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1. 发明申请

WO2009120313A3 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER LIGANDS IN SOY AND RELATED ASSAYS FOR IDENTIFYING BITTER TASTE MODULATORS 审中-公开
标题翻译：识别大豆中双歧杆菌配偶体的人类T2R受体的鉴定和相关测定用于鉴别叮咬调味品
公开(公告)号：WO2009120313A3
公开(公告)日：2009-12-30
申请号：PCT/US2009001829
申请日：2009-03-24
申请人： SENOMYX INC , LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
发明人： LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
IPC分类号： C12Q1/68 , A23L11/00 , A61K36/48 , C07K14/705 , C12Q1/00 , G01N33/566 , G01N33/567
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1, hT2R8, hT2R14, hT2R44, hT2R55, hT2R61, hT2R63, hT2R64, hT2R67 and hT2R71 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。本发明还涉及这些T2R受体在用于鉴定通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。此外，这些T2R配体潜在地可以用作治疗和调节hT2R1，hT2R8，hT2R14，hT2R44，hT2R55，hT2R61，hT2R63，hT2R64，hT2R67和hT2R71相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感染，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等。

2. 发明申请

WO2009025793A3 HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF 审中-公开
标题翻译：人类T2R双相受体受体及其用途
公开(公告)号：WO2009025793A3
公开(公告)日：2009-05-14
申请号：PCT/US2008009864
申请日：2008-08-19
申请人： SENOMYX INC , LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： G01N33/53 , A23L27/00 , A23L27/20
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

3. 发明申请

WO2009025793A8 HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF 审中-公开
标题翻译：人类T2R位点受体及其用途
公开(公告)号：WO2009025793A8
公开(公告)日：2009-07-30
申请号：PCT/US2008009864
申请日：2008-08-19
申请人： SENOMYX INC , LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： G01N33/53 , A23L27/00 , A23L27/20
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及这样的发现，即T2R味觉受体家族中的特定人味觉受体对存在于例如咖啡中的特定苦味化合物产生反应。此外，本发明涉及发现含有该功能的特定化合物和组合物作为苦味阻断剂及其在例如咖啡和咖啡调味食品，饮料和药物中作为苦味阻断剂或风味调节剂的用途。而且，本发明涉及拮抗许多不同的人类T2R的化合物的发现及其在测定中的用途以及用于人和动物摄取的组合物中的苦味阻断剂。

4. 发明申请

WO2008101412A8 THE USE OF EPIMEDIUM FLAVONES AND EFFECTIVE COMPONENTS THEREOF FOR THE PREPARATION OF MEDICAMENTS OF PROMOTING PROLIFERATIONS AND DIFFERENTIATIONS OF NERVE CELLS 审中-公开
标题翻译：用于制备促进增殖和神经细胞分化的药物的有效成分及其有效成分的使用
公开(公告)号：WO2008101412A8
公开(公告)日：2009-10-08
申请号：PCT/CN2008000353
申请日：2008-02-15
申请人： XUANWU HOSPITAL OF CAPITAL MED , LI LIN , ZHANG LAN , WEI HAIFENG , YAO RUIQIN , LI XIAOLI , CHU JIN
发明人： LI LIN , ZHANG LAN , WEI HAIFENG , YAO RUIQIN , LI XIAOLI , CHU JIN
IPC分类号： A61K36/296 , A61K31/7048 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/32
CPC分类号： A61K36/296 , A61K31/7048
摘要： The use of epimedium flavones and/or icariins for the preparation of medicaments of promoting proliferations and/or differentiations of nerve cells, is disclosed.
摘要翻译：公开了淫羊藿黄酮和/或淫羊藿苷用于制备促进神经细胞增殖和/或分化的药物的用途。

