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1. 发明申请

WO2020020850A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020850A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069730
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

2. 发明申请

WO2015128157A1 METHOD OF IDENTIFYING A NUCLEOTIDE AT A DEFINED POSITION AND DETERMINING THE SEQUENCE OF A TARGET POLYNUCLEOTIDE USING AN ELECTRO-SWITCHABLE BIOSENSOR, AS WELL AS DEVICES COMPRISING AN ELECTRO-SWITCHABLE BIOSENSOR AND USES THEREOF 审中-公开
标题翻译：在定义的位置鉴定核苷酸的方法和使用电可切换生物传感器确定目标多核苷酸的序列，以及作为包含电可切换生物传感器的装置及其用途
公开(公告)号：WO2015128157A1
公开(公告)日：2015-09-03
申请号：PCT/EP2015/052131
申请日：2015-02-03
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC. , DYNAMIC BIOSENSORS GMBH
发明人： LANGER, Andreas , RANT, Ulrich , STRASSER, Ralf , HEINDL, Dieter , SCHRAEML, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , G01N27/3276 , C12Q2533/101 , C12Q2563/107 , C12Q2563/116 , C12Q2565/607
摘要： The present invention relates to a method of identifying a nucleotide at a defined position and determining the sequence of a target polynucleotide using an electro-switchable biosensor, as well as devices comprising an electro-switchable biosensor and uses thereof.
摘要翻译：本发明涉及一种在确定的位置鉴定核苷酸并使用可电切换生物传感器确定靶多核苷酸的序列的方法，以及包括可电切换生物传感器及其用途的装置。

3. 发明申请

WO2022084362A1 DETECTION OF AN ANALYTE OF INTEREST BY NANOESI MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2022084362A1
公开(公告)日：2022-04-28
申请号：PCT/EP2021/079018
申请日：2021-10-20
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , REMPT, Martin , ZUTH, Christoph
IPC分类号： G01N33/68 , C07D249/06 , C07K1/36
摘要： The present invention relates to a method, a diagnostic system, a kit and the use thereof for efficiently detection of an analyte of interest by nanoESI mass spectrometry.

4. 发明申请

WO2021234004A1 IMIDAZOLIUM REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021234004A1
公开(公告)日：2021-11-25
申请号：PCT/EP2021/063298
申请日：2021-05-19
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HAHN, Robert , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , KUCHELMEISTER, Hannes , MAZZIER, Daniela , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D233/90
摘要： The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

5. 发明申请

WO2021224361A2 SEMI-SYNTHESIS AND USE OF RACEMIC HEMATOXYLIN 审中-公开
公开(公告)号：WO2021224361A2
公开(公告)日：2021-11-11
申请号：PCT/EP2021/061930
申请日：2021-05-06
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： DURRANT, Edward E. , HEINDL, Dieter , HUBER, Florian , KLEIN, Eric , KOSMEDER, Jerome W. Il , VOSS, Edgar
IPC分类号： G01N1/30
摘要： A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

6. 发明申请

WO2018115237A1 METHOD FOR IDENTIFYING A REAGENT DURING A PROCESS IN AN ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2018115237A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084012
申请日：2017-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , SEIDEL, Christoph , REMPT, Martin
IPC分类号： G01N30/06 , G01N30/28 , G01N30/46 , G01N30/72 , G01N33/58
摘要： A method for identifying a reagent during a process in an analysis system (100) is disclosed. The analysis system (100) comprises a liquid chromatograph (102) and a mass spectrometer (104). The method comprises providing a reagent (130), adding at least one chemical substance (134) to the reagent (130) with a concentration being below a detection level of the mass spectrometer (104), enriching the chemical substance (134) within the liquid chromatograph (102) to a concentration above the detection level of the mass spectrometer (104), processing the reagent (130) together with the enriched chemical substance (134) by means of the analysis system (100), and identifying the reagent (130) based on a detection of a substance detection signal of the mass spectrometer (104) representing the chemical substance (134).

