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1. 发明申请

WO2013037724A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
公开(公告)号：WO2013037724A1
公开(公告)日：2013-03-21
申请号：PCT/EP2012/067622
申请日：2012-09-10
申请人： SANOFI , CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , McCort, Gary
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , McCort, Gary
IPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/427 , A61P9/06 , A61P9/10
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07F9/655345
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1 ), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式I中的取代的2-（色满-6-基氧基） - 噻唑，其中Ar，R 2，R 3和R 4如权利要求中所定义。式I的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态被扰乱的多种疾病，例如作为心律失常，心力衰竭和中风。本发明还涉及式I化合物的制备方法，它们作为药物的用途，以及包含它们的药物组合物。

2. 发明申请

WO2013037388A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
公开(公告)号：WO2013037388A1
公开(公告)日：2013-03-21
申请号：PCT/EP2011/065712
申请日：2011-09-12
申请人： SANOFI , CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , MCCORT, Gary
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , MCCORT, Gary
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula (I), in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式（I）的取代的2-（色满-6-基氧基） - 噻唑，其中Ar，R 2，R 3和R 4如权利要求中所定义。式（I）的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态受到干扰的多种疾病，如心律失常，心力衰竭和中风。本发明还涉及制备式（I）化合物，其作为药物的用途以及包含它们的药物组合物的方法。

3. 发明申请

WO2010025856A1 SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：取代氨基酸及其类似物及其药物用途
公开(公告)号：WO2010025856A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/006135
申请日：2009-08-25
申请人： SANOFI-AVENTIS , RACKELMANN, Nils , BIALY, Laurent , ENGLERT, Heinrich , WIRTH, Klaus , ARNDT, Petra , WESTON, John , HEINELT, Uwe , FOLLMANN, Markus
发明人： RACKELMANN, Nils , BIALY, Laurent , ENGLERT, Heinrich , WIRTH, Klaus , ARNDT, Petra , WESTON, John , HEINELT, Uwe , FOLLMANN, Markus
IPC分类号： C07D207/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4523 , A61P1/00 , A61P3/00 , A61P9/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D211/56 , C07D243/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D487/08
摘要： The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders.
摘要翻译：本发明涉及式（I）的取代氨基茚子及其类似物及其药物用途。包含这种类型化合物的药物适用于预防或治疗多种疾病，例如呼吸系统疾病，囊性纤维化疾病，急性或慢性肾脏疾病或排便障碍。

4. 发明申请

WO2006018259A2 METHOD OF SCREENING FOR A CARNITINE TRANSPORTER AGONIST OR ANTAGONIST AND ITS USES 审中-公开
标题翻译： CARNITINE运输商AGONIST或ANTAGONIST及其用途的筛选方法
公开(公告)号：WO2006018259A2
公开(公告)日：2006-02-23
申请号：PCT/EP2005/008834
申请日：2005-08-13
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , ARNDT, Petra , MARGERIE, Daniel , BRUNNER, Bodo
发明人： ARNDT, Petra , MARGERIE, Daniel , BRUNNER, Bodo
IPC分类号： C12Q1/68
CPC分类号： G01N33/92 , G01N33/5432 , G01N2500/10
摘要： The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a method for the manufacture of a medicament for the treatment of a carnitine transporter deficiency, to methods of diagnosis of a carnitine transporter deficiency, to the use of a protein for the manufacture of an antibody reacting with a carnitine transporter, to an oligonucleotide and to methods of treatment of a carnitine transporter deficiency.
摘要翻译：本发明涉及一种筛选肉碱转运体激动剂或肉碱转运体拮抗剂的方法，用于实施筛选肉碱转运蛋白激动剂或肉碱转运蛋白拮抗剂的方法的试剂盒，用于制造方法用于治疗肉碱转运蛋白缺乏症的药物，肉碱转运蛋白缺乏症的诊断方法，使用蛋白质制造与肉碱转运蛋白反应的抗体的方法，以及治疗方法肉碱转运蛋白缺乏症。

