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1. 发明申请

US20090304744A1 METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL THEREOF 审中-公开
标题翻译：增强室内免疫反应的方法及其有效的化合物
公开(公告)号：US20090304744A1
公开(公告)日：2009-12-10
申请号：US12368864
申请日：2009-02-10
申请人： Robert L. Campbell , Kevin G. Dolan , Jason B. Alarcon , John A. Mikszta , Wendy Woodley , Sheetal Mehta
发明人： Robert L. Campbell , Kevin G. Dolan , Jason B. Alarcon , John A. Mikszta , Wendy Woodley , Sheetal Mehta
IPC分类号： A61K39/145 , A61P37/04
CPC分类号： A61K39/39 , A61K31/7048 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55588 , C12N2760/16134 , Y02A50/388 , Y02A50/466
摘要： The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations.
摘要翻译：本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂，即一旦递送到受试者的皮肤的真皮内隔室，则增强对抗原或免疫原性试剂的免疫应答。本发明的免疫原性组合物包含赋形剂，其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。本发明的免疫原性组合物具有增强的功效，因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答，具有比常规使用的更低剂量的抗原性或免疫原性试剂，并且不需要加强免疫。

2. 发明授权

US07588774B2 Molecules enhancing dermal delivery of influenza vaccines 有权
标题翻译：分子增强流感疫苗的皮肤输送
公开(公告)号：US07588774B2
公开(公告)日：2009-09-15
申请号：US11006422
申请日：2004-12-06
申请人： Robert L. Campbell , Kevin G. Dolan , Wendy D. Woodley
发明人： Robert L. Campbell , Kevin G. Dolan , Wendy D. Woodley
IPC分类号： A61K39/00 , A61K39/39 , A61K39/12 , A61K39/02
CPC分类号： A61K9/0021 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/54 , A61K2039/55555 , A61K2039/55583 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , Y02A50/386
摘要： The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise an antigenic or immunogenic agent, and at least one molecule, e.g., a chemical agent, which enhances the presentation and/or availability of the antigenic or immunogenic agent to the immune cells of the intradermal compartment or epidermal compartment resulting in an enhanced immune response. The dermal vaccine formulations of the invention have enhanced efficacy as the antigenic or immunogenic agent is delivered to the intradermal compartment or epidermal compartment with enhanced presentation and/or availability to the immune cells that reside therein. The enhanced efficacy of the dermal vaccine formulations results in a therapeutically effective immune response after a single intradermal or epidermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations.
摘要翻译：本发明涉及真皮疫苗制剂，其设计用于将免疫原性组合物靶向递送至包括皮内和表皮隔层的皮肤皮肤隔室。本发明的真皮疫苗制剂包含抗原或免疫原性试剂和至少一种分子，例如化学试剂，其增强抗原或免疫原性试剂对皮内隔室或表皮的免疫细胞的呈递和/或可用性隔室导致增强的免疫应答。本发明的真皮疫苗制剂具有增强的功效，因为将抗原性或免疫原性药物递送至真皮内室或表皮隔室，其中存在于其中的免疫细胞具有增强的呈递和/或可用性。真皮疫苗制剂的增强功效在单次真皮内或表皮剂量后产生治疗有效的免疫应答，其具有比常规使用的更低剂量的抗原性或免疫原性剂量，并且不需要加强免疫。

3. 发明授权

US08535211B2 Blood pump with expandable cannula 有权
标题翻译：带可扩张插管的血泵
公开(公告)号：US08535211B2
公开(公告)日：2013-09-17
申请号：US12829359
申请日：2010-07-01
申请人： Robert L. Campbell , Justin M. Walsh , Daniel Metrey , Robert F. Kunz , Thomas M. Mallison , Edward Boone , Eric Myer , Mark W. McBride , Kevin J. Powell , Daniel A. Walters
发明人： Robert L. Campbell , Justin M. Walsh , Daniel Metrey , Robert F. Kunz , Thomas M. Mallison , Edward Boone , Eric Myer , Mark W. McBride , Kevin J. Powell , Daniel A. Walters
IPC分类号： A61N2/00 , A61N1/00
CPC分类号： A61M1/101 , A61M1/1008 , A61M1/1024 , A61M1/1034 , A61M1/1072 , A61M1/122 , A61M1/125
摘要： A blood pump includes an impeller having a plurality of foldable blades and a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller can reside in the expandable portion of the cannula. The cannula has a collapsed condition for percutaneous delivery to a desired location within the body, and an expanded condition in which the impeller can rotate to pump blood. A flexible drive shaft can extend through the cannula for rotationally driving the impeller within the patient's body.
摘要翻译：血泵包括具有多个可折叠刀片的叶轮和具有固定直径的近端部分的套管和具有可扩张直径的远侧部分。叶轮可以驻留在套管的可扩张部分中。套管具有用于经皮输送到体内所需位置的折叠状态，以及扩张状态，其中叶轮可旋转以泵送血液。柔性驱动轴可延伸穿过套管，用于旋转地驱动患者身体内的叶轮。

