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1. 发明申请

WO2009025793A8 HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF 审中-公开
标题翻译：人类T2R位点受体及其用途
公开(公告)号：WO2009025793A8
公开(公告)日：2009-07-30
申请号：PCT/US2008009864
申请日：2008-08-19
申请人： SENOMYX INC , LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： G01N33/53 , A23L27/00 , A23L27/20
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及这样的发现，即T2R味觉受体家族中的特定人味觉受体对存在于例如咖啡中的特定苦味化合物产生反应。此外，本发明涉及发现含有该功能的特定化合物和组合物作为苦味阻断剂及其在例如咖啡和咖啡调味食品，饮料和药物中作为苦味阻断剂或风味调节剂的用途。而且，本发明涉及拮抗许多不同的人类T2R的化合物的发现及其在测定中的用途以及用于人和动物摄取的组合物中的苦味阻断剂。

2. 发明申请

WO2009025793A3 HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF 审中-公开
标题翻译：人类T2R双相受体受体及其用途
公开(公告)号：WO2009025793A3
公开(公告)日：2009-05-14
申请号：PCT/US2008009864
申请日：2008-08-19
申请人： SENOMYX INC , LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： G01N33/53 , A23L27/00 , A23L27/20
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

3. 发明申请

WO2008057470A3 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 审中-公开
标题翻译：识别特异性激活人类T2R受体的双键配体和用于鉴定人类叮咬调味剂的相关测定
公开(公告)号：WO2008057470A3
公开(公告)日：2008-10-23
申请号：PCT/US2007023230
申请日：2007-11-01
申请人： SENOMYX INC , LI XIAODONG , XU HONG , LI QING , TANG HUIXIAN , PRONIN ALEXEY
发明人： LI XIAODONG , XU HONG , LI QING , TANG HUIXIAN , PRONIN ALEXEY
IPC分类号： C12N15/12 , G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's diseae, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。此外，本发明涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。也可以使用T2R配体作为治疗和调节T2R相关胃肠道和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。

4. 发明申请

WO2007047988A3 CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS 审中-公开
标题翻译： CHIMERIC人类SWEET-UMAMI和UMAMI-SWEET TASTE RECEPTORS
公开(公告)号：WO2007047988A3
公开(公告)日：2009-04-23
申请号：PCT/US2006041158
申请日：2006-10-19
申请人： SENOMYX INC , LI XIAODONG , ZHANG FENG , XU HONG , LI QING
发明人： LI XIAODONG , ZHANG FENG , XU HONG , LI QING
IPC分类号： C07K14/705 , C12P21/02
CPC分类号： C07K14/705 , C12N5/0602
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one TlR or a variant or fragment thereof, either TlRl or T1R2, and the transmembrane portion of another TlR or a variant or fragment thereof, either TlRl or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一种TlR的细胞外部分或其变体或片段，即T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

5. 发明申请

WO2007002026A2 IDENTIFICATION OF HUMAN T2R RECEPORS THAT ARE ACTIVATED BY BITTER MOLECULES IN COFFEE (CHLOROGENIC LACTONES) AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 审中-公开
标题翻译：通过咖啡（氯霉素）中的双歧杆分子激活的人类T2R受体的鉴定和用于鉴定人类叮咬调味剂的相关测定
公开(公告)号：WO2007002026A2
公开(公告)日：2007-01-04
申请号：PCT/US2006023892
申请日：2006-06-20
申请人： SENOMYX INC , LI XIADONG , XU HONG , LI QING , TANG HUIXIAN
发明人： LI XIADONG , XU HONG , LI QING , TANG HUIXIAN
IPC分类号： G01N33/53 , A23L11/30
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/00 , G01N2500/10 , Y10S514/974
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便修改（阻断）T2R相关的苦味。优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。

6. 发明专利

AU1512301A A close and no pollution drinking water machine for bottled water 未知
公开(公告)号：AU1512301A
公开(公告)日：2001-06-04
申请号：AU1512301
申请日：2000-11-21
申请人： LI QING
发明人： LI QING
IPC分类号： B67D3/00 , A47J31/00

