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1. 发明授权

US10695519B2 Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles within nasal pillows 有权
公开(公告)号：US10695519B2
公开(公告)日：2020-06-30
申请号：US12753853
申请日：2010-04-02
申请人： Anthony D. Wondka , Todd Allum , Joseph Cipollone , Gregory Kapust , Darius Eghbal , Joey Aguirre , Anthony Gerber
发明人： Anthony D. Wondka , Todd Allum , Joseph Cipollone , Gregory Kapust , Darius Eghbal , Joey Aguirre , Anthony Gerber
IPC分类号： A61M16/08 , A61M16/06 , A61M16/00 , A61M16/10 , A61M16/12 , A61M16/04 , A61M16/16 , A61M16/20
摘要： A non-invasive ventilation system may include a nasal interface. The nasal interface may include a left outer tube with a left distal end adapted to impinge a left nostril, at least one left opening in the left distal end in pneumatic communication with the left nostril, and a left proximal end of the left outer tube in fluid communication with ambient air. The left proximal end of the left outer tube may curve laterally away from a midline of a face. A right outer tube may be similarly provided. One or more left jet nozzles may direct ventilation gas into the left outer tube, and one or more right jet nozzles may direct ventilation gas into the right outer tube. The jet nozzles may be in fluid communication with the pressurized gas supply.

2. 发明授权

US09227034B2 Methods, systems and devices for non-invasive open ventilation for treating airway obstructions 有权
标题翻译：用于非侵入性开放通气治疗气道阻塞的方法，系统和装置
公开(公告)号：US09227034B2
公开(公告)日：2016-01-05
申请号：US12753856
申请日：2010-04-02
申请人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Anthony Gerber , Darius Eghbal , Joey Aguirre , George A. Kassanis
发明人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Anthony Gerber , Darius Eghbal , Joey Aguirre , George A. Kassanis
IPC分类号： F16K31/02 , A61M15/08 , A61M16/06 , A61M16/08 , A61M16/10 , A61M16/12 , A61M16/16 , A61M16/20 , A61M16/00
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.
摘要翻译：用于减少患者气道障碍物的系统可以包括呼吸机，控制单元，具有与呼吸机流体连通的近端的气体输送电路和与鼻部接口流体连通的远端和鼻部接口。鼻部界面可以包括至少一个喷嘴，以及至少一个与控制单元通信的自发呼吸传感器，用于检测呼吸力图案和支持气道通畅的需要。系统可能对环境开放。控制单元可以确定多于一个气体输出速度。多个气体输出速度可以与自发呼吸努力循环的不同部分同步，并且气体输出速度可以由支持气道通畅的需要来确定。

3. 发明申请

US20100252042A1 METHODS, SYSTEMS AND DEVICES FOR NON-INVASIVE OPEN VENTILATION FOR TREATING AIRWAY OBSTRUCTIONS 有权
标题翻译：方法，系统和设备用于非入场通风通风处理空中障碍
公开(公告)号：US20100252042A1
公开(公告)日：2010-10-07
申请号：US12753856
申请日：2010-04-02
申请人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Anthony Gerber , Darius Eghbal , Joey Aguirre
发明人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Anthony Gerber , Darius Eghbal , Joey Aguirre
IPC分类号： A61M16/00
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.
摘要翻译：用于减少患者气道障碍物的系统可以包括呼吸机，控制单元，具有与呼吸机流体连通的近端的气体输送电路和与鼻部接口流体连通的远端和鼻部接口。鼻部界面可以包括至少一个喷嘴，以及至少一个与控制单元通信的自发呼吸传感器，用于检测呼吸力图案和支持气道通畅的需要。系统可能对环境开放。控制单元可以确定多于一个气体输出速度。多个气体输出速度可以与自发呼吸努力循环的不同部分同步，并且气体输出速度可以由支持气道通畅的需要来确定。

