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1. 发明申请

WO2009082597A1 TISSUE ANCHORING CATHETER SYSTEMS AND METHODS 审中-公开
标题翻译：组织锚固导管系统和方法
公开(公告)号：WO2009082597A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/085261
申请日：2008-12-02
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , KAUPHUSMAN, James V. , BYRD, Israel A. , PAUL, Saurav
发明人： KAUPHUSMAN, James V. , BYRD, Israel A. , PAUL, Saurav
IPC分类号： A61M5/32
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system (10) to tissue (25), e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft (16) connected to a catheter handle (12). A delivery sheath (18) is provided within the outer catheter shaft (16), the delivery sheath (18) housing a needle (20). At least one anchor (27, 28) is operatively associated with the delivery sheath (18), the at least one anchor operable at the catheter handle (12) to secure the delivery sheath (18) to tissue (25) for conveying biologic or chemical agents, or other therapeutic fluid from the needle (20) to the tissue (25). The tissue anchoring catheter may further comprise sensing means (55) such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统（10）锚定到组织（25）的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗液体。示例性组织锚定导管包括连接到导管手柄（12）的外导管轴（16）。输送鞘（18）设置在外导管轴（16）内，输送护套（18）容纳针（20）。至少一个锚固件（27,28）与输送护套（18）可操作地相关联，所述至少一个锚固件可在导管手柄（12）处操作以将输送护套（18）固定到组织（25），用于输送生物或化学试剂或从针（20）到组织（25）的其它治疗液。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声传感器的感测装置（55）。

2. 发明申请

WO2012068505A9 ELECTRODE CATHETER DEVICE WITH INDIFFERENT ELECTRODE FOR DIRECT CURRENT TISSUE THERAPIES 审中-公开
公开(公告)号：WO2012068505A9
公开(公告)日：2012-05-24
申请号：PCT/US2011/061475
申请日：2011-11-18
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GRASSE, Martin Maitre , STEHR, Richard E. , BYRD, Israel Alexander , CLARK, Lynn Eleanor , DENO, D. Curtis , TEGG, Troy T. , KAUPHUSMAN, James V. , PAUL, Saurav , SCHWEITZER, Jeffrey A.
发明人： GRASSE, Martin Maitre , STEHR, Richard E. , BYRD, Israel Alexander , CLARK, Lynn Eleanor , DENO, D. Curtis , TEGG, Troy T. , KAUPHUSMAN, James V. , PAUL, Saurav , SCHWEITZER, Jeffrey A.
IPC分类号： A61B18/04
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

3. 发明申请

WO2009085653A1 PHOTODYNAMIC-BASED CARDIAC ABLATION DEVICE AND METHOD 审中-公开
标题翻译：基于光电动力学的心脏消融装置及方法
公开(公告)号：WO2009085653A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/086565
申请日：2008-12-12
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , BYRD, Israel, A. , PAUL, Saurav
发明人： BYRD, Israel, A. , PAUL, Saurav
IPC分类号： A61N5/06
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body (16) defining a proximal end (22) and a distal end (24) is inserted into an esophagus (36) of the living being. The distal end (24) of the elongated body (16) is located proximate the cardiac tissue (12). A first set of electromagnetic radiation is then directed from the distal end (24) of the elongated body (16) towards the cardiac tissue (12). Reflective and opaque surfaces (42, 44) at the distal end (24) of the elongated body (16) may be used to direct the electromagnetic radiation and an expandable membrane (38) at the distal end (24) may be used to urge the distal end of the elongated body (16) to a predetermined position within the esophagus (36).
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端（22）和远端（24）的可变形的细长主体（16）插入生物的食道（36）中。细长体（16）的远端（24）位于心脏组织（12）附近。然后将第一组电磁辐射从细长体（16）的远端（24）引向心脏组织（12）。在细长体（16）的远端（24）处的反射和不透明表面（42,44）可以用于引导电磁辐射，并且可以使用远端（24）处的可膨胀膜（38）来推动细长体（16）的远端到食道（36）内的预定位置。

