在一个或多个预选姿势中插入到磁共振线圈中。脚手架支撑结构安装在所述壳体的内部和支撑在支撑阵列上的多个细长扩散模拟构件。细长的扩散模拟构件被固定到支架支撑结构上，使得细长的扩散模拟构件在基本上模拟生物体中脑脊髓扩散纤维束的3维排列所需的方向上延伸; 以及用于消除基于分辨率偏差，角度精度评估，扩散速率校准和质量保证图像引用的模块。每个细长扩散模拟构件包括可以沿着细长扩散模拟构件扩散的水性组分。幻影包括包含在壳体中的脑脊液组织模拟基质材料，其包围细长的扩散模拟构件阵列。壳体由其磁化率基本上与脑脊液模拟基质材料的磁化率相匹配的材料制成。

9. 发明申请

WO2016054718A1 PHANTOM PRODUCTION TOOL 审中-公开
标题翻译： PHANTOM生产工具
公开(公告)号：WO2016054718A1
公开(公告)日：2016-04-14
申请号：PCT/CA2014/050975
申请日：2014-10-09
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , RICHMOND, Joshua , KERINS, Fergal , THINGVOLD, Sheryl
发明人： RICHMOND, Joshua , KERINS, Fergal , THINGVOLD, Sheryl
IPC分类号： B29C39/22 , A61B19/00 , G09B23/30
CPC分类号： B29C44/1219 , B29C33/10 , B29C33/20 , B29C33/3857 , B29C39/22 , B29C44/02 , B29C64/00 , B29C64/386 , B29K2031/04 , B29K2105/0061 , B29L2031/40 , B29L2031/753 , B33Y10/00 , B33Y50/02 , B33Y80/00 , G09B23/30
摘要： The present disclosure relates to a tool used to producing anatomical phantoms. The tool includes an inner flexible mold which sits inside a rigid, thermally conductive outer shell. The rigid shell may be made out of aluminum. The silicone mold and thermally conductive shell both include at least two interlocking components. The shell is held together by a locking mechanism which can expand upon internal pressure. An anatomical phantom is produced from polyvinyl alcohol hydrogel by freezing and thawing a PVA liquid precursor in the silicone mold and demolding it.
摘要翻译：本公开涉及用于产生解剖体模的工具。该工具包括内部柔性模具，其位于刚性的导热外壳的内部。刚性壳可以由铝制成。硅胶模具和导热壳体都包括至少两个互锁部件。壳体通过可在内部压力下膨胀的锁定机构保持在一起。通过将聚硅氧烷模具中的PVA液体前体冷冻融化并脱模，由聚乙烯醇水凝胶制造解剖幻影。

10. 发明申请

WO2016011539A8 METHOD FOR PRODUCING ANATOMICAL PHANTOMS WITH CONSTITUENTS HAVING VARIABLE DENSITIES 审中-公开
公开(公告)号：WO2016011539A8
公开(公告)日：2016-01-28
申请号：PCT/CA2015/050545
申请日：2015-06-12
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , KERINS, Fergal
发明人： KERINS, Fergal
IPC分类号： B29C39/12 , G09B23/30
摘要： The present disclosure discloses a method of producing an anatomical phantom of an anatomical part having components of different density. The method includes providing a mold of an anatomical part, providing a mold having a size and shape corresponding to a first constituent of the anatomical part. A first liquid is place into the constituent mold and frozen which is placed into the larger anatomical mold and supported in a location corresponding to an actual location of the part in an actual anatomical part. The larger mold is then filled with a second liquid, which forms a gel after a freeze/thaw cycle, to encase the frozen first liquid in the second liquid and the temperature is dropped to freeze the second liquid. The combination is then thawed to produce an anatomical phantom of the anatomical part having a continuous seam between the first constituent part and a remainder of the anatomical part represented by the polyvinyl alcohol based gel. The first and second liquids have a composition such that upon undergoing one freeze thaw cycle, products resulting from the freeze thaw cycle have different densities approximating different constituents of the anatomical part with the second product being a gel encapsulating the first product.

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