5. 发明申请

WO2016081327A2 RECOMBINANT EXPRESSION OF CHLAMYDIA MOMP ANTIGEN 审中-公开
标题翻译： CHLAMYDIA MOMP抗原的重组表达
公开(公告)号：WO2016081327A2
公开(公告)日：2016-05-26
申请号：PCT/US2015060780
申请日：2015-11-16
申请人： MERCK SHARP & DOHME , ZHANG LAN , WEN ZHIYUN , PRZYSIECKI CRAIG T , KHANDELWAL PUNEET , QIU PING
发明人： ZHANG LAN , WEN ZHIYUN , PRZYSIECKI CRAIG T , KHANDELWAL PUNEET , QIU PING
IPC分类号： A61K39/02 , C12P21/02
CPC分类号： A61K39/02 , A61K2039/54 , A61K2039/55511 , C07K14/295
摘要： The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
摘要翻译：本发明涉及重组表达衣原体主要外膜蛋白（MOMP）的方法，包括用表达载体转化大肠杆菌宿主细胞群，所述表达载体包含编码衣原体MOMP的核酸分子并编码前导序列以靶向 MOMP与细胞外膜接触，其中核酸分子与启动子有效连接。本发明的方法允许在细胞的外膜中表达MOMP，其导致与天然MOMP相关的蛋白质折叠相对于细胞内表达的MOMP蛋白质。本发明还提供了重组MOMP在用于治疗和/或预防衣原体感染和/或其效果的药物组合物和方法中的用途。

7. 发明专利

MX2010001995A IDENTIFICACION DE RECEPTORES T2R HUMANOS QUE RESPONDEN A COMPUESTOS AMARGOS QUE PROVOCAN EL SABOR AMARGO EN COMPOSICIONES, Y USO DE LOS MISMOS EN ENSAYOS PARA IDENTIFICAR COMPUESTOS QUE INHIBEN (BLOQUEAN) SABOR AMARGO EN COMPOSICIONES Y USO DE LOS MI 未知
公开(公告)号：MX2010001995A
公开(公告)日：2010-06-09
申请号：MX2010001995
申请日：2008-08-19
申请人： SENOMYX INC
发明人： KARANEWSKY DONALD S , PATRON ANDREW , TACHDJIAN CATHERINE , LI XIAODONG , XU HONG , PRONIN ALEXEY , SERVANT GUY , BRUST PAUL , DARMOHUSODO VINCENT , LI QING , ZHANG LAN , BRADY THOMAS , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： A23L27/00 , G01N33/53 , A23L27/20
摘要： La presente invención se refiere al descubrimiento de que receptores de sabor humanos específicos en la familia de receptores de sabor TR2 responden a compuestos amargos particulares presentes en, por ejemplo, café. También, la invención se refiere al descubrimiento de compuestos y composiciones específicos que contienen esa función como bloqueadores de sabor amargo y al uso de los mismos como bloqueadores de sabor amargo o moduladores de sabor en, por ejemplo, café y alimentos, bebidas y medicamentos con sabor a café. Asimismo, la presente invención se refiere al descubrimiento de un compuesto que antagoniza numerosos T2R5 humanos diferentes y al uso de los mismos en ensayos y como un bloqueador de sabor amargo en composiciones para su ingestión por humanos y animales.

8. 发明专利

CL2008002473A1 Compuestos moduladores del sabor amargo asociado a cafe y/o alimentos saborizados con cafe, bebidas o medicamentos y metodos para la preparacion de dicho compuestos. 未知
公开(公告)号：CL2008002473A1
公开(公告)日：2009-03-27
申请号：CL2008002473
申请日：2008-08-21
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , DARMOHUSODO VINCENT , PRIEST CHAD , KARANEWSKY DONALD S , LI XIAODONG , SERVANT GUY , LING JING , ZHAO WEN , XU HONG , ZHANG LAN , PATRON ANDREW , PRONIN ALEXEY , BRADY THOMAS , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , BRUST PAUL , LI QING
IPC分类号： A61K31/33 , A23L27/00 , A23L27/20 , C07D207/00 , C12N15/12 , C12Q1/00
摘要： Ensayo para identificar un compuesto que modula el sabor amargo; compuestos; método para reducir o aliviar el sabor amargo que comprende agregar dichos compuestos a una composición para la ingesta humana o animal; composición que comprende dichos compuestos; receptor acoplado a proteína g quimérico.

