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1. 发明申请

WO2012068505A1 ELECTRODE CATHETER DEVICE WITH INDIFFERENT ELECTRODE FOR DIRECT CURRENT TISSUE THERAPIES 审中-公开
标题翻译：用于直接电流组织治疗的具有不同电极的电极导管装置
公开(公告)号：WO2012068505A1
公开(公告)日：2012-05-24
申请号：PCT/US2011061475
申请日：2011-11-18
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , GRASSE MARTIN MAITRE , STEHR RICHARD E , BYRD ISRAEL ALEXANDER , CLARK LYNN ELEANOR , DENO D CURTIS , TEGG TROY T , KAUPHUSMAN JAMES V , PAUL SAURAV , SCHWEITZER JEFFREY A
发明人： GRASSE MARTIN MAITRE , STEHR RICHARD E , BYRD ISRAEL ALEXANDER , CLARK LYNN ELEANOR , DENO D CURTIS , TEGG TROY T , KAUPHUSMAN JAMES V , PAUL SAURAV , SCHWEITZER JEFFREY A
IPC分类号： A61B18/04
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.
摘要翻译：公开了一种具有用于直流组织治疗的无电极的电极导管装置。导管装置的示例具有带有至少一个消融电极的柔性管。导管装置还可以与用于将柔性管引入患者体内的护套一起使用。护套上的无电极可以为直流（DC）脉冲提供接地，以传递电能并在组织附近产生电场。还公开了各种其它实施例。

2. 发明申请

WO2011072221A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 审中-公开
标题翻译：系统和方法，用于确定组织中骨髓间充质干细胞
公开(公告)号：WO2011072221A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059884
申请日：2010-12-10
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
发明人： FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system (10) for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system (10) includes an electronic control unit (ECU) (34). The ECU (34) is configured to acquire at least one value of at least one component of a complex impedance between an electrode (16) and the tissue (12). The ECU (34) is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue (12).
摘要翻译：提供了一种用于在其中形成病变期间确定在组织中发生的气压伤的可能性的方法和系统（10）。系统（10）包括电子控制单元（ECU）（34）。 ECU（34）被配置为获取电极（16）和组织（12）之间的复阻抗的至少一个分量的至少一个值。 ECU（34）还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织（12）中发生气压伤的可能性。

3. 发明申请

WO2009079626A8 PHOTODYNAMIC-BASED TISSUE SENSING DEVICE AND METHOD 审中-公开
标题翻译：基于光电动力的组织感测装置和方法
公开(公告)号：WO2009079626A8
公开(公告)日：2010-06-17
申请号：PCT/US2008087426
申请日：2008-12-18
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BYRD ISRAEL
发明人： PAUL SAURAV , BYRD ISRAEL
IPC分类号： A61B8/12 , A61B5/103
CPC分类号： A61N5/062 , A61B5/0084 , A61N5/0601
摘要： A system and method for diagnosis or treatment of tissue is provided. One or more optic fibers are disposed within a deformable, tubular body. An electronic control unit activates an electromagnetic radiation source to direct a first set of electromagnetic radiation through a first optic fiber to the tissue. The unit also receives a signal generated by an electromagnetic radiation sensor in response to a second set of electromagnetic radiation received through the first optic or a second fiber. The second set of electromagnetic radiation originates from the tissue in response to the first set of electromagnetic radiation and may be reflected or emitted by a substance contained in the tissue that alters radiation characteristics of the tissue. Finally, the unit is configured to determine a characteristic of the tissue (e.g. the distance from the tissue to the tubular body) responsive to the signal.
摘要翻译：提供了用于诊断或治疗组织的系统和方法。一个或多个光纤设置在可变形的管状体内。电子控制单元激活电磁辐射源以将第一组电磁辐射通过第一光纤引导到组织。该单元还响应于通过第一光学器件或第二光纤接收的第二组电磁辐射，接收由电磁辐射传感器产生的信号。第二组电磁辐射响应于第一组电磁辐射而从组织起源，并且可以由组织中包含的改变组织辐射特性的物质反射或发射。最后，单元被配置为响应于该信号来确定组织的特征（例如，从组织到管状体的距离）。

