专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

IL254430D0 Heterocyclic compounds useful as inhibitors of tnf 未知
公开(公告)号：IL254430D0
公开(公告)日：2017-11-30
申请号：IL25443017
申请日：2017-09-11
申请人： SQUIBB BRISTOL MYERS CO , MARCIN LAWRENCE R , WROBLESKI STEPHEN T , DHAR T G MURALI
发明人： MARCIN LAWRENCE R , WROBLESKI STEPHEN T , DHAR T G MURALI
IPC分类号： C07D20060101
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CR6 or N; W is: (i) -(CR3R3)1-4- or (ii) -(CR3R3)x-Y-(CR3R3)y-; and Y, R1, R2, R3, R5, R6, R7, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

2. 发明申请

WO2008057775A3 HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：杂环化合物作为激酶抑制剂有用
公开(公告)号：WO2008057775A3
公开(公告)日：2008-07-31
申请号：PCT/US2007082471
申请日：2007-10-25
申请人： SQUIBB BRISTOL MYERS CO , WROBLESKI STEPHEN T , DAS JAGABANDHU , DHAR T G MURALI , DYCKMAN ALARIC J , HYNES JOHN , LEFTHERIS KATERINA , LIN JAMES , LIN SHUQUN
发明人： WROBLESKI STEPHEN T , DAS JAGABANDHU , DHAR T G MURALI , DYCKMAN ALARIC J , HYNES JOHN , LEFTHERIS KATERINA , LIN JAMES , LIN SHUQUN
IPC分类号： A61K31/381 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D261/18 , C07D271/06 , C07D271/10 , C07D275/02
CPC分类号： C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04
摘要： A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
摘要翻译：式I化合物及其对映异构体，非对映异构体和药学上可接受的盐。还公开了含有式I化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

3. 发明专利

IL254520D0 Tricyclic heterocyclic compounds useful as inhibitors of tnf 未知
公开(公告)号：IL254520D0
公开(公告)日：2017-11-30
申请号：IL25452017
申请日：2017-09-15
申请人： SQUIBB BRISTOL MYERS CO , WROBLESKI STEPHEN T , BROWN GREGORY D , LIN SHUQUN , DUAN JINGWU , LU ZHONGHUI , DHAR T G MURALI , XIAO HAI YUN , TEBBEN ANDREW J
发明人： WROBLESKI STEPHEN T , BROWN GREGORY D , LIN SHUQUN , DUAN JINGWU , LU ZHONGHUI , DHAR T G MURALI , XIAO HAI-YUN , TEBBEN ANDREW J
IPC分类号： C07D20060101

4. 发明申请

WO2009058944A3 NONSTEROIDAL COMPOUNDS USEFUL AS MODULATORS OF GLUCOCORTICOID RECEPTOR AP-1 AND /OR NF- KAPPA B ACTIVITY AND USE THEREOF 审中-公开
标题翻译：非甾体化合物作为葡萄糖激素受体AP-1和/或NF-KAPPA B活性的调节剂和其使用有用
公开(公告)号：WO2009058944A3
公开(公告)日：2009-07-02
申请号：PCT/US2008081702
申请日：2008-10-30
申请人： SQUIBB BRISTOL MYERS CO , DHAR T G MURALI , XIAO HAI-YUN
发明人： DHAR T G MURALI , XIAO HAI-YUN
IPC分类号： C07D471/04 , A61K31/4184 , A61P3/04 , A61P3/10 , A61P29/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of Formula (I) wherein: one of A and D is -N- and the other of A and D is -C-; or enantiomers, diastereomers, or pharmaceutically-acceptable salts thereof. Also disclosed are methods of using such compounds to modulate the function of glucocorticoid receptor activity and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的化合物，其中：A和D之一是-N-，A和D中的另一个是-C-; 或其对映异构体，非对映异构体或其药学上可接受的盐。还公开了使用这些化合物调节糖皮质激素受体活性的功能的方法和包含这些化合物的药物组合物。