4. 发明申请

WO2011072221A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 审中-公开
标题翻译：系统和方法，用于确定组织中骨髓间充质干细胞
公开(公告)号：WO2011072221A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059884
申请日：2010-12-10
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
发明人： FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system (10) for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system (10) includes an electronic control unit (ECU) (34). The ECU (34) is configured to acquire at least one value of at least one component of a complex impedance between an electrode (16) and the tissue (12). The ECU (34) is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue (12).
摘要翻译：提供了一种用于在其中形成病变期间确定在组织中发生的气压伤的可能性的方法和系统（10）。系统（10）包括电子控制单元（ECU）（34）。 ECU（34）被配置为获取电极（16）和组织（12）之间的复阻抗的至少一个分量的至少一个值。 ECU（34）还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织（12）中发生气压伤的可能性。

5. 发明申请

WO2010078196A1 FAST-ACTING OR ROTATING TRANSSEPTAL NEEDLE 审中-公开
标题翻译：快速或旋转传递针
公开(公告)号：WO2010078196A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069433
申请日：2009-12-23
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
发明人： PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
IPC分类号： A61B17/00
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

6. 发明申请

WO2008083123A1 DESIGN OF ABLATION ELECTRODE WITH TACTILE SENSOR 审中-公开
标题翻译：消除电极与触觉传感器的设计
公开(公告)号：WO2008083123A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088729
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , THAO, Chou , PAUL, Saurav
发明人： CAO, Hong , THAO, Chou , PAUL, Saurav
IPC分类号： A61B5/04
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

7. 发明申请

WO2007070361A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
标题翻译：电器联合电击组织评估
公开(公告)号：WO2007070361A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046816
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61N1/378
CPC分类号： A61N1/40 , A61B2018/00357 , A61B2018/00875
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

8. 发明申请

WO2007067943A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067943A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/061716
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

9. 发明申请

WO2007067940A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067940A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/061713
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , PAUL, Saurav
发明人： CAO, Hong , PAUL, Saurav
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/00363 , A61B2018/00869 , A61B2018/00898
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

10. 发明申请

WO2009085459A1 FLEXIBLE POLYMER ELECTRODE FOR MRI-GUIDED POSITIONING AND RADIO FREQUENCY ABLATION 审中-公开
标题翻译：用于MRI引导定位和无线电频率消除的柔性聚合物电极
公开(公告)号：WO2009085459A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/084203
申请日：2008-11-20
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , TEGG, Troy T. , THAO, Chou , PURYEAR, Harry
发明人： PAUL, Saurav , TEGG, Troy T. , THAO, Chou , PURYEAR, Harry
IPC分类号： A61B18/24
CPC分类号： A61B18/1492 , A61B5/055 , A61B5/06 , A61B2018/00702 , A61B2018/00791 , A61B2018/00815 , A61B2034/2068 , A61B2090/374 , A61B2090/3954
摘要： An electrode for use on a medical device is disclosed. The electrode (12) may have a main body (14) of electrically conductive material extending along an axis (16) and may have a proximal end (20) and a distal end (18). The electrode (12) may also include a magnetic resonance imaging (MRI) tracking coil (32) disposed in the body (14). The MRI tracking coil (32) may comprise electrically insulated wire. A catheter (10) including an electrode (12), as well as a method for determining the location of an electrode (12), are also disclosed.
摘要翻译：公开了一种用于医疗装置的电极。电极（12）可以具有沿着轴线（16）延伸的导电材料的主体（14），并且可以具有近端（20）和远端（18）。电极（12）还可以包括设置在主体（14）中的磁共振成像（MRI）跟踪线圈（32）。 MRI跟踪线圈（32）可以包括电绝缘线。还公开了包括电极（12）的导管（10）以及用于确定电极（12）的位置的方法。

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