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1. 发明授权

US08961587B2 Branched stent graft 有权
标题翻译：支支架移植
公开(公告)号：US08961587B2
公开(公告)日：2015-02-24
申请号：US13254010
申请日：2010-03-17
申请人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
发明人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
IPC分类号： A61F2/06 , A61F2/07 , A61F2/82 , A61F2/89
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2002/826 , A61F2220/0075
摘要： A branched stent graft comprises a main body portion and a branch portion. Each of the main body portion and the branch portion includes a stent and a tubular graft. The stent of the main body portion includes a plurality of stent segments, at least one of which is a varying-height stent segment (102). The stent of the branch portion includes one or more stent segments, at least one of which is a varying-height stent segment (103). The distance between the proximal-most stent segment of the branch portion and the main body portion is in the range of 2-8 mm. A positioning ring (105) may be used at a side opening which connects the branch portion and the main body portion, and the positioning ring (105) can be sutured inside the graft of the main body, between the graft of the main body and the graft of the branch, or outside the graft of the branch.
摘要翻译：分支支架移植物包括主体部分和分支部分。主体部分和分支部分中的每一个包括支架和管状移植物。主体部分的支架包括多个支架段，其中至少一个是变高高度支架段（102）。分支部分的支架包括一个或多个支架段，其中至少一个是变高高度支架段（103）。分支部的最近侧的支架段与主体部之间的距离在2-8mm的范围内。可以在连接分支部和主体部的侧开口处使用定位环（105），并且可以在主体的移植物之间，在主体的移植物之间缝合定位环（105），并将定位环分支的移植物，或分支的移植物外。

2. 发明申请

US20110319983A1 BRANCHED STENT GRAFT 有权
标题翻译：分支支架
公开(公告)号：US20110319983A1
公开(公告)日：2011-12-29
申请号：US13254010
申请日：2010-03-17
申请人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
发明人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2002/826 , A61F2220/0075
摘要： A branched stent graft comprises a main body portion and a branch portion. Each of the main body portion and the branch portion includes a stent and a tubular graft. The stent of the main body portion includes a plurality of stent segments, at least one of which is a varying-height stent segment (102). The stent of the branch portion includes one or more stent segments, at least one of which is a varying-height stent segment (103). The distance between the proximal-most stent segment of the branch portion and the main body portion is in the range of 2-8 mm. A positioning ring (105) may be used at a side opening which connects the branch portion and the main body portion, and the positioning ring (105) can be sutured inside the graft of the main body, between the graft of the main body and the graft of the branch, or outside the graft of the branch.
摘要翻译：分支支架移植物包括主体部分和分支部分。主体部分和分支部分中的每一个包括支架和管状移植物。主体部分的支架包括多个支架段，其中至少一个是变高高度支架段（102）。分支部分的支架包括一个或多个支架段，其中至少一个是变高高度支架段（103）。分支部的最近侧的支架段与主体部之间的距离在2-8mm的范围内。可以在连接分支部和主体部的侧开口处使用定位环（105），并且可以在主体的移植物之间，在主体的移植物之间缝合定位环（105），并将定位环分支的移植物，或分支的移植物外。

3. 发明授权

US09056000B2 Flexible stent-graft 有权
标题翻译：柔性支架移植
公开(公告)号：US09056000B2
公开(公告)日：2015-06-16
申请号：US11572908
申请日：2006-05-23
申请人： Qiyi Luo , Honglin Nie , Qing Zhu , Weiwen Sheng , Fengliang Zhao , Hui He , Jie Li , Yan-bin Gao
发明人： Qiyi Luo , Honglin Nie , Qing Zhu , Weiwen Sheng , Fengliang Zhao , Hui He , Jie Li , Yan-bin Gao
IPC分类号： A61F2/06 , A61F2/07 , A61F2/82 , A61F2/89
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/075 , A61F2230/0067 , A61F2250/0039
摘要： A stent graft (5) comprises a tubular graft member (4), and a plurality of sloping stent members (3) substantially coaxial with and coupled to the tubular graft member (4). Each of the sloping stent members (3) comprises multiple uneven apexes characterizing a round tubular configuration with a distal end and a proximal end disposed about a longitudinal axis. The distal apexes of the sloping stent member (3) are arranged in substantially the same plane substantially horizontal to the longitudinal axis of the sloping stent member and the proximal apexes are arranged in a sloping plane oblique to the longitudinal axis.
摘要翻译：支架移植物（5）包括管状移植构件（4）和与管状移植构件（4）基本同轴并联接到其上的多个倾斜支架构件（3）。倾斜支架构件（3）中的每一个包括表示圆形管状构造的多个不均匀顶点，其具有远端和围绕纵向轴线设置的近端。倾斜支架构件（3）的远端顶点布置在与倾斜支架构件的纵向轴线基本上水平的基本相同的平面中，并且近侧顶点布置在与纵向轴线相对的倾斜平面中。

