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2. 发明授权

US06189370B1 Fluid dose, flow and coagulation sensor for medical instrument 失效
标题翻译：医疗仪器的流体剂量，流量和凝血传感器
公开(公告)号：US06189370B1
公开(公告)日：2001-02-20
申请号：US09098708
申请日：1998-06-17
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N2103
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： An instrument for determining a characteristic of a biological fluid or a control includes a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. A cuvette for use with the instrument holds a sample of the biological fluid or control the characteristic of which is to be determined. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of said two opposed walls and the radiation reflective surface is disposed adjacent a second of said two opposed walls.
摘要翻译：用于确定生物流体或对照的特征的仪器包括辐射反射表面，用于照射表面的第一源和用于检测从表面反射的辐射的第一检测器。与仪器一起使用的比色皿可容纳生物流体的样品或其特性要被确定的控制。试管具有两个相对的壁，对于源辐射和反射辐射基本上是透明的。第一源极和第一检测器被布置成与所述两个相对的壁中的第一个相邻，并且辐射反射表面邻近所述两个相对的壁中的第二个设置。

3. 发明授权

US07117721B2 Fluid dose, flow and coagulation sensor for medical instrument 失效
公开(公告)号：US07117721B2
公开(公告)日：2006-10-10
申请号：US10357934
申请日：2003-02-04
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N21/03
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： In combination, an instrument for determining a characteristic of a biological fluid or a control, and a cuvette for holding a sample of the biological fluid or control, the characteristic of which is to be determined. The instrument comprises a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls. The radiation reflective surface is disposed adjacent a second of the two opposed walls. A second source is provided for irradiating the surface. The first detector detects radiation from the second source reflected from the surface. The second source is positioned to transmit radiation through the two opposed walls for reflection by the surface and transmission back through the two opposed walls to the first detector to indicate whether a sample has reached a first point in the cuvette.

4. 发明授权

US5789664A Fluid dose, flow and coagulation sensor for medical instrument 失效
标题翻译：医疗仪器的流体剂量，流量和凝血传感器
公开(公告)号：US5789664A
公开(公告)日：1998-08-04
申请号：US623872
申请日：1996-03-29
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N11/00 , G01N11/06 , G01N11/10 , G01N21/03 , G01N21/05 , G01N21/47 , G01N21/75 , G01N21/86 , G01N33/483 , G01N33/49 , G01N33/86 , G01N35/00
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： An instrument and a method for determining a characteristic of a biological fluid or control comprise providing a radiation-reflective surface, a source for irradiating the surface, a detector for detecting radiation reflected from the surface, and a cuvette for holding a sample of the biological fluid or control. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The source and detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent the other wall. The method comprises detecting radiation from the source reflected from the surface using the radiation detector to determine a characteristic of the biological fluid or control.
摘要翻译：用于确定生物流体或对照的特征的仪器和方法包括提供辐射反射表面，用于照射表面的源，用于检测从表面反射的辐射的检测器和用于保持生物体的样品的比色皿流体或控制。比色皿具有两个相对的壁，对源辐射和反射辐射基本上是透明的。源极和检测器被布置成与两个相对的壁中的第一个相邻，并且辐射反射表面邻近另一个壁设置。该方法包括使用辐射检测器检测来自表面反射的源的辐射，以确定生物流体或控制的特性。

5. 发明授权

US5522255A Fluid dose, flow and coagulation sensor for medical instrument 失效
标题翻译：医疗仪器的流体剂量，流量和凝血传感器
公开(公告)号：US5522255A
公开(公告)日：1996-06-04
申请号：US114913
申请日：1993-08-31
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N11/00 , G01N11/06 , G01N11/10 , G01N21/03 , G01N21/05 , G01N21/47 , G01N21/75 , G01N21/86 , G01N33/483 , G01N33/49 , G01N33/86 , G01N35/00
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： An instrument and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. A cuvette holds a sample of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls.
摘要翻译：用于确定血液，血液部分或对照的凝血特征的仪器和方法包括辐射反射表面，用于照射表面的第一源和用于检测从表面反射的辐射的第一检测器。比色皿容纳血液，血液分数或控制凝血特征的样品。试管具有两个相对的壁，对于源辐射和反射辐射基本上是透明的。第一源极和第一检测器被布置成与两个相对的壁中的第一个相邻，并且辐射反射表面邻近两个相对的壁中的第二个设置。

