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    • 3. 发明申请
    • SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD
    • 作为抗真菌剂和抗菌剂和方法有用的取代的杂环衍生物
    • WO2004004655A2
    • 2004-01-15
    • PCT/US0321331
    • 2003-07-08
    • SQUIBB BRISTOL MYERS COCHENG PETER T WCHEN SEANDING CHARLES ZHERPIN TIMOTHY F
    • CHENG PETER T WCHEN SEANDING CHARLES ZHERPIN TIMOTHY F
    • A61K31/41A61K31/42A61K31/435A61K31/50A61K31/52C07D233/54C07D249/06C07D263/32C07D271/06C07D413/12A61K
    • C07D233/64C07D249/06C07D263/32C07D271/06C07D413/12
    • Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding the structure (II) where X2 = N, X3 = C, X4 = O or S, Z = o or a bond; R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R and Y are as defined herein, which compounds are useful in treating diabetes and obesity.
    • 提供可用作抗糖尿病药和抗肥胖剂的化合物,并具有其中m为0,1或2的结构(I); n为0,1或2; Q是C或N; A是(CH 2)x,其中x是1至5,或A是(CH 2)x1,其中x 1是1至5,链烯基或炔基键嵌入链中的任何位置,或A是 - (CH 2) x 2 -O-(CH 2)x 3 - 其中x 2为0至5且x 3为0至5,条件是x 2和x 3中的至少一个为 0以外; B是键或是(CH 2)x 4,其中x 4是1至5; X是CH或N; X2是C,N,O或S; X3为C,N,O或S; X4为C,N,O或S; X5为C,N,O或S; X6为C,N,O或S; 条件是X 2,X 3,X 4 X 5和X 6中的至少一个为N; X2,X3,X4,X5和X6中的至少一个为C,并且具体排除其中X2 = N,X3 = C,X4 = O或S,Z = o或键的结构(II) R 1是H或烷基; R 2是H,烷基,烷氧基,卤素,氨基或取代的氨基或氰基; R 2a,R 2b和R 2c可以相同或不同,并且选自H,烷基,烷氧基,卤素,氨基或取代的氨基或氰基; R 3和Y如本文所定义,该化合物可用于治疗糖尿病和肥胖症。