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1. 发明专利

DE4040802A1 Implement for soil cultivation - has soil ploughing blades, turning blades and compacting heads 未知
公开(公告)号：DE4040802A1
公开(公告)日：1991-08-14
申请号：DE4040802
申请日：1990-12-14
申请人： DOMSCH HORST DR , FISCHER HELMUT , SEIDENSTUECKER ULRICH , RICHTER WOLFGANG , ARNDT PETRA
发明人： DOMSCH HORST DR , FISCHER HELMUT , SEIDENSTUECKER ULRICH , RICHTER WOLFGANG , ARNDT PETRA
IPC分类号： A01B13/14 , A01B49/02
摘要： The implement for combined soil cultivation and seedbed preparation consists of a frame with ploughing, conveying, comminuting, compacting and levelling implements, arranged mirror-image-wise on the longitudinal axis. The clearing tools (2) are four plough blades, arranged in a V-shape, with a pick-up conveyor (3) overlapping their whole working width. Beside and below the conveyor (3) are left- and right-turning implements (5) consisting of plough blades (5.1,5.2), after which come compacting implements (6) consisting of an inner section (6.1) and an outer section (6.2). USE/ADVANTAGE - The machine is simple, compact, and combines tillage and seedbed preparation on heavy soils, inverting the soil by means of soil-layer exchange.

2. 发明专利

DE202013101113U1 Taktstock 未知
公开(公告)号：DE202013101113U1
公开(公告)日：2013-04-30
申请号：DE202013101113
申请日：2013-03-14
申请人： ARNDT PETRA
IPC分类号： G10G7/00 , F21V33/00
摘要： Taktstock (1), mit einem spitz zulaufenden, insbesondere hellen, Stabbereich (2) einerseits sowie einem verdickten Griffbereich (3) andererseits, wobei der Taktstock (1) zum einen mit zumindest einer Lichtquelle und zum anderen mit einer mit der Lichtquelle verbundenen Stromversorgung und/oder Anschlussmöglichkeit für eine Stromversorgung versehen ist, dadurch gekennzeichnet, dass der Stabbereich (2) des Taktstocks (1) mit einer Beleuchtungseinrichtung (4) versehen ist, die sich zu demjenigen Ende des Stabbereichs (2), welches dem Griffbereich des Taktstocks (1) gegenüberliegt, zumindest partiell entlang der Längserstreckung des Stabbereichs (2) ausdehnend vorgesehen ist und derart ausgebildet ist, dass eine Lichtabstrahlung nach außen in diesem Bereich entweder vollständig entlang der Längserstreckung des Stabbereichs (2) oder aber zumindest in Abständen gegeben ist.

3. 发明申请

WO2010025856A1 SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：取代氨基酸及其类似物及其药物用途
公开(公告)号：WO2010025856A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/006135
申请日：2009-08-25
申请人： SANOFI-AVENTIS , RACKELMANN, Nils , BIALY, Laurent , ENGLERT, Heinrich , WIRTH, Klaus , ARNDT, Petra , WESTON, John , HEINELT, Uwe , FOLLMANN, Markus
发明人： RACKELMANN, Nils , BIALY, Laurent , ENGLERT, Heinrich , WIRTH, Klaus , ARNDT, Petra , WESTON, John , HEINELT, Uwe , FOLLMANN, Markus
IPC分类号： C07D207/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4523 , A61P1/00 , A61P3/00 , A61P9/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D211/56 , C07D243/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D487/08
摘要： The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders.
摘要翻译：本发明涉及式（I）的取代氨基茚子及其类似物及其药物用途。包含这种类型化合物的药物适用于预防或治疗多种疾病，例如呼吸系统疾病，囊性纤维化疾病，急性或慢性肾脏疾病或排便障碍。

4. 发明申请

WO2006018259A2 METHOD OF SCREENING FOR A CARNITINE TRANSPORTER AGONIST OR ANTAGONIST AND ITS USES 审中-公开
标题翻译： CARNITINE运输商AGONIST或ANTAGONIST及其用途的筛选方法
公开(公告)号：WO2006018259A2
公开(公告)日：2006-02-23
申请号：PCT/EP2005/008834
申请日：2005-08-13
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , ARNDT, Petra , MARGERIE, Daniel , BRUNNER, Bodo
发明人： ARNDT, Petra , MARGERIE, Daniel , BRUNNER, Bodo
IPC分类号： C12Q1/68
CPC分类号： G01N33/92 , G01N33/5432 , G01N2500/10
摘要： The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a method for the manufacture of a medicament for the treatment of a carnitine transporter deficiency, to methods of diagnosis of a carnitine transporter deficiency, to the use of a protein for the manufacture of an antibody reacting with a carnitine transporter, to an oligonucleotide and to methods of treatment of a carnitine transporter deficiency.
摘要翻译：本发明涉及一种筛选肉碱转运体激动剂或肉碱转运体拮抗剂的方法，用于实施筛选肉碱转运蛋白激动剂或肉碱转运蛋白拮抗剂的方法的试剂盒，用于制造方法用于治疗肉碱转运蛋白缺乏症的药物，肉碱转运蛋白缺乏症的诊断方法，使用蛋白质制造与肉碱转运蛋白反应的抗体的方法，以及治疗方法肉碱转运蛋白缺乏症。

