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1. 发明申请

WO2004003549A2 AUTOMATISCHE UNTERSCHEIDUNG VON PROBEN- UND KONTROLLFLÜSSIGKEIT 审中-公开
标题翻译：样品和控制流体的自动分离
公开(公告)号：WO2004003549A2
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006613
申请日：2003-06-24
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , FREY, Guenter , HORN, Carina , GAA, Otto , KINTZIG, Hans , MURAWSKI, Hans-Ruediger
发明人： FREY, Guenter , HORN, Carina , GAA, Otto , KINTZIG, Hans , MURAWSKI, Hans-Ruediger
IPC分类号： G01N33/50
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/25
摘要： Die Erfindung betrifft ein Verfahren zur automatischen Unterscheidung zwischen einer Probenflüssigkeit und einer Kontrollflüssigkeit, insbesondere im Zusammenhang mit analytischen Messsystemen, wobei zur Unterscheidung das Vorhandensein einer speziellen Eigenschaft der Kontrollflüssigkeit und/oder zumindest zwei Kriterien herangezogen werden. Weiterhin betrifft die Erfindung entsprechende, für das neue Verfahren geeignete Kontrollflüssigkeiten.
摘要翻译：本发明涉及一种用于自动区分样品液体和对照液体的方法，特别是与分析测量系统有关的方法，其中为了区分对照液体的特殊性质的存在和/或至少使用两个标准。此外，本发明涉及适用于新工艺的相应控制液体

2. 发明申请

WO2013131885A1 COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 审中-公开
标题翻译：兼容的溶解性ECTOINE作为其稳定酶的衍生物
公开(公告)号：WO2013131885A1
公开(公告)日：2013-09-12
申请号：PCT/EP2013/054351
申请日：2013-03-05
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHEMNITIUS, Gabriele , GAA, Otto , NAGEL, Thomas , RECHT, Karl
发明人： CHEMNITIUS, Gabriele , GAA, Otto , NAGEL, Thomas , RECHT, Karl
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N2333/902
摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.
摘要翻译：本发明涉及维持和保存酶活性的方法和方法。特别地，本发明涉及一种干组合物，其包含脱氢酶，氧化还原辅因子，能够在氧化还原当量存在下引发指示剂的光学性质的至少一种光学变化的试剂，指示剂试剂和至少一种相容的溶质是ectoine或其衍生物。本发明进一步考虑了用于确定来自体液样品的分析物的诊断测试元件以及用于制造这种测试元件的方法。本发明进一步设想的是使用如上所述的至少一种相容性溶质来减少干燥条件下组合物中至少一种酶的酶活性的降低。此外，预期的是基于根据本发明的测试元件来确定体液样品中存在或量的分析物的方法。

3. 发明申请

WO2014180939A1 STABILIZATION OF ENZYMES BY NICOTINIC ACID 审中-公开
标题翻译：由尼古丁酸稳定酶
公开(公告)号：WO2014180939A1
公开(公告)日：2014-11-13
申请号：PCT/EP2014/059418
申请日：2014-05-08
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl
发明人： CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl
IPC分类号： C12Q1/00 , C12Q1/32 , C12N9/96 , G01N33/52
CPC分类号： C12N9/96 , C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Y101/01 , C12Y101/9901 , G01N33/523 , G01N33/526 , G01N2333/904
摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one measurable change in a property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one pyridine-carboxylic acid or a derivative or salt thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of a pyridine-carboxylic acid or a derivative thereof for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry and/or under humid conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.
摘要翻译：本发明涉及维持和保存酶活性的方法和方法。特别地，本发明涉及一种干组合物，其包含脱氢酶，氧化还原辅因子，能够在氧化还原当量存在下引发指示剂特性的至少一个可测量变化的试剂，指示剂试剂和至少一种吡啶羧酸或其衍生物或盐。本发明进一步考虑了用于确定来自体液样品的分析物的诊断测试元件以及用于制造这种测试元件的方法。本发明进一步设想的是使用吡啶羧酸或其衍生物在干燥和/或潮湿条件下减少组合物中至少一种酶的酶活性降低。此外，预期的是基于根据本发明的测试元件来确定体液样品中存在或量的分析物的方法。

