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1. 发明授权

US06893417B2 Catheter and guide wire exchange system with improved proximal shaft and transition section 失效
标题翻译：导管和导丝交换系统具有改进的近端轴和过渡段
公开(公告)号：US06893417B2
公开(公告)日：2005-05-17
申请号：US10720535
申请日：2003-11-24
申请人： Richard Gribbons , John MacNamara , Niall Duffy , Ash Varma , Gerry Clarke , Mark Casley , Noel Coyle , David Quinn , Rodney Bell , Kevin Boyle , Kevin Treacy , Patrick Duane , Paula McDonnell , Declan Costello
发明人： Richard Gribbons , John MacNamara , Niall Duffy , Ash Varma , Gerry Clarke , Mark Casley , Noel Coyle , David Quinn , Rodney Bell , Kevin Boyle , Kevin Treacy , Patrick Duane , Paula McDonnell , Declan Costello
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02 , A61M31/00
CPC分类号： A61M25/0169 , A61M25/0029 , A61M25/0032 , A61M25/09041 , A61M25/104 , A61M2025/0034 , A61M2025/107 , Y10S977/875
摘要： A catheter and guide wire exchange system including a catheter that has a guide wire lumen with a guide way extending along a length of the proximal shaft. A guide member is slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. A transition section joins the trilumen proximal shaft to a coaxial distal shaft.
摘要翻译：一种导管和导丝线交换系统，包括导管，该导管具有沿着近端轴的长度延伸的引导方式的导丝管腔。引导构件围绕近侧轴线可滑动地设置，用于将引导线引导到导向方式和引导线腔内或引导线腔内。过渡部分将三位一体近轴连接到同轴远端轴。

2. 发明授权

US06800065B2 Catheter and guide wire exchange system 失效
标题翻译：导管和导丝交换系统
公开(公告)号：US06800065B2
公开(公告)日：2004-10-05
申请号：US10116234
申请日：2002-04-04
申请人： Patrick J. Duane , Gerry Clarke , Niall Duffy , Noel Coyle , John MacNamara , David Quinn , Declan Costello , Robert Murray , Ashish Varma , Patrick J. Carmody
发明人： Patrick J. Duane , Gerry Clarke , Niall Duffy , Noel Coyle , John MacNamara , David Quinn , Declan Costello , Robert Murray , Ashish Varma , Patrick J. Carmody
IPC分类号： A61M2900
CPC分类号： A61M25/09041 , A61M2025/0186
摘要： A catheter and guide wire exchange system including a catheter having a guide wire lumen with a guide way extending along the length of a stiffened proximal shaft portion, and a guide member slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. The guide member may be slid along the proximal shaft portion and the guide wire in zipper-like fashion so that the guide wire is contained within the guide wire lumen distal to the guide member and with the guide wire and catheter being separated proximal of the guide member.
摘要翻译：一种导管和导丝线交换系统，其包括具有导丝管腔的导管，所述导管内腔具有沿加强的近侧轴部分的长度延伸的引导方式，以及引导部件，其可滑动地设置在所述近端轴周围，用于引导导丝进入或离开引导方式和导丝管腔。引导构件可以沿着近端轴部分和导丝以拉链方式滑动，使得导丝被容纳在远离引导构件的导丝管腔内，并且导丝和导管被分离在引导件的近侧会员。

3. 发明授权

US06905477B2 Catheter with improved transition section 失效
标题翻译：导管改良过渡段
公开(公告)号：US06905477B2
公开(公告)日：2005-06-14
申请号：US10251477
申请日：2002-09-20
申请人： Paula McDonnell , Mark Casley , Declan Costello , William Hawkins
发明人： Paula McDonnell , Mark Casley , Declan Costello , William Hawkins
IPC分类号： A61M25/01 , A61M29/02 , A61M31/00
CPC分类号： A61M25/0169 , A61M25/104 , A61M2025/107
摘要： A catheter and guide wire exchange system including a catheter that has a guide wire lumen with a guide way extending along a length of the proximal shaft. A guide member is slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. A transition section joins the bilumen proximal shaft to a coaxial distal shaft.
摘要翻译：一种导管和导丝线交换系统，包括导管，该导管具有沿着近端轴的长度延伸的引导方式的导丝管腔。引导构件围绕近侧轴线可滑动地设置，用于将引导线引导到导向方式和引导线腔内或引导线腔内。过渡部分将近侧轴连接到同轴远端轴。

