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    • 7. 发明授权
    • Palatable arginine compounds and uses thereof for cardiovascular health
    • 可口的精氨酸化合物及其用于心血管健康的用途
    • US06794375B2
    • 2004-09-21
    • US10181655
    • 2002-07-19
    • Robert Joseph SaramaRaymond Louis Niehoff
    • Robert Joseph SaramaRaymond Louis Niehoff
    • A61K3156
    • C07D311/72A23G1/305A23G2200/10A23L33/11A23L33/175A23L33/26A23V2002/00C07C279/14C07J41/00A23V2250/5114A23V2250/606A23V2250/0606A23V2250/032A23V2250/702A23V2250/708A23V2250/5488
    • The present invention is directed to a compound having the structure (I): and acceptable salts, polypeptides, and pro-forms thereof, wherein R is selected from the group consisting of: (a) substituted glycerols; wherein n is an integer from 1 to 2; (b) vitamins; wherein n is 1; (c) sterols; wherein n is 1; (d) stanols; wherein n is 1; and (e) C6-C32 alkyl; and (f) C6-C32 alkenyl; wherein n is 1. The present invention is further directed to compositions and kits comprising these compounds as well as methods of using the compounds. The compounds, compositions, kits, and methods herein are useful for providing general health benefits to the consumer, particularly cardiovascular benefits, anti-menopausal benefits and/or treating sexual dysfunction (particularly, erectile dysfunction). Most particularly, the compounds, compositions, kits, and methods herein are useful for providing cardiovascular benefits, including lowering cholesterol in the consumer, treating, preventing, and/or inhibiting heart disease (e.g., atherosclerosis, restenosis, thrombosis) and, for example, treating other conditions such as hypercholesterolemia, hypertension, poor circulation, and complications associated with diabetes.
    • 本发明涉及具有结构(I)的化合物及其可接受的盐,多肽及其前体,其中R选自:(a)取代的甘油; 其中n是1至2的整数; (b)维生素; 其中n为1; (c)甾醇; 其中n为1; (d)甾烷醇; 其中n为1; 和(e)C 6 -C 32烷基; 和(f)C 6 -C 32烯基; 其中n为1.本发明还涉及包含这些化合物的组合物和试剂盒以及使用该化合物的方法。 本文的化合物,组合物,试剂盒和方法可用于向消费者提供一般健康益处,特别是心血管益处,抗绝经益处和/或治疗性功能障碍(特别是勃起功能障碍)。 最特别地,本文的化合物,组合物,试剂盒和方法可用于提供心血管益处,包括降低消费者的胆固醇,治疗,预防和/或抑制心脏病(例如动脉粥样硬化,再狭窄,血栓形成),以及例如 治疗高胆固醇血症,高血压,循环不良,糖尿病并发症等其他病症。