4. 发明申请

US20080135044A1 Methods and devices for minimally invasive respiratory support 有权
标题翻译：用于微创呼吸支持的方法和装置
公开(公告)号：US20080135044A1
公开(公告)日：2008-06-12
申请号：US11882530
申请日：2007-08-03
申请人： Lutz Freitag , Anthony Wondka , Gregory Kapust , Robert Bryan , Michael Khenansho , Anthony Gerber
发明人： Lutz Freitag , Anthony Wondka , Gregory Kapust , Robert Bryan , Michael Khenansho , Anthony Gerber
IPC分类号： A61M16/00 , A61M16/10 , A61M16/20
CPC分类号： A61M16/16 , A61M16/101 , A61M16/107 , A61M2202/0208 , A61M2202/03 , A61M2202/0007
摘要： Modes, methods, systems and devices are described for providing assisted ventilation to a patient, including wearable ventilation systems with integral gas supplies, special gas supply features, ventilation catheters and access devices, and breath sensing techniques.
摘要翻译：描述了用于向患者提供辅助通气的模式，方法，系统和装置，包括具有集成气体供应的特殊气体供应特征，通气导管和进入装置的可佩戴通风系统以及呼吸感测技术。

5. 发明授权

US09180270B2 Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles within an outer tube 有权
标题翻译：用于非外界开放通气的方法，系统和装置，在外管内具有气体输送喷嘴
公开(公告)号：US09180270B2
公开(公告)日：2015-11-10
申请号：US12753851
申请日：2010-04-02
申请人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Joey Aguirre , Darius Eghbal , Anthony Gerber , Lutz Freitag
发明人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Joey Aguirre , Darius Eghbal , Anthony Gerber , Lutz Freitag
IPC分类号： A61M16/00 , A61M16/06 , A61M16/08 , A61M16/10 , A61M16/12 , A61M16/16 , A61M16/20
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A non-invasive ventilation system may include at least one outer tube with a proximal lateral end of the outer tube adapted to extend to a side of a nose. The at least one outer tube may also include a throat section. At least one coupler may be located at a distal section of the outer tube for impinging at least one nostril and positioning the at least one outer tube relative to the at least one nostril. At least one jet nozzle may be positioned within the outer tube at the proximal lateral end and in fluid communication with a pressurized gas supply. At least one opening in the distal section may be adapted to be in fluid communication with the nostril. At least one aperture in the at least one outer tube may be in fluid communication with ambient air. The at least one aperture may be in proximity to the at least one jet nozzle.
摘要翻译：非侵入性通气系统可以包括至少一个外管，外管的近侧横端适于延伸到鼻的一侧。至少一个外管还可以包括喉部。至少一个联接器可以位于外管的远端部分处，用于冲击至少一个鼻孔，并且相对于至少一个鼻孔定位至少一个外管。至少一个喷嘴可以位于外管内的近端横向端并与加压气体源流体连通。远端部分中的至少一个开口可以适于与鼻孔流体连通。至少一个外管中的至少一个孔可以与环境空气流体连通。该至少一个孔口可以接近该至少一个喷嘴。

6. 发明授权

US08940705B2 Method of treating disease and selectively modulating transcriptional regulation by a glucocorticoid receptor by administering aclacinomycin and dexamethasone 有权
标题翻译：通过施用阿卡霉素和地塞米松治疗疾病和选择性调节糖皮质激素受体的转录调节的方法
公开(公告)号：US08940705B2
公开(公告)日：2015-01-27
申请号：US13143727
申请日：2010-01-08
申请人： Marc Diamond , Anthony Gerber
发明人： Marc Diamond , Anthony Gerber
IPC分类号： A61K31/573 , A61K31/704 , A61K31/57 , A61K9/00
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K31/57 , A61K31/704
摘要： The invention relates to assays to detect selective gene regulation by ligand dependent transcription factors. The invention also relates to selective modulators of the glucocortocoid receptor for treatment of inflammation and allergic and immune-mediated diseases.
摘要翻译：本发明涉及通过配体依赖性转录因子检测选择性基因调控的测定法。本发明还涉及用于治疗炎症和变态反应性和免疫介导性疾病的糖团聚糖受体的选择性调节剂。