4. 发明申请

WO2014037462A1 METHOD AND DEVICE FOR DETERMINING SAMPLE APPLICATION 审中-公开
标题翻译：用于确定样品应用的方法和装置
公开(公告)号：WO2014037462A1
公开(公告)日：2014-03-13
申请号：PCT/EP2013/068401
申请日：2013-09-05
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ALBRECHT, Gertrud , GAA, Otto , LORENZ, Robert , RUECKERT, Frank
发明人： ALBRECHT, Gertrud , GAA, Otto , LORENZ, Robert , RUECKERT, Frank
IPC分类号： G01N21/84
CPC分类号： G01N33/66 , G01N21/8483 , Y10T436/144444
摘要： The invention concerns a method and a device for determining sample application on an analytical test element in a photometric reflectance measuring device (10) specifically for glucose measurements, where the following measures are proposed: providing a disposable test element (12) for application of a body fluid sample, taking a sequence of reflectance readings from the test element (12), monitoring a change of the reflectance readings with respect to a sample application condition, adjusting the sample application condition in accordance with a drift correction. A value for drift correction of the reflectance readings caused by ambient measurement conditions, specifically, humidity, temperature, or UV radiation can be considered in a predefined signal decrease or in a predefined signal threshold for adjusting the sample application condition.
摘要翻译：本发明涉及一种用于确定专门用于葡萄糖测量的光度反射测量装置（10）中的分析测试元件上的样品应用的方法和装置，其中提出以下措施：提供一次性测试元件（12），用于施加体液样品，从测试元件（12）获取一系列反射读数，监测相对于样品施加条件的反射读数的变化，根据漂移校正调整样品施加条件。在环境测量条件（特别是湿度，温度或UV辐射）引起的反射率读数的漂移校正值可以在预定义的信号减小或用于调整样品施加条件的预定信号阈值中考虑。

5. 发明申请

WO2010108833A1 MEDIZINISCHES SYSTEM MIT PLUG-AND-PLAY-FUNKTION 审中-公开
标题翻译：带插头和播放功能的医疗系统
公开(公告)号：WO2010108833A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053459
申请日：2010-03-17
申请人： ROCHE DIAGNOSTICIS GMBH , F. HOFFMANN-LA ROCHE AG , RÖSICKE, Bernd , BERNINI, Nicole , BUCK, Harvey , FROECH, Sybille , GAA, Otto , MARQUANT, Michael , RASCH-MENGES, Jürgen , SCHERER, Jörg , EBERHART, Andreas
发明人： RÖSICKE, Bernd , BERNINI, Nicole , BUCK, Harvey , FROECH, Sybille , GAA, Otto , MARQUANT, Michael , RASCH-MENGES, Jürgen , SCHERER, Jörg , EBERHART, Andreas
IPC分类号： A61B5/00
CPC分类号： G06F19/3406 , A61B5/0015 , A61B5/0024 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61B5/7271 , A61B5/74 , A61B90/98 , A61B2560/0406 , A61B2560/045 , A61N1/37235 , G06F19/00 , G06F21/32 , G06F21/445 , G16H40/63 , H04L67/12 , H04W4/70 , H04W4/80
摘要： Es wird ein medizinisches System (144) vorgeschlagen, welches insbesondere zur Überwachung und/oder Steuerung mindestens einer Körperfunktion eines Benutzers (122) einsetzbar sein kann. Das medizinische System (144) umfasst eine Steuervorrichtung (142) und mindestens ein von der Steuervorrichtung (142) getrennt ausgebildetes medizinisches Benutzerelement (140). Das medizinische Benutzerelement (140) und die Steuervorrichtung (142) sind eingerichtet, um drahtlos Daten auszutauschen. Das medizinische System (144) ist eingerichtet, um einen automatischen Zuordnungsschritt zu ermöglichen, wobei durch den automatischen Zuordnungs schritt ein Austausch persönlicher Daten zwischen dem medizinischen Benutzerelement (140) und der Steuervorrichtung (142) freigegeben wird. Das medizinische System (144) ist weiterhin eingerichtet, um den automatischen Zuordnungsschritt durch eine Zuordnungskopplung zwischen dem medizinischen Benutzerelement (140) und der Steuervorrichtung (142) automatisch zu initiieren. Das medizinische System (144) ist weiter eingerichtet, um nach dem Zuordnungsschritt eine Trennung der Zuordnungskopplung für einen medizinischen Betrieb des medizinischen Systems (144) zu ermöglichen.
摘要翻译：公开了一种医疗系统（144），其可以特别地用于监测和/或控制用户（122）的至少一个本体功能。该医疗系统（144）包括控制装置（142）和控制装置（142）分别受过训练的医疗用户元件（140）中的至少一个。医疗用户构件（140）和控制装置（142）适用于交换无线数据。该医疗系统（144）被布置为使能自动的分配步骤，其中，通过自动分配步骤中，医疗用户元件（140）和控制装置（142）之间的个人数据交换被释放。该医疗系统（144）还适合于自动地启动通过医疗用户元件（140）和控制装置（142）之间分配耦合的自动匹配步骤。该医疗系统（144）还适于以允许所述分配步骤中，分配耦合的用于医疗系统（144）的医疗手术的分离。