4. 发明申请

US20130066140A1 HEART ASSIST DEVICE WITH EXPANDABLE IMPELLER PUMP 有权
标题翻译：心脏辅助装置与可扩展的叶轮泵
公开(公告)号：US20130066140A1
公开(公告)日：2013-03-14
申请号：US13618071
申请日：2012-09-14
申请人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
发明人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
IPC分类号： A61M1/12
CPC分类号： A61M1/1012 , A61M1/1008 , A61M1/101 , A61M1/1013 , A61M1/1017 , A61M1/102 , A61M1/1024 , A61M1/1034 , A61M1/122 , A61M1/125 , A61M2205/0266 , B33Y80/00 , F04D3/00 , F04D3/02 , F04D29/181 , F04D29/247 , F04D29/528 , F04D29/542 , F05B2240/311 , F05B2280/5001
摘要： An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.
摘要翻译：叶轮包括轮毂和由轮毂支撑的叶片。叶轮具有存储构造，其中叶片被压缩，使得其远端朝向轮毂移动，以及展开构型，其中叶片远离轮毂延伸。叶轮可以是用于泵送诸如血液的泵的泵的一部分，并且可以包括具有固定直径的近端部分和具有可扩张直径的远侧部分的套管。叶轮可以驻留在套管的可膨胀部分中。套管可以具有压缩直径，其允许其经皮插入患者体内。一旦在期望的位置，插管的可扩张部分可以膨胀并且叶轮膨胀到展开构型。柔性驱动轴可以延伸穿过套管以在患者体内旋转地驱动叶轮。

5. 发明授权

US08376707B2 Expandable impeller pump 有权
公开(公告)号：US08376707B2
公开(公告)日：2013-02-19
申请号：US13072624
申请日：2011-03-25
申请人： Mark W. McBride , Thomas M. Mallison , Gregory P. Dillon , Robert L. Campbell , David A. Boger , Stephen A. Hambric , Robert F. Kunz , James P. Runt , Justin M. Walsh , Boris Leschinsky
发明人： Mark W. McBride , Thomas M. Mallison , Gregory P. Dillon , Robert L. Campbell , David A. Boger , Stephen A. Hambric , Robert F. Kunz , James P. Runt , Justin M. Walsh , Boris Leschinsky
IPC分类号： F04D29/38
CPC分类号： F04D29/181 , A61M1/101 , A61M1/1012 , A61M1/1024 , A61M1/1034 , A61M1/122 , A61M1/125 , B63B2231/42 , B63H1/26 , B63H11/08 , F04D3/00 , F04D3/02 , F04D19/02 , F04D29/026 , F04D29/247 , F04D29/382 , F04D29/526 , F04D29/528 , F05D2210/11 , F05D2250/51 , F05D2250/52 , F05D2300/43 , Y10S415/90 , Y10T29/49229
摘要： An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

6. 发明授权

US06759510B1 Peptides for use in culture media 有权
公开(公告)号：US06759510B1
公开(公告)日：2004-07-06
申请号：US09608892
申请日：2000-06-30
申请人： Perry D. Haaland , Douglas B. Sherman , Robert L. Campbell , Walter William Stewart , Sheila A. Lloyd , Bruce Wayne Erickson
发明人： Perry D. Haaland , Douglas B. Sherman , Robert L. Campbell , Walter William Stewart , Sheila A. Lloyd , Bruce Wayne Erickson
IPC分类号： C07K700
CPC分类号： C07K7/06 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C40B30/06
摘要： The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.

7. 发明授权

US5135763A Method and apparatus for processing food products 失效
标题翻译：加工食品的方法和设备
公开(公告)号：US5135763A
公开(公告)日：1992-08-04
申请号：US654933
申请日：1991-02-13
申请人： Kenneth E. Gillam , Robert L. Campbell
发明人： Kenneth E. Gillam , Robert L. Campbell
IPC分类号： B65B25/08 , B65B61/06
CPC分类号： B65B25/08 , B65B61/06
摘要： A system for stacking food products on cut sheets of paper provides several continuously moving conveyors. Products, such as meat patties, are placed onto continuous sheets of paper suitable for separating them in stacks. The weight of the products pressing the paper against the conveyor simply pulls the paper off of supply rolls at the rate of movement of the conveyor. A sensor detects the position of the food products on the conveyor, causing cutting blades to descend and cut the paper between the food products. Such cutting is performed without stopping the conveyors.
摘要翻译：用于在切纸上堆叠食品的系统提供了几个连续移动的输送机。诸如肉馅饼的产品被放置在适合于将它们分开的纸张的连续纸上。将纸张压靠传送带的产品的重量以传送带的移动速度将纸张从供料辊上拉出。传感器检测食品在输送机上的位置，导致切割刀片在食品之间下降和切割纸张。在不停止输送机的情况下执行这种切割。

