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1. 发明申请

US20090004108A1 Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors 有权
标题翻译： Smmr（小分子代谢记录）用作体内葡萄糖生物传感器
公开(公告)号：US20090004108A1
公开(公告)日：2009-01-01
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07D311/78
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

2. 发明授权

US06927857B2 Process for the detection of marked components of a composite article using infrared blockers 有权
标题翻译：使用红外阻挡剂检测复合制品的标记组分的方法
公开(公告)号：US06927857B2
公开(公告)日：2005-08-09
申请号：US10210685
申请日：2002-07-31
申请人： Matthew L. Koele , Clinton D. Clark , Jerome J. Workman, Jr. , Kent A. Franklin , Thomas M. Flicker , Bradley M. Marohl , Joesph J. Gimenez
发明人： Matthew L. Koele , Clinton D. Clark , Jerome J. Workman, Jr. , Kent A. Franklin , Thomas M. Flicker , Bradley M. Marohl , Joesph J. Gimenez
IPC分类号： A61F13/15 , G01B11/03 , G21K5/04 , G01N21/84
CPC分类号： G21K5/04 , A61F13/15772 , G01N21/35 , G01N21/3563 , G01N21/8806 , G01N21/95
摘要： Disclosed is a process for the detection of marked components of a composite article. The present invention relates to detecting the presence, position, concentration and/or distribution of one or more components in a composite article, and to registration inspection of a composite article using infrared radiation. In one embodiment of the invention, infrared blockers, such as absorbing infrared blockers, are incorporated into the component of interest in the composite to increase the visibility of the marked component during inspection.
摘要翻译：公开了一种用于检测复合制品的标记部件的方法。本发明涉及检测复合制品中一种或多种组分的存在，位置，浓度和/或分布，以及使用红外辐射对复合制品进行配准检查。在本发明的一个实施方案中，将红外阻滞剂（例如吸收红外线阻断剂）并入复合材料中所关注的组分，以增加在检查期间标记组分的可视性。

3. 发明授权

US08029765B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
公开(公告)号：US08029765B2
公开(公告)日：2011-10-04
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

4. 发明授权

US07935296B2 Process for the detection of marked components of a composite article using infrared blockers 有权
标题翻译：使用红外阻挡剂检测复合制品的标记组分的方法
公开(公告)号：US07935296B2
公开(公告)日：2011-05-03
申请号：US11037478
申请日：2005-01-18
申请人： Matthew L. Koele , Clinton D. Clark , Jerome J. Workman, Jr. , Kent A. Franklin , Thomas M. Flicker , Bradley M. Marohl , Joseph J. Gimenez
发明人： Matthew L. Koele , Clinton D. Clark , Jerome J. Workman, Jr. , Kent A. Franklin , Thomas M. Flicker , Bradley M. Marohl , Joseph J. Gimenez
IPC分类号： G01B15/00
CPC分类号： G21K5/04 , A61F13/15772 , G01N21/35 , G01N21/3563 , G01N21/8806 , G01N21/95
摘要： Disclosed is a process for the detection of marked components of a composite article. The present invention relates to detecting the presence, position, concentration and/or distribution of one or more components in a composite article, and to registration inspection of a composite article using infrared radiation. In one embodiment of the invention, infrared blockers, such as absorbing infrared blockers, are incorporated into the component of interest in the composite to increase the visibility of the marked component during inspection.
摘要翻译：公开了一种用于检测复合制品的标记部件的方法。本发明涉及检测复合制品中一种或多种组分的存在，位置，浓度和/或分布，以及使用红外辐射对复合制品进行配准检查。在本发明的一个实施方案中，将红外阻滞剂（例如吸收红外线阻断剂）并入复合材料中所关注的组分，以增加在检查期间标记组分的可视性。

