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1. 发明授权

EP2994536B1 STABILIZATION OF ENZYMES BY NICOTINIC ACID 失效转让
标题翻译：烟碱酸稳定酶
公开(公告)号：EP2994536B1
公开(公告)日：2017-06-14
申请号：EP14722216.0
申请日：2014-05-08
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl , MEIER, Thomas
IPC分类号： C12Q1/00 , C12Q1/32 , C12N9/96 , G01N33/52
CPC分类号： C12N9/96 , C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Y101/01 , C12Y101/9901 , G01N33/523 , G01N33/526 , G01N2333/904

2. 发明申请

WO2014180939A1 STABILIZATION OF ENZYMES BY NICOTINIC ACID 审中-公开
标题翻译：由尼古丁酸稳定酶
公开(公告)号：WO2014180939A1
公开(公告)日：2014-11-13
申请号：PCT/EP2014/059418
申请日：2014-05-08
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl
发明人： CHEMNITIUS, Gabriele , NAGEL, Thomas , GAA, Otto , RECHT, Karl
IPC分类号： C12Q1/00 , C12Q1/32 , C12N9/96 , G01N33/52
CPC分类号： C12N9/96 , C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Y101/01 , C12Y101/9901 , G01N33/523 , G01N33/526 , G01N2333/904
摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one measurable change in a property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one pyridine-carboxylic acid or a derivative or salt thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of a pyridine-carboxylic acid or a derivative thereof for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry and/or under humid conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.
摘要翻译：本发明涉及维持和保存酶活性的方法和方法。特别地，本发明涉及一种干组合物，其包含脱氢酶，氧化还原辅因子，能够在氧化还原当量存在下引发指示剂特性的至少一个可测量变化的试剂，指示剂试剂和至少一种吡啶羧酸或其衍生物或盐。本发明进一步考虑了用于确定来自体液样品的分析物的诊断测试元件以及用于制造这种测试元件的方法。本发明进一步设想的是使用吡啶羧酸或其衍生物在干燥和/或潮湿条件下减少组合物中至少一种酶的酶活性降低。此外，预期的是基于根据本发明的测试元件来确定体液样品中存在或量的分析物的方法。

3. 发明申请

WO2013131885A1 COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 审中-公开
标题翻译：兼容的溶解性ECTOINE作为其稳定酶的衍生物
公开(公告)号：WO2013131885A1
公开(公告)日：2013-09-12
申请号：PCT/EP2013/054351
申请日：2013-03-05
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHEMNITIUS, Gabriele , GAA, Otto , NAGEL, Thomas , RECHT, Karl
发明人： CHEMNITIUS, Gabriele , GAA, Otto , NAGEL, Thomas , RECHT, Karl
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N2333/902
摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.
摘要翻译：本发明涉及维持和保存酶活性的方法和方法。特别地，本发明涉及一种干组合物，其包含脱氢酶，氧化还原辅因子，能够在氧化还原当量存在下引发指示剂的光学性质的至少一种光学变化的试剂，指示剂试剂和至少一种相容的溶质是ectoine或其衍生物。本发明进一步考虑了用于确定来自体液样品的分析物的诊断测试元件以及用于制造这种测试元件的方法。本发明进一步设想的是使用如上所述的至少一种相容性溶质来减少干燥条件下组合物中至少一种酶的酶活性的降低。此外，预期的是基于根据本发明的测试元件来确定体液样品中存在或量的分析物的方法。

4. 发明授权

EP2823052B1 COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 有权转让
标题翻译：兼容解决ECTOIN及其衍生物的酶稳定化
公开(公告)号：EP2823052B1
公开(公告)日：2016-10-26
申请号：EP13707185.8
申请日：2013-03-05
申请人： Roche Diabetes Care GmbH , F.Hoffmann-La Roche AG
发明人： CHEMNITIUS, Gabriele , GAA, Otto , NAGEL, Thomas , RECHT, Karl
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N2333/902

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