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1. 发明申请

US20120303464A1 UNIFIED YIELD MANAGEMENT FOR DISPLAY ADVERTISING 审中-公开
标题翻译：用于展示广告的统一管理
公开(公告)号：US20120303464A1
公开(公告)日：2012-11-29
申请号：US13116949
申请日：2011-05-26
申请人： Robert Paul Gorman , Pavel Berkhin , Nikhil Devanur Rangarajan , Marc Diamond , Peng Han , Bashar Kachachi , Muthukrishnan Paramasivam , John A. Beaver , David G. Heindel , Izzet Can Envarli , Ye Chen
发明人： Robert Paul Gorman , Pavel Berkhin , Nikhil Devanur Rangarajan , Marc Diamond , Peng Han , Bashar Kachachi , Muthukrishnan Paramasivam , John A. Beaver , David G. Heindel , Izzet Can Envarli , Ye Chen
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02
摘要： Systems and method can be provided for selecting advertising payloads for display in an available advertising impression location. The advertising payloads can be selected based on an auction between various types of hosted and third party campaigns, including hosted reserved advertising campaigns and hosted non-reserved advertising campaigns. The rules of the auction can be set and/or updated over time to allow hosted campaigns to meet desired goals, such as delivering a minimum number of impressions or spending an expect budget amount.
摘要翻译：可以提供系统和方法来选择用于在可用的广告印象位置中显示的广告有效载荷。可以基于各种类型的托管和第三方广告系列之间的拍卖来选择广告有效载荷，包括托管的保留广告活动和托管的非保留广告活动。拍卖的规则可以随着时间的推移设置和/或更新，以便托管的广告系列能够达到预期的目标，例如提供最少的展示次数或花费预期的预算金额。

2. 发明授权

US08940705B2 Method of treating disease and selectively modulating transcriptional regulation by a glucocorticoid receptor by administering aclacinomycin and dexamethasone 有权
标题翻译：通过施用阿卡霉素和地塞米松治疗疾病和选择性调节糖皮质激素受体的转录调节的方法
公开(公告)号：US08940705B2
公开(公告)日：2015-01-27
申请号：US13143727
申请日：2010-01-08
申请人： Marc Diamond , Anthony Gerber
发明人： Marc Diamond , Anthony Gerber
IPC分类号： A61K31/573 , A61K31/704 , A61K31/57 , A61K9/00
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K31/57 , A61K31/704
摘要： The invention relates to assays to detect selective gene regulation by ligand dependent transcription factors. The invention also relates to selective modulators of the glucocortocoid receptor for treatment of inflammation and allergic and immune-mediated diseases.
摘要翻译：本发明涉及通过配体依赖性转录因子检测选择性基因调控的测定法。本发明还涉及用于治疗炎症和变态反应性和免疫介导性疾病的糖团聚糖受体的选择性调节剂。

3. 发明申请

US20100168128A1 SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR 有权
标题翻译：雄性受体的小分子抑制剂
公开(公告)号：US20100168128A1
公开(公告)日：2010-07-01
申请号：US12717905
申请日：2010-03-04
申请人： Marc Diamond , Jeremy Jones , Adam Renslo
发明人： Marc Diamond , Jeremy Jones , Adam Renslo
IPC分类号： A61K31/4709 , A61K31/585 , A61K31/57 , A61K31/56 , A61K31/496 , A61P17/00 , A61P35/00 , A61P17/10
CPC分类号： C07D401/06
摘要： The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently hydrogen or C1-6 alkyl. R4 is absent or is hydrogen, C1-6 alkyl or C1-6 alkyl-OH. R5 is hydrogen, C1-6 alkyl or —NR6R7. R6 and R7 are each independently hydrogen or C1-6 alkyl, or are combined with the nitrogen to which they are attached to form a heterocycloalkyl having from 5 to 7 ring members. L is a linker of C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene or C3-6 cycloalkylene. The compounds of Formula I include the salts, hydrates and prodrugs thereof. Each R9 is H, C1-6 alkyl, —OH or —O—C1-6 alkyl. The compounds of Formulas I and II include the salts, hydrates and prodrugs thereof. By administering the compound of Formula I or II, the method inhibits the androgen receptor.
摘要翻译：本发明提供通过给予式I化合物或式II化合物来抑制雄激素受体的方法：其中R 1，R 2，R 3和R 8各自独立地为氢或C 1-6烷基。 R4不存在或为氢，C 1-6烷基或C 1-6烷基-OH。 R5是氢，C1-6烷基或-NR6R7。 R 6和R 7各自独立地为氢或C 1-6烷基，或与它们所连接的氮原子结合形成具有5-7个环成员的杂环烷基。 L是C 1-6亚烷基，C 2-6亚烯基，C 2-6亚炔基或C 3-6亚环烷基的接头。式I的化合物包括其盐，水合物和前药。每个R 9为H，C 1-6烷基，-OH或-O-C 1-6烷基。式I和II的化合物包括其盐，水合物和前药。通过施用式I或II的化合物，该方法抑制雄激素受体。

