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1. 发明授权

US5478752A Analytical method and device containing a fleece layer 失效
标题翻译：包含羊毛层的分析方法和装置
公开(公告)号：US5478752A
公开(公告)日：1995-12-26
申请号：US237410
申请日：1994-05-03
申请人： Rolf Lerch , Heinz Macho
发明人： Rolf Lerch , Heinz Macho
IPC分类号： G01N31/22 , G01N33/52 , G01N21/00
CPC分类号： G01N33/525
摘要： An analytical device is used for the determination of an analyte in a liquid sample. The device includes a fleece layer including fleece material and polyester fibers, and a reagent for determining an analyte. The reagent is for entering into a detectable reaction with the analyte. The polyester fibers are heat-meltable copolyester fibers containing terephthalic acid, isophthalic acid, and 1,4-butanediol.
摘要翻译：分析装置用于测定液体样品中的分析物。该装置包括羊毛材料和聚酯纤维的羊毛层和用于确定分析物的试剂。试剂用于与分析物进行可检测的反应。聚酯纤维是含有对苯二甲酸，间苯二甲酸和1,4-丁二醇的热熔性共聚酯纤维。

2. 发明授权

US5814522A Multilayer analytical element for the determination of an analyte in a liquid 失效
标题翻译：用于测定液体中分析物的多层分析元件
公开(公告)号：US5814522A
公开(公告)日：1998-09-29
申请号：US668059
申请日：1996-06-20
申请人： Volker Zimmer , Heinz Macho , Rolf Lerch
发明人： Volker Zimmer , Heinz Macho , Rolf Lerch
IPC分类号： G01N31/22 , G01N33/52 , G01N33/543 , G01N33/48
CPC分类号： G01N33/525
摘要： A sample application zone and detection zone are arranged on a pile-like complex made of a fleece and a porous membrane which are in a direct or indirect contact that enables passage of liquid through the contact area and the membrane is a polyamide, polyvinylidene difluoride, polyether sulfone or polysulfone membrane which transports liquid significantly slower over the area than the fleece.
摘要翻译：样品施用区域和检测区域布置在由绒毛和多孔膜制成的绒毛状复合体上，所述绒毛状复合物处于直接或间接接触，使得液体能够通过接触区域，并且膜是聚酰胺，聚偏二氟乙烯，聚醚砜或聚砜膜，其运输液体比羊毛在区域上显着更慢。

3. 发明授权

US5451350A Test carrier for the determination of an analyte as well as a process for its production 失效
标题翻译：用于测定分析物的测试载体以及其生产过程
公开(公告)号：US5451350A
公开(公告)日：1995-09-19
申请号：US68110
申请日：1993-05-28
申请人： Heinz Macho , Rolf Lerch , Herbert Harttig , Volker Zimmer
发明人： Heinz Macho , Rolf Lerch , Herbert Harttig , Volker Zimmer
IPC分类号： G01N31/22 , G01N33/52 , G01N37/00 , G01N1/18
CPC分类号： G01N33/521 , Y10S435/805 , Y10S436/81
摘要： An analytical device determines the analytes in a liquid sample. This device includes a layer of flat material which has a sample application area and a detection area thereupon. The detection area includes a reagent for determining the analyte, and the absorbent sample application area and the absorbent detection area are disposed within a liquid impermeable boundary. The layer of flat material also includes an absorbent connector which is disposed such that the sample application area and the detection area are connected by the absorbent connector. The liquid impermeable boundary and the absorbent connector prevents liquid from being transported between the sample application area and the detection area, except through the absorbent connector.
摘要翻译：分析装置确定液体样品中的分析物。该装置包括具有样品应用区域和其上的检测区域的平坦材料层。检测区域包括用于确定分析物的试剂，并且吸收剂样品施加区域和吸收检测区域设置在液体不可渗透的边界内。扁平材料层还包括吸收连接器，其设置成使得样品施加区域和检测区域通过吸收连接器连接。液体不可渗透边界和吸收连接器防止液体在样品施加区域和检测区域之间传输，除了通过吸收连接器。

4. 发明申请

US20110194980A1 Process For Hydrophilizing Surfaces Of Fluidic Components And Systems 有权
标题翻译：流体组分和系统的亲水化表面的方法
公开(公告)号：US20110194980A1
公开(公告)日：2011-08-11
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N30/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

