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    • 8. 发明专利
    • SKIN COSMETIC
    • JPS61221104A
    • 1986-10-01
    • JP6420285
    • 1985-03-28
    • SHISEIDO CO LTD
    • OKUDA TAKAYAUZUKA MAKOTO
    • A61K8/96A61K8/00A61K8/49A61Q19/00A61Q19/02
    • PURPOSE:A skin cosmetic that contains melatonin, thus showing high effect to improve skin roughness, cure wounds, activate skins and lighten skin color. CONSTITUTION:Melatonin, a hormone, which occurs only in pineal body as a water-insoluble substance with a molecular weight of 232 and is produced in pineal body only in the night by biosynthesis from L-triptophane, an essential aminoacid under promotion by serotonin N-acetyl transferase, is added to the cosmetic in an amount of 0.0001-1wt% based on the whole amount of the cosmetic. The active ingredient deeply participates in biorhythm of body and skin metabolism to cause a day-cycle rhythm depending on the melatonin content. Thus, appearance of skins are varied by supplement of nutritions such as food and cosmetics to skin and appropriate physical exercise and appropriate sleeping largely improves skin activity. EFFECT:Irritation and sensitivity to skins are reduced with high stability with the passage of time and good feeling, when applied.