4. 发明申请

WO2009124220A2 PHOTODYNAMIC-BASED MYOCARDIAL MAPPING DEVICE AND METHOD 审中-公开
标题翻译：基于光电动力学的MYOCARDIAL MAPPING设备和方法
公开(公告)号：WO2009124220A2
公开(公告)日：2009-10-08
申请号：PCT/US2009/039367
申请日：2009-04-02
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , JUST, Dale , SKOGLUND, Jamie , BYRD, Israel, Alexander , MCDOWALL, Paul
发明人： PAUL, Saurav , JUST, Dale , SKOGLUND, Jamie , BYRD, Israel, Alexander , MCDOWALL, Paul
IPC分类号： A61B1/05
CPC分类号： A61B5/6859 , A61B1/07 , A61B5/0044 , A61B5/0071 , A61B5/0084 , A61B5/4839 , A61B5/6858 , A61B5/7278 , A61B2562/0233 , A61B2562/046 , A61B2576/023 , A61M5/007 , A61M25/007 , A61M25/0147
摘要： A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances.
摘要翻译：光动力测绘装置包括具有近端和远端的轴，在轴的远端处的至少一个光电极和位于轴内部的至少一个光纤。在实施例中，至少一个光纤从轴的远端延伸并且耦合到设置在设备的外表面处或周围的至少一个光电极。在一个实施例中，至少一个光纤在轴的近端处或周围耦合到耦合的光源和光学传感器。分析仪可以耦合到光学传感器。这种装置的实施例可以被配置为递送物质，例如光动力学治疗物质。

5. 发明申请

WO2009085653A1 PHOTODYNAMIC-BASED CARDIAC ABLATION DEVICE AND METHOD 审中-公开
标题翻译：基于光电动力学的心脏消融装置及方法
公开(公告)号：WO2009085653A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/086565
申请日：2008-12-12
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , BYRD, Israel, A. , PAUL, Saurav
发明人： BYRD, Israel, A. , PAUL, Saurav
IPC分类号： A61N5/06
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body (16) defining a proximal end (22) and a distal end (24) is inserted into an esophagus (36) of the living being. The distal end (24) of the elongated body (16) is located proximate the cardiac tissue (12). A first set of electromagnetic radiation is then directed from the distal end (24) of the elongated body (16) towards the cardiac tissue (12). Reflective and opaque surfaces (42, 44) at the distal end (24) of the elongated body (16) may be used to direct the electromagnetic radiation and an expandable membrane (38) at the distal end (24) may be used to urge the distal end of the elongated body (16) to a predetermined position within the esophagus (36).
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端（22）和远端（24）的可变形的细长主体（16）插入生物的食道（36）中。细长体（16）的远端（24）位于心脏组织（12）附近。然后将第一组电磁辐射从细长体（16）的远端（24）引向心脏组织（12）。在细长体（16）的远端（24）处的反射和不透明表面（42,44）可以用于引导电磁辐射，并且可以使用远端（24）处的可膨胀膜（38）来推动细长体（16）的远端到食道（36）内的预定位置。

6. 发明申请

WO2021113463A1 ELECTROPORATION SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2021113463A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/063039
申请日：2020-12-03
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , BYRD, Israel , OLSON, Eric , DREW, Kenneth , TRANTER, John , TEGG, Troy
发明人： SUTERMEISTER, Derek , DALY, Jake , MOON, Boyce
IPC分类号： A61B18/14 , A61N1/32
摘要： Disclosed herein is an electroporation system including a catheter shaft, at least one electrode coupled to the catheter shaft at a distal end thereof, and an electroporation generator coupled in communication with the at least one electrode. The electroporation generator configured to supply a biphasic pulse signal to the at least one electrode. The biphasic pulse signal includes a first phase having a first polarity and a first pulse duration, and a second phase having a second polarity opposite to the first polarity, and a second pulse duration. Each of the first phase and second phase has a voltage amplitude of at least 500 volts and a pulse duration of less than 20 microseconds. The second phase is generated at a non-zero interval following the first phase.

7. 发明申请

WO2013025257A1 USER INTERFACE DEVICES FOR ELECTROPHYSIOLOGY LAB DIAGNOSTIC AND THERAPEUTIC EQUIPMENT 审中-公开
标题翻译：用于电生理诊断和治疗设备的用户界面装置
公开(公告)号：WO2013025257A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/031008
申请日：2012-03-28
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , BYRD, Charles Bryan , BETZLER, Eric , DANI, Sandeep , BYRD, Israel A. , OLSON, Eric S.
发明人： BYRD, Charles Bryan , BETZLER, Eric , DANI, Sandeep , BYRD, Israel A. , OLSON, Eric S.
IPC分类号： G06F3/033
CPC分类号： G06F3/0482 , A61B90/37 , A61B2560/0493 , G06F3/04883 , G06F3/04886 , G06F3/167 , G06T19/003 , G06T2210/41
摘要： In an electrophysiology (EP) lab, a bedside interface device allows an EP physician to directly control various diagnostic and therapeutic systems, including an electroanatomic mapping system. The bedside interface device can include a computer with wireless communication capability as well as a touch- responsive display panel and voice recognition. The bedside interface device can also be a hand-graspable wireless remote control device configured to detect motions or gestures made with the remote control by the physician, allowing the physician to directly interact with the mapping system. The bedside interface device can also be a motion capture camera configured to determine motion patterns of the physician's arms, legs, trunk, face and the like, which are defined in advance to correspond to commands for the mapping system. The bedside interface device may also include voice recognition capabilities allowing a physician to directly issue verbal commands to the mapping system.
摘要翻译：在电生理学（EP）实验室中，床边接口装置允许EP医师直接控制各种诊断和治疗系统，包括电解剖映射系统。床边接口装置可以包括具有无线通信能力的计算机以及触摸响应显示面板和语音识别。床边接口设备还可以是手握式无线遥控设备，其被配置为检测由医师用遥控器进行的运动或手势，允许医师直接与测绘系统交互。床边接口装置还可以是被配置为确定医师的手臂，腿，躯干，面部等的运动模式的运动捕捉照相机，其预先定义为对应于用于测绘系统的命令。床边接口设备还可以包括允许医师直接向映射系统发出口头命令的语音识别功能。

