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2. 发明授权

US5526111A Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control 失效
$Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control$
标题翻译：用于计算血液样本的血液部分或对照物的凝血特性的方法和装置
公开(公告)号：US5526111A
公开(公告)日：1996-06-11
申请号：US114897
申请日：1993-08-31
申请人： Rick L. Collins , Martin T. Gerber , Zindel H. Heller , James L. Maxwell , Edna C. Probst , Loy M. Vail , Stefan Weinert , Morris J. Young
发明人： Rick L. Collins , Martin T. Gerber , Zindel H. Heller , James L. Maxwell , Edna C. Probst , Loy M. Vail , Stefan Weinert , Morris J. Young
IPC分类号： G01N33/86 , G01N33/49 , G06Q50/00 , G06F159/00
CPC分类号： G01N33/4905 , Y10S128/22
摘要： A method for calculating a coagulation characteristic of a sample of blood, a blood fraction, or a control comprises generating an output signal indicative of coagulation of the sample, sampling the output signal at a sampling rate for a predetermined time to provide a plurality of sampled signal values, storing the sampled signal values, rectifying the stored sampled signal values to provide a plurality of envelope values, and storing the envelope values. The stored envelope values are examined in reverse time order to determine a slope of the envelope at each of the stored envelope values. All relative maxima in the stored envelope values are identified. A range of stored envelope values corresponding to each relative maximum is determined. The identified relative maxima are compared to locate an absolute maximum in the stored envelope values. The coagulation characteristic is then calculated from the stored envelope values within the predetermined range of envelope values corresponding to the absolute maximum.
摘要翻译：用于计算血液，血液分数或对照样品的凝固特性的方法包括产生表示样品凝结的输出信号，以采样速率对输出信号进行采样预定时间以提供多个采样信号值，存储采样的信号值，整理存储的采样信号值以提供多个包络值，以及存储包络值。以反向时间顺序检查存储的包络值，以确定每个存储的包络值处的包络的斜率。识别存储的包络值中的所有相对最大值。确定对应于每个相对最大值的存储包络值的范围。将所识别的相对最大值进行比较，以确定存储的包络值中的绝对最大值。然后从对应于绝对最大值的包络值的预定范围内的存储的包络值计算凝结特性。

3. 发明授权

US09713706B2 Implantable medical elongated member including intermediate fixation 有权
公开(公告)号：US09713706B2
公开(公告)日：2017-07-25
申请号：US11591448
申请日：2006-10-31
申请人： Martin T. Gerber
发明人： Martin T. Gerber
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0529 , A61N1/0534 , A61N1/0536 , A61N1/0539 , A61N1/0553 , A61N1/0558 , A61N1/057
摘要： An implantable medical elongated member extends between a proximal end configured to be coupled to a medical device and a distal end. The implantable elongated member includes one or more fixation elements coupled to at least a middle portion and/or a proximal portion of the elongated member in order to substantially fix a position of the elongated member to tissue at one or more intermediate points between the proximal end and the distal end of the elongated member.

4. 发明授权

US09272140B2 Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves 有权
标题翻译：用于通过电刺激骶神经和/或阴部神经来治疗盆底疾病的方法，系统和装置
公开(公告)号：US09272140B2
公开(公告)日：2016-03-01
申请号：US12059243
申请日：2008-03-31
申请人： Martin T. Gerber
发明人： Martin T. Gerber
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61N1/0507 , A61N1/0521 , A61N1/0551 , A61N1/36071 , A61N1/36107
摘要： Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of tissue volumes at two or more locations adjacent sacral nerves or portions thereof, and/or pudendal nerves or portions thereof. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the respective tissue volumes in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and/or fecal voiding dysfunctions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.
摘要翻译：描述了通过在邻近骶神经或其部分的两个或更多个位置和/或阴部神经或其部分上的组织体积的电刺激来治疗盆底的各种疾病的可植入装置和方法。两种或更多种电刺激方案以连续，交替，间歇或其他方式以相应的组织体积施用，其数量和方式有效地治疗许多障碍，包括但不限于尿和/或粪便排泄功能障碍例如便秘，失禁症例如呼吸频率和尿潴留障碍，性功能障碍如高血压和勃起功能障碍，盆腔疼痛，前列腺炎，前列腺痛和前列腺痛。

5. 发明授权

US09144640B2 Sorbent cartridge configurations for improved dialysate regeneration 有权
标题翻译：吸附剂盒配置，用于改善透析液再生
公开(公告)号：US09144640B2
公开(公告)日：2015-09-29
申请号：US13836973
申请日：2013-03-15
申请人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
发明人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译：一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合并且与第一选择的再生物质流体连通地流过第二再生模块。

6. 发明申请

US20140217028A1 SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION 有权
标题翻译：用于改进的透析再生的SORBENT CARTRIDGE配置
公开(公告)号：US20140217028A1
公开(公告)日：2014-08-07
申请号：US13836973
申请日：2013-03-15
申请人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
发明人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译：一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合并且与第一选择的再生物质流体连通地流过第二再生模块。

