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1. 发明授权

US5795891A Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient 失效
标题翻译：酰基苯基甘氨酸衍生物以及由含有所述化合物作为活性成分的胶原酶活性增加引起的疾病的预防和治疗
公开(公告)号：US5795891A
公开(公告)日：1998-08-18
申请号：US596278
申请日：1996-02-08
申请人： Ryoichi Hirayama , Takahiro Tsukida , Minoru Yamamoto , Shoji Ikeda , Fumio Sakamoto , Yuji Obata , Konomi Matsuo
发明人： Ryoichi Hirayama , Takahiro Tsukida , Minoru Yamamoto , Shoji Ikeda , Fumio Sakamoto , Yuji Obata , Konomi Matsuo
IPC分类号： C07C259/06 , C07D295/15 , A61K31/16
CPC分类号： C07D295/15 , C07C259/06
摘要： An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R.sup.1 represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R.sup.2 represents hydrogen atom, hydroxy, fluorine atom, or C.sub.1 -C.sub.4 linear or branched alkyl; and R.sup.3 represents C.sub.1 -C.sub.4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. ##STR1##
摘要翻译： PCT No.PCT / JP94 / 01284第 371日期1996年2月8日 102（e）日期1996年2月8日PCT 1994年8月3日PCT PCT。公开号WO95 / 04715 日期：1995年2月16日由通式（I）表示的酰基苯基甘氨酸衍生物或其药学上可接受的盐，以及由含有与活性成分相同的增加的胶原酶活性引起的疾病的预防和治疗，其中R1表示氢原子，甲基，甲基氨基甲基或吗啉代甲基; R2表示氢原子，羟基，氟原子或C1-C4直链或支链烷基; R3代表C1-C4直链或支链烷基。化合物（I）和盐在施用后长时间保持在血液中有效的胶原酶抑制剂活性，并且可用作被认为由胶原酶活性增加引起的各种疾病的补救。（一）

2. 发明授权

US4455310A Quinolinecarboxylic acid derivative, and antibacterial agent containing said compound as active ingredient 失效
标题翻译：喹啉羧酸衍生物和含有所述化合物作为活性成分的抗菌剂
公开(公告)号：US4455310A
公开(公告)日：1984-06-19
申请号：US382353
申请日：1982-05-26
申请人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto
发明人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto
IPC分类号： C07D405/12 , A61K31/495 , A61P31/04 , C07D317/40 , C07D403/14
CPC分类号： C07D317/40
摘要： A novel quinolinecarboxylic acid derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are useful as antibacterial agents, and are prepared by a process which comprises reacting a compound of the formula ##STR2## with a compound of the formula ##STR3##wherein X represents a halogen atom, and thereafter, as required, converting the resulting compound to a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的新型喹啉羧酸衍生物或其药学上可接受的盐。这些化合物可用作抗菌剂，并且通过包括使下式化合物（II）与下式化合物（III）反应的方法制备，其中X表示卤素原子，其后，根据需要将所得化合物转化为其药学上可接受的盐。

3. 发明授权

US4448769A Ester of 1,1-dioxopenicillanic acid, and use thereof as .beta.-lactamase inhibitor 失效
标题翻译： 1,1-二氧代青霉烷酸酯，其用作β-内酰胺酶抑制剂
公开(公告)号：US4448769A
公开(公告)日：1984-05-15
申请号：US396471
申请日：1982-07-08
申请人： Shoji Ikeda , Fumio Sakamoto , Goro Tsukamoto , Shigeru Yamabe
发明人： Shoji Ikeda , Fumio Sakamoto , Goro Tsukamoto , Shigeru Yamabe
IPC分类号： C07D317/40 , C07D499/00 , C07D499/32 , A61K31/425
CPC分类号： C07D317/40 , C07D499/00
摘要： A 1,1-dioxopenicillanic acid ester represented by formula (I) ##STR1## wherein R represents a methyl or phenyl group. The ester of formula (I) may be prepared by reacting 1,1-dioxopenicillanic acid or its salt with a compound represented by formula (III) ##STR2## wherein R is as defined above, and X represents a halogen atom, or by oxidizing a compound of formula (V) ##STR3## wherein R is as defined above. The ester of the formula (I) is useful as a .beta.-lactamase inhibitor and may be used in association with a .beta.-lactam antibiotic.
摘要翻译：由式（I）表示的1,1-二氧代青霉烷酸酯其中R表示甲基或苯基。式（I）的酯可以通过使1,1-二氧代青霉烷酸或其盐与式（III）表示的化合物反应制备，其中R如上定义，X表示卤素原子，或通过氧化其中R如上定义的式（V）化合物（V）。式（I）的酯可用作β-内酰胺酶抑制剂，并且可以与β-内酰胺抗生素结合使用。

