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1. 发明申请

US20100017895A1 Small animal model for hcv replication 审中-公开
标题翻译： hcv复制的小动物模型
公开(公告)号：US20100017895A1
公开(公告)日：2010-01-21
申请号：US11989047
申请日：2006-07-15
申请人： Amy Weiner , Sharon Lea Aukerman , Dirk Mendel , Qing Zhu
发明人： Amy Weiner , Sharon Lea Aukerman , Dirk Mendel , Qing Zhu
IPC分类号： A01K67/027 , A61K38/21 , C12N5/10
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0393 , A61K38/00
摘要： An animal model for HCV replication and/or production of virus or virus like particles is provided. The invention utilizes an HCV replicon present in a cell to deliver HCV nucleic acid and replicate and express HCV proteins in an animal model comprising an animal that has been immunocompromised. The invention further provides a method of treatment or prevention of HCV in a mammal which comprises administering to the mammal a combination which comprises an immunomodulatory compound and another antiviral agent. Also provided are cell lines showing a decreased sensitivity to interferon alpha or some other immunomodulator and methods of making or isolating such cell lines.
摘要翻译：提供了用于HCV复制和/或产生病毒或病毒样颗粒的动物模型。本发明利用存在于细胞中的HCV复制子来递送HCV核酸，并在包含已经免疫受损的动物的动物模型中复制和表达HCV蛋白。本发明进一步提供了哺乳动物治疗或预防HCV的方法，其包括向哺乳动物施用包含免疫调节化合物和另一抗病毒剂的组合。还提供了显示对干扰素α或一些其它免疫调节剂的敏感性降低的细胞系以及制备或分离这些细胞系的方法。

2. 发明授权

US09421254B2 Immunostimulatory combinations of TLR ligands and methods of use 有权
标题翻译： TLR配体的免疫刺激组合和使用方法
公开(公告)号：US09421254B2
公开(公告)日：2016-08-23
申请号：US12679881
申请日：2008-09-24
申请人： Jay A. Berzofsky , Qing Zhu , Igor Belyakov
发明人： Jay A. Berzofsky , Qing Zhu , Igor Belyakov
IPC分类号： A61K39/00 , A61K39/38 , A61K45/00 , A61K51/00 , A61K39/39
CPC分类号： A61K39/39 , A61K39/21 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C12N7/00 , C12N2740/16034 , Y02A50/394
摘要： The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions.
摘要翻译：本发明提供了TLR配体的免疫刺激组合以及治疗和/或预防方法，其包括对受试者施用免疫刺激组合。通常，与其它免疫刺激组合和/或组合物相比，本文所述的免疫刺激组合可以提供增加的免疫应答。

3. 发明授权

US08961587B2 Branched stent graft 有权
标题翻译：支支架移植
公开(公告)号：US08961587B2
公开(公告)日：2015-02-24
申请号：US13254010
申请日：2010-03-17
申请人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
发明人： Qing Zhu , Qiyi Luo , Zhenyu Yuan
IPC分类号： A61F2/06 , A61F2/07 , A61F2/82 , A61F2/89
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2002/826 , A61F2220/0075
摘要： A branched stent graft comprises a main body portion and a branch portion. Each of the main body portion and the branch portion includes a stent and a tubular graft. The stent of the main body portion includes a plurality of stent segments, at least one of which is a varying-height stent segment (102). The stent of the branch portion includes one or more stent segments, at least one of which is a varying-height stent segment (103). The distance between the proximal-most stent segment of the branch portion and the main body portion is in the range of 2-8 mm. A positioning ring (105) may be used at a side opening which connects the branch portion and the main body portion, and the positioning ring (105) can be sutured inside the graft of the main body, between the graft of the main body and the graft of the branch, or outside the graft of the branch.
摘要翻译：分支支架移植物包括主体部分和分支部分。主体部分和分支部分中的每一个包括支架和管状移植物。主体部分的支架包括多个支架段，其中至少一个是变高高度支架段（102）。分支部分的支架包括一个或多个支架段，其中至少一个是变高高度支架段（103）。分支部的最近侧的支架段与主体部之间的距离在2-8mm的范围内。可以在连接分支部和主体部的侧开口处使用定位环（105），并且可以在主体的移植物之间，在主体的移植物之间缝合定位环（105），并将定位环分支的移植物，或分支的移植物外。

