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1. 发明申请

WO2017137491A1 MUTANT 3-HYDROXYBUTYRATE DEHYDROGENASE FROM RHODOBACTER SPHAEROIDES AS WELL AS METHODS AND USES INVOLVING THE SAME 审中-公开
标题翻译：来自球形芽孢杆菌的突变3-羟基丁酸脱氢酶以及涉及相同的方法和用途
公开(公告)号：WO2017137491A1
公开(公告)日：2017-08-17
申请号：PCT/EP2017/052855
申请日：2017-02-09
申请人： ROCHE DIABETES CARE GMBH , ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC. , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BECK, Daniela , BOENITZ-DULAT, Mara , KRATZSCH, Peter , STREIDL, Thomas , HORN, Carina
IPC分类号： C12N9/04 , C12Q1/32
CPC分类号： C12N9/0006 , C12Q1/32 , C12Y101/0103
摘要： The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3- HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3- hydroxybutyrate in a sample, and a device for determining the amount or concentration of3-hydroxybutyratein a sample.
摘要翻译：本发明涉及相对于野生型3-HBDH（编码突变体3-HBDH的核酸）性能改善的突变体3-羟基丁酸脱氢酶（3-HBDH），所述细胞包含突变体3-HBDH或核酸，确定样品中3-羟基丁酸的量或浓度的方法，以及确定样品中3-羟基丁酸的量或浓度的装置。

2. 发明申请

WO2018115422A1 GLUCOSE DEHYDROGENASE VARIANTS WITH IMPROVED PROPERTIES 审中-公开
公开(公告)号：WO2018115422A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084347
申请日：2017-12-22
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： BOENITZ-DULAT, Mara , HORN, Carina , KRATZSCH, Peter , MEIER, Thomas , RUDOLPH, Markus , SCHNEIDINGER, Bernd
IPC分类号： C12N9/04 , C12N15/52
摘要： The present invention relates to improved variants of variants of the Glucose Dehydrogenases (GlucDH) derived from Bacillus subtilis having improved properties in the presence of cNAD as cofactor, to genes encoding such variant GlucDHs, to proteins of such GlucDH variants, and to different applications of these GlucDH variants, particularly for determining concentrations of sugars, especially of glucose, in samples such as bodily fluids, especially blood.

3. 发明申请

WO2015150263A1 HIGH LOAD ENZYME IMMOBILISATION BY CROSSLINKING 审中-公开
标题翻译：通过交换来实现高负载消毒
公开(公告)号：WO2015150263A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056732
申请日：2015-03-27
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： HORN, Carina , GAWENDA, Susanne
IPC分类号： C12N9/96 , C12N11/06 , C12N9/04 , G01N33/66
CPC分类号： C12N11/06 , C12N9/0006 , C12N9/96 , C12N11/08 , C12Q1/001 , C12Q1/32 , C12Q1/54 , C12Y101/01047 , G01N2333/904
摘要： The present invention relates to a method for cross-linking polypeptide molecules, comprising the step of combining a cross-linking agent and polypeptide molecules in solution under conditions suitable for a cross-linking reaction to occur and to a preparation comprising cross-linked polypeptide molecules obtainable by said method. The present invention further relates to cross-linked polypeptide molecules, wherein said polypeptide molecules are cross-linked by essentially unbranched cross-linking groups comprising at least 40 contiguous atoms. Moreover, the present invention relates to a test chemistry matrix comprising a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, and an indicator reagent, wherein said chemistry matrix further comprises a preparation of cross-linked polypeptide molecules obtainable by the method according to the present invention and/or cross-linked polypeptide molecules according tothe present invention, as well as to a diagnostic test element comprising said test chemistry matrix. The present invention further relates to a preparation of cross-linked polypeptide molecules obtainable by the method according the present invention and/or cross-linked polypeptide molecules according to the present invention for use in the diagnosis of disease and for use in diagnosis of diabetes, as well as to a method for producing a test chemistry matrix.
摘要翻译：本发明涉及交联多肽分子的方法，其包括在适于发生交联反应的条件下将溶液中的交联剂和多肽分子组合的步骤以及包含交联的多肽分子可通过所述方法获得。本发明还涉及交联的多肽分子，其中所述多肽分子通过基本上无支链的包含至少40个连续原子的交联基团交联。此外，本发明涉及包含氧化还原辅因子，能够在氧化还原当量存在下引发指示剂的至少一种可测量性质的变化的试剂和指示剂的测试化学基质，其中所述化学基质进一步包括通过根据本发明的方法可获得的交联多肽分子的制备和/或根据本发明的交联多肽分子，以及包含所述测试化学基质的诊断测试元件。本发明还涉及通过本发明的方法获得的交联多肽分子的制备和/或根据本发明的交联多肽分子，其用于诊断疾病和用于诊断糖尿病，以及生产测试化学基质的方法。

