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1. 发明申请

WO2005060959A8 PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：吡唑衍生物及其作为OREXIN受体拮抗剂的用途
公开(公告)号：WO2005060959A8
公开(公告)日：2006-01-12
申请号：PCT/HU2004000117
申请日：2004-12-15
申请人： SANOFI AVENTIS , ALETRU MICHEL , ARANYI PETER , BALOGH MARIA , BATORI SANDOR , BENCE JUDIT , BOVY PHILIPPE , KAPUI ZOLTAN , MIKUS ENDRE , NAMANE CLAUDIE , PHILIPPO CHRISTOPHE , SZABO TIBOR , TOEMOESKOEZI ZSUZSANNA , URBAN-SZABO KATALIN
发明人： ALETRU MICHEL , ARANYI PETER , BALOGH MARIA , BATORI SANDOR , BENCE JUDIT , BOVY PHILIPPE , KAPUI ZOLTAN , MIKUS ENDRE , NAMANE CLAUDIE , PHILIPPO CHRISTOPHE , SZABO TIBOR , TOEMOESKOEZI ZSUZSANNA , URBAN-SZABO KATALIN
IPC分类号： C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/415 , A61K31/4155 , A61P1/14 , A61P25/00
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
摘要翻译：本发明涉及食欲素受体拮抗剂通式（I）化合物及其异构体，盐和溶剂合物，其含有它们的药物组合物及其治疗应用。

2. 发明申请

WO2009010660A2 NOVEL SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS 审中-公开
标题翻译：新型替代治疗剂，其制剂及其在治疗中的应用
公开(公告)号：WO2009010660A2
公开(公告)日：2009-01-22
申请号：PCT/FR2008000843
申请日：2008-06-18
申请人： SANOFI AVENTIS , ALETRU MICHEL , DAMOUR DOMINIQUE , MONSEAU CATHERINE , MOUGENOT PATRICK , NAMANE CLAUDIE , NARDI FREDERICO , NEMECEK PATRICK , PHILIPPO CHRISTOPHE
发明人： ALETRU MICHEL , DAMOUR DOMINIQUE , MONSEAU CATHERINE , MOUGENOT PATRICK , NAMANE CLAUDIE , NARDI FREDERICO , NEMECEK PATRICK , PHILIPPO CHRISTOPHE
IPC分类号： C07D401/12 , A61K31/454 , A61K31/4545 , A61P35/00 , C07D211/08 , C07D213/06 , C07D231/56 , C07D233/70 , C07D235/06 , C07D401/14
CPC分类号： C07D401/14 , C07D401/12
摘要： The invention relates to compounds of formula (I) wherein: E is a grouping (i) of formula -NT-CO-O- or -NT-CX-NT'- wherein X is =O or =S and T and T', that can be identical or different and selected independently, from H or an alkyl group, or (ii) forming a five-membered or six-membered ring bound in position 5 or 6 of the indazole nucleus by -NT- or by the nitrogen atom N1; R1 is at least one substituent selected independently when there are several, and being a halogen atom, an alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalcoxy, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, CN, NRR', OR, NO2, COOR, CONRR', or NRCOR' group; R2 is a hydrogen atom, or an alkyl, alkenyl or alkynyl group; R3 is at least one substituent selected independently when there are several, and being a hydrogen atom, an alkyl, alkenyl, alkynyl, halogenoalcoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NRR', CF3, OR, NO2, COOR, CONRR', or NRCOR' group; R4 is a hydrogen atom or a halogen atom, an alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, -NR-CO-R', COOR, NRR', CHO, or CONR(OR') group; R and R' are identical or different and are independently a hydrogen atom, or an alkyl, aryl, heterocycloalkyl, cycloalkyl or heteroaryl group; and n1 is a whole number between 0 and 5, and n3 is a whole number between 0 and 3.
摘要翻译：本发明涉及式（I）化合物，其中：E为式-NT-CO-O-或-NT-CX-NT'-的分组（i），其中X为= O或= S且T和T' ，可以相同或不同，独立地选自H或烷基，或（ii）通过-NT-形成在吲唑核的5或6位上结合的五元或六元环，或通过氮原子N1 当有几个并且是卤素原子时，R1是至少一个取代基，其中烷基，烯基，炔基，卤代烷基，卤代烷氧基，芳基，杂芳基，杂环烷基，环烷基，CN，NRR'，OR，NO2，COOR，CONRR '或NRCOR'组; R2是氢原子，或烷基，烯基或炔基; 当存在数个并且为氢原子的烷基，烯基，炔基，卤代烷氧基，芳基，杂芳基，环烷基，杂环烷基，CN，NRR'，CF 3，OR，NO 2，COOR，CONRR时，R 3是至少一个独立选择的取代基 '或NRCOR'组; R4是氢原子或卤原子，烷基，烯基，炔基，芳基，杂芳基，杂环烷基，-NR-CO-R'，COOR，NRR'，CHO或CONR（OR'）基团; R和R'相同或不同，独立地为氢原子，或烷基，芳基，杂环烷基，环烷基或杂芳基; n1为0〜5之间的整数，n3为0〜3的整数。

