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1. 发明申请

WO2008060347A1 SIMULTANEOUS ASPIRATOR AND DISPENSER FOR MULTIWELL PLATES AND SIMILAR DEVICES 审中-公开
标题翻译：同时用于多层板和类似设备的辅助器和分配器
公开(公告)号：WO2008060347A1
公开(公告)日：2008-05-22
申请号：PCT/US2007/019566
申请日：2007-09-07
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
发明人： LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
IPC分类号： G01N35/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor.. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排列成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管并且相关联分配和抽吸位于沿着一列或多列井的所有井中的端口，以便同时吸取并分配溶液到多孔板的一列或多列中的所有孔。

2. 发明申请

WO2007019024A3 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
公开(公告)号：WO2007019024A3
公开(公告)日：2007-02-15
申请号：PCT/US2006/028473
申请日：2006-07-20
申请人： SRU BIOSYSTEMS, INC. , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
发明人： SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
IPC分类号： G01N21/55 , G01N21/64
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label -free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

3. 发明申请

WO2006127167A2 PROTEOLIPID MEMBRANE & LIPID MEMBRANE BIOSENSOR 审中-公开
标题翻译： PROTEOLIPID膜和脂膜生物传感器
公开(公告)号：WO2006127167A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/013926
申请日：2006-04-12
申请人： SRU BIOSYSTEMS, INC. , BAIRD, Cheryl, L. , WANG, Guo, Bin , LAING, Lance , JOGIKALMATH, Gangadhar , GERSTENMAIER, John
发明人： BAIRD, Cheryl, L. , WANG, Guo, Bin , LAING, Lance , JOGIKALMATH, Gangadhar , GERSTENMAIER, John
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides compositions and methods for detection of interaction of molecules.
摘要翻译：本发明提供了用于检测分子相互作用的组合物和方法。

4. 发明申请

WO2008121250A1 CALIBRATION AND NORMALIZATION METHOD FOR BIOSENSORS 审中-公开
标题翻译：生物传感器的校准和正规化方法
公开(公告)号：WO2008121250A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/003751
申请日：2008-03-21
申请人： SRU BIOSYSTEMS, INC. , NOVARTIS AG , BUDACH, Wolfgang, Ernst, Gustav , NEUSCHAFER, Dieter , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lange, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
发明人： BUDACH, Wolfgang, Ernst, Gustav , NEUSCHAFER, Dieter , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lange, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
IPC分类号： G01N33/48 , C12Q1/00
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/4788 , G01N21/552 , G01N21/554 , G01N21/6428 , G01N21/645 , G01N21/648 , G01N21/7743
摘要： Calibration and normalization methods for a grating-based sensor design are disclosed. The sensor may be constructed in a manner optimized for both label-free and luminescence, e.g . fluorescence, amplification detection in a single device. Such a sensor, based on grating or another periodical structure with appropriate coating, dramatically increases the diversity of applications and allows realizing novel concepts that provide qualitative and quantitative information/data for each location or capture element in the sensor surface. The invention takes advantage of these different modes to carry out a quality control (QC) step and a calibration of each individual location of the sensor. Thus, the assay data can be flagged according to their quality and local density variations, batch variations and variations in the printed deposition of probes or the materials to the surface can be compensated.
摘要翻译：公开了基于光栅的传感器设计的校准和归一化方法。传感器可以以针对无标记和发光两者而优化的方式来构造。荧光，放大检测在单个器件中。这种基于光栅或具有适当涂层的周期性结构的传感器显着地增加了应用的多样性，并且实现了为传感器表面中的每个位置或捕获元件提供定性和定量的信息/数据的新概念。本发明利用这些不同的模式来执行传感器的每个单独位置的质量控制（QC）步骤和校准。因此，可以根据其质量和局部密度变化标记测定数据，可以补偿探针的印刷沉积或表面的材料的批量变化和变化。

5. 发明申请

WO2008156560A1 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：WO2008156560A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007031
申请日：2008-06-03
申请人： SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
发明人： CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
IPC分类号： G01N21/47 , G01N21/55 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。描述了用于生物传感器的各种应用，包括用于评估药物化合物，蛋白质，肽和其他材料对细胞功能的影响的基于细胞的测定。还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。两种不同的发光技术可以组合在相同的生物传感器芯片上。

