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1. 发明授权

US10670566B2 Rapid antimicrobial susceptibility testing using piezoelectric sensor 审中-公开
公开(公告)号：US10670566B2
公开(公告)日：2020-06-02
申请号：US15777750
申请日：2016-11-18
申请人： Wan Y. Shih , Wei-Heng Shih , Christopher Emery , Xin Xu , Suresh Joshi , Wei Wu
发明人： Wan Y. Shih , Wei-Heng Shih , Christopher Emery , Xin Xu , Suresh Joshi , Wei Wu
IPC分类号： C12Q1/18 , G01N29/12 , G01N29/036 , G01N29/02
摘要： A system for and method of antimicrobial susceptibility testing includes detecting a resonance peak of a sensor provided with live microbes on a surface thereof; applying a substance to the live microbes; detecting a resonance peak of said sensor after application of said substance; determining a width of a top of each of said resonance peaks before and after application of the substance from one of: (1) a phase angle versus frequency plot where the phase angle is the phase angle of the electrical impedance of said sensor. (2) a real part of a plot of an electrical impedance versus frequency of said sensor. (3) a plot of a magnitude of electrical impedance versus frequency of said sensor, and (4) a phase angle versus frequency plot where the phase angle is the phase angle between an output voltage and an input voltage of said sensor, and comparing the determined widths of tops of said resonance peaks or standard deviations of the frequency of said resonance peaks to determine antimicrobial susceptibility including the minimum inhibitory concentration (MIC).

2. 发明授权

US10527625B2 Capped and conjugated quantum dots 有权
公开(公告)号：US10527625B2
公开(公告)日：2020-01-07
申请号：US15202710
申请日：2016-07-06
申请人： Wei-Heng Shih , Wan Y. Shih , Giang Au , Ari D. Brooks , Vanlila K. Swami
发明人： Wei-Heng Shih , Wan Y. Shih , Giang Au , Ari D. Brooks , Vanlila K. Swami
IPC分类号： G01N33/551 , G01N33/574 , G01N33/532 , G01N33/58 , B82Y15/00 , C07K16/22 , C07K16/30 , G01N33/533 , B82Y5/00 , B82Y40/00
摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.

3. 发明授权

US10357196B2 Depth measurement in tissue using piezoelectric sensors having different probe sizes 有权
公开(公告)号：US10357196B2
公开(公告)日：2019-07-23
申请号：US15109860
申请日：2015-01-07
申请人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
发明人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
IPC分类号： A61B5/00 , A61B5/107
摘要： An apparatus and method for determining the depth of an object below a surface or the thickness of the dermis. The apparatus and method use a plurality of piezoelectric fingers having probes with differently sized contact areas. A plurality of measurements is taken using each of the probes with differently sized contact areas in order to determine the depth of an object below a surface or the thickness of the dermis.

4. 发明授权

US09846161B2 Water soluble nanocrystalline quantum dots capable of near infrared emissions 有权
公开(公告)号：US09846161B2
公开(公告)日：2017-12-19
申请号：US14484519
申请日：2014-09-12
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Ian McDonald , Andrew Kopek , Ryan O'Malley , Yu-Chieh Lu
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Ian McDonald , Andrew Kopek , Ryan O'Malley , Yu-Chieh Lu
IPC分类号： G01N33/58 , C01B17/20 , B82Y15/00 , B82Y5/00 , G01N33/532
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N33/532 , Y10S977/774
摘要： A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the range of 750 nm to 1100 nm. The quantum dots may be enabled for bioconjugation and may be used in a method for tissue imaging and analyte detection.

5. 发明申请

US20160356769A1 Piezoelectric Plate Sensor and Uses Thereof 审中-公开
标题翻译：压电板传感器及其用途
公开(公告)号：US20160356769A1
公开(公告)日：2016-12-08
申请号：US15101788
申请日：2014-12-19
申请人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
发明人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
IPC分类号： G01N33/543 , G01N29/036 , G01N29/02 , C12Q1/68
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N29/022 , G01N29/036 , G01N33/54393 , G01N2291/0255 , G01N2291/0256 , G01N2291/0427 , C12Q2565/607
摘要： A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.
摘要翻译：一种压电板传感器，包括压电层; 两个电极和绝缘层。通过将压电层和两个电极浸入0.1V / V的水中的巯基丙基三甲氧基硅烷溶液中来制备绝缘层。％至约1v / v％和约8至约150的pH约8至约15小时，巯基丙基三甲氧基硅烷溶液具有约0.01v / v％至约0.5v / v的巯基丙基三甲氧基硅烷浓度％。还提供了使用压电板传感器检测样品中生物分子的方法，特别是在不需要DNA分离或扩增的情况下用PCR灵敏度和特异性检测遗传标记物的方法。压电板传感器可用于诊断包括乳腺癌，心肌梗死，腹泻，艰难梭菌感染和乙型肝炎感染在内的各种疾病。

6. 发明申请

US20150025418A1 SYSTEM AND METHOD FOR EVALUATING TISSUE 审中-公开
标题翻译：用于评估组织的系统和方法
公开(公告)号：US20150025418A1
公开(公告)日：2015-01-22
申请号：US14465520
申请日：2014-08-21
申请人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
发明人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
IPC分类号： A61B5/00
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
摘要翻译：用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种形式的癌症。此外，PEFS系统可用于各种皮肤病学应用。