4. 发明申请

WO2022063847A1 METHOD FOR DETECTING AN ANALYTE WITH THE HELP OF METAL NANOPARTICLES ON AN ELECTRODE 审中-公开
公开(公告)号：WO2022063847A1
公开(公告)日：2022-03-31
申请号：PCT/EP2021/076100
申请日：2021-09-22
申请人： ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： BAEUMNER, Antje , BECK, Franziska , HORN, Carina
IPC分类号： G01N33/543 , G01N33/58 , G01N27/00
摘要： The present invention relates to a method for detecting at least one analyte by electrochemical detection, a working electrode of an analyte sensor and an analyte sensor for detecting at least one analyte in a sample by electrochemical detection. The method of the present invention comprises the following steps: contacting a fluid sample suspected to comprise the at least one analyte with the surface of an electrode comprising at least one binding agent capable of binding to the analyte; contacting the fluid sample suspected to comprise the at least one analyte with at least one detection agent, wherein the at least one detection agent comprises at least a further binding agent capable of binding to the analyte and a label, wherein the label comprises a metal nanoparticle with a standard redox potential E° between 0 V and 1.2 V forming a detection complex on the surface of the electrode comprising at least the at least one binding agent, the at least one detection agent and the analyte; precipitating at least a part of the label onto the electrode surface; and the at least one detecting the at least one analyte by electrochemical detection.

5. 发明申请

WO2016026959A1 REDOXINDICATORS 审中-公开
公开(公告)号：WO2016026959A1
公开(公告)日：2016-02-25
申请号：PCT/EP2015/069249
申请日：2015-08-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GEBAUER, Peter , HEINDL, Dieter , HORN, Carina , FOMIN, Maksim
IPC分类号： C07D401/06 , C07D241/40
CPC分类号： G01N33/52 , C07D241/40 , C07D241/42 , C07D401/06 , C07D403/06 , G01N33/5005
摘要： The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridme-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.
摘要翻译：本发明涉及化合物或其盐或溶剂化物，其为包括共轭π系统的吩嗪，菲啶，菲咯啉，喹啉，喹喔啉，吖啶 - 异喹啉，吡嗪 - 或吡啶衍生物 π-受体基团及其用途。本发明还涉及化学基质和包含本发明化合物的测试元件。本发明还涉及确定测试样品中分析物的量的方法，包括使所述测试样品与化学基质或本发明的测试元件接触，并估算氧化还原当量的量由所述化学基质中包含的化合物或由所述测试元件中包含的化合物在所述测试样品存在下释放或消耗，从而确定所述测试样品中分析物的量。此外，本发明涉及包括根据本发明的测试元件的系统和包括用于测量释放或消耗的氧化还原当量的量的传感器的装置。

6. 发明申请

WO2014195363A1 NOVEL COMPOUNDS USEFUL FOR FRET AND METHODS RELATED THERETO 审中-公开
标题翻译：有用的新型化合物和与之相关的方法
公开(公告)号：WO2014195363A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061589
申请日：2014-06-04
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , HOENES, Joachim , HORN, Carina , MEIER, Thomas , PETRICH, Wolfgang
IPC分类号： C12Q1/00 , C12Q1/26 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/68
CPC分类号： C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
摘要： The invention relates to compounds, which are useful for intramolecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
摘要翻译：本发明涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含基于carbaNADH的第一荧光团的氧化形式和在445至540nm的波长处可激发的第二荧光团，具有大于560nm的发射最大值，以及与其相关的方法，试剂盒和组合物。

7. 发明申请

WO2015078899A1 COMPOSITION COMPRISING UP-CONVERTING PHOSPHORS FOR DETECTING AN ANALYTE 审中-公开
标题翻译：包含用于检测分析仪的上转换磷的组合物
公开(公告)号：WO2015078899A1
公开(公告)日：2015-06-04
申请号：PCT/EP2014/075639
申请日：2014-11-26
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HORN, Carina , VALTA, Timo-Jaakko
IPC分类号： C12Q1/26 , C12Q1/54 , G01N33/52 , G01N33/66
CPC分类号： G01N33/525 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/77 , G01N33/521
摘要： The present invention relates to a detector matrix (130) for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix (130) further comprises up-converting phosphor particles, preferably UV-emitting up-converting phosphor particles. The present invention further relates to a test element (120) and a test device (112) for detecting at least one analyte in a sample comprising the detector matrix (130) of the present invention, as well as to a method for the manufacture of a detector matrix(130), a method for the manufacture of a test element(120), and to a method for detecting an analyte in a sample, comprising contacting a detector matrix (130) according to the present invention with a sample suspected to comprise said analyte.
摘要翻译：本发明涉及一种检测器基体（130），用于检测样品中的至少一种分析物，优选体液样品，所述分析物在所述至少一种分析物和至少一种指示剂试剂存在下包含至少一种酶活性物质改变取决于所述酶的活性的至少一种光学性质，其中所述检测器基质（130）还包括上转换荧光体颗粒，优选UV发射上转换磷光体颗粒。本发明还涉及用于检测包括本发明的检测器基体（130）的样品中的至少一种分析物的测试元件（120）和测试装置（112），以及用于制造检测器基体（130），用于制造测试元件（120）的方法以及用于检测样品中的分析物的方法，包括使根据本发明的检测器基体（130）与怀疑为包括所述分析物。