6. 发明申请

WO2008055080A2 METHOD FOR BLOCKING NON-SPECIFIC PROTEIN BINDING ON A FUNCTIONALIZED SURFACE 审中-公开
标题翻译：阻塞功能性表面上非特异性蛋白质结合的方法
公开(公告)号：WO2008055080A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/082701
申请日：2007-10-26
申请人： SRU BIOSYSTEMS, INC. , JOGIKALMATH, Gangadhar
发明人： JOGIKALMATH, Gangadhar
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/54373
摘要： A method of blocking non-specific protein binding on surfaces, such as protein-coated biosensor surfaces.
摘要翻译：阻止表面上非特异性蛋白质结合的方法，如蛋白质包被的生物传感器表面。

7. 发明申请

WO2011127425A1 SYSTEMS AND METHODS FOR SLUDGE PROCESSING 审中-公开
标题翻译：用于泥沙处理的系统和方法
公开(公告)号：WO2011127425A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031820
申请日：2011-04-08
申请人： NANOPAPER, LLC , JOGIKALMATH, Gangadhar , REIS, Lynn , SOANE, David
发明人： JOGIKALMATH, Gangadhar , REIS, Lynn , SOANE, David
IPC分类号： C02F1/54 , C02F11/12
CPC分类号： C02F11/14 , C02F2103/28
摘要： Systems include a sludge fluid stream containing fines, an activator polymer that associates with the fines, an anchor particle bearing a tether polymer that is capable of interacting with the activator polymer, wherein the anchor particle is mixed into the sludge fluid stream so that the tether polymer interacts with the activator polymer, forming a sludge complex comprising the fines and the anchor particle and a separation system that removes the sludge complex from the sludge fluid stream. Methods include steps: adding an activator polymer to the sludge fluid, preparing a tether-bearing anchor particle by associating a tethering polymer to an anchor particle, wherein the tethering polymer is capable of interacting with the activator polymer; contacting the activator-fines complex with the tether-bearing anchor particle to form an activator-tether-anchor complex comprising the fines and the anchor particle; and removing the activator- tether-anchor complex from the sludge fluid, thereby removing the fines.
摘要翻译：系统包括含有细粒的污泥流体流，与细粒相关联的活化剂聚合物，具有能与活化剂聚合物相互作用的系链聚合物的锚定颗粒，其中锚颗粒混入污泥流体流中，使得系链聚合物与活化剂聚合物相互作用，形成包含细粒和锚粒子的污泥复合物，以及从污泥流体流中除去污泥复合物的分离系统。方法包括以下步骤：将活化剂聚合物加入到污泥流体中，通过将束缚聚合物与锚定颗粒缔合制备带束缚的锚定颗粒，其中所述系链聚合物能够与活化剂聚合物相互作用; 使活化剂 - 细粉络合物与带束缚的锚定颗粒接触以形成包含细粒和锚定颗粒的活化剂 - 锚链 - 复合物; 并从污泥流体中除去活化剂 - 锚链 - 复合物，从而除去细粉。

8. 发明申请

WO2013033368A1 ADDITIVES FOR PAPERMAKING 审中-公开
标题翻译：造纸添加剂
公开(公告)号：WO2013033368A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053098
申请日：2012-08-30
申请人： NANOPAPER, LLC , JOGIKALMATH, Gangadhar , SCHNEIDER, Andrea , SOANE, David, S.
发明人： JOGIKALMATH, Gangadhar , SCHNEIDER, Andrea , SOANE, David, S.
IPC分类号： D21H21/20 , D21H21/00
CPC分类号： D21H21/18 , D21H11/00 , D21H13/00 , D21H13/12 , D21H17/24 , D21H17/28 , D21H17/29 , D21H17/33 , D21H17/67 , D21H17/675 , D21H21/10 , D21H23/04
摘要： The present invention provides systems and methods for papermaking. In embodiments, the systems include a first population of fibers dispersed in an aqueous solution and complexed with an activator, and a second population of composite additive particles bearing a tethering material, wherein the addition of the second population to the first population attaches the composite additive particles to the fibers by the interaction of the activator and the tethering material. Methods for forming a fibrous web are also disclosed, in addition to paper products formed from such fibrous webs.
摘要翻译：本发明提供造纸用的系统和方法。在实施方案中，所述系统包括分散在水溶液中并与活化剂复合的第一纤维群和具有束缚材料的第二种复合添加剂颗粒，其中将第二种群添加至第一种群附着复合添加剂颗粒通过活化剂和束缚材料的相互作用而导入纤维。除了由这种纤维网形成的纸制品之外，还公开了形成纤维幅材的方法。

