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1. 发明授权

EP2914341B1 NON-INVASIVE LUNG PACING 有权
公开(公告)号：EP2914341B1
公开(公告)日：2020-04-15
申请号：EP13795909.4
申请日：2013-11-05
申请人： Regents of the University of Minnesota , Paul, Saurav
发明人： CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
IPC分类号： A61N7/00 , A61B8/00

2. 发明公开

EP2914341A1 NON-INVASIVE LUNG PACING 有权
标题翻译：无创隆起搏
公开(公告)号：EP2914341A1
公开(公告)日：2015-09-09
申请号：EP13795909.4
申请日：2013-11-05
申请人： Regents of the University of Minnesota , Paul, Saurav
发明人： CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
IPC分类号： A61N7/00
摘要： A system for diaphragmatic pacing includes an ultrasonic transducer and a control module. The ultrasonic transducer has an emitting surface. The emitting surface is configured to couple with a tissue of a patient. The transducer is configured to transdermally emit ultrasonic energy and induce movement in a thoracic diaphragm of the patient in response thereto. The control module is coupled to the transducer and has a processor. The processor is configured to execute an algorithm to control operation of the transducer.

3. 发明申请

WO2014071386A1 NON-INVASIVE LUNG PACING 审中-公开
标题翻译：非入侵式肺活检
公开(公告)号：WO2014071386A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068538
申请日：2013-11-05
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
发明人： CABRERA, Jesus Arturo , BALLARD, John R. , KROCAK, James C. , PAUL, Saurav
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/4281 , A61B2018/00839 , A61H31/00 , A61H2031/002 , A61H2230/405 , A61N2007/0026 , A61N2007/0078 , A61N2007/0095
摘要： A system for diaphragmatic pacing includes an ultrasonic transducer and a control module. The ultrasonic transducer has an emitting surface. The emitting surface is configured to couple with a tissue of a patient. The transducer is configured to transdermally emit ultrasonic energy and induce movement in a thoracic diaphragm of the patient in response thereto. The control module is coupled to the transducer and has a processor. The processor is configured to execute an algorithm to control operation of the transducer.
摘要翻译：用于膈肌起搏的系统包括超声换能器和控制模块。超声波换能器具有发射表面。发射表面被配置为与患者的组织联接。换能器被配置为经皮发射超声波能量并且响应于该能量诱导患者的胸膜中的运动。控制模块耦合到换能器并具有处理器。处理器被配置为执行算法来控制换能器的操作。

4. 发明申请

WO2015153427A1 SYSTEMS AND METHODS FOR ELECTRICAL STIMULATION OF THE GASTROINTESTINAL TRACT FOR TREATMENT OF POST-OPERATIVE ILEUS 审中-公开
标题翻译：用于治疗术后ILEUS的胃肠手术电刺激的系统和方法
公开(公告)号：WO2015153427A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/023286
申请日：2015-03-30
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： PAULSEN, Laura , KROCAK, James , CABRERA, Jesus , RIZQ, Raed , KONETY, Badrinath , PAUL, Saurav
IPC分类号： A61N1/36
CPC分类号： A61H9/0007 , A61H2201/0103 , A61M1/008 , A61M25/10 , A61M2025/105 , A61M2210/1042 , A61M2230/005 , A61M2230/08 , A61M2230/20 , A61M2230/63 , A61N1/0509 , A61N1/36007
摘要： The present disclosure is directed to a medical instrument. Systems and methods are provided for stimulation of the gastrointestinal tract. The medical instrument may include an elongate component having a proximal end and a distal end. The medical instrument may be configured for insertion in a natural orifice of a patient and to traverse the gastrointestinal tract of the patient. The medical instrument may include a handle at the proximal end and a stimulator at the distal end wherein the stimulator may be configured to stimulate the gastrointestinal tract to effect coordination of peristaltic waves.
摘要翻译：本公开涉及医疗器械。提供了用于刺激胃肠道的系统和方法。医疗器械可以包括具有近端和远端的细长部件。医疗器械可以被配置为插入患者的自然孔中并穿过患者的胃肠道。医疗器械可以包括在近端处的手柄和在远端处的刺激器，其中刺激器可以被配置成刺激胃肠道以实现蠕动波的协调。

