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1. 发明授权

US07842310B2 Pharmaceutical compositions in particulate form 有权
标题翻译：药物组合物为颗粒形式
公开(公告)号：US07842310B2
公开(公告)日：2010-11-30
申请号：US10299012
申请日：2002-11-19
申请人： Robin Hwang , Vincent Sullivan , Juan Huang , Zhaolin Wang , John A. Mikszta , David Montgomery , Brandi Ford , Anjana Bhuta-Wills
发明人： Robin Hwang , Vincent Sullivan , Juan Huang , Zhaolin Wang , John A. Mikszta , David Montgomery , Brandi Ford , Anjana Bhuta-Wills
IPC分类号： A61K9/19 , F26B5/04 , F26B5/06 , F26B5/00
CPC分类号： A61K9/1694 , A61K9/0019 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1652 , A61K9/1688 , A61K47/26
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径在约35μ至约300μ之间的液滴，和/或所述粉末包含平均直径在约35μ至约300μ之间的干燥颗粒。还描述了通过上述方法制备的组合物，以及使用组合物的方法。

2. 发明申请

US20070190158A1 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
标题翻译：颗粒形式的药物组合物
公开(公告)号：US20070190158A1
公开(公告)日：2007-08-16
申请号：US11691280
申请日：2007-03-26
申请人： Robin Hwang , Vincent Sullivan , Juan Huang , Zhaolin Wang , John Mikszta , David Montgomery , Brandi Ford , Anjana Bhuta-Wills
发明人： Robin Hwang , Vincent Sullivan , Juan Huang , Zhaolin Wang , John Mikszta , David Montgomery , Brandi Ford , Anjana Bhuta-Wills
IPC分类号： A61K9/14
CPC分类号： A61K9/1694 , A61K9/0019 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1652 , A61K9/1688 , A61K47/26
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均平均直径在约35mu至约300mu之间的液滴，和/或所述粉末包含平均直径在约35μm至约300μm之间的干燥颗粒。还描述了通过上述方法制备的组合物，以及使用组合物的方法。

3. 发明申请

US20060280691A1 Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery 审中-公开
标题翻译：喷雾冷冻干燥脂质体环丙沙星粉末气雾剂药物输送
公开(公告)号：US20060280691A1
公开(公告)日：2006-12-14
申请号：US11445347
申请日：2006-06-02
申请人： Zhaolin Wang , Helena Orszanska , Warren Finlay
发明人： Zhaolin Wang , Helena Orszanska , Warren Finlay
IPC分类号： A61K9/127 , A61K9/14 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/127 , A61K9/1617
摘要： A powder for inhalatory aerosol delivery, the powder having: spray freeze dried liposome particles with a biologically active agent, such as an antibiotic, encapsulated within a phospholipid, and a method of producing a powder for inhalatory aerosol delivery, the method including the steps of: mixing a biologically active agent with a phospholipid to form a liquid liposome suspension; and spray freeze drying the liposome suspension to form particles of powder.
摘要翻译：一种用于吸入气雾剂输送的粉末，该粉末具有：具有包封在磷脂内的生物活性剂如抗生素的喷雾冷冻干燥脂质体颗粒，以及生产用于吸入性气雾剂递送的粉末的方法，所述方法包括以下步骤：：将生物活性剂与磷脂混合以形成液体脂质体悬浮液; 并喷雾冷冻干燥脂质体悬浮液以形成粉末颗粒。

4. 发明授权

US08466286B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08466286B2
公开(公告)日：2013-06-18
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： C07F5/02 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , C07D471/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

5. 发明申请

US20120132203A1 DRY POWDER INHALERS 有权
标题翻译：干粉吸入器
公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

6. 发明授权

US07363726B2 Powder formation by atmospheric spray-freeze drying 有权
标题翻译：通过大气喷雾冷冻干燥形成粉末
公开(公告)号：US07363726B2
公开(公告)日：2008-04-29
申请号：US11318864
申请日：2005-12-28
申请人： Zhaolin Wang , Warren H. Finlay
发明人： Zhaolin Wang , Warren H. Finlay
IPC分类号： F26B5/06
CPC分类号： F26B5/06 , F26B13/30
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
摘要翻译：公开了一种制造热敏药用粉末的方法。将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却目的）。颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。该系统适用于形成其他粉末。

7. 发明授权

US11149940B2 Heat exchanger using non-pure water for steam generation 有权
公开(公告)号：US11149940B2
公开(公告)日：2021-10-19
申请号：US15656450
申请日：2017-07-21
申请人： Greg Naterer , Zhaolin Wang , Edward Secnik
发明人： Greg Naterer , Zhaolin Wang , Edward Secnik
IPC分类号： F22B1/06 , C01B3/08 , C01B13/02 , F22B27/16 , F28D3/02 , F28D7/10 , F28D21/00 , C02F1/16 , B01D1/00 , C01B3/04 , F22B37/26 , C02F1/00
摘要： A process and a device are described for producing high purity and high temperature steam from non-pure water which may be used in a variety of industrial processes that involve high temperature heat applications. The process and device may be used with technologies that generate steam using a variety of heat sources, such as, for example industrial furnaces, petrochemical plants, and emissions from incinerators. Of particular interest is the application in a thermochemical hydrogen production cycle such as the Cu—Cl Cycle. Non-pure water is used as the feedstock in the thermochemical hydrogen production cycle, with no need to adopt additional and conventional water pre-treatment and purification processes. The non-pure water may be selected from brackish water, saline water, seawater, used water, effluent treated water, tailings water, and other forms of water that is generally believed to be unusable as a direct feedstock of industrial processes. The direct usage of this water can significantly reduce water supply costs.