9. 发明申请

WO2012135001A2 VOLATILE DEBONDER FORMULATIONS FOR PAPERMAKING 审中-公开
标题翻译：用于造纸的挥发性脱蜡剂配方
公开(公告)号：WO2012135001A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030297
申请日：2012-03-23
申请人： NANOPAPER, LLC , JOGIKALMATH, Gangadhar , REIS, Lynn , SOANE, David, S. , SCHNEIDER, Andrea
发明人： JOGIKALMATH, Gangadhar , REIS, Lynn , SOANE, David, S. , SCHNEIDER, Andrea
IPC分类号： D21C3/20
CPC分类号： D21H23/04 , C08K5/06 , D21H17/06 , D21H21/22 , D21H21/24 , D21H23/28
摘要： Formulations and methods for papermaking are disclosed herein using one or more volatile debonders, where the volatile debonder forms a solution or an emulsion with water in a paper precursor, and where the volatile debonder is evaporable from the paper precursor before the paper precursor is completely dried to form a paper sheet during papermaking. Two volatile debonders having different boiling points can be used, where they are miscible in water and in each other, and where one volatile debonder has a higher molecular weight and the other volatile debonder has a lower boiling point.
摘要翻译：本文公开了使用一种或多种挥发性松解剂的造纸制剂和方法，其中挥发性松解剂与纸前体中的水形成溶液或乳液，并且其中挥发性松解剂可从纸中蒸发在纸前体在造纸过程中完全干燥形成纸张之前。可以使用两种具有不同沸点的挥发性松解剂，它们可以在水和彼此中混溶，并且其中一种挥发性松解剂具有较高的分子量，另一种挥发性松解剂具有较低的沸点。

10. 发明申请

WO2010080958A1 DEBONDERS FOR USE IN PAPERMAKING 审中-公开
标题翻译：使用PAPERMAKING的债权人
公开(公告)号：WO2010080958A1
公开(公告)日：2010-07-15
申请号：PCT/US2010/020440
申请日：2010-01-08
申请人： NANOPAPER, LLC , JOGIKALMATH, Gangadhar , REIS, Lynn , RABIN, Scott, I. , SOANE, David, S.
发明人： JOGIKALMATH, Gangadhar , REIS, Lynn , RABIN, Scott, I. , SOANE, David, S.
IPC分类号： D21H17/35 , D21H17/36 , D21H17/37 , D21H21/22 , D21H21/24 , D21C9/00
CPC分类号： D21H17/52 , D21C9/005 , D21H17/35 , D21H17/36 , D21H17/37 , D21H21/22 , D21H21/24
摘要： Debonding compositions and methods are disclosed for use in fibrous compositions such as paper-based products. In some instances, debonding agents can be combined with fibers (e.g., cellulose-based fibers) to produce a material having substantial wicking properties while decreasing fiber-fiber interactions that can require substantial energy to overcome in materials processing. In some instances, the debonding agent can act to create a paper-based product exhibiting a transition temperature in which the agent has a higher affinity for the fibers at temperatures above the transition temperature, and the product exhibiting enhaced wicking properties at temperatures below the transition temperature. As an example, a debonding agents can include polymers or other material exhibiting a lower critical solution temperature. The disclosed debonding agents can provide benefits over existing debonding agent formulations such as ammonium salts.
摘要翻译：公开了脱模组合物和方法用于纤维组合物如纸基产品中。在一些情况下，脱粘剂可以与纤维（例如基于纤维素的纤维）组合以产生具有相当芯吸性质的材料，同时减少在材料加工中需要大量能量来克服的纤维 - 纤维相互作用。在一些情况下，脱粘剂可用于产生展现出转变温度的纸基产品，其中该试剂在高于转变温度的温度下对纤维具有较高的亲和力，并且该产品在低于转变温度的温度下表现出具有增强的芯吸性能温度。作为示例，脱粘剂可以包括聚合物或具有较低临界溶解温度的其它材料。所公开的脱粘剂可以提供优于现有脱粘剂配方如铵盐的益处。

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