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1. 发明申请

US20090274348A1 IMMUNODIAGNOSTIC TEST APPARATUS HAVING AT LEAST ONE IMAGER TO PROVIDE AGGLUTINATION EVALUATIONS DURING CENTRIFUGRATION CYCLE 审中-公开
标题翻译：具有至少一个成像器的免疫测试装置在离心循环期间提供AGAGUTINATION评估
公开(公告)号：US20090274348A1
公开(公告)日：2009-11-05
申请号：US12112343
申请日：2008-04-30
申请人： Raymond F. Jakubowicz , Donald J. Moran, JR. , Michael L. Dee , Joseph M. Chiapperi , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Donald J. Moran, JR. , Michael L. Dee , Joseph M. Chiapperi , Mark Sawczuk
IPC分类号： G06K9/78
CPC分类号： G01N33/5304 , G01N35/025 , G01N2015/0092 , G01N2035/00495 , G01N2035/0097 , G01N2035/0436
摘要： An immunodiagnostic testing apparatus includes a centrifuge and an imager disposed in relation to the centrifuge wherein at least one image is captured of at least one test element in advance of a complete centrifugation period in order to provide predictive data concerning the presence of an agglutination reaction or failure mode of the apparatus or test element.
摘要翻译：免疫诊断测试装置包括离心机和相对于离心机设置的成像器，其中至少一个图像在完全离心时间段之前被捕获至少一个测试元件，以便提供关于凝集反应的存在的预测数据，或者设备或测试元件的故障模式。

2. 发明申请

US20120094368A1 SPLIT SPIN CENTRIFUGATION OF TEST ELEMENTS 有权
标题翻译：测试元素的分离旋转离心
公开(公告)号：US20120094368A1
公开(公告)日：2012-04-19
申请号：US13323422
申请日：2011-12-12
申请人： Michael L. Dee , Donald J. Moran, JR. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
发明人： Michael L. Dee , Donald J. Moran, JR. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
IPC分类号： C12M1/34 , G01N33/536
CPC分类号： G01N35/0095 , G01N2035/00495
摘要： High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.
摘要翻译：批次样品的高通量离心是通过将一批样品的单次离心流程分成两个或更多个交错的离散旋转而获得的，样品数量较少，其中可用于装载或卸载样品的离心机槽以及随后的传送的实验结果可以提高。该方法在多个样品需要快速处理的情况下特别有用，例如作为输血前紧急护理设施中STAT血液分型程序的一部分。

3. 发明申请

US20090275458A1 SPLIT SPIN CENTRIFUGATION OF TEST ELEMENTS 有权
标题翻译：测试元素的分离旋转离心
公开(公告)号：US20090275458A1
公开(公告)日：2009-11-05
申请号：US12114375
申请日：2008-05-02
申请人： Michael L. Dee , Donald J. Moran, JR. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
发明人： Michael L. Dee , Donald J. Moran, JR. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
IPC分类号： B01D21/26 , B04B7/08
CPC分类号： G01N35/0095 , G01N2035/00495
摘要： High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.
摘要翻译：批次样品的高通量离心是通过将一批样品的单次离心流程分成两个或更多个交错的离散旋转而获得的，样品数量较少，其中可用于装载或卸载样品的离心机槽以及随后的传送的实验结果可以提高。该方法在多个样品需要快速处理的情况下特别有用，例如作为输血前紧急护理设施中STAT血液分型程序的一部分。

4. 发明授权

US08226536B2 Split spin centrifugation of test elements 有权
标题翻译：分离旋转离心试验元件
公开(公告)号：US08226536B2
公开(公告)日：2012-07-24
申请号：US13323422
申请日：2011-12-12
申请人： Michael L. Dee , Donald J. Moran, Jr. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
发明人： Michael L. Dee , Donald J. Moran, Jr. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
IPC分类号： B04B13/00
CPC分类号： G01N35/0095 , G01N2035/00495
摘要： High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.
摘要翻译：批次样品的高通量离心是通过将一批样品的单次离心流程分成两个或更多个交错的离散旋转而获得的，样品数量较少，其中可用于装载或卸载样品的离心机槽以及随后的传送的实验结果可以提高。该方法在多个样品需要快速处理的情况下特别有用，例如作为输血前紧急护理设施中STAT血液分型程序的一部分。

5. 发明授权

US08092361B2 Split spin centrifugation of test elements 有权
公开(公告)号：US08092361B2
公开(公告)日：2012-01-10
申请号：US12114375
申请日：2008-05-02
申请人： Michael L. Dee , Donald J. Moran, Jr. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
发明人： Michael L. Dee , Donald J. Moran, Jr. , Mark Sawczuk , William G. Atterbury , Michael L. Marshall , Douglas E. Boyd
IPC分类号： B01D21/26
CPC分类号： G01N35/0095 , G01N2035/00495
摘要： High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.

