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    • 8. 发明申请
    • Ozonated capacitive deionization process
    • 臭氧化电容去离子过程
    • US20100296999A1
    • 2010-11-25
    • US12805303
    • 2010-07-22
    • Robert L. Campbell
    • Robert L. Campbell
    • C02F9/04C02F1/78C02F1/42C02F1/469C01B5/00
    • C02F1/78C02F1/001C02F1/38C02F1/4604C02F1/52C02F2101/20C02F2103/10
    • Water from coal bed methane production which is suitable for almost nothing, is ozonated in a reactor to oxidize the iron content from +2 to +3, that is from ferrous to ferric, and to oxidize the manganese content from +2 to +4. The water after such first treatment is run through a separation means and then through a rotating filter, and then subjected to capacitive deionization, to yield clean water, which is then treated further to adjust he sodium content to render the water suitable for domestic and agricultural purposes. Some of the produced water is run back through the capacitive deionization cells when no voltage is applied to clean the cells for the next voltage application cycle. Some of the water produced may also be run back through the separation means to help clean out the crud.
    • 在几乎没有任何东西适用于煤层气生产的水中,在反应器中臭氧化,将铁含量从+2降至+3,即从亚铁到铁,并将锰含量从+2氧化为+4。 经过这样的第一次处理之后的水经过分离装置,然后通过旋转过滤器,然后进行电容去离子,产生干净的水,然后再进行处理以调节其钠含量,使水适合家庭和农业 目的 当没有施加电压以清洁下一个电压施加周期的电池时,一些产生的水通过电容去离子电池回流。 产生的一些水也可能通过分离装置回流,以帮助清理原油。
    • 9. 发明申请
    • METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL THEREOF
    • 增强室内免疫反应的方法及其有效的化合物
    • US20090304744A1
    • 2009-12-10
    • US12368864
    • 2009-02-10
    • Robert L. CampbellKevin G. DolanJason B. AlarconJohn A. MiksztaWendy WoodleySheetal Mehta
    • Robert L. CampbellKevin G. DolanJason B. AlarconJohn A. MiksztaWendy WoodleySheetal Mehta
    • A61K39/145A61P37/04
    • A61K39/39A61K31/7048A61K39/12A61K39/145A61K2039/55511A61K2039/55516A61K2039/55555A61K2039/55588C12N2760/16134Y02A50/388Y02A50/466
    • The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations.
    • 本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。 本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂,即一旦递送到受试者的皮肤的真皮内隔室,则增强对抗原或免疫原性试剂的免疫应答。 本发明的免疫原性组合物包含赋形剂,其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。 本发明的免疫原性组合物具有增强的功效,因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室,从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。 本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答,具有比常规使用的更低剂量的抗原性或免疫原性试剂,并且不需要加强免疫。