4. 发明授权

US4428806A Process for producing brominated 1,3-dioxolen-2-ones 失效
标题翻译：生产溴化1,3-二氧戊环-2-酮的方法
公开(公告)号：US4428806A
公开(公告)日：1984-01-31
申请号：US426158
申请日：1982-09-28
申请人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
发明人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
IPC分类号： A61K31/43 , A61P31/04 , A61P43/00 , C07D317/40 , C07D317/46 , C07D499/32 , B01J19/12
CPC分类号： C07D317/46 , C07D317/40
摘要： A process for producing a brominated 1,3-dioxolen-2-one of the following general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group, or an aryl group, and R.sub.2 represents a hydrogen atom, or R.sub.1 and R.sub.2 may be bonded together to form --(CH.sub.2).sub.n -- in which n represents an integer of 3 to 5, which comprises reacting a compound of the following formula (II) ##STR2## wherein R.sub.1 and R.sub.2 are as defined, with bromine under radical generating conditions.
摘要翻译：制备以下通式（I）的溴化1,3-二氧杂环戊烯-2-酮的方法其中R 1表示氢原子，甲基或芳基，R 2表示氢原子或R 1和R 2可以键合在一起形成 - （CH 2）n - ，其中n表示3至5的整数，其包括使下式（II）的化合物其中R 1和 R 2如定义，溴在自由基产生条件下。

5. 发明授权

US4389408A Novel ampicillin esters and production thereof 失效
标题翻译：新型氨苄西林酯及其生产
公开(公告)号：US4389408A
公开(公告)日：1983-06-21
申请号：US327735
申请日：1981-12-04
申请人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
发明人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
IPC分类号： C07D317/40 , C07D317/64 , C07D499/00 , C07D499/12 , C07D499/32 , C07D499/42 , C07D499/68 , A61K31/43
CPC分类号： C07D317/40 , C07D317/64 , C07D499/00
摘要： A novel Ampicillin ester of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an aryl group, and R.sub.2 represents a hydrogen atom or may be taken together with R.sub.1 to form a divalent carbon chain residue, or its acid addition salt.The novel Ampicillin ester or its acid addition salt is prepared by (1) reacting a corresponding 6-N-acylamino penicillanic acid (II) or its salt with a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, and X is a halogen atom, or reacting a compound of the formula ##STR3## wherein R.sub.1 and R.sub.2 are as defined above, or its acid addition salt with a corresponding carboxylic acid (VI) or its reactive derivative, (2) thereafter, if required, when the resulting compound has the protected amino group or the group convertible to an amino group, deprotecting the protected amino group or converting said convertible group to an amino group, and (3) if further required, converting the product to an acid addition salt.The present invention provides also an antibacterial agent comprising the novel Ampicillin ester and a method for the treatment of infectious disease.
摘要翻译：一种通式为“IMAGE”的新型氨苄青霉素酯，其中R 1表示氢原子，甲基或芳基，R 2表示氢原子，或可与R 1一起形成二价碳链残基，或其酸加盐。通过（1）使相应的6-N-酰基氨基青霉烷酸（II）或其盐与式（III）的化合物反应，其中R 1和R 2如上所定义，制备新型氨苄青霉素酯或其酸加成盐或者其中R1和R2如上所定义的式（VI）化合物或其酸加成盐与相应的羧酸（Ⅵ）或其反应性衍生物反应， 2）此后，如果需要，当所得化合物具有被保护的氨基或可转化为氨基的基团时，将保护的氨基脱保护或将所述可转换基团转化为氨基，和（3）如果需要，将产物加酸加成盐。本发明还提供了包含新型氨苄青霉素酯的抗菌剂和治疗感染性疾病的方法。

