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1. 发明授权

US06310337B1 Method of preselecting flashlamp voltages for assays 失效
标题翻译：预先选择用于测定的闪光灯电压的方法
公开(公告)号：US06310337B1
公开(公告)日：2001-10-30
申请号：US09366247
申请日：1999-08-03
申请人： Joseph M. Chiapperi , Donald M. Josephson , Stuart G. MacDonald
发明人： Joseph M. Chiapperi , Donald M. Josephson , Stuart G. MacDonald
IPC分类号： G01J132
CPC分类号： G01J3/10 , G01N21/274 , G01N2021/3174 , G01N2201/0694 , G01N2201/1241 , G01N2201/12776
摘要： A method of detecting an optical change in a series of test assays producing detectable results at varying efficiencies, the method comprising the steps of: a) selecting a test assay from the series, the selected assay having a known end-point photoresponse efficiency and a known filter center wavelength; b) providing a variable-intensity flash lamp illuminator comprising a lamp, a set of multiple filters with pre-selected center wavelengths assigned to particular assays, and a circuit for activating the lamp and comprising a capacitor, a power source, and a variable output voltage converter connected to the source and having its variable voltage output connected across the capacitor, the lamp and the filters providing a known level of system efficiency as a function of the center wavelength of the filter; c) providing a predetermined relationship of levels of illuminating intensities from the lamp as a function of photoresponse efficiencies of the assays and the system efficiencies, in which the photoresponse efficiencies of the assays are inversely proportional to the lamp intensities and the intensities are proportional to the square of the voltages applied to the lamp; d) selecting from the relationship a voltage applied to the lamp, and hence an intensity of the lamp, that corresponds to the known photoresponse efficiency of the assay selected in step (a) and its system efficiency based upon the filter center wavelength for the assay; and e) thereafter exposing the assay to the selected illuminating intensity.
摘要翻译：一种检测一系列测试测定中的光学变化的方法，其以不同的效率产生可检测的结果，所述方法包括以下步骤：a）从该系列中选择测试测定，所选择的测定具有已知的终点光响应效率和已知滤波器中心波长; b）提供可变强度的闪光灯照明器，其包括灯，一组具有分配给特定测定的预选中心波长的多个滤光器，以及用于激活灯的电路，并且包括电容器，电源和可变输出电压转换器连接到源极并且具有连接在电容器两端的可变电压输出，灯和滤波器提供作为滤波器的中心波长的函数的已知的系统效率水平; c）提供来自灯的照明强度水平的预定关系作为测定的光响应效率和系统效率的函数，其中测定的光响应效率与灯的强度成反比，并且强度与施加到灯的电压的平方; d）从所述关系中选择对应于步骤（a）中选择的测定的已知光响应效率的灯施加的电压，并因此选择灯的强度，并且基于用于测定的滤波器中心波长的系统效率 ; 和e）然后将测定暴露于所选择的照射强度。

2. 发明申请

US20090191641A1 IMMUNODIAGNOSTIC TEST CARDS HAVING INDICATING INDICIA 有权
标题翻译：具有指示性的IMMUNODIAGNOSTIC测试卡
公开(公告)号：US20090191641A1
公开(公告)日：2009-07-30
申请号：US12022349
申请日：2008-01-30
申请人： Joseph M. Chiapperi , Mary Kay Golisano
发明人： Joseph M. Chiapperi , Mary Kay Golisano
IPC分类号： G01N33/86 , B28B11/00
CPC分类号： B01L3/5025 , B01L2200/143 , B01L2300/028 , B01L2400/0409 , G01N33/5304 , Y10S436/809 , Y10T436/25
摘要： An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
摘要翻译：免疫诊断测试卡包括多个透明室，其中每个室包括与混合的患者样品组合的一定数量的测试材料以产生凝集反应。设置多个标记以帮助制造和确定试验前卡的可用性，并且还客观地分级形成的凝集反应或不凝集。