8. 发明申请

WO2012068505A9 ELECTRODE CATHETER DEVICE WITH INDIFFERENT ELECTRODE FOR DIRECT CURRENT TISSUE THERAPIES 审中-公开
公开(公告)号：WO2012068505A9
公开(公告)日：2012-05-24
申请号：PCT/US2011/061475
申请日：2011-11-18
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GRASSE, Martin Maitre , STEHR, Richard E. , BYRD, Israel Alexander , CLARK, Lynn Eleanor , DENO, D. Curtis , TEGG, Troy T. , KAUPHUSMAN, James V. , PAUL, Saurav , SCHWEITZER, Jeffrey A.
发明人： GRASSE, Martin Maitre , STEHR, Richard E. , BYRD, Israel Alexander , CLARK, Lynn Eleanor , DENO, D. Curtis , TEGG, Troy T. , KAUPHUSMAN, James V. , PAUL, Saurav , SCHWEITZER, Jeffrey A.
IPC分类号： A61B18/04
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

9. 发明申请

WO2009082597A9 TISSUE ANCHORING CATHETER SYSTEMS AND METHODS 审中-公开
标题翻译：组织锚固导管系统和方法
公开(公告)号：WO2009082597A9
公开(公告)日：2010-09-10
申请号：PCT/US2008085261
申请日：2008-12-02
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , KAUPHUSMAN JAMES V , BYRD ISRAEL A , PAUL SAURAV
发明人： KAUPHUSMAN JAMES V , BYRD ISRAEL A , PAUL SAURAV
IPC分类号： A61M5/32
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system (10) to tissue (25), e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft (16) connected to a catheter handle (12). A delivery sheath (18) is provided within the outer catheter shaft (16), the delivery sheath (18) housing a needle (20). At least one anchor (27, 28) is operatively associated with the delivery sheath (18), the at least one anchor operable at the catheter handle (12) to secure the delivery sheath (18) to tissue (25) for conveying biologic or chemical agents, or other therapeutic fluid from the needle (20) to the tissue (25). The tissue anchoring catheter may further comprise sensing means (55) such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统（10）锚定到组织（25）的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗液体。示例性组织锚定导管包括连接到导管手柄（12）的外导管轴（16）。输送鞘（18）设置在外导管轴（16）内，输送护套（18）容纳针（20）。至少一个锚固件（27,28）与输送护套（18）可操作地相关联，所述至少一个锚固件可在导管手柄（12）处操作以将输送护套（18）固定到组织（25），用于输送生物或化学试剂或从针（20）到组织（25）的其它治疗液。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声传感器的感测装置（55）。

10. 发明申请

WO2009082597A1 TISSUE ANCHORING CATHETER SYSTEMS AND METHODS 审中-公开
标题翻译：组织锚固导管系统和方法
公开(公告)号：WO2009082597A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/085261
申请日：2008-12-02
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , KAUPHUSMAN, James V. , BYRD, Israel A. , PAUL, Saurav
发明人： KAUPHUSMAN, James V. , BYRD, Israel A. , PAUL, Saurav
IPC分类号： A61M5/32
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system (10) to tissue (25), e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft (16) connected to a catheter handle (12). A delivery sheath (18) is provided within the outer catheter shaft (16), the delivery sheath (18) housing a needle (20). At least one anchor (27, 28) is operatively associated with the delivery sheath (18), the at least one anchor operable at the catheter handle (12) to secure the delivery sheath (18) to tissue (25) for conveying biologic or chemical agents, or other therapeutic fluid from the needle (20) to the tissue (25). The tissue anchoring catheter may further comprise sensing means (55) such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统（10）锚定到组织（25）的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗液体。示例性组织锚定导管包括连接到导管手柄（12）的外导管轴（16）。输送鞘（18）设置在外导管轴（16）内，输送护套（18）容纳针（20）。至少一个锚固件（27,28）与输送护套（18）可操作地相关联，所述至少一个锚固件可在导管手柄（12）处操作以将输送护套（18）固定到组织（25），用于输送生物或化学试剂或从针（20）到组织（25）的其它治疗液。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声传感器的感测装置（55）。

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