6. 发明授权

US4416891A Ester of 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid, and its use as antibacterial agent 失效
标题翻译： 6 - [（六氢-1H-吖庚因-1-基）亚甲基氨基]青霉烷酸酯，其用作抗菌剂
公开(公告)号：US4416891A
公开(公告)日：1983-11-22
申请号：US399132
申请日：1982-07-16
申请人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto
发明人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto
IPC分类号： A61K31/43 , A61P31/04 , C07D317/40 , C07D499/00 , C07D499/08 , C07D499/10 , C07D499/21 , C07D499/32 , A61K31/425
CPC分类号： C07D499/00 , C07D317/40
摘要： (5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR1## or its pharmaceutically acceptable acid addition salt. The compound is useful as an antibacterial agent and may be prepared by reacting (5-methyl-2-oxo-1,3-dioxolen-4-yl)-methyl 6-aminopenicillanate of the following formula (II) ##STR2## or its acid addition salt with chloro-N,N-hexamethyleneformiminium chloride, and as required, converting the resulting compound to its pharmaceutically acceptable acid addition salt.
摘要翻译：（I）的（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基6 - [（六氢-1H-吖庚因-1-基）亚甲基氨基]青霉烷酸或其药学上可接受的酸加成盐。该化合物可用作抗菌剂，并且可以通过使下式（II）的（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基） - 6-氨基青霉烷酸甲酯（II））或其与氯-N，N-六亚甲基酰亚胺氯化物的酸加成盐，并根据需要将所得化合物转化为其药学上可接受的酸加成盐。

7. 发明授权

US4342693A 1,3-Dioxolen-2-one derivatives and process for production thereof 失效
标题翻译： 1,3-二氧戊环-2-酮衍生物及其生产方法
公开(公告)号：US4342693A
公开(公告)日：1982-08-03
申请号：US257564
申请日：1981-04-27
申请人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
发明人： Fumio Sakamoto , Shoji Ikeda , Goro Tsukamoto , Isamu Utsumi
IPC分类号： A61K31/335 , A61K31/357 , A61K31/43 , A61P31/04 , A61P43/00 , C07D307/46 , C07D317/40 , C07D317/46 , C07D317/64 , C07D499/00
CPC分类号： C07D307/46 , C07D317/40 , C07D317/46 , C07D317/64 , C07D499/00 , Y02P20/55
摘要： A 1,3-dioxolen-2-one derivative of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group, or an aryl group, R.sub.2 represents a hydrogen atom, or may be taken together with R.sub.1 to form a divalent carbon chain residue, and x represents a halogen atom.The above compounds can be prepared by reacting a compound of the general formula ##STR2## with a halogenating agent, and are useful as protective group-introducing reagents for introducing protective groups into reagents in various chemical reactions, or as modifiers for prodrug preparation in medicine.
摘要翻译：通式“IMAGE”的1,3-二氧杂环戊烯-2-酮衍生物，其中R 1表示氢原子，甲基或芳基，R 2表示氢原子，或者可以与R 1一起形成二价碳链残基，x表示卤素原子。上述化合物可以通过使通式为“IMAGE”的化合物与卤化剂反应制备，并且可用作用于在各种化学反应中将保护基引入试剂的保护基导入试剂，或作为药物中前药制剂的调节剂。

