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1. 发明授权

US5160486A Test carrier utilizing reaction of two bioaffine binding partners 失效
标题翻译：使用两个生物伙伴合作伙伴的测试携带者反应
公开(公告)号：US5160486A
公开(公告)日：1992-11-03
申请号：US450557
申请日：1989-12-14
申请人： Reiner Schlipfenbacher , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
发明人： Reiner Schlipfenbacher , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805
摘要： Test carrier for analysis of a sample liquid with the help of a specific binding reaction of two bioaffine binding partners, one of which is contained in the sample and one in the reagent system of the test carrier, with several capillary-active test zones (11-16; 21-25) arranged substantially next to one another on a base layer (2). The test zones are in liquid contact with one another so that they form a liquid transport path (20, 30) along which a liquid flows, driven by capillary forces, from a start zone (11, 21), a reaction thereby taking place between the first binding partner and the reagent system containing the second reaction partner, which reaction leads to a labelled species characteristic for the desired analysis. A third binding partner specific for the first binding partner sets as capturing reagent which is so arranged in a zone of the liquid transport path (20, 30) and is so measured with regard to the amount used that it binds a part of the first binding partner and thereby removes it from the reaction leading to the characteristic labelled species. A process for the analysis of a liquid sample with the above test carrier is also provided.
摘要翻译：借助于两个生物亚硫酸结合配偶体的特异性结合反应（其中一个包含在样品中，一个在测试载体的试剂系统中）与样品液体分离的测试载体，具有几个毛细管活性测试区（11 -16; 21-25），其基本上彼此相邻布置在基底层（2）上。测试区彼此液体接触，使得它们形成液体输送路径（20,30），液体沿着该液体输送路径（20,30）从毛细作用力从起始区域（11,21）流动，由此发生反应第一结合配偶体和含有第二反应伴侣的试剂系统，该反应导致所需分析的标记物质特征。特定于第一结合伴侣的第三结合配偶体设置为捕获试剂，其被布置在液体输送路径（20,30）的区域中，并且相对于所使用的量如此测量，其结合了第一结合物的一部分从而将其从导致特征标记物种的反应中除去。还提供了使用上述测试载体分析液体样品的方法。

2. 发明授权

US5403706A Carrier matrix with dissolvably impregnated reagent 失效
标题翻译：载体基质与溶解性浸渍试剂
公开(公告)号：US5403706A
公开(公告)日：1995-04-04
申请号：US383759
申请日：1989-07-20
申请人： Hans-Erich Wilk , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
发明人： Hans-Erich Wilk , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
IPC分类号： C12N11/08 , C12Q1/34 , G01N21/78 , G01N33/52 , G01N33/543 , G01N33/552 , C12Q1/00 , C12N11/06 , G01N33/53
CPC分类号： G01N33/525 , C12N11/08 , G01N33/54393 , G01N33/552 , Y10S530/815
摘要： A carrier matrix of polyvinyl alcohol-coated glass is dissolvably impregnated with reagent. The matrix is manufactured by slurrying glass fibers in an excess of water and polyvinyl alcohol and forming a layer, which is then dried and impregnated with reagent.
摘要翻译：聚乙烯醇涂覆的玻璃的载体基质可溶剂地浸渍试剂。该基体通过将玻璃纤维在过量的水和聚乙烯醇中制浆并形成一层来制造，然后将其干燥并用试剂浸渍。

3. 发明授权

US6153192A Peptides with a characteristic antigenic determinant of .alpha.1-microglobulin 失效
标题翻译：具有α1-微球蛋白特征抗原决定簇的肽
公开(公告)号：US6153192A
公开(公告)日：2000-11-28
申请号：US96044
申请日：1993-07-22
申请人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
发明人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/06 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N31/22 , G01N33/53 , A61K39/00 , A61K38/00 , G01N33/566
CPC分类号： C07K16/18 , C07K16/06 , Y10S530/81 , Y10S530/812
摘要： A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.
摘要翻译：根据本发明的肽不超过40个氨基酸长，并且含有与人α1-微球蛋白的氨基酸144和183之间的氨基酸部分序列至少6个氨基酸长的序列或/和该序列与人α1-微球蛋白的氨基酸1和20之间的氨基酸部分序列至少6个氨基酸长。根据本发明的抗体能够与根据本发明的肽以及人α1-微球蛋白特异性结合。为了通过免疫测定法在样品液体中测定人α1-微球蛋白，将样品液体与定义量的组分抗体和肽同时或依次接触，由此其中一种组分被标记，并且测定由该标签的手段。

4. 发明授权

US5188939A Displacement immunoassay utilizing an oligavalent labelled antibody 失效
标题翻译：使用免疫反应标签的免疫球蛋白
公开(公告)号：US5188939A
公开(公告)日：1993-02-23
申请号：US549893
申请日：1990-07-09
申请人： Dieter Mangold , Reiner Schlipfenbacher
发明人： Dieter Mangold , Reiner Schlipfenbacher
IPC分类号： G01N33/53 , G01N33/532 , G01N33/535 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54386 , G01N33/535 , G01N33/6857 , Y10S436/819
摘要： A method for carrying out competitive displacement immunoassays which entails the use of an oligovalent labelled antibody having at least 4 binding sites for the analyte to be determined per label.
摘要翻译：用于进行竞争性置换免疫测定的方法，其需要使用具有至少4个结合位点的寡核苷酸标记抗体来分析每个标签。