7. 发明授权

US07332613B2 Capture and release based isotope tagged peptides and methods for using the same 失效
标题翻译：捕获和释放基于同位素标记的肽及其使用方法
公开(公告)号：US07332613B2
公开(公告)日：2008-02-19
申请号：US10863589
申请日：2004-06-07
申请人： Steven P. Gygi , Scott Anthony Gerber , Carlos Augusto Gartner
发明人： Steven P. Gygi , Scott Anthony Gerber , Carlos Augusto Gartner
IPC分类号： C07D235/02
CPC分类号： G01N33/6848 , G01N33/6842 , G01N2458/15 , Y10T436/24
摘要： The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association with the peptide (e.g., a covalent bond) and an anchoring site (AS) group for reversibly or removably anchoring the tag to a solid phase such as a resin support. Anchoring may be direct or indirect (e.g., through a linker molecule). Preferably, the anchoring site comprises a biotin compound. Preferably, the tag comprises a mass-altering label, such as a stable isotope, such that association of the tag with the peptide can be monitored by mass spectrometry. The reagents can be used for rapid and quantitative analysis of proteins or protein function in mixtures of proteins.
摘要翻译：本发明提供了基于非亲和力的同位素标记的肽，用于制备这些肽的化学物质和使用这些肽的方法。一方面，标签包含用于与蛋白质上的分子反应以与肽（例如共价键）和锚定位点（AS）组稳定结合的反应位点（RS），用于可逆地或可拆卸地锚定标签固相如树脂载体。锚定可以是直接的或间接的（例如通过连接体分子）。优选地，锚定位点包含生物素化合物。优选地，标签包含质量变化标签，例如稳定同位素，使得可以通过质谱法监测标签与肽的缔合。这些试剂可用于蛋白质混合物中蛋白质或蛋白质功能的快速和定量分析。

8. 发明授权

US10046133B2 Methods, systems and devices for non-invasive open ventilation for providing ventilation support 有权
公开(公告)号：US10046133B2
公开(公告)日：2018-08-14
申请号：US12753854
申请日：2010-04-02
申请人： Gregory Kapust , Joseph Cipollone , Anthony D. Wondka , Anthony Gerber , Todd Allum , Darius Eghbal , Joey Aguirre , George A. Kassanis
发明人： Gregory Kapust , Joseph Cipollone , Anthony D. Wondka , Anthony Gerber , Todd Allum , Darius Eghbal , Joey Aguirre , George A. Kassanis
IPC分类号： A61M16/08 , A61M16/04 , A61M16/06 , A61M16/00 , A61M16/10 , A61M16/12 , A61M16/20 , A61M16/16
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A system for providing ventilation support to a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle at the distal end of the gas delivery circuit; and at least one spontaneous respiration sensor for detecting respiration in communication with the control unit. The system may be open to ambient. The control unit may receive signals from the at least one spontaneous respiration sensor and determine gas delivery requirements. The ventilator may deliver gas at a velocity to entrain ambient air and increase lung volume or lung pressure above spontaneously breathing levels to assist in work of breathing, and deliver ventilation gas in a cyclical delivery pattern synchronized with a spontaneous breathing pattern.

