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1. 发明授权

EP2914341B1 NON-INVASIVE LUNG PACING 有权
公开(公告)号：EP2914341B1
公开(公告)日：2020-04-15
申请号：EP13795909.4
申请日：2013-11-05
申请人： Regents of the University of Minnesota , Paul, Saurav
发明人： CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
IPC分类号： A61N7/00 , A61B8/00

2. 发明公开

EP2914341A1 NON-INVASIVE LUNG PACING 有权
标题翻译：无创隆起搏
公开(公告)号：EP2914341A1
公开(公告)日：2015-09-09
申请号：EP13795909.4
申请日：2013-11-05
申请人： Regents of the University of Minnesota , Paul, Saurav
发明人： CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
IPC分类号： A61N7/00
摘要： A system for diaphragmatic pacing includes an ultrasonic transducer and a control module. The ultrasonic transducer has an emitting surface. The emitting surface is configured to couple with a tissue of a patient. The transducer is configured to transdermally emit ultrasonic energy and induce movement in a thoracic diaphragm of the patient in response thereto. The control module is coupled to the transducer and has a processor. The processor is configured to execute an algorithm to control operation of the transducer.

3. 发明申请

WO2012068505A1 ELECTRODE CATHETER DEVICE WITH INDIFFERENT ELECTRODE FOR DIRECT CURRENT TISSUE THERAPIES 审中-公开
标题翻译：用于直接电流组织治疗的具有不同电极的电极导管装置
公开(公告)号：WO2012068505A1
公开(公告)日：2012-05-24
申请号：PCT/US2011061475
申请日：2011-11-18
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , GRASSE MARTIN MAITRE , STEHR RICHARD E , BYRD ISRAEL ALEXANDER , CLARK LYNN ELEANOR , DENO D CURTIS , TEGG TROY T , KAUPHUSMAN JAMES V , PAUL SAURAV , SCHWEITZER JEFFREY A
发明人： GRASSE MARTIN MAITRE , STEHR RICHARD E , BYRD ISRAEL ALEXANDER , CLARK LYNN ELEANOR , DENO D CURTIS , TEGG TROY T , KAUPHUSMAN JAMES V , PAUL SAURAV , SCHWEITZER JEFFREY A
IPC分类号： A61B18/04
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.
摘要翻译：公开了一种具有用于直流组织治疗的无电极的电极导管装置。导管装置的示例具有带有至少一个消融电极的柔性管。导管装置还可以与用于将柔性管引入患者体内的护套一起使用。护套上的无电极可以为直流（DC）脉冲提供接地，以传递电能并在组织附近产生电场。还公开了各种其它实施例。

4. 发明申请

WO2011072221A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 审中-公开
标题翻译：系统和方法，用于确定组织中骨髓间充质干细胞
公开(公告)号：WO2011072221A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059884
申请日：2010-12-10
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
发明人： FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system (10) for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system (10) includes an electronic control unit (ECU) (34). The ECU (34) is configured to acquire at least one value of at least one component of a complex impedance between an electrode (16) and the tissue (12). The ECU (34) is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue (12).
摘要翻译：提供了一种用于在其中形成病变期间确定在组织中发生的气压伤的可能性的方法和系统（10）。系统（10）包括电子控制单元（ECU）（34）。 ECU（34）被配置为获取电极（16）和组织（12）之间的复阻抗的至少一个分量的至少一个值。 ECU（34）还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织（12）中发生气压伤的可能性。

5. 发明申请

WO2010078196A1 FAST-ACTING OR ROTATING TRANSSEPTAL NEEDLE 审中-公开
标题翻译：快速或旋转传递针
公开(公告)号：WO2010078196A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069433
申请日：2009-12-23
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
发明人： PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
IPC分类号： A61B17/00
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