6. 发明公开

EP1520171A2 AUTOMATISCHE UNTERSCHEIDUNG VON PROBEN- UND KONTROLLFL SSIGK EIT 审中-公开
公开(公告)号：EP1520171A2
公开(公告)日：2005-04-06
申请号：EP03761487.2
申请日：2003-06-24
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FREY, Guenter , HORN, Carina , GAA, Otto , KINTZIG, Hans , MURAWSKI, Hans-Ruediger
IPC分类号： G01N33/50
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/25
摘要： The invention relates to a method for automatically differentiating between a sample solution and a control solution, in particular within the context of analytical measuring systems. According to the invention, the differentiation takes place using the existence of a specific characteristic of the control solution and/or at least two criteria. In addition, The invention also relates to corresponding control solutions that are suitable for the novel method.
摘要翻译：本发明涉及用于自动区分样本溶液和对照溶液的方法，特别是在分析测量系统的情况下。根据本发明，使用对照溶液的特定特征的存在和/或至少两个标准来进行分化。另外，本发明还涉及适用于该新颖方法的相应对照解决方案。

7. 发明授权

EP2893328B1 METHOD AND DEVICE FOR DETERMINING SAMPLE APPLICATION 有权转让
标题翻译： VERFAHREN UND VORRICHTUNG ZUR BESTIMMUNG EINER PROBENAUFTRAGUNG
公开(公告)号：EP2893328B1
公开(公告)日：2017-02-22
申请号：EP13758873.7
申请日：2013-09-05
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： ALBRECHT, Gertrud , GAA, Otto , LORENZ, Robert , RUECKERT, Frank
IPC分类号： G01N21/84
CPC分类号： G01N33/66 , G01N21/8483 , Y10T436/144444
摘要： Methods are provided for photometrically determining/detecting sample application to an analytical test element for use with a blood glucose measuring device, where the method includes obtaining a sequence of reflectance readings from the test element with the measuring device, including a blank value prior to sample application, and then monitoring changes of the reflectance readings from the test element with respect to a sample application condition defined by a limit for a reflectance decrease or a reflectance threshold. The methods also can include adjusting the sample application condition in accordance with a drift correction and can include determining an analyte concentration in the body fluid sample. In addition, photometric blood glucose measuring devices are provided that incorporate the methods disclosed herein.
摘要翻译：提供了用于光学测定/检测样品应用于与血糖测量装置一起使用的分析测试元件的方法，其中该方法包括从测试装置获得来自测试元件的反射读数序列，包括样品前的空白值应用，然后监测来自测试元件的反射率读数相对于由反射率降低或反射率阈值的限制定义的样品施加条件的变化。所述方法还可以包括根据漂移校正来调整样品施加条件，并且可以包括确定体液样品中的分析物浓度。此外，提供了结合本文公开的方法的光度血糖测量装置。

8. 发明授权

EP2994536B1 STABILIZATION OF ENZYMES BY NICOTINIC ACID 失效转让
标题翻译：烟碱酸稳定酶
公开(公告)号：EP2994536B1
公开(公告)日：2017-06-14
申请号：EP14722216.0
申请日：2014-05-08
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl , MEIER, Thomas
IPC分类号： C12Q1/00 , C12Q1/32 , C12N9/96 , G01N33/52
CPC分类号： C12N9/96 , C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Y101/01 , C12Y101/9901 , G01N33/523 , G01N33/526 , G01N2333/904

9. 发明公开

EP2893328A1 METHOD AND DEVICE FOR DETERMINING SAMPLE APPLICATION 有权转让
标题翻译：方法和装置用于确定样品应用
公开(公告)号：EP2893328A1
公开(公告)日：2015-07-15
申请号：EP13758873.7
申请日：2013-09-05
申请人： Roche Diagnostics GmbH , F.Hoffmann-La Roche AG
发明人： ALBRECHT, Gertrud , GAA, Otto , LORENZ, Robert , RUECKERT, Frank
IPC分类号： G01N21/84
CPC分类号： G01N33/66 , G01N21/8483 , Y10T436/144444
摘要： Methods are provided for photometrically determining/detecting sample application to an analytical test element for use with a blood glucose measuring device, where the method includes obtaining a sequence of reflectance readings from the test element with the measuring device, including a blank value prior to sample application, and then monitoring changes of the reflectance readings from the test element with respect to a sample application condition defined by a limit for a reflectance decrease or a reflectance threshold. The methods also can include adjusting the sample application condition in accordance with a drift correction and can include determining an analyte concentration in the body fluid sample. In addition, photometric blood glucose measuring devices are provided that incorporate the methods disclosed herein.

10. 发明公开

EP2994536A1 STABILIZATION OF ENZYMES BY NICOTINIC ACID 失效转让
标题翻译：镇定酶烟碱酸的
公开(公告)号：EP2994536A1
公开(公告)日：2016-03-16
申请号：EP14722216.0
申请日：2014-05-08
申请人： Roche Diagnostics GmbH , F.Hoffmann-La Roche AG
发明人： CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl , MEIER, Thomas
IPC分类号： C12Q1/00 , C12Q1/32 , C12N9/96 , G01N33/52
CPC分类号： C12N9/96 , C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Y101/01 , C12Y101/9901 , G01N33/523 , G01N33/526 , G01N2333/904
摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one measurable change in a property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one pyridine-carboxylic acid or a derivative or salt thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of a pyridine-carboxylic acid or a derivative thereof for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry and/or under humid conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.

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