5. 发明授权

US5690529A Adsorber material, apparatus and process for concentrating and recovering trace materials from the gaseous phase 失效
标题翻译：用于从气相中浓缩和回收痕量物质的吸附剂材料，设备和方法
公开(公告)号：US5690529A
公开(公告)日：1997-11-25
申请号：US748618
申请日：1996-11-13
申请人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
发明人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
IPC分类号： B01J20/24 , B01J20/26 , B01J20/28 , G01N1/22 , G01N1/34 , G01N13/00 , D04H3/00 , D04H3/12
CPC分类号： B01J20/28023 , B01J20/2803 , B01J20/28033 , G01N1/405 , G01N1/2214 , Y10T442/696 , Y10T442/697 , Y10T442/698
摘要： An adsorber material for collecting, concentrating and/or recovering gaseous and/or particle-shaped trace substances from an air or gas flow, in which the adsorber material is composed of fibrous elements made of natural and/or synthetic, organic, textile fibers which are worked into a nonwoven web having a planar geometry, the nonwoven web having a thickness of between 100 .mu.m and 2 mm and a weight per unit area of between 20 and 200 g/m.sup.2. Preferably the fibers have a fiber size between 1 and 10 dtex and are composed of cellulose and/or polyester, and if desired, the fibers may be provided with a binding agent and/or a moisture resistance agent. In preferred embodiments the nonwoven adsorber web is a fiber mixture of 80 parts polyester fibers, 20 parts viscose rayon staple fibers, and 20 parts polyvinyl alcohol fibers or a fiber mixture of 50 parts viscose rayon staple fibers and 50 parts linters, which are provided with an epichlorohydrin resin binder. The adsorber webs can be used to detect gaseous or particulate trace contaminants in air or another gas stream.
摘要翻译：用于从空气或气体流中收集，浓缩和/或回收气态和/或颗粒状痕量物质的吸附剂材料，其中吸附材料由天然和/或合成的有机纺织纤维制成的纤维元素组成，被加工成具有平面几何形状的非织造纤维网，非织造纤维网的厚度在100μm和2mm之间，每单位面积的重量在20和200g / m 2之间。优选地，纤维的纤维尺寸在1和10分特之间并且由纤维素和/或聚酯组成，如果需要，纤维可以具有粘合剂和/或防潮剂。在优选的实施方案中，非织造物吸附剂纤维网是80份聚酯纤维，20份粘胶人造丝短纤维和20份聚乙烯醇纤维或50份粘胶人造丝短纤维和50份绒毛的纤维混合物的纤维混合物，它们具有表氯醇树脂粘合剂。吸附器腹板可用于检测空气或其他气体流中的气态或微量痕量污染物。

6. 发明授权

US06231815B1 Storage and transport system for sample material 失效
标题翻译：储存和运输系统样品
公开(公告)号：US06231815B1
公开(公告)日：2001-05-15
申请号：US08974481
申请日：1997-11-20
申请人： Gregor Bainczyk , Rolf Nagel , Helmut Leininger , Rolf Lerch
发明人： Gregor Bainczyk , Rolf Nagel , Helmut Leininger , Rolf Lerch
IPC分类号： G01N110
CPC分类号： B01L3/5023 , B01L2200/18 , B01L2300/042 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406
摘要： The invention concerns a system for the storage and transport of sample material on absorbent material which is characterized in that the system contains no test reagents and it additionally includes a closable container containing a medium that can absorb moisture such as a desiccant in addition to the absorbent material for absorbing a liquid sample. Furthermore the system according to the invention can contain an agent to stabilize the sample material and optionally further auxiliary substances.
摘要翻译：本发明涉及一种用于在吸收材料上储存和运送样品材料的系统，其特征在于该系统不含测试试剂，并且还包括一种可封闭的容器，该容器包含除吸收剂之外还可以吸收湿气的介质，例如干燥剂用于吸收液体样品的材料。此外，根据本发明的系统可以含有用于稳定样品材料和任选的另外的辅助物质的试剂。

7. 发明授权

US5118609A Carrier fleece for use as a reagent carrier from which reagents can be dissolved in immunological analysis 失效
标题翻译：作为试剂载体的携带者可以从免疫分析中分离出试剂
公开(公告)号：US5118609A
公开(公告)日：1992-06-02
申请号：US648685
申请日：1991-01-31
申请人： Manfred Baier , Helmut Jering , Rolf Lerch , Dieter Mangold , Ellen Mossner , Gunter Pappert , Siegfried Notzel
发明人： Manfred Baier , Helmut Jering , Rolf Lerch , Dieter Mangold , Ellen Mossner , Gunter Pappert , Siegfried Notzel
IPC分类号： C07K1/16 , C07K16/00 , C07K17/10 , C12Q1/00 , C12Q1/34 , D04H1/54 , D04H1/58 , D21H11/12 , D21H13/08 , D21H13/16 , D21H13/24 , D21H13/26 , D21H17/34 , D21H17/36 , D21H17/37 , D21H17/39 , G01N33/545 , G01N33/548
CPC分类号： D21H17/34 , G01N33/545 , D21H11/12 , D21H13/08 , D21H13/16 , D21H13/24 , D21H13/26 , D21H17/36 , D21H17/37 , D21H17/39 , Y10S435/805 , Y10S435/97 , Y10S530/814 , Y10S530/815
摘要： A carrier fleece is prepared for use as reagent carrier from which reagents can be dissolved in as assay such as immunological analysis. The carrier fleece contains from 5 to 60% by weight of cellulose-containing fibers, from 40 to 95% by weight of polyester or polyamide polymer fibers or a combination thereof and from 5 to 30% by weight of the fibers of an organic binding agent which has a hydroxyl or an ester group or a combination thereof. In an immunological analysis, the carrier fleece is impregnated with an immunologically active agent such as a beta-galactosidase conjugate and then introduced into a solution of a sample containing an immunologically active substance to be analyzed. The immunologically active agent is eluted into the sample solution and the presence of the immunologically active substance in the sample is determined.
摘要翻译：制备载体羊毛作为试剂载体，试剂可以作为试剂溶解，如免疫分析。载体绒毛含有5至60重量％的含纤维素的纤维，40至95重量％的聚酯或聚酰胺聚合物纤维或其组合，和5至30重量％的有机粘合剂的纤维其具有羟基或酯基或其组合。在免疫学分析中，载体羊毛用免疫活性剂例如β-半乳糖苷酶缀合物浸渍，然后引入含有待分析的免疫活性物质的样品的溶液中。将免疫活性剂洗脱到样品溶液中，并测定样品中免疫活性物质的存在。

