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1. 发明专利

JP2008309799A Label-free high-throughput optical technique for detecting biomolecular interaction 审中-公开
标题翻译：用于检测生物分子相互作用的无标签高分辨率光学技术
公开(公告)号：JP2008309799A
公开(公告)日：2008-12-25
申请号：JP2008208969
申请日：2008-08-14
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/45 , G01N21/47 , G01N33/543 , G01N33/566 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10T436/24
摘要： PROBLEM TO BE SOLVED: To provide a structure and a method for detecting bonding to each bonding partners of ≥1 specific bonding substances. SOLUTION: The method and structure substance are provided for detecting the biomolecular interaction, which are free from using labels. This method can perform high-throughput system. This invention is capable of providing useful optical device as a narrow-frequency band filter. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种结构和方法，用于检测与≥1种特定粘结物质的每个粘合剂的结合。解决方案：提供了用于检测生物分子相互作用的方法和结构物质，其不使用标记。该方法可以执行高吞吐量系统。本发明能够提供有用的光学装置作为窄带滤波器。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010122227A Guided-mode resonant filter biosensor using linear optical surface structure 有权
标题翻译：使用线性光学表面结构的引导型谐振滤波器生物传感器
公开(公告)号：JP2010122227A
公开(公告)日：2010-06-03
申请号：JP2009270534
申请日：2009-11-27
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , QIU JEAN , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/47 , G01N21/78 , G01N33/543 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10S435/808 , Y10S436/805
摘要： PROBLEM TO BE SOLVED: To provide a method and a formation to detect an interaction between biomolecules. SOLUTION: The detection can be carried out in a high throughput system without using a label. An optical device useful as a narrow band filter is offered. One biosensor comprises a one-dimensional grating layer containing a high refractive index material, a low refractive index material layer supporting the one-dimensional grating layer, and one or more specific binding substance immobilized on the surface of the one-dimensional grating layer at the side opposite to the low refractive index material layer. When the biosensor is irradiated, a resonant grating effect occurs on a reflected emission spectrum. Cross-sectional period of the one-dimensional grating is shorter than the wavelength of the resonant grating effect. Another biosensor comprises a one-dimensional grating surface structure containing a low refractive index material, a high refractive index material layer applied to top of the low refractive index one-dimensional grating layer, and one or more specific binding substance immobilized on the surface of the high refractive index material at the side opposite to the one-dimensional grating surface structure containing a low refractive index material. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供检测生物分子之间的相互作用的方法和形式。
解决方案：可以在高吞吐量系统中进行检测，而不使用标签。提供用作窄带滤波器的光学装置。一个生物传感器包括含有高折射率材料的一维光栅层，支撑一维光栅层的低折射率材料层和固定在一维光栅层的表面上的一种或多种特异性结合物质与低折射率材料层相反的一侧。当照射生物传感器时，在反射发射光谱上产生谐振光栅效应。一维光栅的横截面周期短于谐振光栅效应的波长。另一种生物传感器包括一个包含低折射率材料的一维光栅表面结构，施加到低折射率一维光栅层顶部的高折射率材料层和固定在低折射率一维光栅层的表面上的一种或多种特异性结合物质在与包含低折射率材料的一维光栅表面结构相反的一侧的高折射率材料。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009025312A Label-free high-throughput optical technique for detecting biomolecular interaction 审中-公开
标题翻译：用于检测生物分子相互作用的无标签高分辨率光学技术
公开(公告)号：JP2009025312A
公开(公告)日：2009-02-05
申请号：JP2008208966
申请日：2008-08-14
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/45 , G01N21/47 , G01N33/543 , G01N33/566 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10T436/24
摘要： PROBLEM TO BE SOLVED: To provide compositions and methods for detecting a coupling of one or more of specific coupling substances to respective coupling partners. SOLUTION: The present invention discloses the method and the component for detecting biomolecular interactions. The use of labels is not required, and the methods are executed by a high-throughput system. The present invention also provides an optical device which is useful as a narrow band filter. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于检测一种或多种特定偶联物质与各个偶合物的偶联的组合物和方法。解决方案：本发明公开了用于检测生物分子相互作用的方法和组分。不需要使用标签，并且该方法由高吞吐量系统执行。本发明还提供一种用作窄带滤波器的光学装置。版权所有（C）2009，JPO＆INPIT

4. 发明申请

WO2010132890A1 DETECTION OF CHANGES IN CELL POPULATIONS AND MIXED CELL POPULATIONS 审中-公开
标题翻译：检测细胞群体和混合细胞群体的变化
公开(公告)号：WO2010132890A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/035152
申请日：2010-05-17
申请人： SRU BIOSYSTEMS, INC , SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
发明人： SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
IPC分类号： G01N33/543 , G01N33/566 , G01N33/50
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译：本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