5. 发明申请

WO2005023863A1 TEST SYSTEM FOR THE IDENTIFICATION OF APJ RECEPTOR LIGANDS 审中-公开
标题翻译：用于鉴定APJ受体配体的测试系统
公开(公告)号：WO2005023863A1
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009750
申请日：2004-09-02
申请人： AVENTIS PHARMA DEUTSCHLAND GMBH , ARNDT, Petra , MARGERIE, Daniel , MUENCH, Götz , UNGERER, Martin
发明人： ARNDT, Petra , MARGERIE, Daniel , MUENCH, Götz , UNGERER, Martin
IPC分类号： C07K14/705
CPC分类号： C07K14/723 , C07K14/4722 , G01N33/5008 , G01N33/5041 , G01N33/5061 , G01N33/5091 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/02 , G01N2800/32
摘要： The present invention refers to a test system for the identification of a ligand for angiotension receptor like-1 (APJ receptor) comprising an AN receptor or a functional variant thereof and a Gαq or a Gαl protein or a hybrid protein which is assembled from portions of different G proteins like Gαq or Gαl proteins, a method of screening an APJ receptor ligand using the test system, a method for producing a medicament, a method for diagnosis and prognosis of a heart disease and a kit usable for detection or prognosis of a heart disease.
摘要翻译：本发明涉及一种用于鉴定包含AN受体或其功能变体的血管紧张素受体1（APJ受体）的配体和Galphaq或Galphal蛋白质或杂合蛋白质的测试系统，其由不同的G蛋白如Galphaq或Galphal蛋白，使用测试系统筛选APJ受体配体的方法，制备药物的方法，心脏病诊断和预后的方法以及可用于心脏检测或预后的试剂盒疾病。

6. 发明申请

WO2014135674A1 SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：取代的色氨酸-60-环糊精及其作为药物的用途
公开(公告)号：WO2014135674A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/054417
申请日：2014-03-07
申请人： SANOFI
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , KRAFT, Volker , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf
IPC分类号： C07D311/60 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07F9/09 , A61K31/353 , A61P9/00
CPC分类号： C07D311/60 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07F9/65522
摘要： The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式（I）的取代的苯并二氢吡喃-6-基氧基 - 环烷烃，其中Ar，R 1至R 4，p和q如权利要求中所定义。式（I）的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态受到干扰的多种疾病，如心律失常，心力衰竭和中风。本发明还涉及制备式（I）化合物，其作为药物的用途以及包含它们的药物组合物的方法。

7. 发明申请

WO2015018817A1 RECOVERY ASSEMBLY FOR CRYOPRESERVATION APPLICATIONS 审中-公开
标题翻译：回收装置用于CRYOPRESERVATION应用
公开(公告)号：WO2015018817A1
公开(公告)日：2015-02-12
申请号：PCT/EP2014/066792
申请日：2014-08-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： ARNDT, Petra , DERDAU, Volker , SIEFKE-HENZLER, Verena
IPC分类号： A01N1/02
CPC分类号： A01N1/0263 , A01N1/0236 , A01N1/0257 , B01L3/56 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/0615 , B01L2300/0609 , B01L2300/1883
摘要： The present invention relates to a recovery assembly for reducing losses of a cooling agent, such as liquid nitrogen, in a cryopreservation device. The recovery assembly comprises a coneshaped funnel assembly (32) comprising a support (40) for mounting the funnel assembly (32) to an access opening of a cryopreservation container (16) to be at least partially filled with the cooling agent (12). When extracting a specimen holder (18) from the container, excess cooling agent can be collected and fed back into the container by means of the cone-shaped funnel portion. The funnel assembly may comprise an iris blind assembly (36) for modifying the the size of a through opening of the funnel assembly. At least one outwardly extending recess (38) may be provided to support a specimen holder in an inclined orientation above the blind's through opening.
摘要翻译：本发明涉及一种用于在冷冻保存装置中减少冷却剂如液氮的损失的回收组件。回收组件包括锥形漏斗组件（32），其包括用于将漏斗组件（32）安装到至少部分地填充有冷却剂（12）的冷冻保存容器（16）的进入开口的支撑件（40）。当从容器中取出样品架（18）时，可以收集多余的冷却剂，并通过锥形漏斗部分将其反馈回容器。漏斗组件可以包括用于改变漏斗组件的通孔的尺寸的虹膜盲组件（36）。可以提供至少一个向外延伸的凹部（38），以便在盲孔通过开口上方倾斜的取向支撑样本保持器。