8. 发明授权

US4910150A Process for determining coagulation parameter 失效
标题翻译：确定凝血参数的方法
公开(公告)号：US4910150A
公开(公告)日：1990-03-20
申请号：US246366
申请日：1988-09-19
申请人： Jurgen Doeding , Hans Wielinger , Rolf Lerch
发明人： Jurgen Doeding , Hans Wielinger , Rolf Lerch
IPC分类号： C03C25/10 , A61K35/14 , B01J20/26 , C03C17/32 , C12Q1/56 , D06M15/333 , D06M101/00 , D21H13/00 , G01N1/18 , G01N33/48 , G01N33/52 , G01N33/86
CPC分类号： G01N33/52 , D21H13/40 , D21H5/12 , G01N33/86 , Y10T436/25125 , Y10T436/255
摘要： The present invention provides a test carrier for the determination of coagulation parameters, wherein it includes a test layer which contains glass fibres which are coated with polyvinyl alcohol or polyvinyl alcohol/vinyl acetate.The present invention also provides a process for the production of a glass fibre layer, wherein glass fibres are slurried in an excess of water with the addition of polyvinyl alcohol and a layer is formed according to a process conventional for the production of paper and dried at an elevated temperature.Furthermore, the present invention provides a process for the determination of coagulation parameters of blood, wherein it includes a process step in which blood is passed through a glass fibre layer which contains glass fibres which have been coated with polyvinyl alcohol or polyvinyl alcohol/vinyl acetate.

9. 发明授权

US4374575A Winding machine for continuously winding strips of web material into rolls 失效
标题翻译：卷绕机用于将卷筒纸材料条连续缠绕成卷
公开(公告)号：US4374575A
公开(公告)日：1983-02-22
申请号：US213485
申请日：1980-12-05
申请人： Rolf Lerch , Franz Held
发明人： Rolf Lerch , Franz Held
IPC分类号： B65H19/22 , B65H18/10 , B65H18/26 , B65H35/02 , B65H75/02
CPC分类号： B65H35/02 , B65H18/26 , B65H2301/41342 , B65H2301/4148 , B65H2301/41486 , B65H2301/5133
摘要： A winding machine for winding up into rewind rolls a plurality of strips cut from an elongated web includes contact drums respectively bearing against the rewind rolls, the contact drums being independently arranged for independently exerting pressure against their rewind rolls for independently maintaining the necessary gap values between them and the periphery of the main drum about which the strips are partially looped upon entering the machine. Detecting devices associated with pairs of support arms provided for the contact drum operate a motor associated with each of the support arm pairs for each rewind roll for simultaneously rotating a pair of spindles on the support arms so as to pivot them away from the centerline of the machine when the extent of the aforementioned gap at each contact drum is reduced below a desired minimum.
摘要翻译：用于卷绕成倒带辊的卷绕机，从细长腹板切割出的多个条带包括分别承载在倒带辊上的接触鼓，所述接触鼓被独立地设置成独立地施加压力以抵靠它们的倒带辊，以独立地保持第一和第它们和主滚筒的周边，条带在进入机器时部分环绕该主滚筒。与为接触鼓提供的成对的支撑臂相关联的检测装置操作与用于每个倒带辊的每个支撑臂对相关联的马达，用于同时使支撑臂上的一对主轴旋转，以使其远离中心线当在每个接触鼓处的上述间隙的程度减小到所需的最小值以下时。

10. 发明授权

US5910246A Device for isolating nucleic acids 失效
公开(公告)号：US5910246A
公开(公告)日：1999-06-08
申请号：US617696
申请日：1996-04-01
申请人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
发明人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
IPC分类号： G01N33/50 , B01J20/00 , B01L3/14 , B04B5/02 , B04B7/18 , C07H1/06 , C07H21/00 , C12M1/00 , C12Q1/68 , G01N15/06 , G01N33/53
CPC分类号： B01L3/5021 , C07H1/06
摘要： Device for the isolation of nucleic acids from a liquid sample by introducing the liquid into the device through an inlet opening and passage of the sample through a nucleic acid binding material and discharging of the resulting liquid through an outlet opening, wherein the nucleic acid binding material is inserted through the outlet opening during the manufacture of the device and the outlet opening is narrowed in order to hold the material. The device is particularly simple and reliable to manufacture but yet ensures that nucleic acids can be isolated without contamination.

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