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1. 发明申请

US20070259450A1 Method for Increasing the Dynamic Measuring Range of Test Elements Based on Specific Binding Reactions 有权
标题翻译：基于特定结合反应增加测试元件动态测量范围的方法
公开(公告)号：US20070259450A1
公开(公告)日：2007-11-08
申请号：US11557279
申请日：2006-11-07
申请人： Ludger Bodenbach , Juergen Schaeffler , Juergen Spinke
发明人： Ludger Bodenbach , Juergen Schaeffler , Juergen Spinke
IPC分类号： G01N33/558
CPC分类号： G01N33/54386 , G01N33/538
摘要： The invention concerns a method for increasing the dynamic measuring range of especially immunological test elements in particular immunological chromatography test strips that can be evaluated optically that are based on specific binding reactions. The invention enables the dynamic measuring range of test elements based on specific binding reagents, especially of immunological test elements to be shifted towards higher analyte concentrations without impairing the lower detection limit. For this purpose it is proposed according to the invention that at least two zones are provided in or on the test element which contain reagents that generate detectable signals of different strengths due to different affinities for the analyte (for example in the case of antibodies that have different affinities for the analyte) or due to different principles of interaction with the analyte or with other reagents involved in the analyte detection (for example antibodies directed against the analyte in one zone and an analyte analogue in another zone). The signals in the at least two zones are used to evaluate the analyte concentration-signal strength relationship and are used to determine the analyte by means of a suitable method (correlation).
摘要翻译：本发明涉及用于增加特别是免疫学测试元件的动态测量范围的方法，特别是可以根据特异性结合反应光学评估的免疫色谱测试条。本发明使得基于特异性结合试剂，特别是免疫测试元件的测试元件的动态测量范围能够转移到更高的分析物浓度而不损害较低的检测限。为此目的，根据本发明提出，至少两个区域设置在测试元件中或测试元件上，其包含由于分析物的不同亲和力而产生不同强度的可检测信号的试剂（例如在具有分析物的不同亲和力）或由于与分析物或与分析物检测相关的其它试剂（例如针对一个区域中的分析物和另一区域中的分析物类似物的抗体）的相互作用的不同原理。至少两个区域中的信号用于评估分析物浓度 - 信号强度关系，并用于通过合适的方法（相关性）确定分析物。

2. 发明授权

US07955563B2 Methods for applying reactive films containing solids to microporous membranes and membranes produced therefrom 有权
标题翻译：将含有固体的活性膜施加到微孔膜的方法和由其制备的膜
公开(公告)号：US07955563B2
公开(公告)日：2011-06-07
申请号：US11758804
申请日：2007-06-06
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N27/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式制备的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

3. 发明申请

US20070274861A1 MEMBRANES AND METHODS FOR COATING MEMBRANES 有权
标题翻译：膜和涂膜方法
公开(公告)号：US20070274861A1
公开(公告)日：2007-11-29
申请号：US11758804
申请日：2007-06-06
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N31/22
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式制备的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

4. 发明授权

US08354235B2 Method for increasing the dynamic measuring range of test elements based on specific binding reactions 有权
标题翻译：基于特异性结合反应增加测试元件的动态测量范围的方法
公开(公告)号：US08354235B2
公开(公告)日：2013-01-15
申请号：US11557279
申请日：2006-11-07
申请人： Ludger Bodenbach , Juergen Schaeffler , Juergen Spinke
发明人： Ludger Bodenbach , Juergen Schaeffler , Juergen Spinke
IPC分类号： G01N33/533
CPC分类号： G01N33/54386 , G01N33/538
摘要： The invention concerns a method for increasing the dynamic measuring range of especially immunological test elements in particular immunological chromatography test strips that can be evaluated optically that are based on specific binding reactions. The invention enables the dynamic measuring range of test elements based on specific binding reagents, especially of immunological test elements to be shifted towards higher analyte concentrations without impairing the lower detection limit. For this purpose it is proposed according to the invention that at least two zones are provided in or on the test element which contain reagents that generate detectable signals of different strengths due to different affinities for the analyte (for example in the case of antibodies that have different affinities for the analyte) or due to different principles of interaction with the analyte or with other reagents involved in the analyte detection (for example antibodies directed against the analyte in one zone and an analyte analogue in another zone). The signals in the at least two zones are used to evaluate the analyte concentration-signal strength relationship and are used to determine the analyte by means of a suitable method (correlation).
摘要翻译：本发明涉及用于增加特别是免疫学测试元件的动态测量范围的方法，特别是可以根据特异性结合反应光学评估的免疫色谱测试条。本发明使得基于特异性结合试剂，特别是免疫测试元件的测试元件的动态测量范围能够转移到更高的分析物浓度而不损害较低的检测限。为此目的，根据本发明提出，至少两个区域设置在测试元件中或测试元件上，其包含由于分析物的不同亲和力而产生不同强度的可检测信号的试剂（例如在具有分析物的不同亲和力）或由于与分析物或与分析物检测相关的其它试剂（例如针对一个区域中的分析物和另一区域中的分析物类似物的抗体）的相互作用的不同原理。至少两个区域中的信号用于评估分析物浓度 - 信号强度关系，并用于通过合适的方法（相关性）确定分析物。

5. 发明申请

US20110194980A1 Process For Hydrophilizing Surfaces Of Fluidic Components And Systems 有权
标题翻译：流体组分和系统的亲水化表面的方法
公开(公告)号：US20110194980A1
公开(公告)日：2011-08-11
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N30/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

6. 发明授权

US08202490B2 Membranes and methods for coating membranes 有权
标题翻译：膜和膜的涂覆方法
公开(公告)号：US08202490B2
公开(公告)日：2012-06-19
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： B01L3/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

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