6. 发明申请

US20100015726A1 SINGLE COLUMN IMMUNOLOGICAL TEST ELEMENTS 有权
标题翻译：单列免疫测试元素
公开(公告)号：US20100015726A1
公开(公告)日：2010-01-21
申请号：US12175590
申请日：2008-07-18
申请人： Raymond F. Jakubowicz , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Mark Sawczuk
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： B01J19/0046 , B01L3/021 , B01L9/523 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0825 , B01L2300/0829 , B01L2300/0841 , B01L2400/0409 , G01N35/025 , Y10S436/809
摘要： A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
摘要翻译：提供多个单独的单柱测试元件用于临床测试设备。每个测试元件由单个测试柱定义，其包括一定量的测试材料，例如凝胶材料或珠粒矩阵，包括用于访问测试柱的内容物的盖带。可以存储，保留和分配个别测试元素，以测试患者样品。

7. 发明授权

US09052297B2 Single column immunological test elements 有权
标题翻译：单柱免疫测试元件
公开(公告)号：US09052297B2
公开(公告)日：2015-06-09
申请号：US13305086
申请日：2011-11-28
申请人： Raymond F. Jakubowicz , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Mark Sawczuk
IPC分类号： G01N35/02 , G01N33/538 , B01L3/02 , B01L9/00
CPC分类号： B01J19/0046 , B01L3/021 , B01L9/523 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0825 , B01L2300/0829 , B01L2300/0841 , B01L2400/0409 , G01N35/025 , Y10S436/809
摘要： A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
摘要翻译：提供多个单独的单柱测试元件用于临床测试设备。每个测试元件由单个测试柱定义，其包括一定量的测试材料，例如凝胶材料或珠粒矩阵，包括用于访问测试柱的内容物的盖带。可以存储，保留和分配个别测试元素，以测试患者样品。

8. 发明授权

US08076126B2 Single column immunological test elements 有权
标题翻译：单柱免疫测试元件
公开(公告)号：US08076126B2
公开(公告)日：2011-12-13
申请号：US12175590
申请日：2008-07-18
申请人： Raymond F. Jakubowicz , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Mark Sawczuk
IPC分类号： C12M1/34
CPC分类号： B01J19/0046 , B01L3/021 , B01L9/523 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0825 , B01L2300/0829 , B01L2300/0841 , B01L2400/0409 , G01N35/025 , Y10S436/809
摘要： A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
摘要翻译：提供多个单独的单柱测试元件用于临床测试设备。每个测试元件由单个测试柱定义，其包括一定量的测试材料，例如凝胶材料或珠粒矩阵，包括用于访问测试柱的内容物的盖带。可以存储，保留和分配个别测试元素，以测试患者样品。

9. 发明申请

US20120071345A1 SINGLE COLUMN IMMUNOLOGICAL TEST ELEMENTS 有权
标题翻译：单列免疫测试元素
公开(公告)号：US20120071345A1
公开(公告)日：2012-03-22
申请号：US13305086
申请日：2011-11-28
申请人： Raymond F. Jakubowicz , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Mark Sawczuk
IPC分类号： C40B30/04
CPC分类号： B01J19/0046 , B01L3/021 , B01L9/523 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0825 , B01L2300/0829 , B01L2300/0841 , B01L2400/0409 , G01N35/025 , Y10S436/809
摘要： A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
摘要翻译：提供多个单独的单柱测试元件用于临床测试设备。每个测试元件由单个测试柱定义，其包括一定量的测试材料，例如凝胶材料或珠粒矩阵，包括用于访问测试柱的内容物的盖带。可以存储，保留和分配个别测试元素，以测试患者样品。

10. 发明授权

US07634367B1 Estimating fluidic properties and using them to improve the precision/accuracy of metered fluids and to improve the sensitivity/specificity in detecting failure modes 有权
标题翻译：估计流体性质并使用它们来提高计量流体的精确度和精度，并提高检测失效模式的灵敏度/特异性
公开(公告)号：US07634367B1
公开(公告)日：2009-12-15
申请号：US11484115
申请日：2006-07-11
申请人： Zhong Ding , Mark Sawczuk , Scott Stearns
发明人： Zhong Ding , Mark Sawczuk , Scott Stearns
IPC分类号： G01F11/00 , G06F19/00 , G01F22/00 , G01F22/02 , G01F25/00
CPC分类号： G01F22/00
摘要： A method for improving the accuracy or precision of a metered fluid includes: estimating a fluidic property of the fluid being metered; and adjusting one or more control parameters based on the estimated property to improve the accuracy or precision of a metered fluid. Preferably, the estimating the property of the fluid being metered includes: monitoring a physical event during the metering operation to collect sensed data; extracting features from the sensed data; and using the features to estimate fluid properties. In another preferred embodiment, the estimated fluidic property is viscosity and the sensed data is a pressure profile during a fluid aspiration. In another preferred embodiment, the method includes a diagnostic analyzer which includes a metering probe having a hard probe or a probe having a disposable tip and wherein the fluid is a body fluid sample. Another method includes: estimating a fluidic property of the fluid being metered; and adjusting one or more control parameters or thresholds that determine when an error is flagged based on the estimated property to improve the detection of the failure.
摘要翻译：一种用于提高计量流体的精度或精度的方法包括：估计要计量的流体的流体性质; 以及基于估计的性质来调整一个或多个控制参数，以提高计量流体的精度或精度。优选地，估计要计量的流体的性质包括：在计量操作期间监测物理事件以收集感测数据; 从感测数据中提取特征; 并使用特征来估计流体特性。在另一个优选实施例中，估计的流体性质是粘度，并且感测数据是在流体抽吸期间的压力分布。在另一个优选实施例中，该方法包括诊断分析器，其包括具有硬探针的测量探针或具有一次性尖端的探针，并且其中所述流体是体液样品。另一种方法包括：估计要计量的流体的流体性质; 以及调整一个或多个控制参数或阈值，所述控制参数或阈值基于所估计的属性来确定错误何时被标记，以改善故障的检测。

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