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    • 7. 发明授权
    • Food for diabetics
    • 糖尿病食物
    • US07498318B1
    • 2009-03-03
    • US10129095
    • 2000-11-10
    • Bernd StahlMichael KliemSandra FarwerGunther SawatzkiGunther Boehm
    • Bernd StahlMichael KliemSandra FarwerGunther SawatzkiGunther Boehm
    • A61K31/718
    • C12Y204/01019A23L5/00A23L29/30A23L33/125A23L33/20A23L33/21C12P19/14C12P19/18C12Y204/01024
    • Provided is a carbohydrate mixture comprising at least one modified carbohydrate from a base body and a carbohydrate residue coupled therewith. The base body concerned is either a digestible glucose-containing carbohydrate in the form of a digestible glucan or a non-digestible reserve carbohydrate, skeletal carbohydrate or a low-molecular component thereof. By coupling the base body with a carbohydrate residue, the glucose release from the inventive carbohydrate mixture is reduced by at least 10%, determined in an in-vivo digestion system on the basis of pancreatine and compared with a carbohydrate mixture containing the same amount by weight of non-modified carbohydrates. By means of the inventive carbohydrate mixture, the postprandial blood glucose concentration after eating can be moderated. The glucose can thus be metabolized by diabetics in spite of the existing lack of insulin. The inventive carbohydrate mixtures can be used in food for diabetics and in pharmaceuticals.
    • 提供了包含至少一种来自碱体的修饰的碳水化合物和与其偶联的碳水化合物残基的碳水化合物混合物。 所涉及的基体是可消化葡萄糖或不可消化的储备碳水化合物,骨骼碳水化合物或其低分子组分形式的可消化的含葡萄糖的碳水化合物。 通过将基体与碳水化合物残基偶联,将本发明的碳水化合物混合物的葡萄糖释放量减少至少10%,在基于胰腺的体内消化系统中测定,并与含有相同量的碳水化合物混合物 非改性碳水化合物的重量。 通过本发明的碳水化合物混合物,饮食后餐后血糖浓度可以缓和。 糖可以由糖尿病代谢,尽管目前缺乏胰岛素。 本发明的碳水化合物混合物可用于糖尿病患者和药物中。
    • 10. 发明申请
    • Insulin mimetic amino acid sequences
    • 胰岛素模拟氨基酸序列
    • US20050089969A1
    • 2005-04-28
    • US10476184
    • 2002-10-07
    • Josef WisslerGilda GeorgiGunther Boehm
    • Josef WisslerGilda GeorgiGunther Boehm
    • C07K14/62A61K38/00A61K38/28A61K38/30A61P5/48C07K14/415C07K14/47C07K14/475C12N15/17C07H21/04
    • C07K14/415A61K38/00C07K14/4732
    • The invention relates to exsulins or insulin mimetic amino acid sequences with a molecular weight of up to 55,000 daltons and with 1 to 50 basic units of following Formula (1): [−] L,V,I,A]-X1—X2-[L,V,I,A]-[D,E]-[N,Q,M]-X3—[C,H]—X4 [−], whereby; [L,V,I,A], [D,E], [N,Q,M], [C,H] and X1 to 4 represent peptidically linked amino acids; [L,V,I,A] represents leucine (L), valine (V), isoleucine (I) or alanine (A); [D,E] represents asparaginic acid (D) or glutamic acid (E); [N,Q,M] represents asparagine (N), glutamine (Q) or methionine (M); [C,H] represents cysteine (C) or histidine (H); both groups [L,V,I,A] in a basic unit can be identical or different; X1, X2, X3 and X4 represent any type of amino acid and the four amino acids X1 to 4 in a basic unit can be identical or different. The inventive exsulins can be used in dietetic and pharmaceutical agents, and to be precise, can be used for mimicking the properties and functions of members of the family of endogenous insulin and IGF proteohormones/mediators and for preventing, treating and influencing hormonal states and disturbances as well as various degenerative diseases of the body of mammals including various forms of hormonal metabolic disturbances, hormonal resistances, hormonal deficiencies, hyperinsulinemia, diabetes mellitus and autoimmune diseases as well as neurodegenerative and secondary diseases.
    • 本发明涉及分子量高达55,000道尔顿的exsulins或胰岛素模拟氨基酸序列,以及具有1至50个下式(1)的基本单位:[ - ] L,V,I,A] -X < 1 2 - [L,V,I,A] - [D,E] - [N,Q,M] -X 3 - [C,H] -X 4 - [ - ],由此; [L,V,I,A],[D,E],[N,Q,M],[C,H]和X 1〜4代表肽连接的氨基酸; [L,V,I,A]表示亮氨酸(L),缬氨酸(V),异亮氨酸(I)或丙氨酸(A) [D,E]表示天冬氨酸(D)或谷氨酸(E); [N,Q,M]表示天冬酰胺(N),谷氨酰胺(Q)或甲硫氨酸(M); [C,H]表示半胱氨酸(C)或组氨酸(H); 基本单元中的两组[L,V,I,A]可以相同或不同; X 1,X 2,X 3和X 4代表任何类型的氨基酸,并且四个氨基酸 基本单元中的X 1〜4可以相同或不同。 本发明的exsulins可以用于饮食和药物,并且精确地可以用于模拟内源胰岛素和IGF蛋白激素/介体家族成员的性质和功能,并用于预防,治疗和影响荷尔蒙状态和干扰 以及哺乳动物身体的各种退行性疾病,包括各种形式的激素代谢紊乱,激素抵抗,激素缺乏症,高胰岛素血症,糖尿病和自身免疫疾病以及神经变性和继发性疾病。