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1. 发明授权

US07696316B2 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor 失效
标题翻译： 21910,5563,4505,2504,15977,14760,25501,17903,3720,21529,26176,26343,5666,18610,33217,26967，H1983，M1983,38555或593分子及其用途
公开(公告)号：US07696316B2
公开(公告)日：2010-04-13
申请号：US11583766
申请日：2006-10-19
申请人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
发明人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
IPC分类号： C07K14/00 , C07H21/04 , C12P21/04 , C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/1235
摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸分子。本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176，已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白，抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明授权

US06664091B2 53010, a human carboxylesterase family member and uses thereof 失效
标题翻译： 53010，人羧酸酯酶家族成员及其用途
公开(公告)号：US06664091B2
公开(公告)日：2003-12-16
申请号：US10023515
申请日：2001-12-18
申请人： Rory A. J. Curtis , Inmaculada Silos-Santiago
发明人： Rory A. J. Curtis , Inmaculada Silos-Santiago
IPC分类号： C12N918
CPC分类号： C12N9/18
摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人转基因动物。本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。还提供了利用本发明组合物的诊断方法。

3. 发明授权

US07517659B2 Potassium channel molecules and uses therefor 失效
标题翻译：钾通道分子及其用途
公开(公告)号：US07517659B2
公开(公告)日：2009-04-14
申请号：US10701013
申请日：2003-11-04
申请人： Rory A. J. Curtis , Inmaculada Silos-Santiago
发明人： Rory A. J. Curtis , Inmaculada Silos-Santiago
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TWIK核酸分子，其编码参与钾通道介导的活性的蛋白质。本发明还提供了反义核酸分子，含有TWIK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏TWIK基因的非人类转基因动物。本发明还进一步提供了分离的TWIK蛋白，融合蛋白，抗原肽和抗TWIK抗体。还提供了利用本发明组合物的诊断方法。

4. 发明授权

US06664373B1 TWIK-5 potassium channel polypeptides and uses therefor 失效
标题翻译： TWIK-5钾通道多肽及其用途
公开(公告)号：US06664373B1
公开(公告)日：2003-12-16
申请号：US09561763
申请日：2000-04-28
申请人： Rory A. J. Curtis , Inmaculada Silos-Santiago
发明人： Rory A. J. Curtis , Inmaculada Silos-Santiago
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TWIK核酸分子，其编码参与钾通道介导的活性的蛋白质。本发明还提供了反义核酸分子，含有TWIK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏TWIK基因的非人类转基因动物。本发明还进一步提供了分离的TWIK蛋白，融合蛋白，抗原肽和抗TWIK抗体。还提供了利用本发明组合物的诊断方法。

5. 发明授权

US07094589B2 53010, A novel human carboxylesterase family member and uses thereof 失效
标题翻译： 53010，一种新的人羧酸酯酶家族成员及其用途
公开(公告)号：US07094589B2
公开(公告)日：2006-08-22
申请号：US10674636
申请日：2003-09-29
申请人： Rory A. J. Curtis , Inmaculada Silos-Santiago
发明人： Rory A. J. Curtis , Inmaculada Silos-Santiago
IPC分类号： C12N9/48 , C12N15/63 , C12N1/20 , C07H21/04 , C12P21/00
CPC分类号： C12N9/18
摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人类转基因动物。本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。还提供了利用本发明组合物的诊断方法。

6. 发明授权

US06787345B1 55053, a novel human eukaryotic kinase and uses therefor 失效
标题翻译： 55053，一种新型人类真核激酶，并用于此
公开(公告)号：US06787345B1
公开(公告)日：2004-09-07
申请号：US10003690
申请日：2001-11-15
申请人： Rory A. J. Curtis
发明人： Rory A. J. Curtis
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： The invention provides isolated nucleic acids molecules, designated EPK-55053 nucleic acid molecules, which encode novel protein kinase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing EPK-55053 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an EPK-55053 gene has been introduced or disrupted. The invention still further provides isolated EPK-55053 proteins, fusion proteins, antigenic peptides and anti-EPK-55053 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新蛋白激酶多肽的分离的核酸分子，命名为EPK-55053核酸分子。本发明还提供了反义核酸分子，含有EPK-55053核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及EPK-55053基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的EPK-55053蛋白，融合蛋白，抗原肽和抗EPK-55053抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

