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1. 发明申请

US20110004011A1 NOVEL PROCESS 审中-公开
标题翻译：新进程
公开(公告)号：US20110004011A1
公开(公告)日：2011-01-06
申请号：US12823157
申请日：2010-06-25
申请人： Declan Costello , Gerard John Harnett , Pirmin Hidber , Ursula Hoffmann , Thomas McCarthy , Reinhard Reents , Dennis A. Smith , Timothy Smyth
发明人： Declan Costello , Gerard John Harnett , Pirmin Hidber , Ursula Hoffmann , Thomas McCarthy , Reinhard Reents , Dennis A. Smith , Timothy Smyth
IPC分类号： C07C329/04
CPC分类号： C07C327/30 , C07C2601/14
摘要： The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
摘要翻译：本发明涉及制备作为有用的药物活性化合物的S- [2- [1-（2-乙基丁基）环己基羰基氨基] - 苯基] -2-甲硫基丙酸酯的方法。

2. 发明授权

US6060121A Microcontact printing of catalytic colloids 失效
标题翻译：催化胶体的微接触印刷
公开(公告)号：US6060121A
公开(公告)日：2000-05-09
申请号：US616692
申请日：1996-03-15
申请人： Pirmin Hidber , Wolfgang Helbig , Enoch Kim , George M. Whitesides
发明人： Pirmin Hidber , Wolfgang Helbig , Enoch Kim , George M. Whitesides
IPC分类号： C23C18/16 , G03F7/00 , H05K3/18 , B05D5/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23C18/1608 , H05K3/182 , B41M1/04 , B41M1/40 , B41M3/006
摘要： A method of transferring a chemical activating agent from an applicator to a substrate surface involves providing an applicator having a raised application surface, applying a chemical activating agent to the application surface, contacting the substrate surface with the application surface, and removing the applicator. The chemical activating agent is transferred in a form in which it is capable of effecting a chemical reaction, such as catalysis, at the surface. Thus, following transfer of the chemical activating agent to the surface in a pattern, a metal can be plated at the substrate surface in the pattern. The applicator can be an elastomeric stamp having a raised portion defining a stamping surface.
摘要翻译：将化学活化剂从施用器转移到基底表面的方法包括提供具有凸起的施加表面的施用器，向施加表面施加化学活化剂，将基底表面与施加表面接触，以及移除施用器。化学活化剂以其能够在表面进行化学反应（例如催化）的形式转移。因此，在以图案将化学活化剂转移到表面之后，可以以图案在基板表面上镀金属。涂抹器可以是具有限定冲压表面的凸起部分的弹性体印模。

3. 发明授权

US06299906B1 Process for making submicron particles 失效
标题翻译：制造亚微米颗粒的方法
公开(公告)号：US06299906B1
公开(公告)日：2001-10-09
申请号：US09287409
申请日：1999-04-06
申请人： Alexander Bausch , Pirmin Hidber
发明人： Alexander Bausch , Pirmin Hidber
IPC分类号： A61K914
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.
摘要翻译：本发明涉及一种制造亚微米尺寸生物活性化合物的粉末制剂的方法，包括以下步骤：将生物活性化合物在升高的压力下溶解在含有表面改性剂的压缩气体，液体或超临界流体中; 并迅速膨胀压缩溶液从而使溶解的化合物沉淀。一种替代方法包括将生物活性化合物溶解在可任选地含有表面改性剂的压缩二甲醚中; 并在真空，大气压或升高的压力下将压缩的溶液喷雾到任选含有表面改性剂的抗溶剂相中。可选的第三步涉及使用常规粉末处理将抗溶剂相转变成粉状制剂。

4. 发明授权

US07867452B2 Multi-well filtration device 有权
标题翻译：多孔过滤装置
公开(公告)号：US07867452B2
公开(公告)日：2011-01-11
申请号：US11801661
申请日：2007-05-09
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , Y10T436/255
摘要： A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
摘要翻译：用于过滤悬浮液的多孔过滤装置包括具有过滤室的过滤板和具有收集井的收集板。过滤室连接到收集井，过滤室和收集井之间布置过滤元件。在过滤板和与过滤元件相邻的收集板之间布置有分离层。使用这样的分离层允许过滤板从收集板容易地分离。分离的过滤板可以舒适地转移到分析装置中，其中可以通过分离层分离过滤室的固相，而不需要更换固相。