6. 发明授权

US06575017B1 Fluid dose, flow and coagulation sensor for medical instrument 失效
标题翻译：医疗仪器的流体剂量，流量和凝血传感器
公开(公告)号：US06575017B1
公开(公告)日：2003-06-10
申请号：US09724133
申请日：2000-11-28
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N2103
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： In combination, an instrument for determining a characteristic of a biological fluid or a control, and a cuvette for holding a sample of the biological fluid or control, the characteristic of which is to be determined. The instrument comprises a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls. The radiation reflective surface is disposed adjacent a second of the two opposed walls. A second source is provided for irradiating the surface. The first detector detects radiation from the second source reflected from the surface. The second source is positioned to transmit radiation through the two opposed walls for reflection by the surface and transmission back through the two opposed walls to the first detector to indicate whether a sample has reached a first point in the cuvette.
摘要翻译：组合使用用于确定生物流体或对照的特性的仪器，以及用于保持生物流体或对照样品的试管，其特征是确定。仪器包括辐射反射表面，用于照射表面的第一源和用于检测从表面反射的辐射的第一检测器。试管具有两个相对的壁，对于源辐射和反射辐射基本上是透明的。第一源极和第一检测器被布置成与两个相对的壁中的第一个相邻。辐射反射表面邻近两个相对的壁中的第二个设置。提供用于照射表面的第二源。第一检测器检测来自表面反射的第二源的辐射。第二源被定位成通过两个相对的壁透射辐射，用于通过表面反射并将透射通过两个相对的壁传送到第一检测器，以指示样品是否已经到达比色杯中的第一点。

7. 发明授权

US5710622A Fluid dose, flow and coagulation sensor for medical instrument 失效
标题翻译：医疗仪器的流体剂量，流量和凝血传感器
公开(公告)号：US5710622A
公开(公告)日：1998-01-20
申请号：US478409
申请日：1995-06-07
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N11/00 , G01N11/06 , G01N11/10 , G01N21/03 , G01N21/05 , G01N21/47 , G01N21/75 , G01N21/86 , G01N33/483 , G01N33/49 , G01N33/86 , G01N35/00 , G01N33/48
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： A method of immunizing the operation of an instrument which determines a characteristic of a biological fluid or a control against noise. The instrument includes a surface upon which a user deposits a sample of biological fluid or control the characteristic of which is to be determined. The instrument irradiates the sample and detects radiation from the sample to determine the characteristic. The method comprises monitoring the detected radiation a first time to determine if the detected radiation is increasing or decreasing, forming a first change in detected radiation from said first monitoring, subsequently monitoring the detected radiation a second time to determine if the detected radiation is increasing or decreasing, forming a second change in detected radiation from said second monitoring, forming an overall change in detected radiation from the first and second monitorings, establishing a first threshold, establishing a second threshold, comparing the first change to the first threshold, comparing the second change to the first threshold, if the magnitudes of both the first and second changes are greater than the first threshold, comparing the overall change in radiation to the second threshold, and determining the characteristic if the magnitudes of the first and second changes are greater than the first threshold and the overall change is greater than the second threshold.
摘要翻译：一种免疫仪器操作的方法，该仪器确定生物流体的特性或对噪声的控制。仪器包括用户沉积生物流体样品或控制其特性被确定的表面。仪器照射样品并检测来自样品的辐射，以确定其特性。该方法包括：首先监测检测到的辐射，以确定检测到的辐射是否在增加或减少，形成来自所述第一监测的检测到的辐射的第一变化，随后第二次监测检测到的辐射，以确定检测到的辐射是否增加，从所述第二监测中形成检测到的辐射的第二变化，形成来自第一和第二监测的检测到的辐射的总体变化，建立第一阈值，建立第二阈值，将第一变化与第一阈值进行比较，如果第一和第二变化的幅度大于第一阈值，则将辐射的总体变化与第二阈值进行比较，并且如果第一和第二变化的幅度大于第一阈值，则确定特性第一个阈值和总体变化大于第二个阈值阈。

8. 发明授权

US5686659A Fluid dose flow and coagulation sensor for medical instrument 失效
标题翻译：流体剂量流量和医用仪器凝固传感器
公开(公告)号：US5686659A
公开(公告)日：1997-11-11
申请号：US485639
申请日：1995-06-07
申请人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
发明人： Gary T. Neel , James R. Parker , Rick L. Collins , David E. Storvick , Charles L. Thomeczek, Jr. , William J. Murphy , George R. Lennert , Morris J. Young , Daniel L. Kennedy
IPC分类号： G01N11/00 , G01N11/06 , G01N11/10 , G01N21/03 , G01N21/05 , G01N21/47 , G01N21/75 , G01N21/86 , G01N33/483 , G01N33/49 , G01N33/86 , G01N35/00
CPC分类号： G01N35/00594 , G01N11/06 , G01N21/0303 , G01N21/0332 , G01N21/8483 , G01N33/4905 , G01N35/00693
摘要： A method of determining whether a sample or a control has been applied to an instrument for measuring coagulation of a fluid by optically detecting when the fluid that has been applied to the instrument has passed a first and a second points, determining the flow time for the fluid between the two points, establishing a time threshold, and the flow time to the threshold to determining if the fluid is a sample or a control.
摘要翻译：通过光学检测何时已经施加到仪器的流体已经通过了第一和第二点来确定样品或对照是否已经应用于用于测量流体凝结的仪器的方法，确定用于两点之间的流体，建立时间阈值，以及到阈值的流动时间以确定流体是样品还是对照。