6. 发明申请

WO2009079626A8 PHOTODYNAMIC-BASED TISSUE SENSING DEVICE AND METHOD 审中-公开
标题翻译：基于光电动力的组织感测装置和方法
公开(公告)号：WO2009079626A8
公开(公告)日：2010-06-17
申请号：PCT/US2008087426
申请日：2008-12-18
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BYRD ISRAEL
发明人： PAUL SAURAV , BYRD ISRAEL
IPC分类号： A61B8/12 , A61B5/103
CPC分类号： A61N5/062 , A61B5/0084 , A61N5/0601
摘要： A system and method for diagnosis or treatment of tissue is provided. One or more optic fibers are disposed within a deformable, tubular body. An electronic control unit activates an electromagnetic radiation source to direct a first set of electromagnetic radiation through a first optic fiber to the tissue. The unit also receives a signal generated by an electromagnetic radiation sensor in response to a second set of electromagnetic radiation received through the first optic or a second fiber. The second set of electromagnetic radiation originates from the tissue in response to the first set of electromagnetic radiation and may be reflected or emitted by a substance contained in the tissue that alters radiation characteristics of the tissue. Finally, the unit is configured to determine a characteristic of the tissue (e.g. the distance from the tissue to the tubular body) responsive to the signal.
摘要翻译：提供了用于诊断或治疗组织的系统和方法。一个或多个光纤设置在可变形的管状体内。电子控制单元激活电磁辐射源以将第一组电磁辐射通过第一光纤引导到组织。该单元还响应于通过第一光学器件或第二光纤接收的第二组电磁辐射，接收由电磁辐射传感器产生的信号。第二组电磁辐射响应于第一组电磁辐射而从组织起源，并且可以由组织中包含的改变组织辐射特性的物质反射或发射。最后，单元被配置为响应于该信号来确定组织的特征（例如，从组织到管状体的距离）。

7. 发明申请

WO2008082803A3 ABLATION CATHETER THERMALL MEDIATED CATHETER BODY 审中-公开
标题翻译：吸引管热介质导管体
公开(公告)号：WO2008082803A3
公开(公告)日：2008-08-21
申请号：PCT/US2007084690
申请日：2007-11-14
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , CAO HONG , GUO XIAOPING , SHAI ISAAC , YANG MICHAEL , BELHE KEDAR RAVINDRA , THAO CHOU
发明人： PAUL SAURAV , CAO HONG , GUO XIAOPING , SHAI ISAAC , YANG MICHAEL , BELHE KEDAR RAVINDRA , THAO CHOU
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00357
摘要： An ablation catheter (10) is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode (22) is connected relative to the distal end of the catheter (10) for providing ablation energy to patient tissue. A heat sink (40) is provided that is in thermal contact with the ablation electrode (22). The heat sink (40), in addition to being in thermal contact with the ablation electrode (22), is electrically isolated from the ablation electrode (22). This allows the heat sink (40) to conduct heat away from the ablation electrode (22) without dissipating electrical energy from the electrode (22). In this regard, the heat sink (40) may prevent build-up of excess heat within the electrode (22) that may result in blood coagulation and/or tissue charring.
摘要翻译：提供消融导管（10），用于烧蚀患者的内部组织。该导管包括适于相对于其中的期望位置（例如，在心脏内）插入体腔中的远端。消融电极（22）相对于导管（10）的远端连接，用于向患者组织提供消融能量。提供与消融电极（22）热接触的散热器（40）。除了与消融电极（22）热接触之外，散热器（40）与消融电极（22）电隔离。这允许散热器（40）将热量从消融电极（22）导出，而不会从电极（22）中消散电能。在这方面，散热器（40）可防止可能导致血液凝固和/或组织烧焦的电极（22）内的过多热量的累积。

8. 发明申请

WO2008083123A1 DESIGN OF ABLATION ELECTRODE WITH TACTILE SENSOR 审中-公开
标题翻译：消除电极与触觉传感器的设计
公开(公告)号：WO2008083123A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088729
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , THAO, Chou , PAUL, Saurav
发明人： CAO, Hong , THAO, Chou , PAUL, Saurav
IPC分类号： A61B5/04
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

9. 发明申请

WO2008045956A3 TISSUE CONTACT AND THERMAL ASSESSMENT FOR BRUSH ELECTRODES 审中-公开
标题翻译：用于布丝电极的组织接触和热评估
公开(公告)号：WO2008045956A3
公开(公告)日：2008-07-10
申请号：PCT/US2007080981
申请日：2007-10-10
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , THAO CHOU , CAO HONG , PAUL SAURAV
发明人： THAO CHOU , CAO HONG , PAUL SAURAV
IPC分类号： A61B5/103
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00351 , A61B2018/143 , A61B2090/065
摘要： Systems and methods are disclosed for tissue contact and thermal assessment, e.g., for tis
摘要翻译：公开了用于组织接触和热评估的系统和方法，例如用于tis

10. 发明申请

WO2007070361A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
标题翻译：电器联合电击组织评估
公开(公告)号：WO2007070361A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046816
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61N1/378
CPC分类号： A61N1/40 , A61B2018/00357 , A61B2018/00875
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

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