5. 发明申请

WO2010090640A1 HIGH-DENSITY POLYMER SURFACE COATING TO IMMOBILISE CHEMICAL OR BIOLOGICAL MOLECULES 审中-公开
标题翻译：高密度聚合物表面涂层化学或生物分子
公开(公告)号：WO2010090640A1
公开(公告)日：2010-08-12
申请号：PCT/US2009/033266
申请日：2009-02-05
申请人： SRU BIOSYSTEMS, INC. , WANG, Guobin, Frank , LAING, Lance
发明人： WANG, Guobin, Frank , LAING, Lance
IPC分类号： C09D133/02 , C09D133/14 , C09D161/00 , C09D161/20 , C09D139/02
CPC分类号： C09D133/02 , C08F220/06 , C09D139/02
摘要： A method for providing high-density polymer surface for attaching proteins or peptides, and binding proteins, peptides, DNAs, cells, small molecules, and other chemical or biological molecules that are of interests in the areas of proteomic, genomic, pharmaceutical, drug discovery, and diagnostic studies.
摘要翻译：提供用于附着蛋白质或肽的高密度聚合物表面和结合蛋白质，肽，DNA，细胞，小分子以及在蛋白质组学，基因组学，药物学和药物发现领域有兴趣的其它化学或生物分子的方法和诊断研究。

6. 发明申请

WO2008156560A1 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：WO2008156560A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007031
申请日：2008-06-03
申请人： SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
发明人： CUNNINGHAM, Brian, T. , LI, Peter, Y. , LAING, Lance, G. , JOGIKALMATH, Gangadhar , BINDER, Brant
IPC分类号： G01N21/47 , G01N21/55 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。描述了用于生物传感器的各种应用，包括用于评估药物化合物，蛋白质，肽和其他材料对细胞功能的影响的基于细胞的测定。还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。两种不同的发光技术可以组合在相同的生物传感器芯片上。

7. 发明申请

WO2008055080A2 METHOD FOR BLOCKING NON-SPECIFIC PROTEIN BINDING ON A FUNCTIONALIZED SURFACE 审中-公开
标题翻译：阻塞功能性表面上非特异性蛋白质结合的方法
公开(公告)号：WO2008055080A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/082701
申请日：2007-10-26
申请人： SRU BIOSYSTEMS, INC. , JOGIKALMATH, Gangadhar
发明人： JOGIKALMATH, Gangadhar
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/54373
摘要： A method of blocking non-specific protein binding on surfaces, such as protein-coated biosensor surfaces.
摘要翻译：阻止表面上非特异性蛋白质结合的方法，如蛋白质包被的生物传感器表面。

8. 发明申请

WO2006127167A3 PROTEOLIPID MEMBRANE & LIPID MEMBRANE BIOSENSOR 审中-公开
标题翻译： PROTEOLIPID膜和脂膜生物传感器
公开(公告)号：WO2006127167A3
公开(公告)日：2007-03-22
申请号：PCT/US2006013926
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC , BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
发明人： BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N33/543 , G01N33/92
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides label-free methods for performing an assay by using a colorimetric resonant biosensor comprising at least one surface to which is immobilized one or more non-polar molecules.
摘要翻译：本发明提供了通过使用包含固定有一个或多个非极性分子的至少一个表面的比色共振生物传感器来进行测定的无标记方法。

9. 发明申请

WO2007018727A1 METHOD AND APPARATUS FOR GENERATING AN IMAGE OF BIOMOLECULAR SENSOR TARGET AREA 审中-公开
标题翻译：用于生成生物分子传感器目标区域的图像的方法和装置
公开(公告)号：WO2007018727A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/022820
申请日：2006-06-09
申请人： SRU BIOSYSTEMS, INC. , LI, Peter, Y.
发明人： LI, Peter, Y.
CPC分类号： G01N21/55 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0224 , G01J3/10 , G01J3/2823 , G01N21/39 , G01N21/4788 , G01N21/7743 , G01N21/956
摘要： Method and apparatus for imaging a target area. The apparatus comprises an adjustable light emitting device that provides a light beam with a user-defined spectrum. A filter mechanism receives the light beam and directs the light beam towards a target area. A light collection device collects an amount of light reflected from a target area and generates an image from the reflected light.
摘要翻译：用于对目标区域进行成像的方法和装置。该装置包括可调光发射装置，其提供具有用户定义光谱的光束。过滤器机构接收光束并将光束引向目标区域。光采集装置收集从目标区域反射的光量并从反射光产生图像。

10. 发明申请

WO2009149285A1 DETECTION OF PROMISCUOUS SMALL SUBMICROMETER AGGREGATES 审中-公开
标题翻译：检测致病小细胞集落体
公开(公告)号：WO2009149285A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046298
申请日：2009-06-04
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance, G.
发明人： LAING, Lance, G.
IPC分类号： G03C5/02 , G01N21/00
CPC分类号： G01N21/78 , G01N21/253 , G01N21/7743 , G01N33/54373 , G01N2021/7773 , G01N2021/7776
摘要： The invention provides methods for the detection of aggregating molecules that are capable of promiscuous or non-specific binding to proteins in a time efficient manner without the use of labels.
摘要翻译：本发明提供了用于检测能够以时间有效的方式混合或非特异性结合蛋白质的聚集分子的方法，而不使用标记。

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