5. 发明公开

EP3125992A1 SYSTEMS AND METHODS FOR ELECTRICAL STIMULATION OF THE GASTROINTESTINAL TRACT FOR TREATMENT OF POST-OPERATIVE ILEUS 审中-公开
标题翻译：电刺激系统和方法消化道术后肠闭包的处理
公开(公告)号：EP3125992A1
公开(公告)日：2017-02-08
申请号：EP15716326.2
申请日：2015-03-30
申请人： Regents of the University of Minnesota
发明人： PAULSEN, Laura , KROCAK, James , CABRERA, Jesus , RIZQ, Raed , KONETY, Badrinath , PAUL, Saurav
IPC分类号： A61N1/36
CPC分类号： A61H9/0007 , A61H2201/0103 , A61M1/008 , A61M25/10 , A61M2025/105 , A61M2210/1042 , A61M2230/005 , A61M2230/08 , A61M2230/20 , A61M2230/63 , A61N1/0509 , A61N1/36007
摘要： The present disclosure is directed to a medical instrument. Systems and methods are provided for stimulation of the gastrointestinal tract. The medical instrument may include an elongate component having a proximal end and a distal end. The medical instrument may be configured for insertion in a natural orifice of a patient and to traverse the gastrointestinal tract of the patient. The medical instrument may include a handle at the proximal end and a stimulator at the distal end wherein the stimulator may be configured to stimulate the gastrointestinal tract to effect coordination of peristaltic waves.
摘要翻译：本发明涉及一种医疗器械。提供了对胃肠道的刺激作用的系统和方法。所述医疗器械可以包括在具有近端和远端的细长部件。所述医疗器械可以被配置用于插入到患者的自然孔口，并穿过患者的胃肠道中。所述医疗器械可以包括在近端处的手柄，并在worin刺激可以被配置为刺激胃肠道，以实现蠕动波的协调远端刺激剂。

6. 发明申请

WO2011072221A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 审中-公开
标题翻译：系统和方法，用于确定组织中骨髓间充质干细胞
公开(公告)号：WO2011072221A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059884
申请日：2010-12-10
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
发明人： FISH, Jeffrey , BYRD, Israel , CLARK, Lynn , DANDO, Jeremy , GEURKINK, Christopher , LATHIA, Rohan , PURYEAR, Harry , AFONSO, Valtino , PAUL, Saurav
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system (10) for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system (10) includes an electronic control unit (ECU) (34). The ECU (34) is configured to acquire at least one value of at least one component of a complex impedance between an electrode (16) and the tissue (12). The ECU (34) is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue (12).
摘要翻译：提供了一种用于在其中形成病变期间确定在组织中发生的气压伤的可能性的方法和系统（10）。系统（10）包括电子控制单元（ECU）（34）。 ECU（34）被配置为获取电极（16）和组织（12）之间的复阻抗的至少一个分量的至少一个值。 ECU（34）还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织（12）中发生气压伤的可能性。

7. 发明申请

WO2010078196A1 FAST-ACTING OR ROTATING TRANSSEPTAL NEEDLE 审中-公开
标题翻译：快速或旋转传递针
公开(公告)号：WO2010078196A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069433
申请日：2009-12-23
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
发明人： PAUL, Saurav , STANGENES, Todd, Raymond , HEIMBECHER, Reed, R.
IPC分类号： A61B17/00
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

8. 发明申请

WO2008083123A1 DESIGN OF ABLATION ELECTRODE WITH TACTILE SENSOR 审中-公开
标题翻译：消除电极与触觉传感器的设计
公开(公告)号：WO2008083123A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088729
申请日：2007-12-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , CAO, Hong , THAO, Chou , PAUL, Saurav
发明人： CAO, Hong , THAO, Chou , PAUL, Saurav
IPC分类号： A61B5/04
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

9. 发明申请

WO2007070361A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
标题翻译：电器联合电击组织评估
公开(公告)号：WO2007070361A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046816
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , THAO, Chou
IPC分类号： A61N1/378
CPC分类号： A61N1/40 , A61B2018/00357 , A61B2018/00875
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

10. 发明申请

WO2007067943A2 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067943A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/061716
申请日：2006-12-06
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
发明人： PAUL, Saurav , CAO, Hong , BEHLE, Kedar, Ravindra , THAO, Chou
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

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