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1. 发明申请

WO2018115422A1 GLUCOSE DEHYDROGENASE VARIANTS WITH IMPROVED PROPERTIES 审中-公开
公开(公告)号：WO2018115422A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084347
申请日：2017-12-22
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： BOENITZ-DULAT, Mara , HORN, Carina , KRATZSCH, Peter , MEIER, Thomas , RUDOLPH, Markus , SCHNEIDINGER, Bernd
IPC分类号： C12N9/04 , C12N15/52
摘要： The present invention relates to improved variants of variants of the Glucose Dehydrogenases (GlucDH) derived from Bacillus subtilis having improved properties in the presence of cNAD as cofactor, to genes encoding such variant GlucDHs, to proteins of such GlucDH variants, and to different applications of these GlucDH variants, particularly for determining concentrations of sugars, especially of glucose, in samples such as bodily fluids, especially blood.

2. 发明申请

WO2017137491A1 MUTANT 3-HYDROXYBUTYRATE DEHYDROGENASE FROM RHODOBACTER SPHAEROIDES AS WELL AS METHODS AND USES INVOLVING THE SAME 审中-公开
标题翻译：来自球形芽孢杆菌的突变3-羟基丁酸脱氢酶以及涉及相同的方法和用途
公开(公告)号：WO2017137491A1
公开(公告)日：2017-08-17
申请号：PCT/EP2017/052855
申请日：2017-02-09
申请人： ROCHE DIABETES CARE GMBH , ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC. , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BECK, Daniela , BOENITZ-DULAT, Mara , KRATZSCH, Peter , STREIDL, Thomas , HORN, Carina
IPC分类号： C12N9/04 , C12Q1/32
CPC分类号： C12N9/0006 , C12Q1/32 , C12Y101/0103
摘要： The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3- HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3- hydroxybutyrate in a sample, and a device for determining the amount or concentration of3-hydroxybutyratein a sample.
摘要翻译：本发明涉及相对于野生型3-HBDH（编码突变体3-HBDH的核酸）性能改善的突变体3-羟基丁酸脱氢酶（3-HBDH），所述细胞包含突变体3-HBDH或核酸，确定样品中3-羟基丁酸的量或浓度的方法，以及确定样品中3-羟基丁酸的量或浓度的装置。

3. 发明申请

WO2015150263A1 HIGH LOAD ENZYME IMMOBILISATION BY CROSSLINKING 审中-公开
标题翻译：通过交换来实现高负载消毒
公开(公告)号：WO2015150263A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056732
申请日：2015-03-27
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： HORN, Carina , GAWENDA, Susanne
IPC分类号： C12N9/96 , C12N11/06 , C12N9/04 , G01N33/66
CPC分类号： C12N11/06 , C12N9/0006 , C12N9/96 , C12N11/08 , C12Q1/001 , C12Q1/32 , C12Q1/54 , C12Y101/01047 , G01N2333/904
摘要： The present invention relates to a method for cross-linking polypeptide molecules, comprising the step of combining a cross-linking agent and polypeptide molecules in solution under conditions suitable for a cross-linking reaction to occur and to a preparation comprising cross-linked polypeptide molecules obtainable by said method. The present invention further relates to cross-linked polypeptide molecules, wherein said polypeptide molecules are cross-linked by essentially unbranched cross-linking groups comprising at least 40 contiguous atoms. Moreover, the present invention relates to a test chemistry matrix comprising a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, and an indicator reagent, wherein said chemistry matrix further comprises a preparation of cross-linked polypeptide molecules obtainable by the method according to the present invention and/or cross-linked polypeptide molecules according tothe present invention, as well as to a diagnostic test element comprising said test chemistry matrix. The present invention further relates to a preparation of cross-linked polypeptide molecules obtainable by the method according the present invention and/or cross-linked polypeptide molecules according to the present invention for use in the diagnosis of disease and for use in diagnosis of diabetes, as well as to a method for producing a test chemistry matrix.
摘要翻译：本发明涉及交联多肽分子的方法，其包括在适于发生交联反应的条件下将溶液中的交联剂和多肽分子组合的步骤以及包含交联的多肽分子可通过所述方法获得。本发明还涉及交联的多肽分子，其中所述多肽分子通过基本上无支链的包含至少40个连续原子的交联基团交联。此外，本发明涉及包含氧化还原辅因子，能够在氧化还原当量存在下引发指示剂的至少一种可测量性质的变化的试剂和指示剂的测试化学基质，其中所述化学基质进一步包括通过根据本发明的方法可获得的交联多肽分子的制备和/或根据本发明的交联多肽分子，以及包含所述测试化学基质的诊断测试元件。本发明还涉及通过本发明的方法获得的交联多肽分子的制备和/或根据本发明的交联多肽分子，其用于诊断疾病和用于诊断糖尿病，以及生产测试化学基质的方法。