7. 发明专利

CA3141467A1 OPTO-ELECTRONIC DEVICE FABRICATION METHOD AND ELECTRONIC CIRCUIT 未知
公开(公告)号：CA3141467A1
公开(公告)日：2020-12-03
申请号：CA3141467
申请日：2019-06-25
申请人： LI QING , SACHDEV MANOJ , WONG WILLIAM , ASAD MOHSEN
发明人： LI QING , SACHDEV MANOJ , WONG WILLIAM , ASAD MOHSEN
IPC分类号： H01L23/58 , G02B6/136 , H01L21/70 , H01L49/02
摘要： An electronic circuit for thin-film transistors, the circuit including: a driving TFT; an input signal; a compensation TFT provided between gate and source terminals of the driving TFT; a storage TFT provided between the input signal and the gate of the driving TFT; a plurality of switching TFTs configured to charge the storage TFT from the input signal in one cycle and then charge the compensation TFT from the storage TFT during another cycle, such that the compensation TFT compensates for degradation of the driving TFT. An opto-electronic fabrication method including: forming an opto-electronic device on a growth substrate; temporarily bonding the opto-electronic device to a carrier substrate; removal of the growth substrate; etching the opto- electronic device to a predetermined height; coating the opto-electronic device with a functional metal layer; bonding the opto-electronic device onto a final receiver substrate; and removing the carrier substrate.

8. 发明申请

WO2011039355A3 COMMUNICATION CONVERTER FOR CONNECTING AN AUTOMATION DEVICE TO A COMPUTER AND METHOD FOR CONTROLLING THE COMMUNICATION CONVERTER 审中-公开
标题翻译：用于将自动装置连接到计算机的通信转换器以及用于控制通信转换器的方法
公开(公告)号：WO2011039355A3
公开(公告)日：2011-07-07
申请号：PCT/EP2010064668
申请日：2010-10-01
申请人： SCHNEIDER ELECTRIC AUTOMATION , HORTIG MICHAEL , GOUTAUDIER PHILIPPE , YE JUN , LI QING
发明人： HORTIG MICHAEL , GOUTAUDIER PHILIPPE , YE JUN , LI QING
IPC分类号： G06F13/38 , G06F1/26
CPC分类号： G06F13/4027 , G06F1/266 , G06F13/387 , G06F2213/3852
摘要： The invention relates to a communication converter (10) for connecting automation devices (14) having different operating voltages to a host computer (18), comprising an interface component (30) for converting data to be transmitted and a transceiver component (34) coupled to the interface component (30), wherein the interface component (30) is connected on the input side via a host connector (24) to a host interface (16) of the host computer (18) and the transceiver component (34) is connected via a device connector (28) to a device interface (12) of the automation device (14), and a voltage transformer (44), which on the input side is connected via the host interface (16) to an operating voltage and on the output side to a voltage supply line (PS) of the device interface (12). In order for the communication converter to be able to communicate with devices having different interface standards, said converter comprises a first current/voltage measuring unit (48) for detecting a current or a voltage of the voltage supply line (PS), a second current/voltage measuring unit (54) for detecting a current or a voltage of a control line (CTRL) of the device interface (12), and a switching means (60) for controlling an impedance of the control line (CTRL), and the voltage transformer (44) is designed as a controllable voltage transformer, the output voltage of which can be controlled to the operating voltage of the connected automation device (14) by means of a logic unit (40) integrated in the communication converter (10) depending on the current/voltage values present on the control line (CTROL) and the voltage supply line.
摘要翻译：本发明涉及一种用于具有不同操作电压与主计算机（18），包括用于将数据转换的接口模块（30）的自动化设备的连接（14）的通信转换器（10），以与所述接口模块来发送，以及一个耦合（30），发射器/接收器模块（34），其中，所述接口组件（30）最初彼此经由主机连接器（24）与所述主计算机（18）的主机接口（16）和传输 - 经由设备连接器/接收模块（34），（28）被连接到可编程控制器（14）的设备接口（12），和一个电压转换器（44），其最初彼此经由主机接口（16）具有工作电压并且输出侧连接有装置接口（12）的电源线（PS）。为了实现该通信转换器可以与不同接口标准的设备通信时，它提供了用于检测电流或电压供应线路（PS）的电压，第二电流/电压测量装置，第一电流/电压测量装置（48）（54）用于检测当前或设备接口（12）的控制线（CTRL）的电压和开关装置（60），用于控制所述控制线（CTRL）的阻抗，在形成为可控制的电压转换器的电压转换器（44）取决于在控制线（CTRL）被施加通过在通信转换器（10）逻辑单元（40）的装置集成的输出电压和电压供应线路（PS）电流/电压值到所连接的自动化单元的操作电压（14）的可控是。