9. 发明专利

CA2982520A1 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER COMPOUNDS THAT ELICIT THE BITTER TASTE IN COMPOSITIONS, AND THE USE THEREOF IN ASSAYS TO IDENTIFY COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITIONS AND USE THEREOF 未知
公开(公告)号：CA2982520A1
公开(公告)日：2009-02-26
申请号：CA2982520
申请日：2008-08-19
申请人： SENOMYX INC
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： C07C311/21 , A23L27/00 , A23L27/20 , A61K47/06 , A61K47/20 , A61K47/22 , C07D217/08 , C07D217/20 , C07D223/18 , C07D239/96 , C07D241/44 , C07D307/52 , C07D401/12 , C07D405/12 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , G01N33/566 , G01N33/567
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

10. 发明专利

AR112196A2 COMPUESTOS DERIVADOS DE HIDANTOÍNA COMO BLOQUEADORES DEL SABOR AMARGO 未知
公开(公告)号：AR112196A2
公开(公告)日：2019-10-02
申请号：ARP180101708
申请日：2018-06-18
申请人： SENOMYX INC
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： C07D413/14
摘要： Compuestos derivados de hidantoína como antagonistas de receptores de hT2R8 y hT2R14 que inhiben o bloquean el sabor amargo del café y productos relacionados. Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1) o una de sus sales, hidratos, solvatos, N-óxidos o profármacos, en donde Alk es CH₂; G es C=O y Q es CR⁵¹R⁵² o NR⁵¹, en donde R⁵¹ y R⁵² son, iguales o diferentes, de modo independiente entre sí, (a) H; (b) metilo opcionalmente sustituido con grupo isopropilo, ciclopentilo, ciclohexilo, hidroxi, metoxi, benciloxi, o carboxilo; (c) etilo opcionalmente sustituido con grupo metoxi o fenoxi; (d) propilo opcionalmente sustituido con grupo fenilo; (e) isopropilo; (f) butilo; (g) -CH₂-C(O)-NH-Ph; (h) -C(O)-O-CH₂CH₃; (i) -CH₂-Ph opcionalmente sustituido con de 1 a 2 sustituyentes independientemente seleccionados en cada ocurrencia de los mismos entre grupo metoxi o hidroxi; (j) CH₂-CH₂-Ph opcionalmente sustituido con halógeno; o (k) -CH₂-C(O)-NH-CH₂-Ph opcionalmente sustituido con grupo metoxi; M¹ es N o CR⁴⁹, en donde R⁴⁹, es H; M² es N o CR⁵⁰, en donde R⁵⁰ es H; R³⁸ es (a) H; (b) metilo opcionalmente sustituido con grupo ciclohexilo, metoxi, o tetrahidrofuranilo; (c) etilo opcionalmente sustituido con grupo metoxi, fenoxi, o naftilo; (d) propilo; (e) butilo; (f) -C(O)-O-CH₂CH₃; (g) -CH₂-Ph opcionalmente sustituido con de 1 a 2 sustituyentes independientemente seleccionados en cada ocurrencia de los mismos entre halógeno, metilo, -CF₃, hidroxi, metoxi, -O(CH₂)₂OCH₃, -COOMe, -CH₂OH, carboxilo, -C(O)N(H)Me, metiltio, -S(O)CH₃, ciano, nitro, -C(O)H, amino, -O(CH₂)O-, -CH₂N(CH₃)₂, o -CH₂-NH-C(O)-C(CH₃)₃; (h) -CH₂-CH₂-Ph opcionalmente sustituido con de 1 a 2 sustituyentes independientemente seleccionados en cada ocurrencia de los mismos entre halógeno, hidroxi, o metoxi; (i) un resto de fórmula (2) opcionalmente sustituido 1 ó 2 veces con metilo; (j) un resto de fórmula (3) opcionalmente sustituido 1 ó 2 veces con metilo; (k) un resto de fórmula (4) opcionalmente sustituido 1 ó 2 veces con metilo; o (l) un resto de fórmula (5) opcionalmente sustituido con de 1 a 2 sustituyentes independientemente seleccionados en cada ocurrencia de los mismos entre metoxi o -CH₂OH; R⁴⁷ es metilo; y R⁴⁸ es metilo.

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