4. 发明申请

US20150046249A1 METHOD AND SYSTEM FOR MEASURING WEB ADVERTISING EFFECT BASED ON MULTIPLE-CONTACT ATTRIBUTION MODEL 审中-公开
标题翻译：基于多联接引导模型测量网页广告效果的方法与系统
公开(公告)号：US20150046249A1
公开(公告)日：2015-02-12
申请号：US14386389
申请日：2012-07-25
申请人： Guosheng Qi , Kaiduo He , Jian Huang , Wentao Zhang , Qing Zhu , Yongjian Huang
发明人： Guosheng Qi , Kaiduo He , Jian Huang , Wentao Zhang , Qing Zhu , Yongjian Huang
IPC分类号： G06Q30/02 , G06F17/30
CPC分类号： G06Q30/0242 , G06F16/2365 , G06F16/283 , G06Q30/0241 , G06Q50/00
摘要： The disclosure discloses a method and a system for measuring a web advertising effect based on a multiple-contact attribution model. The method comprises: collecting user access information and purchase transformation information of a website, and uploading the user access information and purchase transformation information to a server side; cleaning data for the user access information and the purchase transformation information on a server side; calculating contact contribution value data and importing the contribution value serving as fundamental metrics and contact information serving as dimensionalities into OLAP database, and aggregating data. The method and the system can help an advertiser to understand actual web advertising effect from a number of perspectives to accurately measure underestimated or overestimated channel value in conventional methods, thereby providing the most accurate data support for optimizing web advertising and improving rate of return on investment.
摘要翻译：本公开公开了一种基于多重联系归属模型来测量网络广告效果的方法和系统。该方法包括：收集用户访问信息和购买网站的转换信息，并将用户访问信息上传并购买转换信息到服务器端; 在服务器侧清理用户访问信息和购买转换信息的数据; 计算接触贡献值数据，并将用作维度的基本度量和联系人信息的贡献值导入到OLAP数据库中，并聚合数据。该方法和系统可以帮助广告客户从多个角度了解实际的网络广告效果，以准确测量传统方法中的低估或过高估计的渠道价值，从而为优化网络广告和提高投资回报率提供最准确的数据支持。

5. 发明申请

US20120156235A1 Antibodies Against And Methods For Producing Vaccines For Respiratory Syncytial Virus 有权
标题翻译：针对呼吸道合胞病毒生产疫苗的抗体和方法
公开(公告)号：US20120156235A1
公开(公告)日：2012-06-21
申请号：US13147051
申请日：2009-12-23
申请人： Josephine McAuliffe , Frances Palmer-Hill , Qing Zhu , Joann Suzich
发明人： Josephine McAuliffe , Frances Palmer-Hill , Qing Zhu , Joann Suzich
IPC分类号： A61K39/12 , C07K14/00 , A61P37/04 , C07K14/765 , A61K38/16 , A61P31/12 , G01N33/566 , C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18551 , G01N33/6854
摘要： The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.
摘要翻译：本发明涉及新型呼吸道合胞病毒（RSV）F肽及其组合物。本发明还涉及评估结合F肽的抗RSV抗体的方法。本发明还涉及免疫特异性结合本发明的F肽的抗体。本发明还提供了用于预防，中和，治疗RSV感染的F肽和/或免疫特异性结合F肽的抗体的方法和方案。此外，本发明的方法可用于治疗，预防和改善与RSV感染相关的症状。

6. 发明申请

US20110124124A1 ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 有权
标题翻译：用压电微型传感器增强检测灵敏度
公开(公告)号：US20110124124A1
公开(公告)日：2011-05-26
申请号：US12921756
申请日：2009-03-04
申请人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
发明人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
IPC分类号： G01N33/53 , B01J19/00
CPC分类号： G01N29/2437 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezoelectric microcantilever sensor or a combination of binding and application of a DC bias electric field Significantly enhanced detection sensitivity results from the changed Young's modulus of the piezoelectric layer.
摘要翻译：一种提高压电微悬臂梁传感器检测灵敏度的方法。该方法可以包括提供压电微悬臂梁并在感兴趣的物种的检测期间引起杨氏模量的变化。杨氏模量的变化可以通过向压电层施加直流偏压电场而引起或增强，这增强了压电层的非180°极化域切换。杨氏模量的变化也可以由感兴趣的物质与压电微悬臂梁传感器的结合或直流偏置电场的结合和施加的组合引起。显着增强的检测灵敏度来自压电层的改变的杨氏模量。