9. 发明申请

US20100252041A1 METHODS, SYSTEMS AND DEVICES FOR NON-INVASIVE OPEN VENTILATION FOR PROVIDING VENTILATION SUPPORT 审中-公开
标题翻译：用于提供通风支持的非开放式通风通道的方法，系统和设备
公开(公告)号：US20100252041A1
公开(公告)日：2010-10-07
申请号：US12753854
申请日：2010-04-02
申请人： Gregory Kapust , Joseph Cipollone , Anthony D. Wondka , Anthony Gerber , Todd Allum , Darius Eghbal , Joey Aguirre
发明人： Gregory Kapust , Joseph Cipollone , Anthony D. Wondka , Anthony Gerber , Todd Allum , Darius Eghbal , Joey Aguirre
IPC分类号： A61M16/00
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A system for providing ventilation support to a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle at the distal end of the gas delivery circuit; and at least one spontaneous respiration sensor for detecting respiration in communication with the control unit. The system may be open to ambient. The control unit may receive signals from the at least one spontaneous respiration sensor and determine gas delivery requirements. The ventilator may deliver gas at a velocity to entrain ambient air and increase lung volume or lung pressure above spontaneously breathing levels to assist in work of breathing, and deliver ventilation gas in a cyclical delivery pattern synchronized with a spontaneous breathing pattern.
摘要翻译：用于向患者提供通气支撑的系统可以包括呼吸机，控制单元，具有与呼吸机流体连通的近端的气体输送电路和与鼻接口流体连通的远端和鼻接口。鼻接口可以包括在气体输送回路的远端处的至少一个喷嘴; 以及至少一个用于检测与所述控制单元通信的呼吸的自发呼吸传感器。系统可能对环境开放。控制单元可以从至少一个自发呼吸传感器接收信号并确定气体输送要求。呼吸机可以以速度输送气体以夹带环境空气并将肺容积或肺压力增加到高于自发呼吸水平以辅助呼吸工作，并且以与自发呼吸模式同步的循环递送模式递送通气气体。

10. 发明申请

US20100252040A1 METHODS, SYSTEMS AND DEVICES FOR NON-INVASIVE OPEN VENTILATION WITH GAS DELIVERY NOZZLES WITHIN AN OUTER TUBE 有权
标题翻译：方法，系统和设备，用于在外管中使用气体输送喷嘴进行非开启通气
公开(公告)号：US20100252040A1
公开(公告)日：2010-10-07
申请号：US12753851
申请日：2010-04-02
申请人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Joey Aguirre , Darius Eghbal , Anthony Gerber
发明人： Gregory Kapust , Todd Allum , Anthony D. Wondka , Joseph Cipollone , Joey Aguirre , Darius Eghbal , Anthony Gerber
IPC分类号： A61M16/00
CPC分类号： A61M16/0883 , A61M16/0003 , A61M16/0006 , A61M16/0057 , A61M16/0069 , A61M16/0096 , A61M16/0493 , A61M16/0605 , A61M16/0622 , A61M16/0666 , A61M16/0677 , A61M16/0683 , A61M16/0688 , A61M16/0825 , A61M16/0841 , A61M16/0858 , A61M16/0875 , A61M16/101 , A61M16/107 , A61M16/127 , A61M16/16 , A61M16/201 , A61M16/208 , A61M2016/0015 , A61M2016/0021 , A61M2016/0024 , A61M2016/0661 , A61M2202/0208 , A61M2202/03 , A61M2205/0205 , A61M2205/17 , A61M2205/3334 , A61M2205/8206 , A61M2230/40 , A61M2202/0007
摘要： A non-invasive ventilation system may include at least one outer tube with a proximal lateral end of the outer tube adapted to extend to a side of a nose. The at least one outer tube may also include a throat section. At least one coupler may be located at a distal section of the outer tube for impinging at least one nostril and positioning the at least one outer tube relative to the at least one nostril. At least one jet nozzle may be positioned within the outer tube at the proximal lateral end and in fluid communication with a pressurized gas supply. At least one opening in the distal section may be adapted to be in fluid communication with the nostril. At least one aperture in the at least one outer tube may be in fluid communication with ambient air. The at least one aperture may be in proximity to the at least one jet nozzle.
摘要翻译：非侵入性通气系统可以包括至少一个外管，外管的近侧横端适于延伸到鼻的一侧。至少一个外管还可以包括喉部。至少一个联接器可以位于外管的远端部分处，用于冲击至少一个鼻孔，并且相对于至少一个鼻孔定位至少一个外管。至少一个喷嘴可以位于外管内的近端横向端并与加压气体源流体连通。远端部分中的至少一个开口可以适于与鼻孔流体连通。至少一个外管中的至少一个孔可以与环境空气流体连通。该至少一个孔口可以接近该至少一个喷嘴。

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