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1. 发明专利

JP2007330268A New flavor, flavor modifier, tastant, taste enhancer, delicious and sweet testant and/or enhancer and use thereof 有权
标题翻译：新风味，调味剂，TASTANT，TASTE增强剂，甜味剂和甜味剂和/或增强剂及其用途
公开(公告)号：JP2007330268A
公开(公告)日：2007-12-27
申请号：JP2007203679
申请日：2007-08-03
申请人： Senomyx Inc , セノミックス、インコーポレイテッド
发明人： TACHDJIAN CATHERINE , PATRON ANDREW P , ADAMSKI-WERNER SARA L , BAKIR FARID , CHEN QING , DARMOHUSODO VINCENT , HOBSON STEPHEN TERRENCE , LI XIADONG , QI MING , ROGERS DANIEL HARRY , RINNOVA MARKETA , SERVANT GUY , TANG XIAO-QING , ZOLLER MARK , WALLACE MARK , XING AMY , GUBERNATOR KLAUS
IPC分类号： A23L1/226 , A21D2/24 , A21D13/08 , A23L1/39 , A23L2/00 , A23L2/02 , A61K9/00 , A61K47/00 , A61K47/14 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D207/337 , C07D209/30 , C07D213/40 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/14 , C07D235/24 , C07D241/24 , C07D263/54 , C07D263/58 , C07D271/06 , C07D277/20 , C07D277/56 , C07D277/62 , C07D307/54 , C07D307/68 , C07D307/84 , C07D307/85 , C07D317/62 , C07D317/68 , C07D319/10 , C07D321/10 , C07D333/24 , C07D333/40 , C07D333/70 , C07D401/04 , C07D407/12 , C07D409/04 , G01N33/566 , G01N33/74
CPC分类号： G01N33/543 , A23L2/56 , A23L27/202 , A23L27/203 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K8/4973 , A61K8/55 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D307/84 , C07D317/68 , C07D405/12 , C07F9/65517 , G01N33/5041 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： PROBLEM TO BE SOLVED: To provide a flavor or taste modifier and a flavor or taste enhancer for foods, drinks and other victuals, or orally administrable medicines and compositions. SOLUTION: The method for controlling tastes of victuals or medicines comprises following steps. (a) A step for providing at least one victual, medicine or precursor thereof; and (b) a step for mixing the victual or the medicine with at least spice controlling amount of at least one non-natural amide compound or an edible salt thereof to form a modified victual or medicine, wherein the amide compound has ≤500 g/mole molecular weight. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于食品，饮料和其他胜利的风味或味道调节剂和风味或味觉增强剂，或口服给药的药物和组合物。
解决方案：控制胜利或药物品味的方法包括以下步骤。（a）提供至少一种胜利，药物或其前体的步骤; 和（b）将所述药剂与所述至少一种非天然酰胺化合物或其食用盐的至少香料控制量混合以形成修饰的药物或者药物的步骤，其中所述酰胺化合物的≤500g/ 摩尔分子量。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2009000109A Use of specific t2r taste receptor to identify compound that blocks bitter taste 有权
标题翻译：特异性T2R受体受体的鉴别鉴别化合物的使用
公开(公告)号：JP2009000109A
公开(公告)日：2009-01-08
申请号：JP2008150862
申请日：2008-06-09
申请人： Senomyx Inc , セノミックス、インコーポレイテッド
发明人： PRONIN ALEXEY , CONNOR JUDY , TANG HUIXIAN , KEUNG WALTER , SERVANT GUY , ADLER JON ELLIOT , O'CONNELL SHAWN , BRUST PAUL
IPC分类号： C12Q1/02 , G01N21/64 , C07K14/705 , C12N15/09 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide an assay method for identifying compounds that modulate, preferably inhibit bitter taste. SOLUTION: Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to the assays should modulate , e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. The compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于鉴定调节，优选抑制苦味的化合物的测定方法。解决方案：提供用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的测定。根据测定鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹那铵）相关的苦味。这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2010042013A Use of specific t2r taste receptor to identify compound that blocks bitter taste 审中-公开
标题翻译：特异性T2R受体受体的鉴别鉴别化合物的使用
公开(公告)号：JP2010042013A
公开(公告)日：2010-02-25
申请号：JP2009230918
申请日：2009-10-02
申请人： Senomyx Inc , セノミックスインコーポレイテッド
发明人： PRONIN ALEXEY , CONNOR JUDY , TANG HUIXIAN , KEUNG WALTER , SERVANT GUY , ADLER JON ELLIOT , O'CONNELL SHAWN , BRUST PAUL
IPC分类号： C12Q1/02 , G01N21/64 , C12N15/09 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/58 , G01N33/84 , G01N37/00
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide an assay for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61. SOLUTION: The assay for identifying compounds that inhibit the activation of hT2R4, hT2R44 and hT2R61 receptors by related compounds including quinine, 6-nitrosaccharin, saccharin, denatonium and saccharin is provided. Preferably, the uses of hT2R4, hT2R44 and hT2R61 in a related high-throughput assay are provided. The compounds identified by this assay modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. Therefore, these compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的测定。提供了用于鉴定抑制hT2R4，hT2R44和hT2R61受体的相关化合物（包括奎宁，6-亚硝基糖精，糖精，丹参和糖精）的受体激活化合物的测定法。优选地，提供hT2R4，hT2R44和hT2R61在相关高通量测定中的用途。通过该测定鉴定的化合物调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或denatonium）相关的苦味。因此，这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。版权所有（C）2010，JPO＆INPIT