4. 发明申请

US20080195191A1 Flexible Stent-Graft 有权
标题翻译：弹性支架移植
公开(公告)号：US20080195191A1
公开(公告)日：2008-08-14
申请号：US11572908
申请日：2006-05-23
申请人： Qiyi Luo , Honglin Nie , Qing Zhu , Weiwen Sheng , Fengliang Zhao , Hui He , Jie Li , Yan-bin Gao
发明人： Qiyi Luo , Honglin Nie , Qing Zhu , Weiwen Sheng , Fengliang Zhao , Hui He , Jie Li , Yan-bin Gao
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/075 , A61F2230/0067 , A61F2250/0039
摘要： A stent graft (5) comprises a tubular graft member (4), and a plurality of sloping stent members (3) substantially coaxial with and coupled to the tubular graft member (4). Each of the sloping stent members (3) comprises multiple uneven apexes characterizing a round tubular configuration with a distal end and a proximal end disposed about a longitudinal axis. The distal apexes of the sloping stent member (3) are arranged in substantially the same plane substantially horizontal to the longitudinal axis of the sloping stent member and the proximal apexes are arranged in a sloping plane oblique to the longitudinal axis.
摘要翻译：支架移植物（5）包括管状移植构件（4）和与管状移植构件（4）基本同轴并联接到其上的多个倾斜支架构件（3）。倾斜支架构件（3）中的每一个包括表示圆形管状构造的多个不均匀顶点，其具有远端和围绕纵向轴线设置的近端。倾斜支架构件（3）的远端顶点布置在与倾斜支架构件的纵向轴线基本上水平的基本相同的平面中，并且近端顶点布置在与纵向轴线相对的倾斜平面中。

5. 发明申请

US20120101563A1 DELIVERY SYSTEM FOR BRANCHED STENT GRAFT 审中-公开
标题翻译：用于分支支架的输送系统
公开(公告)号：US20120101563A1
公开(公告)日：2012-04-26
申请号：US13322256
申请日：2010-04-28
申请人： Qing Zhu , Qiyi Luo , Dingguo Huang , Yanbin Gao , Zaiping Jing , Qingsheng Lu
发明人： Qing Zhu , Qiyi Luo , Dingguo Huang , Yanbin Gao , Zaiping Jing , Qingsheng Lu
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/07 , A61F2/954 , A61F2002/061 , A61F2002/065
摘要： A delivery system for a branched stent graft comprises a double-layer sheath (3, 13) containing the stent graft and a towing and releasing mechanism which tows and releases the stent graft from the double-layer sheath (3, 13). After being bound, a stent main body (8) and a stent branch (11) of the stent graft are movably and entirely positioned within the double-layer sheath (3, 13). The stent main body (8) is connected with a control guiding assembly and is towed and released by the control guiding assembly. The stent branch (11) is towed by a branch guiding assembly and is connected with the control guiding assembly, so as to be released by the control guiding assembly.
摘要翻译：用于分支支架移植物的递送系统包括含有支架移植物的双层护套（3,13）和牵引并从双层护套（3,13）释放支架移植物的牵引和释放机构。绑定后，支架主体（8）和支架支架（11）可移动地并整体地位于双层护套（3,13）内。支架主体（8）与控制引导组件连接，并被控制引导组件牵引和释放。支架分支（11）由分支引导组件牵引并与控制引导组件连接，以便由控制引导组件释放。

6. 发明授权

US09421254B2 Immunostimulatory combinations of TLR ligands and methods of use 有权
标题翻译： TLR配体的免疫刺激组合和使用方法
公开(公告)号：US09421254B2
公开(公告)日：2016-08-23
申请号：US12679881
申请日：2008-09-24
申请人： Jay A. Berzofsky , Qing Zhu , Igor Belyakov
发明人： Jay A. Berzofsky , Qing Zhu , Igor Belyakov
IPC分类号： A61K39/00 , A61K39/38 , A61K45/00 , A61K51/00 , A61K39/39
CPC分类号： A61K39/39 , A61K39/21 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C12N7/00 , C12N2740/16034 , Y02A50/394
摘要： The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions.
摘要翻译：本发明提供了TLR配体的免疫刺激组合以及治疗和/或预防方法，其包括对受试者施用免疫刺激组合。通常，与其它免疫刺激组合和/或组合物相比，本文所述的免疫刺激组合可以提供增加的免疫应答。

