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1. 发明申请

US20070043203A1 Copolyetherimides 有权
标题翻译：共聚酰亚胺
公开(公告)号：US20070043203A1
公开(公告)日：2007-02-22
申请号：US11210164
申请日：2005-08-22
申请人： Qing Ye , David Hall , William Richards , Daniel Brunelle , Havva Acar
发明人： Qing Ye , David Hall , William Richards , Daniel Brunelle , Havva Acar
IPC分类号： C08G69/08
CPC分类号： C08G73/1046 , C08G73/124
摘要： Copolyetherimides compositions having high glass transition temperatures and outstanding ductility are presented. The copolyetherimides having Mw of at least 40,000 comprising isomeric bis(phthalimide) structural units within a relatively narrow range of isomer proportions exhibited Tgs of at least 240° C. and outstanding Notched Izod values. The copolyetherimides comprise oxydianiline residues and structural units of the formulas (I) and (II) (III). The copolyetherimides are characterized by a mole percentage of structural units derived from 4,4′-biphenol in a range from about 55% to about 85% of all bisphenol-derived structural units present in the copolyetherimide composition; a mole percentage of structural units derived from bisphenol A in a range from about 45% to about 15% of all bisphenol-derived structural units present in the copolyetherimide composition; and a total mole percentage of structural units derived from bisphenol A or 4,4′-biphenol of at least 95% of all bisphenol-derived structural units present in the copolyetherimide composition.
摘要翻译：提出了具有高玻璃化转变温度和优异延展性的共聚酰亚胺组合物。具有至少40,000的含有异构双（邻苯二甲酰亚胺）结构单元的异构体双组分（邻苯二甲酰亚胺）结构单元的共聚醚酰亚胺具有至少240℃的Tg和优异的缺口伊佐德值。共聚醚酰亚胺包括氧化二苯胺残基和式（I）和（II）（III）的结构单元。共聚醚酰亚胺的特征在于衍生自4,4'-联苯酚的结构单元的百分比在共聚醚酰亚胺组合物中存在的所有双酚衍生的结构单元的约55％至约85％的范围内; 来自双酚A的结构单元的摩尔百分比在存在于共聚醚酰亚胺组合物中的所有双酚衍生的结构单元的约45％至约15％的范围内; 并且衍生自双酚A或4,4'-联苯酚的结构单元的总摩尔百分比为存在于共聚醚酰亚胺组合物中的所有双酚衍生的结构单元的至少95％。

2. 发明授权

US08609023B1 Memory management method and apparatus for automated biological reaction system 有权
标题翻译：用于自动生物反应系统的记忆管理方法和装置
公开(公告)号：US08609023B1
公开(公告)日：2013-12-17
申请号：US09571989
申请日：2000-05-16
申请人： Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： G01N21/00
CPC分类号： G01N35/1002 , G01N1/312 , G01N35/1016 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/25 , Y10T436/2575
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of liquid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of liquid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的液体一直放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被移除，并且通过分配器的液体流被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

3. 发明授权

US08137619B2 Memory management method and apparatus for automated biological reaction system 有权
标题翻译：用于自动生物反应系统的记忆管理方法和装置
公开(公告)号：US08137619B2
公开(公告)日：2012-03-20
申请号：US11234726
申请日：2005-09-23
申请人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Roberta Druyor-Sanchez , Bronwen Heilman , Wayne Showalter
发明人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Roberta Druyor-Sanchez , Bronwen Heilman , Wayne Showalter
IPC分类号： G01N21/00 , G01N35/00 , G01N21/75 , G01N1/00
CPC分类号： G01N35/00732 , G01N1/31 , G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2035/00673 , G01N2035/00782 , G01N2035/00811 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/25 , Y10T436/2575
摘要： A reagent management system for an automated biological reaction apparatus including an automated biological reaction apparatus including at least one reagent dispenser for applying a reagent to a sample, a memory device containing data for a reagent device selected from the group consisting of a reagent dispenser or a reagent kit used in the automated biological reaction apparatus, a host device comprising a processor and a host device memory connected to the processor, the host memory device including a reagent table, and a scanner for transferring the memory device data to the host device memory.
摘要翻译：一种用于自动化生物反应装置的试剂管理系统，其包括自动化生物反应装置，其包括至少一个试剂分配器，用于向样品施加试剂;存储装置，其含有试剂装置的数据，所述试剂装置选自试剂分配器或用于自动生物反应装置中的试剂盒，主机装置，包括处理器和连接到处理器的主机设备存储器，主机存储器装置包括试剂台以及用于将存储器件数据传送到主机设备存储器的扫描器。

4. 发明申请

US20110168744A1 METHOD AND APPARATUS FOR MODIFYING PRESSURE WITHIN A FLUID DISPENSER 有权
标题翻译：用于在流体分配器中调节压力的方法和装置
公开(公告)号：US20110168744A1
公开(公告)日：2011-07-14
申请号：US13050707
申请日：2011-03-17
申请人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： B67D7/06
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
摘要翻译：一种流体分配器，包括具有储存室的桶，所述桶具有上部，连接到储存室的盖，所述盖具有带有至少一个孔的表面，包括偏置构件和孔封闭器的阀，阀邻近储存室，具有分配室的联接器和位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。