4. 发明申请

WO2009025793A3 HUMAN T2R BITTERNESS RECEPTORS AND USES THEREOF 审中-公开
标题翻译：人类T2R双相受体受体及其用途
公开(公告)号：WO2009025793A3
公开(公告)日：2009-05-14
申请号：PCT/US2008009864
申请日：2008-08-19
申请人： SENOMYX INC , LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
发明人： LI XIAODONG , PATRON ANDREW , TACHDJIAN CATHERINE , XU HONG , LI QING , PRONIN ALEXEY , SERVANT GUY , ZHANG LAN , BRADY THOMAS , DARMOHUSODO VINCENT , ARELLANO MELISSA , SELCHAU VICTOR , CHING BRETT WEYLAN , KARANEWSKY DONALD S , BRUST PAUL , LING JING , ZHAO WEN , PRIEST CHAD
IPC分类号： G01N33/53 , A23L27/00 , A23L27/20
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

5. 发明申请

WO2005014848A3 IMPROVED ELECTROPHYSIOLOGICAL ASSAYS USING OOCYTES THAT EXPRESS HUMAN ENaC AND THE USE OF PHENAMIL TO IMPROVE THE EFFECT OF ENaC ENHANCERS IN ASSAYS USING MEMBRANE POTENTIAL REPORTING DYES 审中-公开
标题翻译：采用膜表达人类表达和使用苯胺类改善ENaC增强剂在测定中使用膜电位报告染料的效果的改进的电生理学测定
公开(公告)号：WO2005014848A3
公开(公告)日：2005-05-06
申请号：PCT/US2004021853
申请日：2004-07-09
申请人： SENOMYX INC , SERVANT GUY , CHANG HONG , REDCROW CYRIL , RAY SUMITA , CLARK IMRAN
发明人： SERVANT GUY , CHANG HONG , REDCROW CYRIL , RAY SUMITA , CLARK IMRAN
IPC分类号： C07H21/04 , C07K1/00 , C12N1/20 , C12P21/06 , C12Q20060101 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/68
CPC分类号： C12Q1/025 , C12N15/85 , C12N2320/10 , C12N2503/02 , G01N33/5044 , G01N33/6872 , G01N2500/10
摘要： In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans.
摘要翻译：一方面，本发明涉及用于分析和筛选从人肾c-DNA文库克隆的人上皮钠通道（hENaC）的基于哺乳动物细胞的高通量测定法，并且还在包括人味觉的其他组织中表达组织。本发明进一步涉及用于鉴定人ENaC调节剂，优选ENaC增强子的基于两栖动物卵母细胞的中等通量电生理测定。预期在基于细胞的ENaC测定中调节ENaC功能的化合物会影响人类的咸味。本文所述的测定相对于现有的细胞表达系统具有优势。在哺乳动物细胞的情况下，这种测定可以在高通量模式下在标准96或384孔培养板中进行，通过使用抑制ENaC功能的化合物，优选阿米洛利衍生物如Phenamil实现增强的测定结果。在本发明的卵母细胞电生理学测定法（双电极电压钳技术）的情况下，这些测定法有助于鉴定特异性调节人ENaC的化合物。本发明的测定法提供了用于检测促进（增强）或抑制hENaC功能的化合物的强力筛选。因此增强或阻断人类ENaC通道活性的化合物应该调节人类的咸味。