5. 发明申请

WO0181340A3 HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME 审中-公开
标题翻译：杂环化合物是印度酶的抑制剂
公开(公告)号：WO0181340A3
公开(公告)日：2002-05-23
申请号：PCT/US0112900
申请日：2001-04-19
申请人： SQUIBB BRISTOL MYERS CO , IWANOWICZ EDWIN J , WATTERSON SCOTT H , DHAR T G MURALI , PITTS WILLIAM J , GU HENRY H
发明人： IWANOWICZ EDWIN J , WATTERSON SCOTT H , DHAR T G MURALI , PITTS WILLIAM J , GU HENRY H
IPC分类号： C07D215/22 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/5415 , A61K45/00 , A61P1/18 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D215/48 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/33 , C07D521/00
CPC分类号： C07D413/04 , C07D215/48 , C07D413/14 , C07D417/04
摘要： Compounds of formula (I) wherein X is C(O), -S(O)-, or -S(O)2-; X is CR or N; X is -NH-, -O-, or -S-; X is CR or N; X is CR or N; and X is CR or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH- associated disorders.
摘要翻译：其中X 1为C（O），-S（O） - 或-S（O）2 - 的式（I）化合物; X 2是CR 3或N; X 3是-NH-，-O-或-S-; X 4是CR 4或N; X 5为CR 5或N; 且X 6为CR 6或N可用作IMPDH酶的抑制剂。因此，这些化合物可以用作IMPDH-相关疾病的治疗剂。

6. 发明申请

WO2008057862A3 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-?B ACTIVITY AND USE THEREOF 审中-公开
标题翻译：糖皮质激素受体，AP-1和/或NF-κB活性的调节剂及其用途
公开(公告)号：WO2008057862A3
公开(公告)日：2008-10-16
申请号：PCT/US2007083094
申请日：2007-10-31
申请人： SQUIBB BRISTOL MYERS CO , YANG BINGWEI VERA , DOWEYKO LIDIA M , VACCARO WAYNE , HUYNH TRAM N , TORTOLANI DAVID R , DHAR T G MURALI
发明人： YANG BINGWEI VERA , DOWEYKO LIDIA M , VACCARO WAYNE , HUYNH TRAM N , TORTOLANI DAVID R , DHAR T G MURALI
IPC分类号： C07C235/36 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D241/20 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/10 , C07D417/12
CPC分类号： C07D211/58 , C07C235/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D277/46 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/10 , C07D417/12
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I) an enantiomer, diastereomer, tautomer, solvate (e.g. a hydrate), or a pharmaceutically-acceptable salt, thereof, wherein: M is selected from alkyl, substituted alkyl, cycloalkyl, aryl, heterocyclo, and heteroaryl, provided that if M is alkyl then R 6 and R 7 taken together with the carbon atom to which they are both attached are selected from a group other than cycloalkyl; Q is selected from (i) hydrogen, C 1 -C 4 alkyl, and substituted C 1 -C 4 alkyl; or (ii) Q and R 6 are combined with the carbon atoms to which they are attached to form a 3- to 6-membered cycloalkyl; or (iii) Q and M a M are combined with the carbon atom(s) to which they are attached to form a 3- to 7-membered ring containing 1-2 heteroatoms which are independently selected from the group consisting of O, S, SO 2 , and N which ring may be optionally substituted with 0-2 R 5 groups or carbonyl; Z is selected from cycloalkyl, heterocyclo, aryl, or heteroaryl; and M a , Z a , R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , and R 22 are as defined herein. Also provided are pharmaceutical compositions and methods of treating metabolic and inflammatory- or immune-associated diseases or disorders using said compounds.
摘要翻译：提供了新颖的非类固醇化合物，其用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括具有式（I）结构的炎性和免疫疾病，肥胖症和糖尿病，其中：M选自烷基，取代的烷基，环烷基，芳基，杂环基和杂芳基，条件是如果M是烷基，则M是烷基，取代的烷基，环烷基， R 6和R 7与它们都连接的碳原子一起选自除环烷基以外的基团; Q选自（i）氢，C 1 -C 4烷基和取代的C 1 -C 4 SUB 烷基; 或（ii）Q和R 6与它们所连接的碳原子结合形成3至6元环烷基; 或（iii）Q和MASS a M与它们所连接的碳原子结合形成含有1-2个独立选自以下的杂原子的3-至7-元环：由O，S，SO 2，N和N组成的组，该环可以任选地被0-2个R 5基团或羰基取代; Z选自环烷基，杂环基，芳基或杂芳基; 和_{a ，Z _{a ，_{1 ，_{2 ，_{3 ，R 4，R 6，R 7，和R 22如本文所定义。还提供了使用所述化合物治疗代谢和炎症或免疫相关疾病或病症的药物组合物和方法。}}}}}

