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    • 8. 发明申请
    • Bronchorelaxing compounds
    • 支气管放生化合物
    • US20060040919A1
    • 2006-02-23
    • US11186841
    • 2005-07-22
    • Staffan SkogvallHenrik BjorkPer BerglundMaria Dalence GuzmanOlov Sterner
    • Staffan SkogvallHenrik BjorkPer BerglundMaria Dalence GuzmanOlov Sterner
    • A61K31/55C07D223/16
    • C07D223/16C07D217/06
    • A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts wherein A is CHR9, wherein R9 is H, C1-C6 alkyl; n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S; E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl, R13 is H or C1-C6 alkyl; F is C1-C18 alkyl or R4-R7 cycloalkyl, which may be mono- or di-unsaturated and/or substituted, is useful in treating and preventing pulmonary disease characterized by bronchoconstriction; also disclosed is a pharmaceutical composition comprising the compound of formula (I), a pharmaceutical carrier and, optionally, an anti-asthmatic, a method for its manufacture, and a method for treating or preventing such disease.
    • 包括其药学上可接受的酸加成盐的通式(I)的化合物,其中A是CHR 9,其中R 9是H,C 1 H 12 -C 6 -C 6烷基; n为1-3; B是CHR 10 N,其中R 10是H,C 1 -C 6烷基; m为1或2; D为O或S; E是CR 11 R 12或NR 13,其中R 11和R 12是/或 >彼此独立地为H或C 1 -C 6烷基,R 13为H或C 1〜 C 1 -C 6烷基; F是C 1 -C 18烷基或R 4 -R 7 R 7环烷基,其可以是单 - 或二 - 二不饱和和/或取代的,可用于治疗和预防以支气管收缩为特征的肺部疾病; 还公开了包含式(I)化合物,药物载体和任选的抗哮喘,其制备方法,以及治疗或预防这种疾病的方法的药物组合物。