4. 发明申请

US20130261737A1 Dual Valve Prosthesis for Transcatheter Valve Implantation 有权
标题翻译：用于经导管瓣植入的双瓣假体
公开(公告)号：US20130261737A1
公开(公告)日：2013-10-03
申请号：US13432497
申请日：2012-03-28
申请人： Declan Costello
发明人： Declan Costello
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2230/0054
摘要： A dual valve prosthesis having first and second prosthetic valve sections is disclosed. The first prosthetic valve section includes a stent structure with a first prosthetic valve secured therein and the second prosthetic valve section includes an annular frame with a second prosthetic valve secured therein. When the dual valve prosthesis is in an expanded configuration, the annular frame extends from the stent structure such that the first and second prosthetic valves are laterally offset from each other. In a method in accordance herewith, the first and second prosthetic valve sections include prosthetic aortic and mitral valves, respectively, and the dual heart valve prosthesis is configured to replace both the native aortic and mitral valves of the heart in a single transcatheter heart valve implantation procedure.
摘要翻译：公开了一种具有第一和第二假体瓣膜部分的双瓣膜假体。第一假体瓣膜部分包括具有固定在其中的第一假体瓣膜的支架结构，第二假体瓣膜部分包括固定在其中的第二假体瓣膜的环形框架。当双瓣膜假体处于膨胀构型时，环形框架从支架结构延伸，使得第一和第二假体瓣彼此横向偏移。在根据本发明的方法中，第一和第二假体瓣膜部分分别包括假体主动脉和二尖瓣，并且双心脏瓣膜假体构造成在单个经导管心脏瓣膜植入中替换心脏的天然主动脉瓣和二尖瓣程序。

5. 发明授权

US08926694B2 Dual valve prosthesis for transcatheter valve implantation 有权
标题翻译：用于经导管瓣膜植入的双瓣膜假体
公开(公告)号：US08926694B2
公开(公告)日：2015-01-06
申请号：US13432497
申请日：2012-03-28
申请人： Declan Costello
发明人： Declan Costello
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2230/0054
摘要： A dual valve prosthesis having first and second prosthetic valve sections is disclosed. The first prosthetic valve section includes a stent structure with a first prosthetic valve secured therein and the second prosthetic valve section includes an annular frame with a second prosthetic valve secured therein. When the dual valve prosthesis is in an expanded configuration, the annular frame extends from the stent structure such that the first and second prosthetic valves are laterally offset from each other. In a method in accordance herewith, the first and second prosthetic valve sections include prosthetic aortic and mitral valves, respectively, and the dual heart valve prosthesis is configured to replace both the native aortic and mitral valves of the heart in a single transcatheter heart valve implantation procedure.
摘要翻译：公开了一种具有第一和第二假体瓣膜部分的双瓣膜假体。第一假体瓣膜部分包括具有固定在其中的第一假体瓣膜的支架结构，第二假体瓣膜部分包括固定在其中的第二假体瓣膜的环形框架。当双瓣膜假体处于膨胀构型时，环形框架从支架结构延伸，使得第一和第二假体瓣彼此横向偏移。在根据本发明的方法中，第一和第二假体瓣膜部分分别包括假体主动脉和二尖瓣，并且双心脏瓣膜假体构造成在单个经导管心脏瓣膜植入中替换心脏的天然主动脉瓣和二尖瓣程序。

6. 发明申请

US20140067050A1 Trans-Aortic Delivery System With Containment Capsule Centering Device 有权
标题翻译：具有遏制胶囊定心装置的主动脉递送系统
公开(公告)号：US20140067050A1
公开(公告)日：2014-03-06
申请号：US13604150
申请日：2012-09-05
申请人： Declan Costello , Patrick Griffin , John Gallagher , Gavin Kenny , Edmond Sheahan
发明人： Declan Costello , Patrick Griffin , John Gallagher , Gavin Kenny , Edmond Sheahan
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9665
摘要： Heart valve delivery systems and methods of delivering and implanting heart valves using delivery catheters are disclosed. The delivery systems can include a handle assembly which can include a first control mechanism, a second control mechanism, and a decoupling mechanism. The delivery systems can also include a delivery catheter extending from the handle assembly. The delivery catheter can include an outer shaft, which can be controlled by the first control mechanism; a prosthesis containing capsule comprising a proximal capsule portion connected to the outer shaft, and a distal capsule portion releasably coupled to the proximal capsule portion. After deploying a valve prosthesis, the capsule can be closed by activating the decoupling mechanism in the handle to rapidly close the distal and proximal capsule portions together. The delivery system can also include a centering element to guide the distal and proximal capsule portions together.
摘要翻译：公开了使用输送导管递送和植入心脏瓣膜的心脏瓣膜输送系统和方法。输送系统可以包括手柄组件，其可以包括第一控制机构，第二控制机构和解耦机构。递送系统还可以包括从手柄组件延伸的递送导管。输送导管可包括可由第一控制机构控制的外轴; 包含胶囊的假体，其包括连接到所述外轴的近端胶囊部分和可释放地联接到所述近端胶囊部分的远端胶囊部分。在部署阀门假体之后，可以通过启动手柄中的解耦机构来关闭胶囊，以将远端和近端胶囊部分快速关闭在一起。输送系统还可以包括将远端和近端胶囊部分一起引导的定心元件。