7. 发明申请

WO2008057856A2 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-?B ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-κB活性及其用途
公开(公告)号：WO2008057856A2
公开(公告)日：2008-05-15
申请号：PCT/US2007083084
申请日：2007-10-31
申请人： SQUIBB BRISTOL MYERS CO , SHEPPECK JAMES E , GILMORE JOHN L , DHAR T G MURALI , XIAO HAI-YUN
发明人： SHEPPECK JAMES E , GILMORE JOHN L , DHAR T G MURALI , XIAO HAI-YUN
IPC分类号： C07D417/12 , A61K31/427 , A61P29/00 , C07D231/56 , C07D403/12 , C07D409/12 , C07D417/14 , C07D471/04
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1, and/or NF-?B activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein (Ia) is heterocycle or heteroaryl; J, Ja, E, F, G, Ma, M, Q, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
摘要翻译：提供新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，和/或AP-1和/或NF-κB活性相关的疾病，包括具有结构式的炎性和免疫疾病，肥胖症和糖尿病（I）化合物，其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中（Ia）是杂环或杂芳基; J，Ja，E，F，G，Ma，M，Q，Za和Z如本文所定义。还提供了使用所述化合物治疗炎性或免疫相关疾病和肥胖症和糖尿病的药物组合物和方法。

8. 发明申请

WO2004000214A2 USE OF COMPOUNDS HAVING AN AMINE NUCLEUS IN MANUFACTURE OF A MEDICAMENT USEFUL FOR TREATING FACTOR VIIA-ASSOCIATED CONDITIONS 审中-公开
标题翻译：在制造有用于治疗因子VIIA相关条件的药物中使用氨基核的化合物的使用
公开(公告)号：WO2004000214A2
公开(公告)日：2003-12-31
申请号：PCT/US0319155
申请日：2003-06-17
申请人： SQUIBB BRISTOL MYERS CO , HERPIN TIMOTHY , BISACCHI GREGORY S , PI ZULAN , PRIESTLEY E SCOTT , DHAR T G MURALI
发明人： HERPIN TIMOTHY , BISACCHI GREGORY S , PI ZULAN , PRIESTLEY E SCOTT , DHAR T G MURALI
IPC分类号： A61K31/415 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/422 , A61P9/08 , C07D263/48 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00 , A61K
CPC分类号： C07D231/12 , A61K31/415 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/422 , C07D233/56 , C07D249/08 , C07D263/48 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Use of at least one compound having the formula (I), or a pharmaceutically-acceptable salt, hydrate or prodrug thereof, in the manufacture of a medicament useful for treating conditions associated with the activity of Factor VIIa is described.
摘要翻译：描述了至少一种具有式（I）化合物或其药学上可接受的盐，水合物或前药在制备用于治疗与因子VIIa活性相关的病症的药物中的用途。