5. 发明申请

US20070297950A1 Equilibration device 审中-公开
标题翻译：平衡装置
公开(公告)号：US20070297950A1
公开(公告)日：2007-12-27
申请号：US11818597
申请日：2007-06-14
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L9/06 , B01L2200/141 , B01L2300/044 , B01L2300/0829 , B01L2300/0887 , B01L2300/123
摘要： An equilibration device for equilibrating a comparably economic equilibration of a fluid. A first sealing layer is adjacent to the surface side between the plate and the cover. A second sealing layer is arrangeable adjacent to the cover between the plate and the cover and a tube with an open end, which is inside the well such that the open end of the tube projects above the opening of the well. The use of two sealing layers in the equilibration device allows combining the advantages of a material of the first sealing layer, e.g. high flexibility to seal uneven areas and to compensate the step formed by the tube projecting above the opening of the well, as well as the advantages of the second sealing layer, e.g. inexpensiveness, can come to combined effect when the two sealing layers are arranged appropriately.
摘要翻译：用于平衡流体相对经济平衡的平衡装置。第一密封层邻近板和盖之间的表面侧。第二密封层可布置成邻近板和盖之间的盖，以及具有开口端的管，其在井内，使得管的开口端突出在井的开口上方。在平衡装置中使用两个密封层允许组合第一密封层的材料的优点。高度的柔性以密封不均匀区域并且补偿由突出在井的开口上方的管形成的台阶以及第二密封层的优点，例如，当两个密封层适当布置时，可以实现廉价的组合效果。

6. 发明申请

US20070264163A1 Multi-well filtration device 有权
标题翻译：多孔过滤装置
公开(公告)号：US20070264163A1
公开(公告)日：2007-11-15
申请号：US11801661
申请日：2007-05-09
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , Y10T436/255
摘要： A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
摘要翻译：用于过滤悬浮液的多孔过滤装置包括具有过滤室的过滤板和具有收集井的收集板。过滤室连接到收集井，过滤室和收集井之间布置过滤元件。在过滤板和与过滤元件相邻的收集板之间布置有分离层。使用这样的分离层允许过滤板从收集板容易地分离。分离的过滤板可以舒适地转移到分析装置中，其中可以通过分离层分离过滤室的固相，而不需要更换固相。

7. 发明授权

US07148231B2 [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph 有权
标题翻译： [6,7-双（2-甲氧基 - 乙氧基） - 喹唑啉-4-基] - （3-乙炔基 - 苯基）胺盐酸盐多晶型
公开(公告)号：US07148231B2
公开(公告)日：2006-12-12
申请号：US10771217
申请日：2004-02-03
申请人： Andre Gerard Bubendorf , Michael Hennig , Pirmin Hidber , Goesta Rimmler , Franziska Rohrer
发明人： Andre Gerard Bubendorf , Michael Hennig , Pirmin Hidber , Goesta Rimmler , Franziska Rohrer
IPC分类号： A61K31/505 , C07D239/04
CPC分类号： A61K31/517 , C07D239/94
摘要： The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.
摘要翻译：本发明涉及[6,7-双（2-甲氧基 - 乙氧基） - 喹唑啉-4-基] - （3-乙炔基 - 苯基）胺盐酸盐的新型多晶型物。与先前已知的[6,7-双（2-甲氧基 - 乙氧基） - 喹唑啉-4-基] - （3-乙炔基 - 苯基）胺盐酸盐形式相比，该多晶型物显示出优异的性能。 [6,7-双（2-甲氧基 - 乙氧基） - 喹唑啉-4-基] - （3-乙炔基 - 苯基）胺盐酸盐是酪氨酸激酶的抑制剂，可用于治疗癌症。还公开了制备和使用新型多晶型物的方法，以及含有新型多晶型物的药物组合物。

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