9. 发明授权

US5841023A Magnet for medical instrument 失效
标题翻译：磁铁用于医疗仪器
公开(公告)号：US5841023A
公开(公告)日：1998-11-24
申请号：US114896
申请日：1993-08-31
申请人： James R. Parker , William J. Murphy , Charles L. Thomeczek, Jr. , Daniel L. Kennedy , Gary T. Neel , David E. Storvick
发明人： James R. Parker , William J. Murphy , Charles L. Thomeczek, Jr. , Daniel L. Kennedy , Gary T. Neel , David E. Storvick
IPC分类号： G01N33/86 , G01N11/10 , G01N11/16 , G01N27/74 , G01N33/49 , G01N1/12
CPC分类号： G01N33/4905 , G01N11/16
摘要： An instrument monitors the coangulation of coagulable fluid blood, blood fraction or a control by combining the coagulable fluid with particles which are affected by a magnetic field so that the particles become suspended relatively freely in the fluid. A time-varying magnetic field causes the particles to be reoriented as the magnetic field varies. The reorientation changes as the fluid coagulates owing to the fluid's changing viscosity. An electromagnet creates the time-varying magnetic field. The electromagnet includes a core comprising a first leg an electrically conductive coil for creating a time-varying magnetic flux in the core, and a return for the time-varying magnetic flux. The first leg and the flux return together comprise a generally H-shaped core of ferromagnetic material. A bobbin is provided on the first leg and the electrically conductive coil is wound on the bobbin.
摘要翻译：仪器通过将可凝结流体与受磁场影响的颗粒组合来监测可凝结液体血液，血液部分或对照物的组合，使得颗粒在流体中相对自由地悬浮。随着磁场变化，时变磁场使得颗粒被重新定向。当流体由于流体变化的粘度而凝结时，重新定向变化。电磁铁产生时变磁场。电磁铁包括：芯，其包括用于在芯中产生时变磁通的导电线圈和用于时变磁通的返回的第一支路。第一支腿和通量返回在一起包括铁磁材料的大致H形芯。线轴被设置在第一支腿上，并且导电线圈缠绕在线轴上。

10. 发明授权

US5246858A Apparatus and method for analyzing a body fluid 失效
标题翻译：用于分析身体液体的装置和方法
公开(公告)号：US5246858A
公开(公告)日：1993-09-21
申请号：US661810
申请日：1991-02-27
申请人： Steven R. Arbuckle , William R. Boyd , Michael E. Grant , Mark A. Gregory , Russell T. Gray , Friedrich Jost , Daniel L. Kennedy , Dino Perin , Richard Riedel , David E. Storvick , John W. Stoughton
发明人： Steven R. Arbuckle , William R. Boyd , Michael E. Grant , Mark A. Gregory , Russell T. Gray , Friedrich Jost , Daniel L. Kennedy , Dino Perin , Richard Riedel , David E. Storvick , John W. Stoughton
IPC分类号： G01N21/47 , G01N21/77 , G01N21/86 , G01N33/52
CPC分类号： G01N21/8483 , G01N2021/478 , G01N2201/1214 , G01N2201/122 , G01N2201/12723 , Y10T436/10
摘要： A method and apparatus (10) for determining the remission of a chemistry (106) which reacts with a medically significant component of a body fluid. The remission of the chemistry (106) changes as it reacts. The method and apparatus (10) include irradiating the chemistry (106) with a radiation source (182), detecting remissions of radiation from the chemistry (106) with a radiation detector (300), providing a radiation pathway (164) between the source (182) and the chemistry (106), providing a remission pathway (164) between the chemistry (106) and the detector (300), and detecting the rate of change of remission of the chemistry (106) with respect to time. The irradiating, detecting and rate detecting steps and apparatus comprise initially irradiating the chemistry (106) at a first time rate and detecting remissions therefrom, comparing remission data from remission readings spaced apart by a first number of intervening remission readings, and determining when the difference between compared readings exceeds a first predetermined limit. The time rate of irradiation of the chemistry is changed once the difference between compared readings exceeds the first limit. Remission data from remission readings spaced apart by a second number of intervening remission readings are then compared. The method and apparatus next determine when the difference between compared readings no longer exceeds a second predetermined limit. The last remission reading is then converted to the concentration of the medically significant component of the body fluid.
摘要翻译：一种用于确定化学物质（106）的缓解的方法和装置（10），其与体液的医学上重要的组分反应。化学物质（106）的缓解随着反应而发生变化。该方法和装置（10）包括用辐射源（182）照射化学物质（106），用辐射检测器（300）检测来自化学物质（106）的辐射的放射，提供源之间的辐射通路（164）（106）和化学物质（106），在化学物质（106）和检测器（300）之间提供缓释途径（164），以及检测化学物质（106）相对于时间的缓解变化率。照射，检测和速率检测步骤和装置包括首先以第一时间速率辐射化学物质（106）并检测其中的缓解，将缓释数据与间隔开的缓冲读数与第一数量的介入缓解读数进行比较，以及确定何时差异比较读数超过第一预定极限。一旦比较读数之间的差超过第一限制，化学物质的照射时间变化就会改变。然后比较缓冲读数与间隔第二数量的介入缓解读数的缓解数据。该方法和装置接下来确定比较读数之间的差异何时不再超过第二预定极限。然后将最后的缓解读数转化为体液的医学重要组分的浓度。

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