8. 发明授权

US08628725B2 Production of hydrogen from water using a thermochemical copper-chlorine cycle 有权
标题翻译：使用热化学铜 - 氯循环从水生产氢气
公开(公告)号：US08628725B2
公开(公告)日：2014-01-14
申请号：US12292722
申请日：2008-11-25
申请人： Kamiel Samy Gabriel , Zhaolin Wang , Greg Naterer
发明人： Kamiel Samy Gabriel , Zhaolin Wang , Greg Naterer
IPC分类号： B01J8/22 , C25C1/12
CPC分类号： B01J10/005 , B01J7/00 , B01J8/002 , B01J8/003 , B01J8/0453 , B01J8/0496 , B01J2208/00752 , B01J2219/00006 , C01B3/068 , C01B13/0207 , C25C1/12 , Y02E60/36
摘要： A system for producing hydrogen gas from water decomposition using a thermochemical CuCl cycle, the improvement comprising the use of an insulated hydrogen production reactor comprising a reaction chamber and a separation chamber; the reaction chamber having a hydrogen chloride gas inlet and a solid copper inlet; one or more levels provided in the reaction chamber, the number of which is dependant on production scale and pressure drop; each level comprising a perforated plate with associated filter media, the perforations of the plate and media being of decreasing size from top to bottom of the reaction chamber, and being sized to permit downward flow of the hydrogen gas and molten CuCl products, as well as the HCL gas reactant, and to prevent entrainment of solid copper in the molten CuCl; the separation chamber being located below the reaction chamber and being of greater cross section than the reaction chamber and comprising a first hydrogen removal and entrained copper removal zone and a second molten CuCl removal zone; removal of the reaction products being controlled so as to substantially decrease the amount of entrained copper in the molten CuCl; and the first zone having outlets for removal of hydrogen gas and entrained copper particles, with the second zone having an outlet for removal of molten CuCl.
摘要翻译：使用热化学CuCl循环从水分解产生氢气的系统，其改进包括使用包含反应室和分离室的绝热氢气生产反应器; 反应室具有氯化氢气体入口和固体铜入口; 在反应室中提供一个或多个水平，其数量取决于生产规模和压降; 每个级别包括具有相关过滤介质的多孔板，板和介质的穿孔从反应室的顶部到底部具有减小的尺寸，并且其尺寸允许氢气和熔融的CuCl产物向下流动，以及 HCL气体反应物，并防止在熔融的CuCl中夹带固体铜; 所述分离室位于所述反应室下方并且具有比所述反应室更大的横截面，并且包括第一除氢和夹带的铜去除区和第二熔融的CuCl去除区; 控制反应产物的去除以显着减少熔融的CuCl中夹带的铜的量; 并且第一区域具有用于除去氢气和夹带的铜颗粒的出口，其中第二区域具有用于除去熔融的CuCl的出口。

9. 发明申请

US20090004108A1 Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors 有权
标题翻译： Smmr（小分子代谢记录）用作体内葡萄糖生物传感器
公开(公告)号：US20090004108A1
公开(公告)日：2009-01-01
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07D311/78
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

10. 发明申请

US20070125375A1 Device and method for deagglomeration of powder for inhalation 审中-公开
标题翻译：用于吸入粉末解聚的装置和方法
公开(公告)号：US20070125375A1
公开(公告)日：2007-06-07
申请号：US11476899
申请日：2006-06-29
申请人： Warren Finlay , Zhaolin Wang
发明人： Warren Finlay , Zhaolin Wang
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/0021 , A61M2202/064 , A61M2206/16
摘要： A device and method for deagglomerating powder agglomerates for inhalation. The device includes an inlet connected to a chamber and to a powder source for supplying the chamber with powder agglomerates and a flow of gas that define a swirling fluid flow inside the chamber. The device also includes an outlet connected to the chamber for inhalation such that the swirling fluid flow in the chamber can exit from the chamber as a longitudinal fluid flow that is directed along a longitudinal axis of the outlet, and a secondary fluid flow that is directed away from the longitudinal axis of the outlet. A mesh in the outlet prevents powder agglomerates above a predetermined size from traversing the mesh, and reduces the secondary fluid flow relative to the longitudinal fluid flow exiting from the chamber to thereby reduce powder deposition in a mouth and throat of a user.
摘要翻译：用于吸入的粉末团块解聚集的装置和方法。该装置包括连接到室的入口和用于向腔室供应粉末团聚体和在腔室内限定旋转流体流的气流的粉末源。该装置还包括连接到腔室以用于吸入的出口，使得腔室内的旋流流体可以沿着沿着出口的纵向轴线引导的纵向流体流动而从腔室排出，并且引导的次级流体流远离出口的纵向轴线。出口中的网格防止超过预定尺寸的粉末团聚物穿过网，并且相对于从室离开的纵向流体流减少二次流体流动，从而减少用户口腔和喉部中的粉末沉积。

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