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1. 发明申请

WO2004004665A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：用作抗糖尿病药和抗衰老药的取代的杂环衍生物和方法
公开(公告)号：WO2004004665A2
公开(公告)日：2004-01-15
申请号：PCT/US0322149
申请日：2003-07-02
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
发明人： CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
IPC分类号： A61K31/155 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/397 , A61K31/401 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/14 , C07D413/12 , C07D413/14 , A61K
CPC分类号： C07D413/12 , C07D413/14
摘要： Formula, wherein Z is (CH2)q or C=O; Z is (CH2)p or C=O; D is -CH= or C=O or (CH2)m where m is 0, 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2; q = 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x , where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R , E, Z and Y are as defined herein.
摘要翻译：式，其中Z 1是（CH 2）q或C = O; Z 2是（CH 2）p或C = O; D是-CH =或C = O或（CH 2）m，其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; A是（CH 2）x，其中x是1至5，或A是（CH 2）x 1，其中x 1是1至5且链中任何位置嵌入烯基键或炔基键，或A是 - （CH 2）x 2 -O-（CH 2）x 3 - 其中x 2为0至5且x 3为0至5，条件是x 2和x中的至少一个 <3>不是0; B是键或是（CH 2）x 4，其中x 4是1至5; X是CH或N; X2是C，N，O或S; X3是C，N，O或S; X4是C，N，O或S; X5是C，N，O或S; X6是C，N，O或S; 条件是X2，X3，X4，X5和X6中的至少一个是N; 并且X 2，X 3，X 4，X 5和X 6中的至少一个是C.R 1是H或烷基; R 2是H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; R 2a，R 2b和R 2c可以相同或不同，并且选自H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; 并且R 3，E，Z和Y如本文所定义。

2. 发明申请

WO2004004655A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：作为抗真菌剂和抗菌剂和方法有用的取代的杂环衍生物
公开(公告)号：WO2004004655A2
公开(公告)日：2004-01-15
申请号：PCT/US0321331
申请日：2003-07-08
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
发明人： CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
IPC分类号： A61K31/41 , A61K31/42 , A61K31/435 , A61K31/50 , A61K31/52 , C07D233/54 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12 , A61K
CPC分类号： C07D233/64 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12
摘要： Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding the structure (II) where X2 = N, X3 = C, X4 = O or S, Z = o or a bond; R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R and Y are as defined herein, which compounds are useful in treating diabetes and obesity.
摘要翻译：提供可用作抗糖尿病药和抗肥胖剂的化合物，并具有其中m为0,1或2的结构（I）; n为0,1或2; Q是C或N; A是（CH 2）x，其中x是1至5，或A是（CH 2）x1，其中x 1是1至5，链烯基或炔基键嵌入链中的任何位置，或A是 - （CH 2） x 2 -O-（CH 2）x 3 - 其中x 2为0至5且x 3为0至5，条件是x 2和x 3中的至少一个为 0以外; B是键或是（CH 2）x 4，其中x 4是1至5; X是CH或N; X2是C，N，O或S; X3为C，N，O或S; X4为C，N，O或S; X5为C，N，O或S; X6为C，N，O或S; 条件是X 2，X 3，X 4 X 5和X 6中的至少一个为N; X2，X3，X4，X5和X6中的至少一个为C，并且具体排除其中X2 = N，X3 = C，X4 = O或S，Z = o或键的结构（II） R 1是H或烷基; R 2是H，烷基，烷氧基，卤素，氨基或取代的氨基或氰基; R 2a，R 2b和R 2c可以相同或不同，并且选自H，烷基，烷氧基，卤素，氨基或取代的氨基或氰基; R 3和Y如本文所定义，该化合物可用于治疗糖尿病和肥胖症。

3. 发明申请

WO03050261A2 (1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F>10< ATP HYDROLASE 审中-公开
标题翻译：（1-苯基-2-异丙基）乙基 - 胍基化合物作为MITOCHONDRIAL F> 10
公开(公告)号：WO03050261A2
公开(公告)日：2003-06-19
申请号：PCT/US0239478
申请日：2002-12-10
申请人： SQUIBB BRISTOL MYERS CO , ATWAL KARNAIL S , GROVER GARY J , DING CHARLES Z , STEIN PHILIP D , LLOYD JOHN , AHMAD SALEEM , HAMANN LAWRENCE G , GREEN DAVID , FERRARA FRANCIS N
发明人： ATWAL KARNAIL S , GROVER GARY J , DING CHARLES Z , STEIN PHILIP D , LLOYD JOHN , AHMAD SALEEM , HAMANN LAWRENCE G , GREEN DAVID , FERRARA FRANCIS N
IPC分类号： A61P9/00 , C07D231/12 , C07D233/54 , C07D235/06 , C07D235/10 , C07D235/14 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , C12N
CPC分类号： C07D233/54 , C07D231/12 , C07D233/56 , C07D235/06 , C07D235/14 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds having formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F>10
摘要翻译：具有式（I）的化合物及其药学上可接受的盐可用于调节线粒体F> 10