7. 发明申请

WO2016026959A1 REDOXINDICATORS 审中-公开
公开(公告)号：WO2016026959A1
公开(公告)日：2016-02-25
申请号：PCT/EP2015/069249
申请日：2015-08-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GEBAUER, Peter , HEINDL, Dieter , HORN, Carina , FOMIN, Maksim
IPC分类号： C07D401/06 , C07D241/40
CPC分类号： G01N33/52 , C07D241/40 , C07D241/42 , C07D401/06 , C07D403/06 , G01N33/5005
摘要： The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridme-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.
摘要翻译：本发明涉及化合物或其盐或溶剂化物，其为包括共轭π系统的吩嗪，菲啶，菲咯啉，喹啉，喹喔啉，吖啶 - 异喹啉，吡嗪 - 或吡啶衍生物 π-受体基团及其用途。本发明还涉及化学基质和包含本发明化合物的测试元件。本发明还涉及确定测试样品中分析物的量的方法，包括使所述测试样品与化学基质或本发明的测试元件接触，并估算氧化还原当量的量由所述化学基质中包含的化合物或由所述测试元件中包含的化合物在所述测试样品存在下释放或消耗，从而确定所述测试样品中分析物的量。此外，本发明涉及包括根据本发明的测试元件的系统和包括用于测量释放或消耗的氧化还原当量的量的传感器的装置。

8. 发明申请

WO2015091958A1 COMPOUNDS COMPRISING ONE OR MORE HYDROPHOBIC DOMAINS AND A HYDROPHILIC DOMAIN COMPRISING PEG MOIETIES, USEFUL FOR BINDING CELLS 审中-公开
标题翻译：包含一个或多个疏水性域的化合物和包含PEG活性的亲水性域，有用于结合细胞
公开(公告)号：WO2015091958A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078758
申请日：2014-12-19
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： JOSEL, Hans-Peter , HEINDL, Dieter , FROEHLICH, Thomas , FROEHNER, Stefanie
IPC分类号： G01N33/50 , C07J51/00 , C12N5/00 , C12N11/00 , C12N11/06 , G01N33/543
CPC分类号： G01N33/56972 , C07D311/04 , C07D311/82 , C07D495/04 , C07J9/00 , C07J17/00 , C07J51/00 , C12N11/06 , G01N33/5005 , G01N33/54353 , G01N33/56966 , G01N33/582
摘要： The present invention relates to novel compounds comprising one or more hydrophobic domains and a hydrophilic domain comprising PEG moieties, useful for binding cells, as well as uses and compositions related thereto. The compounds are useful for immobilizing and/or stabilizing cells.
摘要翻译：本发明涉及包含一个或多个疏水结构域和包含PEG部分的亲水结构域，可用于结合细胞的新型化合物，以及与其相关的用途和组合物。这些化合物可用于固定和/或稳定细胞。

9. 发明申请

WO2014195363A1 NOVEL COMPOUNDS USEFUL FOR FRET AND METHODS RELATED THERETO 审中-公开
标题翻译：有用的新型化合物和与之相关的方法
公开(公告)号：WO2014195363A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061589
申请日：2014-06-04
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , HOENES, Joachim , HORN, Carina , MEIER, Thomas , PETRICH, Wolfgang
IPC分类号： C12Q1/00 , C12Q1/26 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/68
CPC分类号： C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
摘要： The invention relates to compounds, which are useful for intramolecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
摘要翻译：本发明涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含基于carbaNADH的第一荧光团的氧化形式和在445至540nm的波长处可激发的第二荧光团，具有大于560nm的发射最大值，以及与其相关的方法，试剂盒和组合物。

10. 发明申请

WO2023083895A1 HYDROPHILIC AZADIBENZOCYCLOOCTYNE DERIVATIVES AND METAL-FREE CLICK REACTIONS WITH THESE HYDROPHILIC AZADIBENZOCYCLOOCTYNE DERIVATIVES 审中-公开
公开(公告)号：WO2023083895A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/081339
申请日：2022-11-09
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BERGMANN, Frank , HEINDL, Dieter , WINTER, Nils
IPC分类号： C07D225/08 , A61K47/50
摘要： The invention relates in a first aspect to an azadibenzocyclooctyne derivative according to formula (I) or a salt thereof having specific substituents at the benzo rings of the DIBAC structure and having specific substituents connected to the nitrogen atom of the DIBAC structure. A second aspect of the invention is directed to a conjugate of formula (II), wherein a substituent R6 is connected to the N atom of the 8 membered ring of the DIBAC structure via a linker structure –C(=O)-[L]n-Z-. A third aspect of the invention relates to a method for the modification of a target molecule, wherein a conjugate according to the second aspect is reacted with a target molecule comprising a 1,3-dipole group or a 1,3-(hetero)diene group. In a fourth aspect, the invention is directed to the use of the conjugate according to the second aspect for bioorthogonal labeling and/or modification of a target molecule. A fifth aspect of the invention relates to a modified target molecule comprising the reaction product of a conjugate according to the second aspect and a target molecule comprising a 1,3-dipole group or a 1,3-(hetero)diene group, obtained or obtainable from the method of the third aspect. In a sixth aspect, the invention is related to a kit comprising a modified target molecule according to the fifth aspect as detector reagent and a suitable capture reagent.

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