7. 发明申请

US20140217027A1 SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL 有权
标题翻译：多功能体积流体控制系统与方法
公开(公告)号：US20140217027A1
公开(公告)日：2014-08-07
申请号：US13757709
申请日：2013-02-01
申请人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
发明人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/1621 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/165 , A61M1/1652 , A61M1/1656 , A61M1/1658 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1676 , A61M1/169 , A61M1/1696 , A61M1/3413 , A61M1/3437 , A61M1/3609 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/365 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2209/06 , A61M2230/65
摘要： Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.
摘要翻译：用于控制受试者和受控顺应流动路径之间的流体运动和流体体积的系统和方法。受控制的柔性流动路径具有用于选择性地计量来自受控制的顺应流动路径的流体的计量装置。体外流路与跨过半透膜的受控顺应性流动路径流体连通，其中体外流路具有第一末端和第二末端。

8. 发明授权

US08788055B2 Multi-location posture sensing 有权
标题翻译：多位置姿态检测
公开(公告)号：US08788055B2
公开(公告)日：2014-07-22
申请号：US11800653
申请日：2007-05-07
申请人： Martin T. Gerber , John C. Rondoni
发明人： Martin T. Gerber , John C. Rondoni
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36135 , A61N1/0551 , A61N1/36514 , A61N1/36535 , A61N1/36542
摘要： Techniques for controlling therapy delivery based on the relative orientation and/or motion of a device accelerometer and a lead accelerometer are described. In one embodiment, a therapy system includes an electrical stimulator and a lead. The electrical stimulator comprises a processor that controls delivery of a therapy to a target stimulation site in a patient and a device accelerometer coupled to the electrical stimulator. The lead is coupled to the electrical stimulator to deliver the therapy from the electrical stimulator to the target stimulation site in the patient, and includes a lead accelerometer. The processor compares signals from the accelerometers, and controls delivery of the therapy to the patient based on the comparison. In this manner, the processor may adjust stimulation to, for example, address movement of electrodes relative to target tissue when a patient changes postures.
摘要翻译：描述了基于设备加速度计和线加速度计的相对取向和/或运动来控制治疗递送的技术。在一个实施例中，治疗系统包括电刺激器和引线。电刺激器包括处理器，其控制对患者的目标刺激部位的治疗传递和耦合到电刺激器的装置加速度计。引线耦合到电刺激器以将治疗从电刺激器传递到患者中的目标刺激部位，并且包括引线加速度计。处理器比较来自加速度计的信号，并且基于比较来控制对患者的治疗传递。以这种方式，当患者改变姿势时，处理器可以将刺激调整为例如电极相对于靶组织的地址移动。

9. 发明申请

US20140158588A1 pH AND BUFFER MANAGEMENT SYSTEM FOR HEMODIALYSIS SYSTEMS 审中-公开
标题翻译： pH值和缓冲管理系统的HEMODIALYSIS系统
公开(公告)号：US20140158588A1
公开(公告)日：2014-06-12
申请号：US13757792
申请日：2013-02-02
申请人： Bryant J. PUDIL , Martin T. Gerber , David B. Lura , Thomas E. Meyer
发明人： Bryant J. PUDIL , Martin T. Gerber , David B. Lura , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/1696 , A61M1/16 , A61M1/1605 , A61M1/165 , A61M1/287 , A61M1/34 , A61M1/3406 , A61M1/3413 , A61M1/3437 , A61M2205/33 , A61M2205/3324 , A61M2205/50
摘要： Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.
摘要翻译：用于在血液透析治疗期间管理透析液的pH的系统和方法。系统和方法调节透析液pH和缓冲液浓度，以在进入透析器的透析液中产生预定的总碳酸氢盐缓冲液浓度。

10. 发明授权

US08554331B2 Therapy program modification 有权
标题翻译：治疗方案修改
公开(公告)号：US08554331B2
公开(公告)日：2013-10-08
申请号：US12989763
申请日：2009-01-23
申请人： Martin T. Gerber , John C. Rondoni
发明人： Martin T. Gerber , John C. Rondoni
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/36007
摘要： A therapy program may be generated based on an algorithmic model of a baseline therapy field, which may represent a therapy field resulting from therapy delivery via the first therapy system based on a first therapy program. A second therapy program that controls therapy delivery by a second therapy system may be generated based on the baseline therapy field model. For example, therapy parameter values of the second therapy program may be selected to maintain at least one field characteristic of the baseline therapy field model. In some examples, the second therapy system may result from a hardware modification to the first therapy system. In other examples, the first and second therapy systems may be associated with different patients. For example, the baseline therapy field model may be an efficacious therapy field for a patient class, and a second therapy program may be generated for a patient in the class.
摘要翻译：可以基于基线治疗领域的算法模型来产生治疗程序，其可以代表由基于第一治疗程序的经由第一治疗系统的治疗递送产生的治疗领域。可以基于基线治疗场模型来产生控制第二疗法系统治疗传递的第二疗法程序。例如，可以选择第二治疗程序的治疗参数值以保持基线治疗场模型的至少一个场特征。在一些示例中，第二治疗系统可能由对第一治疗系统的硬件修改而产生。在其他实施例中，第一和第二治疗系统可以与不同的患者相关联。例如，基线治疗场模型可以是患者类别的有效治疗领域，并且可以为该类别中的患者生成第二治疗程序。

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