8. 发明申请

US20110071338A1 HEART ASSIST DEVICE WITH EXPANDABLE IMPELLER PUMP 有权
标题翻译：心脏辅助装置与可扩展的叶轮泵
公开(公告)号：US20110071338A1
公开(公告)日：2011-03-24
申请号：US12945594
申请日：2010-11-12
申请人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
发明人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
IPC分类号： A61M1/12
CPC分类号： A61M1/1012 , A61M1/1008 , A61M1/101 , A61M1/1013 , A61M1/1017 , A61M1/102 , A61M1/1024 , A61M1/1034 , A61M1/122 , A61M1/125 , A61M2205/0266 , B33Y80/00 , F04D3/00 , F04D3/02 , F04D29/181 , F04D29/247 , F04D29/528 , F04D29/542 , F05B2240/311 , F05B2280/5001
摘要： An impeller includes a hub and at least one blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as pumping blood within a patient. A blood pump may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient's body.
摘要翻译：叶轮包括轮毂和由轮毂支撑的至少一个叶片。叶轮具有存储构造，其中叶片被压缩，使得其远端朝向轮毂移动，以及展开构型，其中叶片远离轮毂延伸。叶轮可以是用于泵送流体的泵的一部分，例如泵送患者体内的血液。血泵可以包括具有固定直径的近端部分和具有可扩张直径的远端部分的套管。叶轮可以驻留在套管的可膨胀部分中。套管可以具有压缩直径，其允许其经皮插入患者体内。一旦在期望的位置，插管的可扩张部分可以膨胀并且叶轮膨胀到展开构型。柔性驱动轴可延伸穿过套管，用于旋转地驱动患者体内的叶轮。

9. 发明授权

US07841976B2 Heart assist device with expandable impeller pump 有权
标题翻译：带可扩张式叶轮泵的心脏辅助装置
公开(公告)号：US07841976B2
公开(公告)日：2010-11-30
申请号：US11728051
申请日：2007-03-23
申请人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
发明人： Mark W. McBride , David A. Boger , Robert L. Campbell , Gregory P. Dillon , Stephen A. Hambric , Robert F. Kunz , Boris Leschinsky , Thomas M. Mallison , James P. Runt , Justin M. Walsh
IPC分类号： A61M1/12 , F04D29/38
CPC分类号： A61M1/1012 , A61M1/1008 , A61M1/101 , A61M1/1013 , A61M1/1017 , A61M1/102 , A61M1/1024 , A61M1/1034 , A61M1/122 , A61M1/125 , A61M2205/0266 , B33Y80/00 , F04D3/00 , F04D3/02 , F04D29/181 , F04D29/247 , F04D29/528 , F04D29/542 , F05B2240/311 , F05B2280/5001
摘要： An impeller includes a hub and at least one blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as pumping blood within a patient. A blood pump may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient's body.
摘要翻译：叶轮包括轮毂和由轮毂支撑的至少一个叶片。叶轮具有存储构造，其中叶片被压缩，使得其远端朝向轮毂移动，以及展开构型，其中叶片远离轮毂延伸。叶轮可以是用于泵送流体的泵的一部分，例如泵送患者体内的血液。血泵可以包括具有固定直径的近端部分和具有可扩张直径的远端部分的套管。叶轮可以驻留在套管的可膨胀部分中。套管可以具有压缩直径，其允许其经皮插入患者体内。一旦在期望的位置，插管的可扩张部分可以膨胀并且叶轮膨胀到展开构型。柔性驱动轴可延伸穿过套管，用于旋转地驱动患者体内的叶轮。

10. 发明申请

US20100296999A1 Ozonated capacitive deionization process 审中-公开
标题翻译：臭氧化电容去离子过程
公开(公告)号：US20100296999A1
公开(公告)日：2010-11-25
申请号：US12805303
申请日：2010-07-22
申请人： Robert L. Campbell
发明人： Robert L. Campbell
IPC分类号： C02F9/04 , C02F1/78 , C02F1/42 , C02F1/469 , C01B5/00
CPC分类号： C02F1/78 , C02F1/001 , C02F1/38 , C02F1/4604 , C02F1/52 , C02F2101/20 , C02F2103/10
摘要： Water from coal bed methane production which is suitable for almost nothing, is ozonated in a reactor to oxidize the iron content from +2 to +3, that is from ferrous to ferric, and to oxidize the manganese content from +2 to +4. The water after such first treatment is run through a separation means and then through a rotating filter, and then subjected to capacitive deionization, to yield clean water, which is then treated further to adjust he sodium content to render the water suitable for domestic and agricultural purposes. Some of the produced water is run back through the capacitive deionization cells when no voltage is applied to clean the cells for the next voltage application cycle. Some of the water produced may also be run back through the separation means to help clean out the crud.
摘要翻译：在几乎没有任何东西适用于煤层气生产的水中，在反应器中臭氧化，将铁含量从+2降至+3，即从亚铁到铁，并将锰含量从+2氧化为+4。经过这样的第一次处理之后的水经过分离装置，然后通过旋转过滤器，然后进行电容去离子，产生干净的水，然后再进行处理以调节其钠含量，使水适合家庭和农业目的当没有施加电压以清洁下一个电压施加周期的电池时，一些产生的水通过电容去离子电池回流。产生的一些水也可能通过分离装置回流，以帮助清理原油。

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