5. 发明申请

WO2013037724A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
公开(公告)号：WO2013037724A1
公开(公告)日：2013-03-21
申请号：PCT/EP2012/067622
申请日：2012-09-10
申请人： SANOFI , CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , McCort, Gary
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , McCort, Gary
IPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/427 , A61P9/06 , A61P9/10
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07F9/655345
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1 ), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式I中的取代的2-（色满-6-基氧基） - 噻唑，其中Ar，R 2，R 3和R 4如权利要求中所定义。式I的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态被扰乱的多种疾病，例如作为心律失常，心力衰竭和中风。本发明还涉及式I化合物的制备方法，它们作为药物的用途，以及包含它们的药物组合物。

6. 发明申请

WO2013037388A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
公开(公告)号：WO2013037388A1
公开(公告)日：2013-03-21
申请号：PCT/EP2011/065712
申请日：2011-09-12
申请人： SANOFI , CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , MCCORT, Gary
发明人： CZECHTIZKY, Werngard , WESTON, John , RACKELMANN, Nils , PODESCHWA, Michael , ARNDT, Petra , WIRTH, Klaus , GOEGELEIN, Heinz , RITZELER, Olaf , KRAFT, Volker , BELLEVERGUE, Patrice , MCCORT, Gary
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula (I), in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式（I）的取代的2-（色满-6-基氧基） - 噻唑，其中Ar，R 2，R 3和R 4如权利要求中所定义。式（I）的化合物是钠 - 钙交换剂（NCX）的抑制剂，特别是亚型1型（NCX1）的钠 - 钙交换剂的抑制剂，并且适用于治疗细胞内钙稳态受到干扰的多种疾病，如心律失常，心力衰竭和中风。本发明还涉及制备式（I）化合物，其作为药物的用途以及包含它们的药物组合物的方法。

7. 发明申请

WO2006018259A3 METHOD OF SCREENING FOR A CARNITINE TRANSPORTER AGONIST OR ANTAGONIST AND ITS USES 审中-公开
标题翻译：一种肉碱转运体激动剂或拮抗剂的筛选方法及其用途
公开(公告)号：WO2006018259A3
公开(公告)日：2006-06-22
申请号：PCT/EP2005008834
申请日：2005-08-13
申请人： SANOFI AVENTIS DEUTSCHLAND , ARNDT PETRA , MARGERIE DANIEL , BRUNNER BODO
发明人： ARNDT PETRA , MARGERIE DANIEL , BRUNNER BODO
IPC分类号： C12Q1/68
CPC分类号： G01N33/92 , G01N33/5432 , G01N2500/10
摘要： The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a method for the manufacture of a medicament for the treatment of a carnitine transporter deficiency, to methods of diagnosis of a carnitine transporter deficiency, to the use of a protein for the manufacture of an antibody reacting with a carnitine transporter, to an oligonucleotide and to methods of treatment of a carnitine transporter deficiency.
摘要翻译：本发明涉及筛选肉毒碱转运蛋白激动剂或肉碱转运蛋白拮抗剂的方法，用于实施筛选肉毒碱转运蛋白激动剂或肉碱转运蛋白拮抗剂的方法的试剂盒，制备该方法的方法用于治疗肉毒碱转运蛋白缺陷症的药物，诊断肉毒碱转运蛋白缺陷症的方法，涉及使用蛋白质制造与肉毒碱转运蛋白反应的抗体，涉及寡核苷酸和治疗肉碱转运蛋白缺乏。

8. 发明申请

WO2005023863A1 TEST SYSTEM FOR THE IDENTIFICATION OF APJ RECEPTOR LIGANDS 审中-公开
标题翻译：用于鉴定APJ受体配体的测试系统
公开(公告)号：WO2005023863A1
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009750
申请日：2004-09-02
申请人： AVENTIS PHARMA DEUTSCHLAND GMBH , ARNDT, Petra , MARGERIE, Daniel , MUENCH, Götz , UNGERER, Martin
发明人： ARNDT, Petra , MARGERIE, Daniel , MUENCH, Götz , UNGERER, Martin
IPC分类号： C07K14/705
CPC分类号： C07K14/723 , C07K14/4722 , G01N33/5008 , G01N33/5041 , G01N33/5061 , G01N33/5091 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/02 , G01N2800/32
摘要： The present invention refers to a test system for the identification of a ligand for angiotension receptor like-1 (APJ receptor) comprising an AN receptor or a functional variant thereof and a Gαq or a Gαl protein or a hybrid protein which is assembled from portions of different G proteins like Gαq or Gαl proteins, a method of screening an APJ receptor ligand using the test system, a method for producing a medicament, a method for diagnosis and prognosis of a heart disease and a kit usable for detection or prognosis of a heart disease.
摘要翻译：本发明涉及一种用于鉴定包含AN受体或其功能变体的血管紧张素受体1（APJ受体）的配体和Galphaq或Galphal蛋白质或杂合蛋白质的测试系统，其由不同的G蛋白如Galphaq或Galphal蛋白，使用测试系统筛选APJ受体配体的方法，制备药物的方法，心脏病诊断和预后的方法以及可用于心脏检测或预后的试剂盒疾病。

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