3. 发明申请

WO2008000951A2 UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 审中-公开
标题翻译：特罗烷的尿素衍生物，它们的制备和它们的治疗应用
公开(公告)号：WO2008000951A2
公开(公告)日：2008-01-03
申请号：PCT/FR2007001070
申请日：2007-06-26
申请人： SANOFI AVENTIS , ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
发明人： ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
IPC分类号： C07D471/08 , A61K31/4709 , A61P3/04 , A61P3/10 , A61P9/10 , A61P25/28 , C07D207/09 , C07D211/18 , C07D213/54 , C07D215/08
CPC分类号： C07D471/08
摘要： The invention relates to compounds of the formula (I): in which R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 3 , R 4 , p, r and X are as defined in the description. Preparation process and therapeutic application.
摘要翻译：本发明涉及式（I）的化合物：其中R 1a，R 1b，1b，1c，1d，1d， R 2，R 2，R 2，R 3，R 4，p，r和X是如描述中所定义的。制备过程和治疗应用。

4. 发明申请

WO2008000950A3 DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE 审中-公开
标题翻译：哌啶或吡咯烷脲的衍生物，它们的制备及其治疗用途
公开(公告)号：WO2008000950A3
公开(公告)日：2008-02-14
申请号：PCT/FR2007001069
申请日：2007-06-26
申请人： SANOFI AVENTIS , BRAUN ALAIN , GUSSREGEN STEFAN , MOUGENOT PATRICK , NAMANE CLAUDIE , NICOLAI ERIC , PACQUET FRANCOIS , PHILIPPO CHRISTOPHE , VENIER OLIVIER , CRESPIN OLIVIER , PASCAL CECILE , ALETRU MICHEL
发明人： BRAUN ALAIN , GUSSREGEN STEFAN , MOUGENOT PATRICK , NAMANE CLAUDIE , NICOLAI ERIC , PACQUET FRANCOIS , PHILIPPO CHRISTOPHE , VENIER OLIVIER , CRESPIN OLIVIER , PASCAL CECILE , ALETRU MICHEL
IPC分类号： C07D401/14 , A61K31/4709 , A61K31/536 , A61P3/00 , C07D401/06 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , C07D401/06 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要： The invention concerns compounds corresponding to formula (I) in which R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 4 , n, i, j, o, p, q, r and X are as defined in the description. Preparation method and therapeutic use.
摘要翻译：本发明涉及对应于式（I）的化合物，其中R 1a，R 1b，1b，1c，1d R 2，R 2，R 2，R 3，R 3，R 3，R 3，R 3，其中，R，R，R，X，R，R和X如说明书中所定义。制备方法和治疗用途。