5. 发明授权

US07618807B2 Apparatus for electrophoretic in situ tissue staining 有权
标题翻译：电泳原位组织染色装置
公开(公告)号：US07618807B2
公开(公告)日：2009-11-17
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42 , C12M3/00
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

6. 发明授权

US07396508B1 Automated molecular pathology apparatus having independent slide heaters 有权
标题翻译：具有独立滑动加热器的自动分子病理装置
公开(公告)号：US07396508B1
公开(公告)日：2008-07-08
申请号：US09614401
申请日：2000-07-12
申请人： William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
发明人： William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
IPC分类号： G01N31/00 , G01N1/10 , G01N35/02 , G01N35/10 , B01L3/02
CPC分类号： G01N1/312 , B01L7/00 , G01N15/0255 , G01N2035/00366 , Y10T436/11 , Y10T436/111666 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.
摘要翻译：提供了用于自动染色或处理安装在显微镜载玻片上的多个组织样品的装置和方法。个体化的滑块温度控制由根据本发明的加热系统实现，其具有径向安装到转盘上的热平台，用于加热滑块并感测每个的温度。如果需要，加热系统还允许自动脱蜡。

7. 发明申请

US20070086917A1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS 审中-公开
标题翻译：具有固定滑动平台的自动分子病理学设备
公开(公告)号：US20070086917A1
公开(公告)日：2007-04-19
申请号：US11558257
申请日：2006-11-09
申请人： Charles LEMME , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
发明人： Charles LEMME , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
IPC分类号： G01N33/00
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。

8. 发明申请

US20060093520A1 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US20060093520A1
公开(公告)日：2006-05-04
申请号：US11293489
申请日：2005-12-02
申请人： Charles Lemme , William Richards , Wayne Showalter
发明人： Charles Lemme , William Richards , Wayne Showalter
IPC分类号： G01N35/00
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤溶液带到载玻片上。

9. 发明授权

US06945128B2 Fluid dispenser 有权
标题翻译：流体分配器
公开(公告)号：US06945128B2
公开(公告)日：2005-09-20
申请号：US09896649
申请日：2001-06-29
申请人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Wayne Showalter , Bobbi Druyor-Sanchez , Bronwen Heilman , Brian McGraw
发明人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Wayne Showalter , Bobbi Druyor-Sanchez , Bronwen Heilman , Brian McGraw
IPC分类号： G01N1/00 , A47K5/12 , B67D7/06 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/10 , B01L3/02
CPC分类号： G01N35/1016 , G01N1/312 , G01N35/00871 , G01N35/1002 , G01N2001/317 , G01N2035/00881 , G01N2035/1034 , Y10T137/7873 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

10. 发明申请

US20050202292A1 Portable fuel cell power supply 审中-公开
标题翻译：便携式燃料电池电源
公开(公告)号：US20050202292A1
公开(公告)日：2005-09-15
申请号：US11075892
申请日：2005-03-10
申请人： William Richards , Alan Volker , Jaspal Brar
发明人： William Richards , Alan Volker , Jaspal Brar
IPC分类号： H01M8/04 , H01M8/10
CPC分类号： H01M8/04089 , H01M8/04201 , H01M8/04208 , H01M8/0432 , H01M8/04365 , H01M8/0444 , H01M8/04664 , H01M8/04686 , H01M2008/1095 , H01M2250/30 , Y02B90/18
摘要： A portable proton exchange membrane fuel cell power supply system has a high pressure hydrogen gas supply that is provided from hydrogen storage cylinders that are enclosed in a case that has through holes for ventilation to prevent hydrogen gas concentrations from reaching explosive levels. Enclosed in a second case are a fuel cell stack, control unit, variable speed air compressor and power inverter. The cases incorporate lightweight, high-strength non-metallic materials and foam insulation to render the contents shock resistant. In operation a hydrogen gas connection line is made to extend between the hydrogen cylinders and the fuel cell that is connected through quick disconnect valves. The compressor is also connected to the fuel cell through a quick disconnect valve. Start up of the fuel cell is accomplished with a battery supplying power to the compressor while hydrogen gas is supplied at the same time.
摘要翻译：便携式质子交换膜燃料电池电源系统具有由氢气储存筒提供的高压氢气供应，所述氢气储存缸被封闭在具有用于通风的通孔的壳体中，以防止氢气浓度达到爆炸水平。封闭在第二种情况是燃料电池堆，控制单元，变速空气压缩机和电力逆变器。这些情况包括轻质，高强度非金属材料和泡沫绝缘，使内容物抗冲击。在操作中，氢气连接管线在氢气缸和通过快速断开阀连接的燃料电池之间延伸。压缩机还通过快速断开阀连接到燃料电池。在同时供给氢气的同时，通过向压缩机供电的电池来实现燃料电池的启动。

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