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1. 发明授权

US5205459A Surgical anastomosis stapling instrument 失效
标题翻译：手术吻合吻合器械
公开(公告)号：US5205459A
公开(公告)日：1993-04-27
申请号：US938982
申请日：1992-09-01
申请人： Ronald J. Brinkerhoff , Rudolph H. Nobis , Helmut Wolf , Federico Bilotti , William Fox , Mark S. Zeiner , E. David Allen
发明人： Ronald J. Brinkerhoff , Rudolph H. Nobis , Helmut Wolf , Federico Bilotti , William Fox , Mark S. Zeiner , E. David Allen
IPC分类号： A61B20060101 , A61B17/115 , A61B17/28
CPC分类号： A61B17/115 , A61B17/1155 , A61B2017/07257 , A61B2017/2905 , A61B2017/2919
摘要： A surgical stapling instrument for performing a circular anastomosis stapling operation is provided. The surgical instrument includes a stapling head assembly mounted by a curved shaft to an actuator handle assembly and incorporates an improved actuator mechanism for transmitting the required operating forces and movements from the actuator handle assembly through the curved shaft to an anvil and staple driver of the stapling head assembly. The stapling head assembly includes a longitudinally movable trocar detachably secured by one or more retainer clips on a hollow shaft of the anvil. When the trocar is retracted, the anvil shaft slides into a central support tube which aligns the anvil axially and circumferentially with a staple holder on the stapling head assembly. The retainer clips are locked against the trocar by the support tube and transmit tension from the trocar to the anvil with no tension load on the anvil shaft. The aotuator mechanism permits adjustment of the anvil gap to produce a desired staple heiqht and precludes actuation of the staple head assembly if the anvil gap is set outside of a predetermined range. Also, the actuator mechanism is adapted to both advance and retract the staple driver relative to the staple holder in the stapling head assembly. Further, an improved arrangement for attaching the support shaft to the stapling head assembly and to the actuator handle assembly is provided.
摘要翻译：提供了一种用于执行圆形吻合缝合操作的外科缝合器械。手术器械包括一个装订头组件，该装订头组件通过弯曲的轴安装到致动器手柄组件上并且包括改进的致动器机构，用于将所需的操作力和从致动器手柄组件通过弯曲轴的运动传递到钉子的砧座和缝钉驱动器头组件。缝合头组件包括可由一个或多个保持夹固定在砧座的空心轴上的可纵向移动的套管针。当套管针缩回时，砧座轴滑入中心支撑管，该中心支撑管使砧座轴向和周向与钉在钉头组件上的缝钉保持架对准。保持夹通过支撑管锁定在套针针上，并将张力从套管针传递到砧座，在砧座轴上没有张力负载。调节器机构允许调整砧座间隙以产生期望的缝合钉，并且如果砧座间隙设定在预定范围之外，则阻止钉头组件的致动。此外，致动器机构适于相对于缝合头组件中的缝钉保持器使订书钉驱动器前进和缩回。此外，提供了一种用于将支撑轴附接到装订头组件和致动器手柄组件的改进的布置。