4. 发明申请

WO03106628A2 BENZODIAZEPINE INHIBITORS OF MITOCHONDIAL F>10< ATP HYDROLASE AND METHODS OF INHIBITING F>10< ATP HYDROLASE 审中-公开
标题翻译： MITOCHONDIAL F> 10 10
公开(公告)号：WO03106628A2
公开(公告)日：2003-12-24
申请号：PCT/US0318552
申请日：2003-06-13
申请人： SQUIBB BRISTOL MYERS CO , DING CHARLES Z , HAMANN LAWRENCE G , STEIN PHILIP D , PUDZIANOWSKI ANDREW T
发明人： DING CHARLES Z , HAMANN LAWRENCE G , STEIN PHILIP D , PUDZIANOWSKI ANDREW T
IPC分类号： A61P9/00 , C07D243/14 , C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/14 , C12N
CPC分类号： C07D413/14 , C07D243/14 , C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Compounds having the formula (I), are useful as inhibitors of mitochondrial F>10 5 7 2 3 4 2 2 2 2 2 2 p 10 11 10 6 10 11
摘要翻译：具有式（I）的化合物可用作线粒体F> 10 2 - ， - SO 2， - ， - CH 2， - CH 2，C（= O） - 和-C O）C（= O） - 或Z可以不存在; R和T是CH 2，-C（= O） - 或-CH [（CH 2））p（Q）] - ，其中Q是NR> 10 11， > 10

5. 发明公开

EP1656368A4 SUBSTITUTED HERTOCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译： AS抗糖尿病和手段对抗肥胖合适的取代的杂环衍生物方法
公开(公告)号：EP1656368A4
公开(公告)日：2009-08-26
申请号：EP03763485
申请日：2003-07-02
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
IPC分类号： C07D403/06 , A61K31/155 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/397 , A61K31/401 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/08 , C07D403/10 , C07D403/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12 , C07D413/14

6. 发明公开

EP1531810A4 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 有权
标题翻译：取代的杂环衍生物作为预防糖尿病剂和肥胖程序
公开(公告)号：EP1531810A4
公开(公告)日：2008-05-28
申请号：EP03763345
申请日：2003-07-08
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
IPC分类号： A61K31/41 , A61K31/42 , A61K31/435 , A61K31/50 , A61K31/52 , C07D233/54 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12
CPC分类号： C07D233/64 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12

7. 发明公开

EP0918771A4 THIADIOXOBENZODIAZEPINE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE 失效
标题翻译：三硝基苯并咪唑 - 抑制蛋白转运蛋白
公开(公告)号：EP0918771A4
公开(公告)日：2001-02-07
申请号：EP97936043
申请日：1997-07-08
申请人： SQUIBB BRISTOL MYERS CO
发明人： DING CHARLES Z
IPC分类号： A61K31/554 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/28 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D417/06 , C07D417/14 , C07D417/02 , A61K31/55
CPC分类号： C07D417/06 , C07D417/14

8. 发明公开

EP1450901A4 (1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F1F0 ATP HYDROLASE 审中-公开
标题翻译：（1-苯基-2-杂芳基）乙基胍化合物作为线粒体F1F0 ATP水解酶的抑制剂
公开(公告)号：EP1450901A4
公开(公告)日：2005-05-25
申请号：EP02804765
申请日：2002-12-10
申请人： SQUIBB BRISTOL MYERS CO
发明人： ATWAL KARNAIL S , GROVER GARY J , DING CHARLES Z , STEIN PHILIP D , LLOYD JOHN , AHMAD SALEEM , HAMANN LAWRENCE G , GREEN DAVID , FERRARA FRANCIS N
IPC分类号： A61P9/00 , C07D231/12 , C07D233/54 , C07D235/06 , C07D235/10 , C07D235/14 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/55
CPC分类号： C07D233/54 , C07D231/12 , C07D233/56 , C07D235/06 , C07D235/14 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12

10. 发明公开

EP0994856A4 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE 失效
公开(公告)号：EP0994856A4
公开(公告)日：2000-12-06
申请号：EP98930299
申请日：1998-06-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHIDE RAJEEV S , DING CHARLES Z , HUNT JOHN T , KIM SOONG-HOON , LEFTHERIS KATERINA
IPC分类号： C07D403/08 , A61K31/4709 , A61K31/55 , A61P35/00 , A61P37/02 , A61P43/00 , C07D233/54 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D233/02 , C07D233/04 , C07D235/02 , C07D249/00 , C07D249/16 , C07D257/04 , C07D257/10 , C07D403/00 , C07D403/02
CPC分类号： C07D401/06 , C07D403/06 , C07D403/12 , C07D409/14

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