4. 发明公开

EP3559218A1 GLUCOSE DEHYDROGENASE VARIANTS WITH IMPROVED PROPERTIES 审中-公开
公开(公告)号：EP3559218A1
公开(公告)日：2019-10-30
申请号：EP17832074.3
申请日：2017-12-22
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： BOENITZ-DULAT, Mara , HORN, Carina , KRATZSCH, Peter , MEIER, Thomas , RUDOLPH, Markus , SCHNEIDINGER, Bernd
IPC分类号： C12N9/04 , C12N15/52

5. 发明授权

EP3074204B1 A METHOD FOR LASER WELDING A DISPOSABLE TEST-UNIT 有权
标题翻译：激光焊接一次性试验单元的方法
公开(公告)号：EP3074204B1
公开(公告)日：2017-12-27
申请号：EP14802875.6
申请日：2014-11-24
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： BABIC, Branislav , HORN, Carina
IPC分类号： B29C65/16 , B01L3/00 , B81C3/00
CPC分类号： G01N21/77 , B01L3/502707 , B01L2300/044 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B23K26/0006 , B23K26/0063 , B23K2203/42 , B23K2203/50 , B29C65/1635 , B29C65/1654 , B29C65/1677 , B29C65/1683 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/24 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/73343 , B29C66/73365 , B29C66/73921 , B29C66/81267 , B29C66/8242 , B29C66/8322 , B29K2995/0027 , B29L2031/756 , G01N33/50 , G01N2021/7769 , B29K2069/00

6. 发明授权

EP2936124B1 METHODS FOR EVALUATING MEDICAL MEASUREMENT CURVES 有权转让
标题翻译： VERFAHREN ZUR BEURTEILUNG MEDISINISCHER MESSKURVEN
公开(公告)号：EP2936124B1
公开(公告)日：2017-03-15
申请号：EP13811932.6
申请日：2013-12-19
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： AIGNER, Simon , CHEMNITIUS, Gabriele , HORN, Carina , LIMBURG, Bernd , OTTENSTEIN, Timo , PETRICH, Wolfgang , PLUM, Markus , RINGEMANN, Christian , SERR, Markus
IPC分类号： G01N21/77 , G01N21/84 , G01N21/27
CPC分类号： G06F19/24 , G01N21/274 , G01N21/77 , G01N21/8483 , G01N33/66 , G01N33/80 , G01N2201/129 , Y10T436/144444

7. 发明公开

EP3063169A1 NANO-ENZYME CONTAINERS FOR TEST ELEMENTS 有权
标题翻译： NANOENZYMBEHÄLTERFÜRTESTELEMENTE
公开(公告)号：EP3063169A1
公开(公告)日：2016-09-07
申请号：EP14793493.9
申请日：2014-10-27
申请人： F. Hoffmann-La Roche AG , Roche Diabetes Care GmbH
发明人： BAIER, Grit , HORN, Carina , LANDFESTER, Katharina , MUSYANOVYCH, Anna , PAIPHANSIRI, Umaporn
IPC分类号： C07K14/435
CPC分类号： G01N33/5432 , C08G18/289 , C12N9/0006 , C12N11/08 , C12Q1/006 , C12Q1/32 , C12Q1/54 , G01N33/48721 , G01N33/5038 , G01N33/54346
摘要： The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.
摘要翻译：本发明涉及用于检测包含酶的分析物的测试元件，其中将酶掺入纳米胶囊中。

8. 发明授权

EP3063169B1 NANO-ENZYME CONTAINERS FOR TEST ELEMENTS 有权
公开(公告)号：EP3063169B1
公开(公告)日：2018-10-10
申请号：EP14793493.9
申请日：2014-10-27
申请人： F. Hoffmann-La Roche AG , Roche Diabetes Care GmbH
发明人： BAIER, Grit , HORN, Carina , LANDFESTER, Katharina , MUSYANOVYCH, Anna , PAIPHANSIRI, Umaporn
IPC分类号： C07K14/435
CPC分类号： G01N33/5432 , C08G18/289 , C12N9/0006 , C12N11/08 , C12Q1/006 , C12Q1/32 , C12Q1/54 , G01N33/48721 , G01N33/5038 , G01N33/54346
摘要： The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.