6. 发明申请

WO2008013969A3 IMPROVED CELL-BASED FLUORESCENT ASSAYS FOR IDENTIFYING ALPHA AND DELTA ENaC MODULATORS 审中-公开
标题翻译：改进的基于细胞的荧光测定用于鉴定ALPHA和DELTA ENCC调制器
公开(公告)号：WO2008013969A3
公开(公告)日：2008-03-20
申请号：PCT/US2007016963
申请日：2007-07-30
申请人： SENOMYX INC , SERVANT GUY , BRUST PAUL , RAY SUMITA , HUNG NING
发明人： SERVANT GUY , BRUST PAUL , RAY SUMITA , HUNG NING
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/5008 , G01N33/566
摘要： This invention relates to improved electrophysiological assays that measure sodium conductance activity of a delta or alpha human epithelial sodium channel (ENaC) expressed in a test cell in the presence and absence of delta hENaC enhancers. The improvement comprises contacting the test cells with an amount of sodium ion, typically from at least 15 mM to 140 mM, for a time sufficient, e.g. for at least 5 minutes to an hour, prior to the test cells being screened against at least one putative enhancer. It has been surprisingly discovered that this sodium pretreatment enhances assay sensitivity, especially assays that use membrane potential or ion sensitive dyes that detect changes in conductance fluorimetrically. These enhancer compounds have potential application in modulating (enhancing) salty taste perception and for treating disorders involving aberrant hENaC function.
摘要翻译：本发明涉及改进的电生理测定法，其测量在存在和不存在δHENaC增强子的情况下在测试细胞中表达的δ或α人上皮钠通道（ENaC）的钠电导活性。该改进包括将测试细胞与一定量的钠离子（通常为至少15mM至140mM）接触足够的时间，例如，在至少5分钟至1小时之前，在测试细胞被针对至少一个推定的增强子进行筛选之前。已经惊奇地发现，这种钠预处理增强了测定灵敏度，特别是使用膜电位或离子敏感染料检测荧光测量电导的变化的测定法。这些增强剂化合物在调节（增强）咸味感觉和治疗涉及异常hENaC功能的病症中具有潜在的应用。