7. 发明申请

US20140352448A1 ALL ELECTRIC PIEZOELECTRIC FINGER SENSOR (PEFS) FOR SOFT MATERIAL STIFFNESS MEASUREMENT 审中-公开
标题翻译：用于软质材料强度测量的所有电动压电手指传感器（PEFS）
公开(公告)号：US20140352448A1
公开(公告)日：2014-12-04
申请号：US14459993
申请日：2014-08-14
申请人： WAN Y. SHIH , WEI-HENG SHIH , ANNA MARKIDOU , STEVEN T. SZWECZYK , HAKKI YEGINGIL
发明人： WAN Y. SHIH , WEI-HENG SHIH , ANNA MARKIDOU , STEVEN T. SZWECZYK , HAKKI YEGINGIL
IPC分类号： G01N33/483 , A61B5/00 , G01N3/08 , G01N3/24 , G01N19/00 , G01L1/16
CPC分类号： G01N33/4833 , A61B5/0053 , A61B5/0057 , A61B5/4312 , A61B5/441 , A61B5/442 , A61B5/444 , A61B2562/0247 , A61B2562/046 , G01L1/16 , G01N3/08 , G01N3/24 , G01N19/00 , G01N2203/0025 , G01N2203/0089 , G01N2203/0094
摘要： A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-held device is also disclosed. The PEF offers superior sensitivity.
摘要翻译： PEFS（压电手指传感器）充当“电子手指”，可以对表面轻柔的接触的组织的杨氏压缩模量和剪切模量进行精确和非破坏性的测量。 PEFS测量组织中的杨氏压缩模量和剪切模量变化，产生小于1毫米的空间分辨率，直到几厘米的深度。这为疾病的体内早期检测提供了巨大的潜力。还公开了便携式手持装置。 PEF提供卓越的灵敏度。

8. 发明授权

US08491818B2 Synthesis of water soluble non-toxic nanocrystalline quantum dots and uses thereof 有权
标题翻译：水溶性无毒纳米晶量子点的合成及其用途
公开(公告)号：US08491818B2
公开(公告)日：2013-07-23
申请号：US11943790
申请日：2007-11-21
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li
IPC分类号： C09K11/70 , C09K11/72 , C09K11/77 , C09K11/54 , C09K11/56
CPC分类号： C09K11/565 , B82Y30/00 , C01G9/08 , C01G11/02 , C01P2002/72 , C01P2002/82 , C01P2002/84 , C01P2004/04 , C01P2004/64 , C01P2006/22 , C01P2006/60 , Y10T428/2982
摘要： An economic, direct synthetic method for producing water soluble ZnS QDs that are ready for bioconjugation is provided. The method can produce aqueous ZnS QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. The aqueous ZnS QDs are stable in biological fluids over a long period of time. In addition, non-toxic ZnS QDs have been produced with good photoluminescence properties.
摘要翻译：提供了一种用于生产可用于生物共轭的水溶性ZnS量子点的经济，直接的合成方法。该方法可以产生发射波长从400nm到700nm变化的ZnS量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。 ZnS量子点在长时间内在生物体液中是稳定的。此外，已经生产具有良好的光致发光性质的无毒ZnS量子点。

9. 发明授权

US08080229B2 Water soluble nanocrystalline quantum dots 有权
标题翻译：水溶性纳米晶体量子点
公开(公告)号：US08080229B2
公开(公告)日：2011-12-20
申请号：US13155141
申请日：2011-06-07
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
IPC分类号： C01B17/20 , C01G21/21 , C01G11/02 , C01G9/08 , C01G45/00
CPC分类号： C09K11/565 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C09K11/883 , Y10S977/774
摘要： An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
摘要翻译：提供了一种用于生产水溶性量子点的经济，直接的合成方法，可用于生物共轭。该方法可以产生发射波长从400nm到700nm变化的含水量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。水质量子在长时间内在生物体液中是稳定的。此外，通过在一段时间内回流ZnS QD悬浮液，已经生产出具有良好光致发光性质的无毒ZnS量子点。

10. 发明授权

US08033185B2 All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement 有权
标题翻译：所有电动压电手指传感器（PEFS）用于软质材料刚度测量
公开(公告)号：US08033185B2
公开(公告)日：2011-10-11
申请号：US12837590
申请日：2010-07-16
申请人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
发明人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
IPC分类号： G01L1/04
CPC分类号： G01N33/4833 , A61B5/0053 , A61B5/0057 , A61B5/4312 , A61B5/441 , A61B5/442 , A61B5/444 , A61B2562/0247 , A61B2562/046 , G01L1/16 , G01N3/08 , G01N3/24 , G01N19/00 , G01N2203/0025 , G01N2203/0089 , G01N2203/0094
摘要： A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-held device is also disclosed. The PEF offers superior sensitivity.
摘要翻译： PEFS（压电手指传感器）充当“电子手指”，可以对表面轻柔的接触的组织的杨氏压缩模量和剪切模量进行精确和非破坏性的测量。 PEFS测量组织中的杨氏压缩模量和剪切模量变化，产生小于1毫米的空间分辨率，直到几厘米的深度。这为疾病的体内早期检测提供了巨大的潜力。还公开了便携式手持装置。 PEF提供卓越的灵敏度。

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