9. 发明申请

WO2008058167A3 METHOD FOR TREATING DISORDERS ASSOCIATED WITH COMPLEMENT ACTIVATION 审中-公开
标题翻译：治疗与补充激活有关的疾病的方法
公开(公告)号：WO2008058167A3
公开(公告)日：2008-12-24
申请号：PCT/US2007083860
申请日：2007-11-07
申请人： UNIV CASE WESTERN RESERVE , MEDOF M EDWARD , LIN FENG , LI QING
发明人： MEDOF M EDWARD , LIN FENG , LI QING
IPC分类号： A61K31/155
CPC分类号： A61K31/245 , A61K31/24
摘要： A method for treating or preventing a complement activated T-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes at least one amidine compound or pharmaceutically acceptable salt.
摘要翻译：用于治疗或预防受试者中补体激活的T细胞介导的病症的方法包括向受试者施用治疗有效量的药物组合物。该药物组合物包含至少一种脒化合物或药学上可接受的盐。

10. 发明申请

WO2008103301A3 TREATMENT OF THE EYE USING MACROPHAGES AND/OR AGENTS ABLE TO AFFECT BLOOD VESSEL MORPHOLOGY 审中-公开
标题翻译：用巨噬细胞和/或药剂治疗眼睛可影响血管形态
公开(公告)号：WO2008103301A3
公开(公告)日：2008-10-09
申请号：PCT/US2008002063
申请日：2008-02-15
申请人： HARVARD COLLEGE , OLSEN BJORN R , LI QING
发明人： OLSEN BJORN R , LI QING
IPC分类号： A61K35/14 , A61K35/28 , A61K38/17 , A61K38/18 , A61K38/19 , A61K45/06 , A61P27/02
CPC分类号： A61K35/15 , A61K38/179 , A61K38/193 , A61K45/06 , A61K2300/00
摘要： The present invention generally relates to treatments of the eye and, in particular, to treatments of the eye using macrophages. Diseases including retinopathies (such as diabetic retinopathy or hypertensive retinopathy), osteoporosis pseudoglioma, macular degeneration (such as age-related macular degeneration), or diseases characterized by a high level of VEGF in the retina may be treated in such a fashion. Macrophages are believed to play a role in angiogenesis by phagocytosizing epithelial cells and the like within the retina. In some cases, the macrophages may produce relatively high levels of soluble VEGF receptor, which may also be useful for reducing overall VEGF concentrations within the retina. In certain embodiments of the invention, the macrophages may also be transfected, e.g., with a gene for expressing soluble VEGF receptor, another VEGF antagonist, and/or other suitable genes, and in certain cases, the macrophages may be combined with other cell-based therapies.
摘要翻译：本发明一般涉及眼睛的治疗，特别涉及使用巨噬细胞治疗眼睛。可以以这种方式治疗包括视网膜病（诸如糖尿病性视网膜病或高血压性视网膜病），骨质疏松症假性神经胶瘤，黄斑变性（诸如年龄相关性黄斑变性）或以视网膜中高水平VEGF为特征的疾病。据信巨噬细胞通过吞噬视网膜内的上皮细胞等而在血管发生中起作用。在一些情况下，巨噬细胞可产生相对较高水平的可溶性VEGF受体，其也可用于降低视网膜内的总体VEGF浓度。在本发明的某些实施方案中，巨噬细胞还可以例如用表达可溶性VEGF受体的基因，另一种VEGF拮抗剂和/或其他合适的基因进行转染，并且在某些情况下，巨噬细胞可以与其他细胞介导的细胞相结合，基于疗法。

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