9. 发明申请

WO2008057855A9 HETEROCYCLIC COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-I, AND/OR NP-KAPPA-B ACTIVITY 审中-公开
标题翻译：作为GLUCOCORTICOID受体，AP-I和/或NP-KAPPA-B活性的调节剂的杂环化合物
公开(公告)号：WO2008057855A9
公开(公告)日：2009-06-18
申请号：PCT/US2007083083
申请日：2007-10-31
申请人： SQUIBB BRISTOL MYERS CO , DHAR T G MURALI , XIAO HAI-YUN , SHEPPECK JAMES E
发明人： DHAR T G MURALI , XIAO HAI-YUN , SHEPPECK JAMES E
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1 and/or NF-?B activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I):, its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein the group X is O or (Rx)(Ry); is heterocyclo or heteroaryl; E is -N-, -NR1-, -O-, -C(=O), -S-, -SO2-, or -CR2-; F is -N-, -NR1a, -O-, -C(=O), -S-, -SO2-, or -CR2a-; G is independently N, -NR1b-, -O-, -C(=O), -S-, -SO2- or -CR2b- provided that the heterocyclic ring formed does not contain a S-S or S-O bond and at least one of E, F and G is a hetero atom; and Ma, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, R4, R5a, R6, R7, X, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases employing said compounds.
摘要翻译：提供新的非甾体化合物，其可用于治疗与糖皮质激素受体和/或AP-1和/或NF-κB活性相关的疾病，包括具有结构式（1）的炎性和免疫疾病，肥胖症和糖尿病 I）：其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中基团X为O或（Rx）（Ry）; 是杂环基或杂芳基; E是-N-，-NR1 - ， - O - ， - C（= O），-S-，-SO2-或-CR2-; F是-N-，-NR1a，-O-，-C（= O），-S-，-SO2 - 或-CR2a; G独立地为N，-NR1b - ， - O - ， - C（= O）， - S - ， - SO2-或-CR2b-，条件是所形成的杂环不含有SS或SO键， E，F和G是杂原子; 并且Ma，Rx，Ry，R1，R1a，R1b，R2，R2a，R2b，R4，R5a，R6，R7，X，Za和Z如本文所定义。还提供了使用所述化合物治疗炎性或免疫相关疾病的药物组合物和方法。

10. 发明申请

WO2008057855A2 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-κB活性及其用途
公开(公告)号：WO2008057855A2
公开(公告)日：2008-05-15
申请号：PCT/US2007083083
申请日：2007-10-31
申请人： SQUIBB BRISTOL MYERS CO , DHAR T G MURALI , XIAO HAI-YUN , SHEPPECK JAMES E
发明人： DHAR T G MURALI , XIAO HAI-YUN , SHEPPECK JAMES E
CPC分类号： C07D471/04
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1 and/or NF-?B activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula I:, its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein the group X is O or (R x )(R y ); is heterocyclo or heteroaryl; E is -N-, -NR 1 -, -O-, -C(=O), -S-, -SO 2 -, or -CR 2 -; F is -N-, -NR 1a , -O-, -C(=O), -S-, -SO 2 -, or -CR 2a -; G is independently N, -NR 1b -, -O-, -C(=O), -S-, -SO 2 - or -CR 2b - provided that the heterocyclic ring formed does not contain a S-S or S-O bond and at least one of E, F and G is a hetero atom; and Ma, R x , R y , R 1 , R 1a , R 1b , R 2 , R 2a , R 2b , R 4 , R 5a , R 6 , R 7 , X, Z a and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases employing said compounds.
摘要翻译：提供了新的非甾体化合物，其可用于治疗与糖皮质激素受体的调节有关的疾病和/或AP-1和/或NF-κB活性，包括具有式I结构的炎性和免疫疾病，肥胖症和糖尿病：其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中基团X为O或（R x x）O（R y）; 是杂环基或杂芳基; E是-N-，-NR 1 - ， - O - ， - C（= O），-S - ， - SO 2 - 或-CR _{2 - ; F是-N，-NR 1a，-O - ， - C（= O）， - S - ， - SO 2 - 或-CR 图2a - ; G独立地为N，-NR1B1 - ， - O - ， - C（= O），-S-，-SO2-或-CR2b - 条件是所形成的杂环不含有SS或SO键，并且E，F和G中的至少一个为杂原子; 和M a，R x，R y，R 1，R 1a，R 1b， R 2，R 2，R 2a，R 2b，R 4，R 5a， R 6，R 6，R 7，X，Z a a和Z如本文所定义。还提供了使用所述化合物治疗炎性或免疫相关疾病的药物组合物和方法。}

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式