8. 发明授权

US5589722A Sheet coil motor and method of fabricating the same 失效
标题翻译：片式线圈马达及其制造方法
公开(公告)号：US5589722A
公开(公告)日：1996-12-31
申请号：US227792
申请日：1994-04-14
申请人： Takahiro Sakaguchi , Fumio Sakamoto
发明人： Takahiro Sakaguchi , Fumio Sakamoto
IPC分类号： H02K3/26 , H02K21/24 , H02K29/08 , H02K19/26 , H02K21/12
CPC分类号： H02K3/26 , H02K21/24 , H02K29/08
摘要： A sheet coil motor is configured such that a plurality of coil units are attached to a circuit substrate at a predetermined interval, the interval separating the coil units are regular. Each of the plurality of coil units includes a plurality of coils and has a shape of a sector. Accordingly, the sheet coil motor can be made thin, the number of driving sheet coils can be reduced, and the production cost can be reduced. A method of fabricating the sheet coil motor includes the steps of printing, on a sheet base, a plurality of sheet coil units, in which units a plurality of sector-shaped coils are provided, such that the coil units lie in alternately opposite directions, cutting out the sheet coil units from the sheet base, attaching sheet coil units, in which units a plurality of sector-shaped coils are provided, on a substrate at an arbitrary distance from each other, and attaching driving sheet coils thus fabricated to the substrate so as to be opposite a rotor magnet at a close distance. Accordingly, the number of sheet coil units printed on and cut out from a sheet base can be increased so that the efficiency of production can be improved.
摘要翻译：片状线圈电动机被构造为使得多个线圈单元以预定间隔附接到电路基板，分隔线圈单元的间隔是规则的。多个线圈单元中的每一个包括多个线圈并且具有扇形的形状。因此，可以使片状线圈电动机变薄，可以减少驱动片材线圈的数量，并且可以降低制造成本。制造片状线圈电动机的方法包括以下步骤：在片材基底上印刷多个片状线圈单元，其中设置有多个扇形线圈的单元，使得线圈单元位于交替相反的方向，从片材基底切出片状线圈单元，将彼此以任意距离的在其上设置有多个扇形线圈的单元的片状线圈单元附接在基板上，并且将如此制造的驱动片线圈附接到基板以便在较近的距离处与转子磁体相对。因此，可以增加印刷在片材基底上并从片材基底切出的片状线圈单元的数量，从而可以提高生产效率。

9. 发明授权

US07207858B2 Method for manufacturing plasma display panel 失效
标题翻译：等离子显示面板制造方法
公开(公告)号：US07207858B2
公开(公告)日：2007-04-24
申请号：US10485415
申请日：2003-04-02
申请人： Akihiro Matsuda , Fumio Sakamoto , Kenji Date , Koji Aoto
发明人： Akihiro Matsuda , Fumio Sakamoto , Kenji Date , Koji Aoto
IPC分类号： H01J9/00
CPC分类号： H01J9/445
摘要： Disclosed is a method of manufacturing plasma display panels for carrying out aging with high productivity. In an aging process for applying a predetermined voltage and driving plasma display panels 21 for display operation, each plasma display panel is set into an aging unit provided with cooling means, and the aging is carried out on the plasma display panel while cooling the plasma display panel by the cooling means provided in the aging unit. This method can thus reduce temperature rise of the panel and prevent the panel from being cracked during the aging process.
摘要翻译：公开了一种用于以高生产率进行老化的等离子体显示面板的制造方法。在施加预定电压和驱动等离子体显示面板21进行显示操作的老化处理中，将每个等离子体显示面板设置成具有冷却装置的老化单元，并且在等离子体显示面板上进行老化，同时冷却等离子体显示通过设置在老化单元中的冷却装置。因此，该方法可以降低面板的温度上升并防止面板在老化过程中破裂。

10. 发明授权

US5191079A Quinolinecarboxylic acid derivatives 失效
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：US5191079A
公开(公告)日：1993-03-02
申请号：US907184
申请日：1992-06-30
申请人： Hirosato Kondo , Masahiro Taguchi , Yoshikazu Jinbo , Yoshimasa Inoue , Yasuo Kotera , Fumio Sakamoto
发明人： Hirosato Kondo , Masahiro Taguchi , Yoshikazu Jinbo , Yoshimasa Inoue , Yasuo Kotera , Fumio Sakamoto
IPC分类号： C07D513/16 , C07D519/00
CPC分类号： C07D513/16 , C07D519/00
摘要： Novel quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein Z is ##STR2## in which R.sup.1 is hydrogen atom, a halogen atom, hydroxy or a lower alkyloxy; R.sup.2 is a halogen atom, hydroxy or a lower alkyloxy; R.sup.3 is a lower alkyl; and R.sup.4 is hydroxy or a di(lower alkyl)amino, and a pharmaceutically acceptable salt thereof, which have excellent antibacterial activities and are useful as an antibacterial agent, a pharmaceutical composition containing the same, and process for preparing the same.

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