7. 发明申请

WO2007047985A2 TRPM5 BASED ASSAYS AND THE USE THEREOF FOR THE IDENTIFICATION OF MODULATORS OF SWEET, BITTER OR UMAMI (SAVORY) TASTE 审中-公开
标题翻译：基于TRPM5的测定及其用于鉴定甜味剂，铋或麝香（调味品）调味剂的调味品的用途
公开(公告)号：WO2007047985A2
公开(公告)日：2007-04-26
申请号：PCT/US2006041152
申请日：2006-10-19
申请人： SENOMYX INC , SERVANT GUY , WILLIAMS MARK , PATRON ANDREW , KAMDAR POONIT , CHEN QING , MOYER BRYAN , DAHAN DAVID , DITSCHUN TANYA , RAY SUMITA , LIGANI AMY
发明人： SERVANT GUY , WILLIAMS MARK , PATRON ANDREW , KAMDAR POONIT , CHEN QING , MOYER BRYAN , DAHAN DAVID , DITSCHUN TANYA , RAY SUMITA , LIGANI AMY
IPC分类号： E01C3/06
CPC分类号： E01C3/06
摘要： Robust cell based assays are provided that use cells that express wild-type or modified TRPM5 nucleic acid sequences in order to identify putative taste modulators, preferably sweet, bitter and umami taste modulators. The preferred assays use HEK-293 cells that express TRPM5, optionally at least one GPCR, preferably a taste specific GPCR, and a G protein that couples therewith. These assays detect TRPM5 modulators by use of membrane potential dyes that emit fluorescence on changes in TRPM5 activity based on changes in membrane potential and these changes in fluorescence are detectable using Fluorimetric Imaging Plate Readers (FLIPR).
摘要翻译：提供了基于稳健细胞的测定法，其使用表达野生型或修饰型TRPM5核酸序列的细胞，以鉴定推定的味觉调节剂，优选甜味，苦味和鲜味调味剂。优选的测定法使用表达TRPM5，任选地至少一种GPCR，优选味道特异性GPCR的HEK-293细胞和与其偶联的G蛋白。这些测定法通过使用膜电位染料检测TRPM5调节剂，其基于膜电位的变化发射荧光的TRPM5活性的变化，并且使用荧光成像板读数器（FLIPR）检测这些荧光变化。

8. 发明公开

EP2254891A4 ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS 审中-公开
标题翻译： ISOSORBIDDERIVATE及其作为口味变换器，调味剂和口味放大器采用
公开(公告)号：EP2254891A4
公开(公告)日：2011-07-27
申请号：EP09717709
申请日：2009-03-03
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S , ADAMSKI-WERNER SARA L , YAMAMOTO JEFFREY M , SERVANT GUY
IPC分类号： A23L27/00 , C07D493/04 , A23L27/20 , C07D493/02
CPC分类号： A23L1/22664 , A23L2/60 , A23L27/205 , A23L27/2052 , C07D493/04

9. 发明公开

EP1659881A4 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF 有权
标题翻译：新的传统，风味改良剂，味，增味剂，调味剂FOR UMAMI或甜和/或放大器和使用
公开(公告)号：EP1659881A4
公开(公告)日：2013-05-15
申请号：EP04816798
申请日：2004-08-06
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , PATRON ANDREW P , ADAMSKI-WERNER SARA L , BAKIR FARID , CHEN QING , DARMOHUSODO VINCENT , HOBSON STEPHEN TERRENCE , LI XIADONG , QI MING , ROGERS DANIEL HARRY , RINNOVA MARKETA , SERVANT GUY , TANG XIAO-QING , ZOLLER MARK , WALLACE MARK , XING AMY , GUBERNATOR KLAUS
IPC分类号： A23L1/226 , A61K9/00 , A61K47/00 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D307/84 , C07D317/68 , G01N33/566 , G01N33/74
CPC分类号： G01N33/543 , A23L2/56 , A23L27/202 , A23L27/203 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K8/4973 , A61K8/55 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D307/84 , C07D317/68 , C07D405/12 , C07F9/65517 , G01N33/5041 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

10. 发明公开

EP1502112A4 USE OF SPECIFIC T2R TASTE RECEPTORS TO IDENTIFY COMPOUNDS THAT BLOCK BITTER TASTE 审中-公开
标题翻译：具体T2R味觉受体数识别苦味块的化合物一起使用
公开(公告)号：EP1502112A4
公开(公告)日：2008-07-23
申请号：EP02748108
申请日：2002-07-10
申请人： SENOMYX INC
发明人： PRONIN ALEXEY , CONNOR JUDY , TANG HUIXIAN , KEUNG WALTER , SERVANT GUY , ADLER JON ELLIOT , O'CONNELL SHAWN , BRUST PAUL
IPC分类号： G01N21/64 , C12N15/09 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/567 , C07H21/04 , C07K1/00 , C12N1/20 , C12P21/06
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.

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