7. 发明申请

US20150046249A1 METHOD AND SYSTEM FOR MEASURING WEB ADVERTISING EFFECT BASED ON MULTIPLE-CONTACT ATTRIBUTION MODEL 审中-公开
标题翻译：基于多联接引导模型测量网页广告效果的方法与系统
公开(公告)号：US20150046249A1
公开(公告)日：2015-02-12
申请号：US14386389
申请日：2012-07-25
申请人： Guosheng Qi , Kaiduo He , Jian Huang , Wentao Zhang , Qing Zhu , Yongjian Huang
发明人： Guosheng Qi , Kaiduo He , Jian Huang , Wentao Zhang , Qing Zhu , Yongjian Huang
IPC分类号： G06Q30/02 , G06F17/30
CPC分类号： G06Q30/0242 , G06F16/2365 , G06F16/283 , G06Q30/0241 , G06Q50/00
摘要： The disclosure discloses a method and a system for measuring a web advertising effect based on a multiple-contact attribution model. The method comprises: collecting user access information and purchase transformation information of a website, and uploading the user access information and purchase transformation information to a server side; cleaning data for the user access information and the purchase transformation information on a server side; calculating contact contribution value data and importing the contribution value serving as fundamental metrics and contact information serving as dimensionalities into OLAP database, and aggregating data. The method and the system can help an advertiser to understand actual web advertising effect from a number of perspectives to accurately measure underestimated or overestimated channel value in conventional methods, thereby providing the most accurate data support for optimizing web advertising and improving rate of return on investment.
摘要翻译：本公开公开了一种基于多重联系归属模型来测量网络广告效果的方法和系统。该方法包括：收集用户访问信息和购买网站的转换信息，并将用户访问信息上传并购买转换信息到服务器端; 在服务器侧清理用户访问信息和购买转换信息的数据; 计算接触贡献值数据，并将用作维度的基本度量和联系人信息的贡献值导入到OLAP数据库中，并聚合数据。该方法和系统可以帮助广告客户从多个角度了解实际的网络广告效果，以准确测量传统方法中的低估或过高估计的渠道价值，从而为优化网络广告和提高投资回报率提供最准确的数据支持。

8. 发明申请

US20120156235A1 Antibodies Against And Methods For Producing Vaccines For Respiratory Syncytial Virus 有权
标题翻译：针对呼吸道合胞病毒生产疫苗的抗体和方法
公开(公告)号：US20120156235A1
公开(公告)日：2012-06-21
申请号：US13147051
申请日：2009-12-23
申请人： Josephine McAuliffe , Frances Palmer-Hill , Qing Zhu , Joann Suzich
发明人： Josephine McAuliffe , Frances Palmer-Hill , Qing Zhu , Joann Suzich
IPC分类号： A61K39/12 , C07K14/00 , A61P37/04 , C07K14/765 , A61K38/16 , A61P31/12 , G01N33/566 , C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18551 , G01N33/6854
摘要： The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.
摘要翻译：本发明涉及新型呼吸道合胞病毒（RSV）F肽及其组合物。本发明还涉及评估结合F肽的抗RSV抗体的方法。本发明还涉及免疫特异性结合本发明的F肽的抗体。本发明还提供了用于预防，中和，治疗RSV感染的F肽和/或免疫特异性结合F肽的抗体的方法和方案。此外，本发明的方法可用于治疗，预防和改善与RSV感染相关的症状。

9. 发明申请

US20110124124A1 ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 有权
标题翻译：用压电微型传感器增强检测灵敏度
公开(公告)号：US20110124124A1
公开(公告)日：2011-05-26
申请号：US12921756
申请日：2009-03-04
申请人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
发明人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
IPC分类号： G01N33/53 , B01J19/00
CPC分类号： G01N29/2437 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezoelectric microcantilever sensor or a combination of binding and application of a DC bias electric field Significantly enhanced detection sensitivity results from the changed Young's modulus of the piezoelectric layer.
摘要翻译：一种提高压电微悬臂梁传感器检测灵敏度的方法。该方法可以包括提供压电微悬臂梁并在感兴趣的物种的检测期间引起杨氏模量的变化。杨氏模量的变化可以通过向压电层施加直流偏压电场而引起或增强，这增强了压电层的非180°极化域切换。杨氏模量的变化也可以由感兴趣的物质与压电微悬臂梁传感器的结合或直流偏置电场的结合和施加的组合引起。显着增强的检测灵敏度来自压电层的改变的杨氏模量。

10. 发明申请

US20100017895A1 Small animal model for hcv replication 审中-公开
标题翻译： hcv复制的小动物模型
公开(公告)号：US20100017895A1
公开(公告)日：2010-01-21
申请号：US11989047
申请日：2006-07-15
申请人： Amy Weiner , Sharon Lea Aukerman , Dirk Mendel , Qing Zhu
发明人： Amy Weiner , Sharon Lea Aukerman , Dirk Mendel , Qing Zhu
IPC分类号： A01K67/027 , A61K38/21 , C12N5/10
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0393 , A61K38/00
摘要： An animal model for HCV replication and/or production of virus or virus like particles is provided. The invention utilizes an HCV replicon present in a cell to deliver HCV nucleic acid and replicate and express HCV proteins in an animal model comprising an animal that has been immunocompromised. The invention further provides a method of treatment or prevention of HCV in a mammal which comprises administering to the mammal a combination which comprises an immunomodulatory compound and another antiviral agent. Also provided are cell lines showing a decreased sensitivity to interferon alpha or some other immunomodulator and methods of making or isolating such cell lines.
摘要翻译：提供了用于HCV复制和/或产生病毒或病毒样颗粒的动物模型。本发明利用存在于细胞中的HCV复制子来递送HCV核酸，并在包含已经免疫受损的动物的动物模型中复制和表达HCV蛋白。本发明进一步提供了哺乳动物治疗或预防HCV的方法，其包括向哺乳动物施用包含免疫调节化合物和另一抗病毒剂的组合。还提供了显示对干扰素α或一些其它免疫调节剂的敏感性降低的细胞系以及制备或分离这些细胞系的方法。

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