2. 发明授权

US5275322A Surgical anastomosis stapling instrument 失效
标题翻译：手术吻合吻合器械
公开(公告)号：US5275322A
公开(公告)日：1994-01-04
申请号：US10682
申请日：1993-01-28
申请人： Ronald J. Brinkerhoff , Rudolph H. Nobis , Helmut Wolf , Federico Bilotti , William Fox , Mark S. Zeiner , E. David Allen , Richard Smith , Jerome Reckelhoff , Philip Churchill , Richard Grant , Roger Hildwein , J. David Hughett , Clifton Coles , W. Thompson Lawrence
发明人： Ronald J. Brinkerhoff , Rudolph H. Nobis , Helmut Wolf , Federico Bilotti , William Fox , Mark S. Zeiner , E. David Allen , Richard Smith , Jerome Reckelhoff , Philip Churchill , Richard Grant , Roger Hildwein , J. David Hughett , Clifton Coles , W. Thompson Lawrence
IPC分类号： A61B20060101 , A61B17/115 , A61B17/28 , A61B17/068
CPC分类号： A61B17/115 , A61B17/1155 , A61B2017/07257 , A61B2017/2905 , A61B2017/2919
摘要： A surgical stapling instrument for performing a circular anastomosis stapling operation is provided. The surgical instrument includes a stapling head assembly mounted by a curved shaft to an actuator handle assembly and incorporates an improved actuator mechanism for transmitting the required operating forces and movements from the actuator handle assembly through the curved shaft to an anvil and staple driver of the stapling head assembly. The stapling head assembly includes a longitudinally movable trocar detachably secured by one or more retainer clips on a hollow shaft of the anvil. When the trocar is retracted, the anvil shaft slides into a central support tube which aligns the anvil axially and circumferentially with a staple holder on the stapling head assembly. The retainer clips are locked against the trocar by the support tube and transmit tension from the trocar to the anvil with no tension load on the anvil shaft. The actuator mechanism permits adjustment of the anvil gap to produce a desired staple height and precludes actuation of the staple head assembly if the anvil gap is set outside of a predetermined range. Also, the actuator mechanism is adapted to both advance and retract the staple driver relative to the staple holder in the stapling head assembly. Further, an improved arrangement for attaching the support shaft to the stapling head assembly and to the actuator handle assembly is provided.
摘要翻译：提供了一种用于执行圆形吻合缝合操作的外科缝合器械。手术器械包括一个装订头组件，该装订头组件通过弯曲的轴安装到致动器手柄组件上并且包括改进的致动器机构，用于将所需的操作力和从致动器手柄组件通过弯曲轴的运动传递到钉子的砧座和缝钉驱动器头组件。缝合头组件包括可由一个或多个保持夹固定在砧座的空心轴上的可纵向移动的套管针。当套管针缩回时，砧座轴滑入中心支撑管，该中心支撑管使砧座轴向和周向与钉在钉头组件上的缝钉保持架对准。保持夹通过支撑管锁定在套针针上，并将张力从套管针传递到砧座，在砧座轴上没有张力负载。致动器机构允许调整砧座间隙以产生期望的钉高度，并且如果砧座间隙设定在预定范围之外，则阻止钉头组件的致动。此外，致动器机构适于相对于缝合头组件中的缝钉保持器使订书钉驱动器前进和缩回。此外，提供了一种用于将支撑轴附接到装订头组件和致动器手柄组件的改进的布置。

3. 发明授权

US5285945A Surgical anastomosis stapling instrument 失效
公开(公告)号：US5285945A
公开(公告)日：1994-02-15
申请号：US998285
申请日：1992-12-30
申请人： Ronald J. Brinkerhoff , Rudolph H. Nobis , William Fox , Mark S. Zeiner , E. David Allen , Richard Smith , Jerome Reckelhoff , Philip Churchill
发明人： Ronald J. Brinkerhoff , Rudolph H. Nobis , William Fox , Mark S. Zeiner , E. David Allen , Richard Smith , Jerome Reckelhoff , Philip Churchill
IPC分类号： A61B20060101 , A61B17/115 , A61B17/28 , A61B17/068
CPC分类号： A61B17/115 , A61B17/1155 , A61B2017/07257 , A61B2017/2905 , A61B2017/2919
摘要： A surgical stapling instrument for performing a circular anastomosis stapling operation is provided. The surgical instrument includes a stapling head assembly mounted by a curved shaft to an actuator handle assembly and incorporates an improved actuator mechanism for transmitting the required operating forces and movements from the actuator handle assembly through the curved shaft to an anvil and staple driver of the stapling head assembly. The stapling head assembly includes a longitudinally movable trocar detachably secured by one or more retainer clips on a hollow shaft of the anvil. When the trocar is retracted, the anvil shaft slides into a central support tube which aligns the anvil axially and circumferentially with a staple holder on the stapling head assembly. The retainer clips are locked against the trocar by the support tube and transmit tension from the trocar to the anvil with no tension load on the anvil shaft. The actuator mechanism permits adjustment of the anvil gap to produce a desired staple height and precludes actuation of the staple head assembly if the anvil gap is set outside of a predetermined range. Also, the actuator mechanism is adapted to both advance and retract the staple driver relative to the staple holder in the stapling head assembly. Further, an improved arrangement for attaching the support shaft to the stapling head assembly and to the actuator handle assembly is provided.