5. 发明申请

WO0144228A2 DERIVATIVES OF QUINAZOLINEDIONE PHTHALIMIDE, PREPARATIONS THEREOF AND THEIR THERAPEUTIC USES 审中-公开
标题翻译：喹诺酮类化合物的衍生物，其制备方法及其治疗用途
公开(公告)号：WO0144228A2
公开(公告)日：2001-06-21
申请号：PCT/FR0003534
申请日：2000-12-14
申请人： SANOFI SYNTHELABO , ALETRU MICHEL , BOVY PHILIPPE R , NAMANE CLAUDIE
发明人： ALETRU MICHEL , BOVY PHILIPPE R , NAMANE CLAUDIE
IPC分类号： A61P1/00 , A61P11/00 , A61P15/06 , C07D403/06 , C07D403/14 , C07D401/06 , A61K31/517 , C07D209/48 , C07D239/96
CPC分类号： C07D403/06 , C07D403/14
摘要： The invention relates to a compound of general formula (I), wherein R1 represents a C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, hydroxy-C1-6 alkyl or C1-3alkoxy-C1-6 alkyl group, R2 represents a NR8R9, -O-C1-6 alkylene-NR4R5, -O-C1-6alkylene-CONR4R5 or -O-C1-6 alkylene-CO2R6 group or a group of formula (a), R3 represents a hydrogen atom, a hydroxy, a halogen atom, a cyano, a nitro, an amino or a C1-3 alkyl group, and W represents a C1-3 alkylene or C2-3 alkenylene group; and to their salts and hydrates. The invention also relates to the therapeutic uses of the inventive derivatives.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1表示C 1-6烷基，C 2-6烯基，C 3-6环烷基，羟基-C 1-6烷基或C 1-3烷氧基-C 1-6烷基，R 2 表示NR 8 R 9，-O-C 1-6亚烷基-NR 4 R 5，-O-C 1-6亚烷基-CONR 4 R 5或-O-C 1-6亚烷基-CO 2 R 6基团或式（a）的基团，R 3表示氢原子，羟基卤素原子，氰基，硝基，氨基或C1-3烷基，W表示C1-3亚烷基或C2-3亚烯基; 以及它们的盐和水合物。本发明还涉及本发明衍生物的治疗用途。

6. 发明专利

PL2046791T3 Mocznikowe pochodne tropanu, ich wytwarzanie i ich zastosowanie w lecznictwie 未知
公开(公告)号：PL2046791T3
公开(公告)日：2010-08-31
申请号：PL07803782
申请日：2007-06-26
申请人： SANOFI AVENTIS
发明人： ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
IPC分类号： C07D471/08 , A61K31/46 , A61P3/04 , A61P3/10 , A61P9/10 , A61P19/10 , A61P25/28

7. 发明专利

MX277822B UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. 未知
公开(公告)号：MX277822B
公开(公告)日：2010-08-03
申请号：MX2008016492
申请日：2007-06-26
申请人： SANOFI AVENTIS
发明人： BRAUN ALAIN , ALETRU MICHEL , NAMANE CLAUDINE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11&bgr;-hydroxysteroid dehydrogenase type 1 (11&bgr;HSD1).

8. 发明专利

SI2046791T1 Sečninski derivati tropana, njihova priprava in njihova terapevtska uporaba 未知
公开(公告)号：SI2046791T1
公开(公告)日：2010-07-30
申请号：SI200730258
申请日：2007-06-26
申请人： SANOFI AVENTIS
发明人： ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
IPC分类号： C07D471/00 , A61K31/00 , A61P3/00 , A61P9/00 , A61P19/00 , A61P25/00

9. 发明专利

DK2046791T3 Ureaderivater af tropan, fremstilling deraf og terepeutisk anvendelse deraf 未知
公开(公告)号：DK2046791T3
公开(公告)日：2010-07-19
申请号：DK07803782
申请日：2007-06-26
申请人： SANOFI AVENTIS
发明人： ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
IPC分类号： C07D471/08 , A61K31/46 , A61P3/04 , A61P3/10 , A61P9/10 , A61P19/10 , A61P25/28

10. 发明专利

AT461930T 未知
公开(公告)号：AT461930T
公开(公告)日：2010-04-15
申请号：AT07803782
申请日：2007-06-26
申请人： SANOFI AVENTIS
发明人： ALETRU MICHEL , BRAUN ALAIN , NAMANE CLAUDIE , VENIER OLIVIER , PHILIPPO CHRISTOPHE , MOUGENOT PATRICK , NICOLAI ERIC , GUSSREGEN STEFAN
IPC分类号： C07D471/08 , A61K31/46 , A61P3/04 , A61P3/10 , A61P9/10 , A61P19/10 , A61P25/28
摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11&bgr;-hydroxysteroid dehydrogenase type 1 (11&bgr;HSD1).

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