9. 发明公开

EP3126493A1 HIGH LOAD ENZYME IMMOBILISATION BY CROSSLINKING 有权
标题翻译：通过交联高负载酶的固定化
公开(公告)号：EP3126493A1
公开(公告)日：2017-02-08
申请号：EP15713455.2
申请日：2015-03-27
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： HORN, Carina , GAWENDA, Susanne
IPC分类号： C12N9/96 , C12N11/06 , C12N9/04 , G01N33/66
CPC分类号： C12N11/06 , C12N9/0006 , C12N9/96 , C12N11/08 , C12Q1/001 , C12Q1/32 , C12Q1/54 , C12Y101/01047 , G01N2333/904
摘要： The present invention relates to a method for cross-linking polypeptide molecules, comprising the step of combining a cross-linking agent and polypeptide molecules in solution under conditions suitable for a cross-linking reaction to occur and to a preparation comprising cross-linked polypeptide molecules obtainable by said method. The present invention further relates to cross-linked polypeptide molecules, wherein said polypeptide molecules are cross-linked by essentially unbranched cross-linking groups comprising at least 40 contiguous atoms. Moreover, the present invention relates to a test chemistry matrix comprising a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, and an indicator reagent, wherein said chemistry matrix further comprises a preparation of cross-linked polypeptide molecules obtainable by the method according to the present invention and/or cross-linked polypeptide molecules according to the present invention, as well as to a diagnostic test element comprising said test chemistry matrix. The present invention further relates to a preparation of cross-linked polypeptide molecules obtainable by the method according the present invention and/or cross-linked polypeptide molecules according to the present invention for use in the diagnosis of disease and for use in diagnosis of diabetes, as well as to a method for producing a test chemistry matrix.
摘要翻译：本发明涉及用于交联多肽分子的方法，其包括在适合于发生交联反应的条件下将溶液中的交联剂和多肽分子结合的步骤，以及包含交联多肽分子可通过所述方法获得。本发明进一步涉及交联的多肽分子，其中所述多肽分子通过包含至少40个连续原子的基本上无支链的交联基团交联。此外，本发明涉及测试化学基质，其包含氧化还原辅因子，能够在氧化还原等价物存在下引发指示剂至少一种可测量性质的变化的试剂和指示剂，其中所述化学基质进一步包括通过根据本发明的方法可获得的交联多肽分子和/或根据本发明的交联多肽分子的制备物，以及包含所述测试化学物质基质的诊断测试元件。本发明进一步涉及根据本发明的可通过本发明方法获得的交联多肽分子和/或根据本发明的交联多肽分子制备用于疾病诊断和用于诊断糖尿病，以及用于生产测试化学基质的方法。

10. 发明公开

EP3074204A1 A METHOD FOR LASER WELDING A DISPOSABLE TEST-UNIT 有权
标题翻译： VERFAHREN ZUM LASERSCHWISSEN EINER WEGWERF-TESTEINHEIT
公开(公告)号：EP3074204A1
公开(公告)日：2016-10-05
申请号：EP14802875.6
申请日：2014-11-24
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： BABIC, Branislav , HORN, Carina
IPC分类号： B29C65/16 , G01N33/48 , B01L3/00 , B81C3/00
CPC分类号： G01N21/77 , B01L3/502707 , B01L2300/044 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B23K26/0006 , B23K26/0063 , B23K2203/42 , B23K2203/50 , B29C65/1635 , B29C65/1654 , B29C65/1677 , B29C65/1683 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/24 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/73343 , B29C66/73365 , B29C66/73921 , B29C66/81267 , B29C66/8242 , B29C66/8322 , B29K2995/0027 , B29L2031/756 , G01N33/50 , G01N2021/7769 , B29K2069/00
摘要： Methods are provided for manufacturing disposable diagnostic test elements via laser welding, where the methods include providing, in a stacked or layered arrangement, a base layer, a cover layer, and optionally an intermediate layer, where one of the layers is an absorbing layer and at least one other of the layers is a transparent layer, and where one of the layers includes a coating adapted to interact with a body fluid sample when conducting a test on the resulting test element; directing a laser beam in a weld area through the at least one transparent layer and against the absorbing layer; and fusing the transparent and the absorbing layers together to form the test element, where the coating covers the weld area at least in part and absorbs and/or scatters radiation from the laser beam at least in part. Disposable diagnostic test elements also are provided.
摘要翻译：提供了用于通过激光焊接制造一次性诊断测试元件的方法，其中所述方法包括以堆叠或分层布置提供基底层，覆盖层和任选的中间层，其中一个层是吸收层，层中的至少另一个是透明层，并且其中一个层包括适于在对所得到的测试元件进行测试时与体液样品相互作用的涂层; 将激光束引导到焊接区域中，穿过所述至少一个透明层并抵靠所述吸收层; 以及将所述透明层和所述吸收层融合在一起以形成所述测试元件，其中所述涂层至少部分地覆盖所述焊接区域并且至少部分地从所述激光束吸收和/或散射辐射。还提供了一次性诊断测试元件。

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