4. 发明申请

US20110295151A1 Enteroendocrine Manipulation for Metabolic Effect 审中-公开
标题翻译：肠内分泌操作代谢作用
公开(公告)号：US20110295151A1
公开(公告)日：2011-12-01
申请号：US13104282
申请日：2011-05-10
申请人： Gregory J. Bakos , Edward G. Chekan , Denzel Z. Herrera-Davis , Jason L. Harris , Gary L. Long , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , David N. Plescia , Randy J. Seeley , William B. Weisenburgh, II , Tamara S. Vetro Widenhouse , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Gregory J. Bakos , Edward G. Chekan , Denzel Z. Herrera-Davis , Jason L. Harris , Gary L. Long , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , David N. Plescia , Randy J. Seeley , William B. Weisenburgh, II , Tamara S. Vetro Widenhouse , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M37/00 , A61P3/00 , A61K9/00 , A61F2/04 , A61K49/00 , A61P3/04 , A61B10/02 , A61M5/00 , A61K35/55 , A61K9/20
CPC分类号： C12N5/0679 , A61K35/12 , A61K35/38 , A61L27/14 , A61L27/3882 , A61L27/58 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/64
摘要： L-cells may be introduced in the gastrointestinal tract. L-cells are used in the digestive process to produce a more efficient and lasting means of regulating feelings of satiation in a patient. Desired metabolic effects may be achieved by manipulating L-cells via delivery sites, frequency of delivery, or type of biological substance delivered.
摘要翻译： L细胞可能被引入胃肠道。 L细胞用于消化过程，以产生更有效和持久的调节患者饱腹感的手段。所需的代谢作用可以通过经由递送部位操纵L细胞，递送频率或递送的生物物质的类型来实现。

5. 发明授权

US4892244A Surgical stapler cartridge lockout device 失效
标题翻译：手术吻合器卡锁装置
公开(公告)号：US4892244A
公开(公告)日：1990-01-09
申请号：US267907
申请日：1988-11-07
申请人： William D. Fox , Rudolph H. Nobis , Richard P. Nuchols , Mark S. Zeiner
发明人： William D. Fox , Rudolph H. Nobis , Richard P. Nuchols , Mark S. Zeiner
IPC分类号： A61B17/068 , A61B17/072 , A61B19/00 , B25C5/16
CPC分类号： B25C5/1686 , A61B17/068 , A61B17/07207 , A61B2017/07214 , A61B2017/2945 , A61B2090/0814
摘要： A lockout mechanism actuable upon the firing of staples in a surgical staple cartridge such that the lockout mechanism prevents the refiring of the spent staple cartridge when that cartridge remains loaded within the surgical stapler. In addition, the lockout mechanism will prevent reloading of a spent staple cartridge within a surgical stapler after the spent staple cartridge has been removed from the surgical stapler.

6. 发明申请

US20120165793A1 Pill Catchers 审中-公开
标题翻译：药丸捕手
公开(公告)号：US20120165793A1
公开(公告)日：2012-06-28
申请号：US12976745
申请日：2010-12-22
申请人： Mark S. Ortiz , Christopher J. Hess , Jason L. Harris , James T. Spivey , Michael J. Stokes , Thomas E. Albrecht , James W. Voegele , William B. Weisenburgh, II , Rudolph H. Nobis , Mark S. Zeiner , Mark D. Overmyer , Darrel M. Powell , Joseph Bernard Kraimer , James Anthony Topich , Jeremy David Jarrett , Daniel James Prenger , Matthew D. Rohr Daniel
发明人： Mark S. Ortiz , Christopher J. Hess , Jason L. Harris , James T. Spivey , Michael J. Stokes , Thomas E. Albrecht , James W. Voegele , William B. Weisenburgh, II , Rudolph H. Nobis , Mark S. Zeiner , Mark D. Overmyer , Darrel M. Powell , Joseph Bernard Kraimer , James Anthony Topich , Jeremy David Jarrett , Daniel James Prenger , Matthew D. Rohr Daniel
IPC分类号： A61K9/22
CPC分类号： A61M31/002 , A61B1/041
摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.
摘要翻译：提供了设备和相关方法，用于将治疗剂控制递送到身体内的目标位置。更具体地，提供了用于控制经口给药的药丸通过身体的速率的方法和装置，以及用于控制体内在特定位置处的丸剂内的治疗剂的递送。提供了在本文中通常被称为“捕获器”的各种类型的装置，其可以在通过身体时主动地捕捉药丸。捕获器可以将药丸保持在体内的特定位置，直到发生预定事件，例如在丸中部分或完全施用治疗剂。然后，捕手可以在命令和/或发生预定事件时释放药片以允许药丸从身体中流出。在其他实施例中，提供了可以主动地接合捕获器并保持与捕获器接合的各种类型的药丸，直到发生预定事件。

