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1. 发明申请

US20090004108A1 Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors 有权
标题翻译： Smmr（小分子代谢记录）用作体内葡萄糖生物传感器
公开(公告)号：US20090004108A1
公开(公告)日：2009-01-01
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07D311/78
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

2. 发明授权

US08466286B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08466286B2
公开(公告)日：2013-06-18
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： C07F5/02 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , C07D471/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

3. 发明授权

US08029765B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
公开(公告)号：US08029765B2
公开(公告)日：2011-10-04
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

4. 发明申请

US20120052018A1 SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS 有权
标题翻译：用于葡萄糖生物传感器的SMMR（小分子代谢报告物）
公开(公告)号：US20120052018A1
公开(公告)日：2012-03-01
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07F5/02
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

5. 发明授权

US08008088B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08008088B2
公开(公告)日：2011-08-30
申请号：US11475784
申请日：2006-06-26
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： G01N33/00 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

6. 发明授权

US08509867B2 Non-invasive measurement of analytes 有权
标题翻译：非侵入性测量分析物
公开(公告)号：US08509867B2
公开(公告)日：2013-08-13
申请号：US11349731
申请日：2006-02-07
申请人： Jerome J. Workman , Christopher R. Lambert , Robert L. Coleman
发明人： Jerome J. Workman , Christopher R. Lambert , Robert L. Coleman
IPC分类号： A61B5/145 , A61B5/1455
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/14539 , A61B5/1455 , A61B5/413 , A61B5/415 , A61B5/418 , A61K49/0041 , A61K49/0052 , Y10T436/144444
摘要： This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.
摘要翻译：本发明提供用于测定生物样品中的一种或多种代谢物或分析物的浓度的装置，组合物和方法，包括细胞，组织，器官，生物和生物流体。特别地，本发明提供了用于基于在皮肤中发现的一种或多种生物活性分子的体内测量来确定体内血糖浓度水平的几种非侵入性技术的材料，装置和方法。

7. 发明授权

US08140500B2 Spectral measurement with assisted data analysis 有权
标题翻译：辅助数据分析进行光谱测量
公开(公告)号：US08140500B2
公开(公告)日：2012-03-20
申请号：US11725097
申请日：2007-03-16
申请人： Jerome J. Workman , Stephen R. Lowry , Nicholas Simon Nunn , Kathleen J. Schulting
发明人： Jerome J. Workman , Stephen R. Lowry , Nicholas Simon Nunn , Kathleen J. Schulting
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0291 , G01N21/31
摘要： A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the component substances are then inserted into database search queries related to matters such as handling precautions, causes/sources of the substances, remedies and neutralizing agents for the substances, regulations related to the substances, etc. The results of the search queries are then provided to the personnel who made the measurements, preferably wirelessly and almost immediately after the measurements were made. The system therefore provides nearly immediate guidance as to what substances are present and how to handle them, which can be useful for inexperienced personnel in hazardous response, contraband detection, industrial process control, and other situations.
摘要翻译：提供了一种系统，其中来自其他分析仪器的光谱仪测量和/或测量被传送到确定经受测量的样品的组分物质的处理站。然后将组分物质的名称插入与物质的处理注意事项，原因/来源，物质的补救措施和中和剂等与物质有关的规定等事项相关的数据库查询查询。搜索查询的结果然后提供给进行测量的人员，优选地在测量之后无线地且几乎立即进行。因此，该系统提供了关于哪些物质存在和如何处理这些物质的几乎立即的指导，这对于没有经验的危险反应人员，违禁品检测，工业过程控制和其他情况可能是有用的。

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