5. 发明授权

US06452679B1 Method and apparatus for controlling the manufacturing quality of a moving web 失效
标题翻译：用于控制移动幅材的制造质量的方法和装置
公开(公告)号：US06452679B1
公开(公告)日：2002-09-17
申请号：US09474720
申请日：1999-12-29
申请人： Jerome J. Workman, Jr.
发明人： Jerome J. Workman, Jr.
IPC分类号： G01N2184
CPC分类号： G01N21/86 , D21H23/78 , G01N2021/3129
摘要： A method and apparatus for detecting the composition of a moving web product on a real-time basis during the manufacturing process. Spectrometric monitoring equipment operates to derive information regarding physical and/or chemical properties of the web at multiple locations in the web's cross direction. Data from a plurality of spectral regions can be combined to produce a vector containing accurate information regarding the web's composition. This information is derived using multivariate mathematical techniques to yield a spatial data matrix for each component of interest. Composition information contained in the spatial data matrix can be reprojected as a “virtual composition map,” or compared against ideal profiles stored in a computer memory.
摘要翻译：一种用于在制造过程中实时检测移动腹板产品的组成的方法和装置。光谱测量监测设备用于获取有关网络横向上多个位置的网络的物理和/或化学性质的信息。可以组合来自多个光谱区域的数据以产生包含关于网络组成的准确信息的向量。使用多变量数学技术导出该信息，以产生每个感兴趣的分量的空间数据矩阵。包含在空间数据矩阵中的合成信息可以重新投射为“虚拟合成图”，或者与存储在计算机存储器中的理想简档进行比较。

6. 发明授权

US08509867B2 Non-invasive measurement of analytes 有权
标题翻译：非侵入性测量分析物
公开(公告)号：US08509867B2
公开(公告)日：2013-08-13
申请号：US11349731
申请日：2006-02-07
申请人： Jerome J. Workman , Christopher R. Lambert , Robert L. Coleman
发明人： Jerome J. Workman , Christopher R. Lambert , Robert L. Coleman
IPC分类号： A61B5/145 , A61B5/1455
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/14539 , A61B5/1455 , A61B5/413 , A61B5/415 , A61B5/418 , A61K49/0041 , A61K49/0052 , Y10T436/144444
摘要： This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.
摘要翻译：本发明提供用于测定生物样品中的一种或多种代谢物或分析物的浓度的装置，组合物和方法，包括细胞，组织，器官，生物和生物流体。特别地，本发明提供了用于基于在皮肤中发现的一种或多种生物活性分子的体内测量来确定体内血糖浓度水平的几种非侵入性技术的材料，装置和方法。

7. 发明授权

US08466286B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08466286B2
公开(公告)日：2013-06-18
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： C07F5/02 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , C07D471/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

8. 发明授权

US08140500B2 Spectral measurement with assisted data analysis 有权
标题翻译：辅助数据分析进行光谱测量
公开(公告)号：US08140500B2
公开(公告)日：2012-03-20
申请号：US11725097
申请日：2007-03-16
申请人： Jerome J. Workman , Stephen R. Lowry , Nicholas Simon Nunn , Kathleen J. Schulting
发明人： Jerome J. Workman , Stephen R. Lowry , Nicholas Simon Nunn , Kathleen J. Schulting
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0291 , G01N21/31
摘要： A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the component substances are then inserted into database search queries related to matters such as handling precautions, causes/sources of the substances, remedies and neutralizing agents for the substances, regulations related to the substances, etc. The results of the search queries are then provided to the personnel who made the measurements, preferably wirelessly and almost immediately after the measurements were made. The system therefore provides nearly immediate guidance as to what substances are present and how to handle them, which can be useful for inexperienced personnel in hazardous response, contraband detection, industrial process control, and other situations.
摘要翻译：提供了一种系统，其中来自其他分析仪器的光谱仪测量和/或测量被传送到确定经受测量的样品的组分物质的处理站。然后将组分物质的名称插入与物质的处理注意事项，原因/来源，物质的补救措施和中和剂等与物质有关的规定等事项相关的数据库查询查询。搜索查询的结果然后提供给进行测量的人员，优选地在测量之后无线地且几乎立即进行。因此，该系统提供了关于哪些物质存在和如何处理这些物质的几乎立即的指导，这对于没有经验的危险反应人员，违禁品检测，工业过程控制和其他情况可能是有用的。

9. 发明申请

US20120052018A1 SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS 有权
标题翻译：用于葡萄糖生物传感器的SMMR（小分子代谢报告物）
公开(公告)号：US20120052018A1
公开(公告)日：2012-03-01
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07F5/02
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

10. 发明授权

US08008088B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08008088B2
公开(公告)日：2011-08-30
申请号：US11475784
申请日：2006-06-26
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： G01N33/00 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

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