7. 再颁专利

USRE34519E Surgical stapler cartridge lockout device 失效
标题翻译：手术吻合器卡锁装置
公开(公告)号：USRE34519E
公开(公告)日：1994-01-25
申请号：US815235
申请日：1991-12-31
申请人： William D. Fox , Rudolph H. Nobis , Richard P. Nuchols , Mark S. Zeiner
发明人： William D. Fox , Rudolph H. Nobis , Richard P. Nuchols , Mark S. Zeiner
IPC分类号： A61B17/068 , A61B17/072 , A61B19/00 , B25C5/16
CPC分类号： B25C5/1686 , A61B17/068 , A61B17/07207 , A61B2017/07214 , A61B2017/2945 , A61B2090/0814
摘要： A lockout mechanism actuable upon the firing of staples in a surgical staple cartridge such that the lockout mechanism prevents the refiring of the spent staple cartridge when the cartridge remains loaded within the surgical stapler. In addition, the lockout mechanism will prevent reloading of a spent staple cartridge within a surgical stapler after the spent staple cartridge has been removed from the surgical stapler.
摘要翻译：一种锁定机构，其能够在外科手术钉仓中订制钉时致动，使得当所述药筒保持装载在所述外科缝合器内时，所述锁定机构防止所述用过的钉仓的再填充。此外，锁定机构将防止在从外科缝合器上取出用过的钉仓之后，将消耗的钉仓重新装载在外科缝合器内。

8. 发明授权

US5222963A Pull-through circular anastomosic intraluminal stapler with absorbable fastener means 失效
标题翻译：具有可吸收紧固器功能的通过通孔的圆锥形腔内平台
公开(公告)号：US5222963A
公开(公告)日：1993-06-29
申请号：US642496
申请日：1991-01-17
申请人： Ronald J. Brinkerhoff , Mark S. Zeiner , Michael B. Miller , James A. Transue
发明人： Ronald J. Brinkerhoff , Mark S. Zeiner , Michael B. Miller , James A. Transue
IPC分类号： A61B17/00 , A61B17/11 , A61B17/115 , A61F2/00
CPC分类号： A61B17/115 , A61B17/11 , A61B17/1114 , A61B17/1155 , A61B2017/00004 , A61F2002/305 , A61F2220/0025 , Y10T24/45534
摘要： A mechanism which is capable of anastomosis of two lumens by an absorbable fastener. The fastener is made from two washer-like plates. One such plate has holes to receive latching prongs protruding from the other plate. Fastening is done through a single linear motion that causes the prongs to pierce the tissue, latches the prongs into a receiver and causes a knife blade to cut through excess fastener material and tissue. The ease of removal, by pulling the mechanism thorugh the formed anastomosis, is greatly enhanced. The system can be used such that the plates can be placed in any configuration to properly anastomose tissue.

9. 发明授权

US10350050B2 Method for gastric volume reduction surgery 有权
公开(公告)号：US10350050B2
公开(公告)日：2019-07-16
申请号：US12113784
申请日：2008-05-01
申请人： Jason L. Harris , Mark S. Zeiner , Michael J. Stokes
发明人： Jason L. Harris , Mark S. Zeiner , Michael J. Stokes
IPC分类号： A61F2/04 , A61F2/07 , A61M29/00 , A61B17/04 , A61B17/11 , A61F5/00 , A61B17/00 , A61B17/06 , A61M25/00
摘要： A method for treating a patient includes creating at least one incision to gain access to an peritoneal cavity, performing a gastric volume reduction procedure and introducing a device to prevent gastric contents from interacting with at least a portion of the duodenum.

10. 发明授权

US09713468B2 Surgical stapler for applying a large staple through a small delivery port and a method of using the stapler to secure a tissue fold 有权
公开(公告)号：US09713468B2
公开(公告)日：2017-07-25
申请号：US12608860
申请日：2009-10-29
申请人： Jason L. Harris , Lawrence Crainich , Michael J. Stokes , Mark S. Zeiner , Darrel M. Powell
发明人： Jason L. Harris , Lawrence Crainich , Michael J. Stokes , Mark S. Zeiner , Darrel M. Powell
IPC分类号： A61B17/10 , A61B17/064 , A61B17/068 , A61B17/00 , A61B17/29
CPC分类号： A61B17/0644 , A61B17/0682 , A61B2017/00818 , A61B2017/2925 , A61B2017/2946
摘要： A method of deploying a surgical fastener into a patient by introducing the fastener into a body of a patient while the fastener is in a first shape having a first loop with a back span and an original size and shape. The method then involves moving end segments of the fastener away from each other substantially along an entire length thereof while keeping the back span in substantially its original size and shape. The method then involves forming the fastener into a second loop having a width greater than a width of the first loop.

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