3. 发明授权

US08211365B2 Immunodiagnostic test cards having indicating indicia 有权
标题翻译：具有指示标记的免疫诊断测试卡
公开(公告)号：US08211365B2
公开(公告)日：2012-07-03
申请号：US13270758
申请日：2011-10-11
申请人： Joseph M. Chiapperi , Mary Kay Golisano
发明人： Joseph M. Chiapperi , Mary Kay Golisano
IPC分类号： G01N21/03 , G01N33/86
CPC分类号： B01L3/5025 , B01L2200/143 , B01L2300/028 , B01L2400/0409 , G01N33/5304 , Y10S436/809 , Y10T436/25
摘要： An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
摘要翻译：免疫诊断测试卡包括多个透明室，其中每个室包括与混合的患者样品组合的一定数量的测试材料以产生凝集反应。设置多个标记以帮助制造和确定试验前卡的可用性，并且还客观地分级形成的凝集反应或不凝集。

4. 发明申请

US20120028344A1 IMMUNODIAGNOSTIC TEST CARDS HAVING INDICATING INDICIA 有权
标题翻译：具有指示性的IMMUNODIAGNOSTIC测试卡
公开(公告)号：US20120028344A1
公开(公告)日：2012-02-02
申请号：US13270758
申请日：2011-10-11
申请人： Joseph M. Chiapperi , Mary Kay Golisano
发明人： Joseph M. Chiapperi , Mary Kay Golisano
IPC分类号： C12M1/34 , G01N21/00
CPC分类号： B01L3/5025 , B01L2200/143 , B01L2300/028 , B01L2400/0409 , G01N33/5304 , Y10S436/809 , Y10T436/25
摘要： An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
摘要翻译：免疫诊断测试卡包括多个透明室，其中每个室包括与混合的患者样品组合的一定数量的测试材料以产生凝集反应。设置多个标记以帮助制造和确定试验前卡的可用性，并且还客观地分级形成的凝集反应或不凝集。

5. 发明授权

US08058073B2 Immunodiagnostic test cards having indicating indicia 有权
标题翻译：具有指示标记的免疫诊断测试卡
公开(公告)号：US08058073B2
公开(公告)日：2011-11-15
申请号：US12022349
申请日：2008-01-30
申请人： Joseph M. Chiapperi , Mary Kay Golisano
发明人： Joseph M. Chiapperi , Mary Kay Golisano
IPC分类号： G01N21/03 , G01N33/86
CPC分类号： B01L3/5025 , B01L2200/143 , B01L2300/028 , B01L2400/0409 , G01N33/5304 , Y10S436/809 , Y10T436/25
摘要： An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
摘要翻译：免疫诊断测试卡包括多个透明室，其中每个室包含与混合的患者样品组合的一定量的测试材料以产生凝集反应。设置多个标记以帮助制造和确定试验前卡的可用性，并且还客观地分级形成的凝集反应或不凝集。

6. 发明申请

US20090274348A1 IMMUNODIAGNOSTIC TEST APPARATUS HAVING AT LEAST ONE IMAGER TO PROVIDE AGGLUTINATION EVALUATIONS DURING CENTRIFUGRATION CYCLE 审中-公开
标题翻译：具有至少一个成像器的免疫测试装置在离心循环期间提供AGAGUTINATION评估
公开(公告)号：US20090274348A1
公开(公告)日：2009-11-05
申请号：US12112343
申请日：2008-04-30
申请人： Raymond F. Jakubowicz , Donald J. Moran, JR. , Michael L. Dee , Joseph M. Chiapperi , Mark Sawczuk
发明人： Raymond F. Jakubowicz , Donald J. Moran, JR. , Michael L. Dee , Joseph M. Chiapperi , Mark Sawczuk
IPC分类号： G06K9/78
CPC分类号： G01N33/5304 , G01N35/025 , G01N2015/0092 , G01N2035/00495 , G01N2035/0097 , G01N2035/0436
摘要： An immunodiagnostic testing apparatus includes a centrifuge and an imager disposed in relation to the centrifuge wherein at least one image is captured of at least one test element in advance of a complete centrifugation period in order to provide predictive data concerning the presence of an agglutination reaction or failure mode of the apparatus or test element.
摘要翻译：免疫诊断测试装置包括离心机和相对于离心机设置的成像器，其中至少一个图像在完全离心时间段之前被捕获至少一个测试元件，以便提供关于凝集反应的存在的预测数据，或者设备或测试元件的故障模式。

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