8. 发明申请

WO2015018816A1 RECOVERY ASSEMBLY FOR CRYOPRESERVATION APPLICATIONS 审中-公开
标题翻译：回收装置用于CRYOPRESERVATION应用
公开(公告)号：WO2015018816A1
公开(公告)日：2015-02-12
申请号：PCT/EP2014/066791
申请日：2014-08-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： DERDAU, Volker , WOLF, Andreas , ARNDT, Petra , SIEFKE-HENZLER, Verena , DETTE, Christoph , MILBERT, Ulrike
IPC分类号： A01N1/02
CPC分类号： B01L7/50 , A01N1/0236 , A01N1/0257 , B01L9/00
摘要： A recovery assembly (22) for a crypreservation device comprises: - a support (26) for mounting the recovery assembly to an access opening (42) of a cryopreservation container (1 6) to be at least partially filled with a cooling agent (12), and - at least one flow channel (32) to form at least one protective gas stream (34) to reduce escapement of the cooling agent from the container. The recovery assembly preferably comprises a cone-shaped funnel portion (24). The flow channel is to be connected with e.g. a suction blower, by way of which a helically converging (e.g. cyclone type) protective gas stream is generated. In this way, evaporating cooling agent escaping through the access opening is accelerated and slaved by the protective gas stream. Liquid particles of the cooling agent are accelerated accordingly, hit the inside-facing wall of funnel portion and may thus be collected.
摘要翻译：一种用于防腐设备的回收组件（22）包括： - 用于将所述回收组件安装到冷冻保存容器（16）的进入开口（42）的支撑件（26），以至少部分地填充有冷却剂（12））和至少一个流动通道（32）以形成至少一个保护气流（34），以减少冷却剂从容器的逸出。回收组件优选地包括锥形漏斗部分（24）。流动通道将与例如连接。抽吸鼓风机，通过该鼓风机产生螺旋收敛（例如旋风型）保护气流。以这种方式，通过进入口排出的蒸发冷却剂被保护气流加速并且被从动。相应地，冷却剂的液体颗粒被加速，撞击漏斗部分的面向内的壁并因此被收集。

9. 发明公开

EP2755970A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS 有权
标题翻译：取代的2-（苯并二氢吡喃-6-基氧基）-thiazoles及其用作药物
公开(公告)号：EP2755970A1
公开(公告)日：2014-07-23
申请号：EP12756214.8
申请日：2012-09-10
申请人： SANOFI
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , McCort, Gary
IPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/427 , A61P9/06 , A61P9/10
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07F9/655345
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1 ), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

10. 发明公开

EP3030074A1 RECOVERY ASSEMBLY FOR CRYOPRESERVATION APPLICATIONS 审中-公开
标题翻译：恢复组装用于冷冻保存应用
公开(公告)号：EP3030074A1
公开(公告)日：2016-06-15
申请号：EP14747386.2
申请日：2014-08-05
申请人： Sanofi-Aventis Deutschland GmbH
发明人： DERDAU, Volker , WOLF, Andreas , ARNDT, Petra , SIEFKE-HENZLER, Verena , DETTE, Christoph , MILBERT, Ulrike
IPC分类号： A01N1/02
CPC分类号： B01L7/50 , A01N1/0236 , A01N1/0257 , B01L9/00
摘要： A recovery assembly (22) for a crypreservation device comprises: - a support (26) for mounting the recovery assembly to an access opening (42) of a cryopreservation container (1 6) to be at least partially filled with a cooling agent (12), and - at least one flow channel (32) to form at least one protective gas stream (34) to reduce escapement of the cooling agent from the container. The recovery assembly preferably comprises a cone-shaped funnel portion (24). The flow channel is to be connected with e.g. a suction blower, by way of which a helically converging (e.g. cyclone type) protective gas stream is generated. In this way, evaporating cooling agent escaping through the access opening is accelerated and slaved by the protective gas stream. Liquid particles of the cooling agent are accelerated accordingly, hit the inside-facing wall of funnel portion and may thus be collected.
摘要翻译：一种用于低温保存装置的回收组件（22），包括： - 支承件（26），用于将回收组件安装到冷冻保存容器（16）的进入开口（42），以至少部分地填充冷却剂（12 ），以及 - 至少一个流动通道（32），以形成至少一个保护气流（34）以减少冷却剂从容器中逸出。回收组件优选地包括锥形漏斗部分（24）。流动通道将与例如抽风机，通过该抽风机产生螺旋会聚（例如旋风式）保护气流。以这种方式，通过进入开口逸出的蒸发冷却剂被加速并被保护气流所驱动。冷却剂的液体颗粒因此被加速，撞击漏斗部分的面向内部的壁并且因此可以被收集。

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