7. 发明申请

US20140067049A1 Integrated Dilation Balloon and Valve Prosthesis Delivery System 审中-公开
标题翻译：综合放大气球和瓣膜假体输送系统
公开(公告)号：US20140067049A1
公开(公告)日：2014-03-06
申请号：US13604098
申请日：2012-09-05
申请人： Declan Costello
发明人： Declan Costello
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2433 , A61F2/958 , A61F2/966
摘要： An integrated balloon dilation and valve prosthesis delivery device is provided having a capsule that is configured to surround a collapsed valve prosthesis and that contains a balloon on an exterior surface.
摘要翻译：提供了一种集成的球囊扩张和瓣膜假体递送装置，其具有构造成围绕塌缩瓣膜假体并且在外表面上包含气囊的胶囊。

8. 发明授权

US10376362B2 Valve introducers with adjustable deployment mechanism and implantation depth gauge 有权
公开(公告)号：US10376362B2
公开(公告)日：2019-08-13
申请号：US13440967
申请日：2012-04-05
申请人： Declan Costello , Ronan Rogers , Edmond Sheahan , Damian Carr
发明人： Declan Costello , Ronan Rogers , Edmond Sheahan , Damian Carr
IPC分类号： A61F2/24 , A61F2/95
摘要： Valve introducer systems and methods for implanting heart valve prostheses are disclosed, where a valve introducer includes an adjustable deployment mechanism comprising a deployment element and an implantation depth controlling element having a distal end and an adjustable length. The valve introducer also includes a tubular member having a distal end, configured to deliver a heart valve prosthesis, and a length extending from a fixed reference point. The implantation depth controlling element can comprise an inner and an outer cylinder, such as where the outer cylinder has interior threads, and the inner cylinder has exterior threads. The adjustable deployment element can include a depth gauge, wherein the depth gauge indicates the length the tubular member extends beyond a fixed reference point. In certain embodiments, the adjustable deployment element can also be configured to be secured to a cannula.

9. 发明申请

US20110004011A1 NOVEL PROCESS 审中-公开
标题翻译：新进程
公开(公告)号：US20110004011A1
公开(公告)日：2011-01-06
申请号：US12823157
申请日：2010-06-25
申请人： Declan Costello , Gerard John Harnett , Pirmin Hidber , Ursula Hoffmann , Thomas McCarthy , Reinhard Reents , Dennis A. Smith , Timothy Smyth
发明人： Declan Costello , Gerard John Harnett , Pirmin Hidber , Ursula Hoffmann , Thomas McCarthy , Reinhard Reents , Dennis A. Smith , Timothy Smyth
IPC分类号： C07C329/04
CPC分类号： C07C327/30 , C07C2601/14
摘要： The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
摘要翻译：本发明涉及制备作为有用的药物活性化合物的S- [2- [1-（2-乙基丁基）环己基羰基氨基] - 苯基] -2-甲硫基丙酸酯的方法。

10. 发明授权

US09717595B2 Trans-aortic delivery system with containment capsule centering device 有权
公开(公告)号：US09717595B2
公开(公告)日：2017-08-01
申请号：US13604150
申请日：2012-09-05
申请人： Declan Costello , Patrick Griffin , John Gallagher , Gavin Kenny , Edmond Sheahan
发明人： Declan Costello , Patrick Griffin , John Gallagher , Gavin Kenny , Edmond Sheahan
IPC分类号： A61F2/24 , A61F2/962 , A61F2/95
CPC分类号： A61F2/2436 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9665
摘要： Heart valve delivery systems and methods of delivering and implanting heart valves using delivery catheters are disclosed. The delivery systems can include a handle assembly which can include a first control mechanism, a second control mechanism, and a decoupling mechanism. The delivery systems can also include a delivery catheter extending from the handle assembly. The delivery catheter can include an outer shaft, which can be controlled by the first control mechanism; a prosthesis containing capsule comprising a proximal capsule portion connected to the outer shaft, and a distal capsule portion releasably coupled to the proximal capsule portion. After deploying a valve prosthesis, the capsule can be closed by activating the decoupling mechanism in the handle to rapidly close the distal and proximal capsule portions together. The delivery system can also include a centering element to guide the distal and proximal capsule portions together.

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