5. 发明授权

US5310885A Process for immobilizing a protein containing substance on a solid phase 失效
标题翻译：将含蛋白质的物质固定在固相上的方法
公开(公告)号：US5310885A
公开(公告)日：1994-05-10
申请号：US887239
申请日：1992-05-19
申请人： Josef Maier , Dieter Mangold , Reiner Schlipfenbacher
发明人： Josef Maier , Dieter Mangold , Reiner Schlipfenbacher
IPC分类号： B01J20/281 , C07K14/76 , C07K16/00 , C07K17/08 , C07K17/10 , G01N30/88 , G01N33/543 , C07K3/18 , C07K17/02 , C07K17/12
CPC分类号： G01N33/543 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815 , Y10S530/817
摘要： The present invention provides a process for immobilizing a protein or protein containing substance. The material to be immobilized is aggregated, contacted in a liquid with a hydrophilic solid phase and the solid phase, after contact has taken place, is dried. The present invention is also concerned with the solid phase prepared by this process and with the use thereof for analytical determination.
摘要翻译：本发明提供一种固定含有蛋白质或蛋白质的物质的方法。要固定的材料在接触发生后被聚集，在具有亲水性固相的液体中并且固相被干燥。本发明还涉及通过该方法制备的固相及其用于分析测定的用途。

6. 发明授权

US5118609A Carrier fleece for use as a reagent carrier from which reagents can be dissolved in immunological analysis 失效
标题翻译：作为试剂载体的携带者可以从免疫分析中分离出试剂
公开(公告)号：US5118609A
公开(公告)日：1992-06-02
申请号：US648685
申请日：1991-01-31
申请人： Manfred Baier , Helmut Jering , Rolf Lerch , Dieter Mangold , Ellen Mossner , Gunter Pappert , Siegfried Notzel
发明人： Manfred Baier , Helmut Jering , Rolf Lerch , Dieter Mangold , Ellen Mossner , Gunter Pappert , Siegfried Notzel
IPC分类号： C07K1/16 , C07K16/00 , C07K17/10 , C12Q1/00 , C12Q1/34 , D04H1/54 , D04H1/58 , D21H11/12 , D21H13/08 , D21H13/16 , D21H13/24 , D21H13/26 , D21H17/34 , D21H17/36 , D21H17/37 , D21H17/39 , G01N33/545 , G01N33/548
CPC分类号： D21H17/34 , G01N33/545 , D21H11/12 , D21H13/08 , D21H13/16 , D21H13/24 , D21H13/26 , D21H17/36 , D21H17/37 , D21H17/39 , Y10S435/805 , Y10S435/97 , Y10S530/814 , Y10S530/815
摘要： A carrier fleece is prepared for use as reagent carrier from which reagents can be dissolved in as assay such as immunological analysis. The carrier fleece contains from 5 to 60% by weight of cellulose-containing fibers, from 40 to 95% by weight of polyester or polyamide polymer fibers or a combination thereof and from 5 to 30% by weight of the fibers of an organic binding agent which has a hydroxyl or an ester group or a combination thereof. In an immunological analysis, the carrier fleece is impregnated with an immunologically active agent such as a beta-galactosidase conjugate and then introduced into a solution of a sample containing an immunologically active substance to be analyzed. The immunologically active agent is eluted into the sample solution and the presence of the immunologically active substance in the sample is determined.
摘要翻译：制备载体羊毛作为试剂载体，试剂可以作为试剂溶解，如免疫分析。载体绒毛含有5至60重量％的含纤维素的纤维，40至95重量％的聚酯或聚酰胺聚合物纤维或其组合，和5至30重量％的有机粘合剂的纤维其具有羟基或酯基或其组合。在免疫学分析中，载体羊毛用免疫活性剂例如β-半乳糖苷酶缀合物浸渍，然后引入含有待分析的免疫活性物质的样品的溶液中。将免疫活性剂洗脱到样品溶液中，并测定样品中免疫活性物质的存在。

7. 发明申请

US20110194980A1 Process For Hydrophilizing Surfaces Of Fluidic Components And Systems 有权
标题翻译：流体组分和系统的亲水化表面的方法
公开(公告)号：US20110194980A1
公开(公告)日：2011-08-11
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N30/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

8. 发明授权

US08202490B2 Membranes and methods for coating membranes 有权
标题翻译：膜和膜的涂覆方法
公开(公告)号：US08202490B2
公开(公告)日：2012-06-19
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： B01L3/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

9. 发明授权

US5177022A Immune reactive porous carrier material 失效
标题翻译：免疫反应性多孔载体材料
公开(公告)号：US5177022A
公开(公告)日：1993-01-05
申请号：US236458
申请日：1988-08-25
申请人： Dieter Mangold , Siegfried Noetzel , Rolf Lerch , Jelmut Jering
发明人： Dieter Mangold , Siegfried Noetzel , Rolf Lerch , Jelmut Jering
IPC分类号： A61K39/00 , C07K16/00 , C07K17/12 , G01N33/543 , G01N33/78
CPC分类号： G01N33/54393 , G01N33/54386 , G01N33/78
摘要： The present invention provides an immune reactive porous carrier material comprising a porous carrier material with immune complexes precipitated thereon, wherein the porous carrier material is treated with at least one wet-strength agent.The present invention also provides processes for the production of this immune reactive porous carrier material.
摘要翻译：本发明提供一种免疫反应性多孔载体材料，其包含其上沉淀有免疫复合物的多孔载体材料，其中所述多孔载体材料用至少一种湿强度剂处理。本发明还提供了生产这种免疫反应性多孔载体材料的方法。

10. 发明授权

US07955563B2 Methods for applying reactive films containing solids to microporous membranes and membranes produced therefrom 有权
标题翻译：将含有固体的活性膜施加到微孔膜的方法和由其制备的膜
公开(公告)号：US07955563B2
公开(公告)日：2011-06-07
申请号：US11758804
申请日：2007-06-06
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N27/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式制备的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

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