7. 发明授权

US06740514B2 Nucleic acids corresponding to 46798 a novel human matrix metalloproteinase and uses thereof 失效
标题翻译：对应于46798的新型人类基质金属蛋白酶的核酸及其用途
公开(公告)号：US06740514B2
公开(公告)日：2004-05-25
申请号：US09950510
申请日：2001-09-10
申请人： Rory A. J. Curtis
发明人： Rory A. J. Curtis
IPC分类号： C12N964
CPC分类号： C12N9/6489
摘要： The invention provides isolated nucleic acids molecules, designated 46798 nucleic acid molecules, which encode a novel matrix metalloproteinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46798 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 46798 gene has been introduced or disrupted. The invention still further provides isolated 46798 proteins, fusion proteins, antigenic peptides and anti-46798 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新基质金属蛋白酶的分离的核酸分子，命名为46798核酸分子。本发明还提供了反义核酸分子，含有46798个核酸分子的重组表达载体，已导入其中的表达载体的宿主细胞，以及导入或破坏46798基因的非人转基因动物。本发明还进一步提供分离的46798蛋白，融合蛋白，抗原肽和抗-46798抗体。还提供了利用本发明组合物的诊断方法。

8. 发明授权

US06730491B2 2504, 15977, and 14760, novel protein kinase family members and uses therefor 失效
标题翻译： 2504,15977和14760，新型蛋白激酶家族成员及其用途
公开(公告)号：US06730491B2
公开(公告)日：2004-05-04
申请号：US09797039
申请日：2001-02-28
申请人： Rosana Kapeller-Libermann , Rachel A. Meyers , Rory A. J. Curtis
发明人： Rosana Kapeller-Libermann , Rachel A. Meyers , Rory A. J. Curtis
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K2039/505 , C07K16/40
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为2504,15977或14760核酸分子，其编码新的蛋白激酶家族成员。本发明还提供了反义核酸分子，含有2504,15977或14760个核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中已经存在2504,15977或14760基因的非人转基因动物引入或中断本发明还进一步提供分离的2504,15977或14760蛋白，融合蛋白，抗原肽和抗2504,15977或14760抗体。还提供了利用本发明组合物的诊断方法。

9. 发明授权

US07807388B2 Members of the Capsaicin/Vanilloid receptor family of proteins and uses thereof 失效
标题翻译：蛋白质辣椒素/香草素受体家族成员及其用途
公开(公告)号：US07807388B2
公开(公告)日：2010-10-05
申请号：US11967558
申请日：2007-12-31
申请人： Rory A. J. Curtis
发明人： Rory A. J. Curtis
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码辣椒素/香草素受体家族的新成员的分离的核酸分子，命名为hVR-1，hVR-2和rVR-2核酸分子。本发明还提供反义核酸分子，含有hVR-1，hVR-2和rVR-2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中hVR-1 ，hVR-2和rVR-2基因已被引入或破坏。本发明还进一步提供了分离的hVR-1，hVR-2和rVR-2蛋白，融合蛋白，抗原肽和抗hVR-1，抗hVR-2和抗rVR-2抗体。还提供了利用本发明组合物的诊断方法。

10. 发明授权

US07485308B2 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor 有权
标题翻译： 26199,33530,3949,47148,50226,58764,612113,32144,32235,23565,13305,14911,86216,25206和8843分子及其用途
公开(公告)号：US07485308B2
公开(公告)日：2009-02-03
申请号：US11493347
申请日：2006-07-26
申请人： Rachel E. Meyers , Kyle J. MacBeth , Rory A. J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
发明人： Rachel E. Meyers , Kyle J. MacBeth , Rory A. J. Curtis , Laura A. Rudolph-Owen , Nadine S. Weich , Peter J. Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph M. Carroll
IPC分类号： A61K39/00 , C12P21/06
CPC分类号： C12N9/001 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/0006 , C12N9/10 , C12N9/1048 , C12N9/1096 , C12N9/12 , C12N9/1205 , C12N9/16 , C12N9/48 , C12N9/80 , C12N2799/021 , C12Q1/32 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N2500/10 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。还提供了利用本发明组合物的诊断和治疗方法。

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