4. 发明申请

US20080293766A1 SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR 有权
标题翻译：雄性受体的小分子抑制剂
公开(公告)号：US20080293766A1
公开(公告)日：2008-11-27
申请号：US12101680
申请日：2008-04-11
申请人： Marc Diamond , Jeremy Jones , Adam Renslo
发明人： Marc Diamond , Jeremy Jones , Adam Renslo
IPC分类号： A61K31/4709 , C07D215/38 , A61P35/00
CPC分类号： C07D401/06
摘要： The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently hydrogen or C1-6 alkyl. R4 is absent or is hydrogen, C1-6 alkyl or C1-6 alkyl-OH. R5 is hydrogen, C1-6 alkyl or —NR6R7. R6 and R7 are each independently hydrogen or C1-6 alkyl, or are combined with the nitrogen to which they are attached to form a heterocycloalkyl having from 5 to 7 ring members. L is a linker of C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene or C3-6 cycloalkylene. The compounds of Formula I include the salts, hydrates and prodrugs thereof. Each R9 is H, C1-6 alkyl, —OH or —O—C1-6 alkyl. The compounds of Formulas I and II include the salts, hydrates and prodrugs thereof. By administering the compound of Formula I or II, the method inhibits the androgen receptor.
摘要翻译：本发明提供通过给予式I化合物或式II化合物来抑制雄激素受体的方法：其中R 1，R 2，R 3和R 8各自独立地为氢或C 1-6烷基。 R4不存在或为氢，C 1-6烷基或C 1-6烷基-OH。 R5是氢，C1-6烷基或-NR6R7。 R 6和R 7各自独立地为氢或C 1-6烷基，或与它们所连接的氮原子结合形成具有5-7个环成员的杂环烷基。 L是C 1-6亚烷基，C 2-6亚烯基，C 2-6亚炔基或C 3-6亚环烷基的接头。式I的化合物包括其盐，水合物和前药。每个R 9为H，C 1-6烷基，-OH或-O-C 1-6烷基。式I和II的化合物包括其盐，水合物和前药。通过施用式I或II的化合物，该方法抑制雄激素受体。

5. 发明授权

US08354538B2 Small-molecule inhibitors of the androgen receptor 有权
公开(公告)号：US08354538B2
公开(公告)日：2013-01-15
申请号：US12989389
申请日：2009-04-24
申请人： Marc Diamond , Jeremy Jones , Adam Renslo
发明人： Marc Diamond , Jeremy Jones , Adam Renslo
IPC分类号： C07D263/56 , C07D401/06
CPC分类号： A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/585 , A61K45/06 , C07D263/56 , C07D401/06
摘要： The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof.

6. 发明授权

US08119660B2 Small-molecule inhibitors of the androgen receptor 有权
标题翻译：雄激素受体的小分子抑制剂
公开(公告)号：US08119660B2
公开(公告)日：2012-02-21
申请号：US12717905
申请日：2010-03-04
申请人： Marc Diamond , Jeremy Jones , Adam Renslo
发明人： Marc Diamond , Jeremy Jones , Adam Renslo
IPC分类号： A61K31/4709 , G01N33/53
CPC分类号： C07D401/06
摘要： The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently hydrogen or C1-6 alkyl. R4 is absent or is hydrogen, C1-6 alkyl or C1-6 alkyl-OH. R5 is hydrogen, C1-6 alkyl or —NR6R7. R6 and R7 are each independently hydrogen or C1-6 alkyl, or are combined with the nitrogen to which they are attached to form a heterocycloalkyl having from 5 to 7 ring members. L is a linker of C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene or C3-6 cycloalkylene. The compounds of Formula I include the salts, hydrates and prodrugs thereof. Each R9 is H, C1-6 alkyl, —OH or —O—C1-6 alkyl. The compounds of Formulas I and II include the salts, hydrates and prodrugs thereof. By administering the compound of Formula I or II, the method inhibits the androgen receptor.
摘要翻译：本发明提供通过给予式I化合物或式II化合物来抑制雄激素受体的方法：其中R 1，R 2，R 3和R 8各自独立地为氢或C 1-6烷基。 R4不存在或为氢，C 1-6烷基或C 1-6烷基-OH。 R5是氢，C1-6烷基或-NR6R7。 R 6和R 7各自独立地为氢或C 1-6烷基，或与它们所连接的氮原子结合形成具有5-7个环成员的杂环烷基。 L是C 1-6亚烷基，C 2-6亚烯基，C 2-6亚炔基或C 3-6亚环烷基的接头。式I的化合物包括其盐，水合物和前药。每个R 9为H，C 1-6烷基，-OH或-O-C 1-6烷基。式I和II的化合物包括其盐，水合物和前药。通过施用式I或II的化合物，该方法抑制雄激素受体。