8. 发明申请

WO2019115687A1 METHOD AND DEVICE FOR DETERMINING AN INFORMATION ON AN EQUIVALENT SERIES RESISTANCE 审中-公开
公开(公告)号：WO2019115687A1
公开(公告)日：2019-06-20
申请号：PCT/EP2018/084750
申请日：2018-12-13
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： LAMBERTSON, Michael , BAUER-ESPINDOLA, Klaus , EVGIN, Samuel , HORN, Carina , MARQUANT, Michael
IPC分类号： G01N27/327
摘要： A method for determining an information on an equivalent series resistance is disclosed. The method comprises the following steps: - generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes (116); - measuring a response signal; - determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; - determining the information on the equivalent series resistance from the ohmic signal portion.

9. 发明申请

WO2015078821A1 A METHOD FOR LASER WELDING A DISPOSABLE TEST-UNIT 审中-公开
标题翻译：一种用于激光焊接可替换测试单元的方法
公开(公告)号：WO2015078821A1
公开(公告)日：2015-06-04
申请号：PCT/EP2014/075429
申请日：2014-11-24
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BABIC, Branislav , HORN, Carina
IPC分类号： B29C65/16 , G01N33/48 , B01L3/00 , B81C3/00
CPC分类号： G01N21/77 , B01L3/502707 , B01L2300/044 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B23K26/0006 , B23K26/0063 , B23K2203/42 , B23K2203/50 , B29C65/1635 , B29C65/1654 , B29C65/1677 , B29C65/1683 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/24 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/73343 , B29C66/73365 , B29C66/73921 , B29C66/81267 , B29C66/8242 , B29C66/8322 , B29K2995/0027 , B29L2031/756 , G01N33/50 , G01N2021/7769 , B29K2069/00
摘要： The invention concerns a method for laser welding a disposable test-unit (10) comprising: providing in a stacked manner a base element (14), a cover element (16) and optionally an intermediate element (22), wherein one of said elements is an absorbing element and at least one other of said elements is a transparent element, directing a laser beam in a weld area (12) through the at least one transparent element and against the absorbing element, fusing together the transparent and the absorbing elements to form a test-unit (10), providing one of said elements (14, 16, 22) in the initial step with a coating (20; 26) adapted to interact with the body fluid when conducting a test, wherein said coating (20; 26) covers the weld area (12) at least in part and absorbs and/or scatters the laser radiation at least in part.
摘要翻译：本发明涉及一种用于激光焊接一次性测试单元（10）的方法，包括：以堆叠的方式提供基座元件（14），盖元件（16）和可选的中间元件（22），其中所述元件是吸收元件，并且所述元件中的至少另一个是透明元件，将激光束引导通过所述至少一个透明元件的焊接区域（12）并抵靠所述吸收元件，将所述透明元件和所述吸收元件熔合在一起形成测试单元（10），在初始步骤中提供一个所述元件（14,16,22），其中涂层（20; 26）适于在进行测试时与体液相互作用，其中所述涂层 ; 26）至少部分地覆盖焊接区域（12）并且至少部分地吸收和/或散射激光辐射。

10. 发明申请

WO2015063025A1 NANO-ENZYME CONTAINERS FOR TEST ELEMENTS 审中-公开
标题翻译：用于测试元件的纳诺酶容器
公开(公告)号：WO2015063025A1
公开(公告)日：2015-05-07
申请号：PCT/EP2014/072994
申请日：2014-10-27
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAIER, Grit , HORN, Carina , LANDFESTER, Katharina , MUSYANOVYCH, Anna , PAIPHANSIRI, Umaporn
IPC分类号： C07K14/435
CPC分类号： G01N33/5432 , C08G18/289 , C12N9/0006 , C12N11/08 , C12Q1/006 , C12Q1/32 , C12Q1/54 , G01N33/48721 , G01N33/5038 , G01N33/54346
摘要： The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.
摘要翻译：本发明涉及用于检测包含酶的分析物的测试元件，其中将酶掺入纳米胶囊中。

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