7. 发明授权

US07450848B2 High-speed fiber-to-the-premise optical communication system 有权
标题翻译：高速光纤到户内光通信系统
公开(公告)号：US07450848B2
公开(公告)日：2008-11-11
申请号：US11413405
申请日：2006-04-28
申请人： Wen Li , Qing Zhu
发明人： Wen Li , Qing Zhu
IPC分类号： H04J14/00
CPC分类号： H04J14/02 , H04J14/0226 , H04J14/0227 , H04J14/0246 , H04J14/025 , H04J14/0282
摘要： An optical communication system including a plurality of transceiver ports each including a transmitter configured to produce a downstream MLM-spectrum signal and a receiver configured to receive an upstream spectrum-sliced signal. The spectrum of the downstream MLM-spectrum signal comprises a plurality of distinct narrow-spectrum peaks each corresponding to a longitudinal mode. The optical communication system also includes a wavelength filter that includes a plurality of branching ports each associated with a specific wavelength channel, wherein each of the branching ports is in connection with a transceiver port and is configured to receive the downstream MLM-spectrum signal from the transmitter and send an upstream spectrum-sliced signal to the receiver, and a common port configured to output a downstream spectrum-sliced signal in response to the downstream MLM-spectrum signal, wherein the spectrum of the downstream spectrum-sliced signal is located in a wavelength channel specifically associated with the branching port at which the downstream MLM-spectrum signal is received.
摘要翻译：一种光通信系统，包括多个收发器端口，每个收发器端口包括被配置为产生下游MLM频谱信号的发射机和被配置为接收上行频谱切片信号的接收机。下游MLM频谱信号的频谱包括多个不同的窄谱峰，每个峰对应于纵向模式。光通信系统还包括波长滤波器，其包括多个分支端口，每个分支端口与特定波长信道相关联，其中每个分支端口与收发器端口连接，并且被配置为从该收发器端口接收下游MLM频谱信号发送并向接收机发送上行频谱分片信号，以及公共端口，配置为响应于下游MLM频谱信号输出下行频谱分片信号，其中下行频谱分片信号的频谱位于与接收下游MLM频谱信号的分支端口特别相关的波长信道。

8. 发明授权

US07416840B2 Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells 有权
标题翻译：在非肝上皮和小鼠肝细胞中复制丙型肝炎病毒
公开(公告)号：US07416840B2
公开(公告)日：2008-08-26
申请号：US10536955
申请日：2003-12-12
申请人： Qing Zhu , Ju-Tao Guo , Christoph Seeger
发明人： Qing Zhu , Ju-Tao Guo , Christoph Seeger
IPC分类号： C12Q1/70 , C12N5/10 , C12N15/87
CPC分类号： C12N7/00 , C07K14/005 , C12N2770/24051 , C12N2770/24221 , C12N2770/24222 , G01N2333/18 , G01N2500/10
摘要： Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection.
摘要翻译：公开了复制非肝人和非人源HCV的细胞和细胞系。还提供了使用这种细胞和细胞系鉴定用于治疗HCV感染的抗HCV药物的方法。

9. 发明授权

US07317874B2 Adaptive optical transceiver for fiber access communications 有权
标题翻译：用于光纤接入通信的自适应光收发器
公开(公告)号：US07317874B2
公开(公告)日：2008-01-08
申请号：US11446276
申请日：2006-06-02
申请人： Wen Li , Qing Zhu
发明人： Wen Li , Qing Zhu
IPC分类号： H04J14/00
CPC分类号： H04B10/506 , H04J14/02 , H04J14/0226 , H04J14/0227 , H04J14/0246 , H04J14/025 , H04J14/0282
摘要： An optical module includes a transmitter optical sub-assembly comprising a transmitter configured to emit a multi-longitudinal-mode (MLM) spectrum signal having an emission spectrum comprising a plurality of distinct narrow-spectrum peaks each corresponding to a longitudinal mode in the transmitter. The emission spectrum can be shifted in wavelength by a change in the transmitter temperature. The optical module also includes a heating and cooling device configured to control the temperature of the transmitter in response to a temperature-control signal and a receiver optical sub-assembly configured to output a pair of differential digital signals in response to an input optical signal.
摘要翻译：光学模块包括发射机光学子组件，发射机光学子组件包括被配置为发射具有发射光谱的多纵向模式（MLM）频谱信号的发射机，发射光谱包括多个不同的窄谱峰值，每个窄谱峰值对应于发射机中的纵向模式。发射光谱可以通过发射器温度的变化在波长上移动。光学模块还包括加热和冷却装置，其被配置为响应于温度控制信号控制发射器的温度，并且接收器光学子组件被配置为响应于输入光信号输出一对差分数字信号。

10. 发明申请

US20060128011A1 Replication of hepatitis c virus in non-hepatic epithelial and mouse hepatic cells 有权
标题翻译：在非肝上皮和小鼠肝细胞中复制丙型肝炎病毒
公开(公告)号：US20060128011A1
公开(公告)日：2006-06-15
申请号：US10536955
申请日：2003-12-12
申请人： Qing Zhu , Ju-Tao Guo , Christoph Seeger
发明人： Qing Zhu , Ju-Tao Guo , Christoph Seeger
IPC分类号： C12Q1/68 , C12N7/00 , C12N5/00 , C12N7/01 , C12N5/02
CPC分类号： C12N7/00 , C07K14/005 , C12N2770/24051 , C12N2770/24221 , C12N2770/24222 , G01N2333/18 , G01N2500/10
摘要： Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection.
摘要翻译：公开了复制非肝人和非人源HCV的细胞和细胞系。还提供了使用这种细胞和细胞系鉴定用于治疗HCV感染的抗HCV药物的方法。

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