7. 发明申请

US20080077448A1 Financial insurance product 审中-公开
标题翻译：金融保险产品
公开(公告)号：US20080077448A1
公开(公告)日：2008-03-27
申请号：US11525314
申请日：2006-09-22
申请人： Marc Diamond
发明人： Marc Diamond
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08
摘要： The invention pertains to a financial product having an insurance component covering only an amount of capital at risk that exceeds a replacement cost of an asset collateralizing the capital. The product includes a payment component that provides a payment equal to at least a portion of the amount of capital at risk in excess of the replacement cost of the asset, upon loss of the asset. In the preferred embodiment the payment may be substantially equal to the amount of capital at risk in excess of the replacement cost.
摘要翻译：本发明涉及一种具有仅覆盖风险资本量的保险成分超过资本抵押资产重置成本的金融产品。该产品包括付款组件，在资产损失时，提供等于超过资产重置成本的风险资本金额的至少一部分的付款。在优选实施例中，支付可以基本上等于超过重置成本的风险资本的金额。

8. 发明申请

US20120094945A1 Discovery of Selective Glucocorticoid Receptor Modulators by Multiplexed Reporter Screening 有权
标题翻译：通过多重报道筛查发现选择性糖皮质激素受体调节剂
公开(公告)号：US20120094945A1
公开(公告)日：2012-04-19
申请号：US13143727
申请日：2010-01-08
申请人： Marc Diamond , Anthony Gerber
发明人： Marc Diamond , Anthony Gerber
IPC分类号： A61K31/704 , A61K31/56 , A61P29/00 , A61P41/00 , A61P37/08 , A61P35/00 , A61P19/02 , A61K31/7048 , A61P11/06
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K31/57 , A61K31/704
摘要： The invention relates to assays to detect selective gene regulation by ligand dependent transcription factors. The invention also relates to selective modulators of the glucocortocoid receptor for treatment of inflammation and allergic and immune-mediated diseases.
摘要翻译：本发明涉及通过配体依赖性转录因子检测选择性基因调控的测定法。本发明还涉及用于治疗炎症和变态反应性和免疫介导性疾病的糖团聚糖受体的选择性调节剂。

9. 发明授权

US4232582A Acoustical stringed musical instrument pick-up 失效
标题翻译：声乐乐器拾音
公开(公告)号：US4232582A
公开(公告)日：1980-11-11
申请号：US26873
申请日：1979-04-04
申请人： Marc Diamond
发明人： Marc Diamond
IPC分类号： G10D1/08 , G10D3/00 , G10K11/22 , A61B7/02
CPC分类号： G10K11/22 , G10D1/08 , G10D3/00
摘要： An apparatus for transmitting acoustical energy from a stringed musical instrument having a bridge and string anchor to a listener comprising an energy pick-up chamber, an energy transmission member and a means for transmitting said energy to a listener is disclosed. The pick-up chamber is located at said bridge and is in resonant contact with the strings. It has at least one opening through which an elongated, hollow, energy transmission member is connected to the interior of the chamber. The means is mounted on the other end of the hollow member for transmitting the musical energy to the ears of a listener.
摘要翻译：公开了一种用于从具有桥梁和弦锚的弦乐器发送声能的装置，其包括能量拾取室，能量传递构件和用于将所述能量发送到收听者的装置。拾取室位于所述桥上，与琴弦共振接触。它具有至少一个开口，细长的，中空的能量传递构件通过该开口连接到腔室的内部。该装置安装在中空构件的另一端上，用于将音乐能量传递给收听者的耳朵。

10. 发明申请

US20110224253A1 SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR 有权
标题翻译：雄性受体的小分子抑制剂
公开(公告)号：US20110224253A1
公开(公告)日：2011-09-15
申请号：US12989389
申请日：2009-04-24
申请人： Marc Diamond , Jeremy Jones , Adam Renslo
发明人： Marc Diamond , Jeremy Jones , Adam Renslo
IPC分类号： A61K31/4709 , C07D401/06 , C07D263/56 , A61K31/423 , A61P35/00 , A61P17/10 , A61P15/00 , A61P5/26 , A61P43/00
CPC分类号： A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/585 , A61K45/06 , C07D263/56 , C07D401/06
摘要： The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof.
摘要翻译：本发明提供四氢卟啉（THP），其衍生物，苯并恶唑化合物及其衍生物。本发明提供了使用四氢ium嗪（THP），其衍生物，苯并恶唑化合物及其衍生物的方法。

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